Q9MB95 (1A11_PRUMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-aminocyclopropane-1-carboxylate synthase 1
Short name=ACC synthase 1
EC=4.4.1.14

Alternative name(s):
S-adenosyl-L-methionine methylthioadenosine-lyase

Gene names

Name:

ACS1

Organism

Prunus mume (Japanese apricot) (Armeniaca mume)

Taxonomic identifier

102107 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Rosales › Rosaceae › Maloideae › Amygdaleae › Prunus

Protein attributes

Sequence length	492 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the formation of 1-aminocyclopropane-1-carboxylate, a direct precursor of ethylene in higher plants.
Catalytic activity	S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine.
Cofactor	Pyridoxal phosphate.
Pathway	Alkene biosynthesis; ethylene biosynthesis via S-adenosyl-L-methionine; ethylene from S-adenosyl-L-methionine: step 1/2.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Biological process	Ethylene biosynthesis Fruit ripening
Ligand	Pyridoxal phosphate S-adenosyl-L-methionine
Molecular function	Lyase
Gene Ontology (GO)
Biological process	ethylene biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW ripening Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-aminocyclopropane-1-carboxylate synthase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transferase activity, transferring nitrogenous groups Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 492	492	1-aminocyclopropane-1-carboxylate synthase 1		PRO_0000123918
Amino acid modifications
	Modified residue	277	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9MB95 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 2002047AF2B43D89	FASTA	492	55,066
	10 20 30 40 50 60 MGSSSATANR FLLSKIATSE GHGENSPYFD GWKAYDRNPF HPTKNPEGVI QMGLAENQLS 70 80 90 100 110 120 FDSIEDWIKK NPKASICTPE GVEEFKNVAI FQDYHGFPEF RKAVAMFMSK ARGGRVTFDP 130 140 150 160 170 180 NRVVMSGGAT GANELVMFCL ADPGDAFLVP SPYYPAFFRD LGWRTGVQIV PVDCDSSNNF 190 200 210 220 230 240 KITKEALEAA YEKAQKNNIN VKGLIITNPS NPLGTTLDRN TLESLVEFIN QKNIHLVCDE 250 260 270 280 290 300 IYAATVFSSP TFTCISEVIQ NMNCNPNLIH IVYSLSKDMG LPGLRVGIVY SYNDDVVNIG 310 320 330 340 350 360 RKMSSFGLVS SQTQHMLPSM LLDEEFVARF LETSPKRLAK RHGVFTKGLE EVGINCLKSN 370 380 390 400 410 420 AGLFCWMDLR RLLEDQTFDG EMVLWRVIVN EVGPNVSPGS SFKCVEPGWF RVCFANMDDE 430 440 450 460 470 480 TLEVALKRIR TFVRQGKKAQ DQVVQVKSPK RWKSNLRLSF SSSSTRRFDQ ESVNVLSPHM 490 MSPHSPLVRA KT

References

[1]	"Expression of ACC synthase is enhanced earlier than that of ACC oxidase during fruit ripening of mume (Prunus mume)." Mita S., Kirita C., Kato M., Hyodo H. Physiol. Plantarum 107:319-328(1999) Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB031026 mRNA. Translation: BAA90549.1.
3D structure databases
ProteinModelPortal	Q9MB95.
SMR	Q9MB95. Positions 12-433.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001176. ACC_synthase. IPR004839. Aminotransferase_I/II. IPR004838. NHTrfase_class1_PyrdxlP-BS. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00753. ACCSYNTHASE.
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

1A11_PRUMU

Accession

Primary (citable) accession number: Q9MB95

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	October 1, 2000
Last modified:	October 19, 2011
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program