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Protein

Sulfate transporter 1.2

Gene

SULTR1;2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High-affinity H+/sulfate cotransporter that mediates the uptake of the environmental sulfate by plant roots. Plays a central role in the regulation of sulfate assimilation. Unable to transport molybdate.3 Publications

Miscellaneous

Sel1 mutations in the gene lead to the resistance of the plant to selenate, a toxic analog of sulfate.

Enzyme regulationi

Interaction with OASA1 negatively impacts the transporter activity.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to sulfate starvation Source: TAIR

Keywordsi

Biological processSulfate transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-ATH-174362 Transport and synthesis of PAPS
R-ATH-427601 Multifunctional anion exchangers

Protein family/group databases

TCDBi2.A.53.1.6 the sulfate permease (sulp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate transporter 1.2
Gene namesi
Name:SULTR1;2
Ordered Locus Names:At1g78000
ORF Names:F28K19.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G78000
TAIRilocus:2029396 AT1G78000

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 91CytoplasmicSequence analysisAdd BLAST91
Transmembranei92 – 112HelicalSequence analysisAdd BLAST21
Topological domaini113 – 116ExtracellularSequence analysis4
Transmembranei117 – 137HelicalSequence analysisAdd BLAST21
Topological domaini138 – 141CytoplasmicSequence analysis4
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 173ExtracellularSequence analysisAdd BLAST11
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei195 – 215HelicalSequence analysisAdd BLAST21
Topological domaini216 – 253ExtracellularSequence analysisAdd BLAST38
Transmembranei254 – 274HelicalSequence analysisAdd BLAST21
Topological domaini275 – 280CytoplasmicSequence analysis6
Transmembranei281 – 301HelicalSequence analysisAdd BLAST21
Topological domaini302 – 339ExtracellularSequence analysisAdd BLAST38
Transmembranei340 – 360HelicalSequence analysisAdd BLAST21
Topological domaini361 – 372CytoplasmicSequence analysisAdd BLAST12
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 409ExtracellularSequence analysisAdd BLAST16
Transmembranei410 – 430HelicalSequence analysisAdd BLAST21
Topological domaini431 – 438CytoplasmicSequence analysis8
Transmembranei439 – 459HelicalSequence analysisAdd BLAST21
Topological domaini460 – 466ExtracellularSequence analysis7
Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 653CytoplasmicSequence analysisAdd BLAST166

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi511I → T in sel1-8; reduces drastically sulfate transport activity. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000801731 – 653Sulfate transporter 1.2Add BLAST653

Proteomic databases

PaxDbiQ9MAX3

PTM databases

iPTMnetiQ9MAX3

Expressioni

Tissue specificityi

Expressed in lateral root cap, root hairs, epidermal and cortical cells of roots.1 Publication

Inductioni

In roots by sulfate starvation.1 Publication

Gene expression databases

ExpressionAtlasiQ9MAX3 baseline and differential
GenevisibleiQ9MAX3 AT

Interactioni

Subunit structurei

Homodimer. Interacts with OASA1 through its STAS domain.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
OASA1P479985EBI-8772960,EBI-1633418

Protein-protein interaction databases

BioGridi29354, 4 interactors
IntActiQ9MAX3, 1 interactor
STRINGi3702.AT1G78000.1

Structurei

3D structure databases

ProteinModelPortaliQ9MAX3
SMRiQ9MAX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini522 – 645STASPROSITE-ProRule annotationAdd BLAST124

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236 Eukaryota
COG0659 LUCA
HOGENOMiHOG000199842
InParanoidiQ9MAX3
KOiK17470
OMAiAGQEPIY
OrthoDBiEOG0936049H
PhylomeDBiQ9MAX3

Family and domain databases

Gene3Di3.30.750.24, 1 hit
InterProiView protein in InterPro
IPR030314 High_sul_transp
IPR018045 S04_transporter_CS
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR002645 STAS_dom
IPR036513 STAS_dom_sf
PANTHERiPTHR11814 PTHR11814, 1 hit
PTHR11814:SF65 PTHR11814:SF65, 1 hit
PfamiView protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit
SUPFAMiSSF52091 SSF52091, 1 hit
TIGRFAMsiTIGR00815 sulP, 1 hit
PROSITEiView protein in PROSITE
PS01130 SLC26A, 1 hit
PS50801 STAS, 1 hit

Sequencei

Sequence statusi: Complete.

Q9MAX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRAHPVDG SPATDGGHVP MKPSPTRHKV GIPPKQNMFK DFMYTFKETF
60 70 80 90 100
FHDDPLRDFK DQPKSKQFML GLQSVFPVFD WGRNYTFKKF RGDLISGLTI
110 120 130 140 150
ASLCIPQDIG YAKLANLDPK YGLYSSFVPP LVYACMGSSR DIAIGPVAVV
160 170 180 190 200
SLLLGTLLRA EIDPNTSPDE YLRLAFTATF FAGITEAALG FFRLGFLIDF
210 220 230 240 250
LSHAAVVGFM GGAAITIALQ QLKGFLGIKK FTKKTDIISV LESVFKAAHH
260 270 280 290 300
GWNWQTILIG ASFLTFLLTS KIIGKKSKKL FWVPAIAPLI SVIVSTFFVY
310 320 330 340 350
ITRADKQGVQ IVKHLDQGIN PSSFHLIYFT GDNLAKGIRI GVVAGMVALT
360 370 380 390 400
EAVAIGRTFA AMKDYQIDGN KEMVALGMMN VVGSMSSCYV ATGSFSRSAV
410 420 430 440 450
NFMAGCQTAV SNIIMSIVVL LTLLFLTPLF KYTPNAILAA IIINAVIPLI
460 470 480 490 500
DIQAAILIFK VDKLDFIACI GAFFGVIFVS VEIGLLIAVS ISFAKILLQV
510 520 530 540 550
TRPRTAVLGN IPRTSVYRNI QQYPEATMVP GVLTIRVDSA IYFSNSNYVR
560 570 580 590 600
ERIQRWLHEE EEKVKAASLP RIQFLIIEMS PVTDIDTSGI HALEDLYKSL
610 620 630 640 650
QKRDIQLILA NPGPLVIGKL HLSHFADMLG QDNIYLTVAD AVEACCPKLS

NEV
Length:653
Mass (Da):71,707
Last modified:October 1, 2000 - v1
Checksum:iB019CADDD9ADED46
GO

Sequence cautioni

The sequence AAF17685 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042322 mRNA Translation: BAA95484.1
AC009243 Genomic DNA Translation: AAF17685.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE36055.1
CP002684 Genomic DNA Translation: AEE36056.1
CP002684 Genomic DNA Translation: ANM58967.1
AK227518 mRNA Translation: BAE99518.1
PIRiD96809
RefSeqiNP_001321366.1, NM_001334809.1
NP_565166.1, NM_106449.3
NP_849899.1, NM_179568.2
UniGeneiAt.10549

Genome annotation databases

EnsemblPlantsiAT1G78000.1; AT1G78000.1; AT1G78000
AT1G78000.2; AT1G78000.2; AT1G78000
AT1G78000.3; AT1G78000.3; AT1G78000
GeneIDi844135
GrameneiAT1G78000.1; AT1G78000.1; AT1G78000
AT1G78000.2; AT1G78000.2; AT1G78000
AT1G78000.3; AT1G78000.3; AT1G78000
KEGGiath:AT1G78000

Similar proteinsi

Entry informationi

Entry nameiSUT12_ARATH
AccessioniPrimary (citable) accession number: Q9MAX3
Secondary accession number(s): Q0WTN0, Q9SH00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health