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Protein

Sulfate transporter 1.2

Gene

SULTR1;2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

High-affinity H+/sulfate cotransporter that mediates the uptake of the environmental sulfate by plant roots. Plays a central role in the regulation of sulfate assimilation. Unable to transport molybdate.3 Publications

Enzyme regulationi

Interaction with OASA1 negatively impacts the transporter activity.1 Publication

GO - Molecular functioni

GO - Biological processi

  • cellular response to sulfate starvation Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Sulfate transport, Symport, Transport

Protein family/group databases

TCDBi2.A.53.1.6. the sulfate permease (sulp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfate transporter 1.2
Gene namesi
Name:SULTR1;2
Ordered Locus Names:At1g78000
ORF Names:F28K19.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G78000.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 9191CytoplasmicSequence analysisAdd
BLAST
Transmembranei92 – 11221HelicalSequence analysisAdd
BLAST
Topological domaini113 – 1164ExtracellularSequence analysis
Transmembranei117 – 13721HelicalSequence analysisAdd
BLAST
Topological domaini138 – 1414CytoplasmicSequence analysis
Transmembranei142 – 16221HelicalSequence analysisAdd
BLAST
Topological domaini163 – 17311ExtracellularSequence analysisAdd
BLAST
Transmembranei174 – 19421HelicalSequence analysisAdd
BLAST
Transmembranei195 – 21521HelicalSequence analysisAdd
BLAST
Topological domaini216 – 25338ExtracellularSequence analysisAdd
BLAST
Transmembranei254 – 27421HelicalSequence analysisAdd
BLAST
Topological domaini275 – 2806CytoplasmicSequence analysis
Transmembranei281 – 30121HelicalSequence analysisAdd
BLAST
Topological domaini302 – 33938ExtracellularSequence analysisAdd
BLAST
Transmembranei340 – 36021HelicalSequence analysisAdd
BLAST
Topological domaini361 – 37212CytoplasmicSequence analysisAdd
BLAST
Transmembranei373 – 39321HelicalSequence analysisAdd
BLAST
Topological domaini394 – 40916ExtracellularSequence analysisAdd
BLAST
Transmembranei410 – 43021HelicalSequence analysisAdd
BLAST
Topological domaini431 – 4388CytoplasmicSequence analysis
Transmembranei439 – 45921HelicalSequence analysisAdd
BLAST
Topological domaini460 – 4667ExtracellularSequence analysis
Transmembranei467 – 48721HelicalSequence analysisAdd
BLAST
Topological domaini488 – 653166CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi511 – 5111I → T in sel1-8; reduces drastically sulfate transport activity.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 653653Sulfate transporter 1.2PRO_0000080173Add
BLAST

Proteomic databases

PaxDbiQ9MAX3.
PRIDEiQ9MAX3.

PTM databases

iPTMnetiQ9MAX3.

Expressioni

Tissue specificityi

Expressed in lateral root cap, root hairs, epidermal and cortical cells of roots.1 Publication

Inductioni

In roots by sulfate starvation.1 Publication

Gene expression databases

GenevisibleiQ9MAX3. AT.

Interactioni

Subunit structurei

Homodimer. Interacts with OASA1 through its STAS domain.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
OASA1P479985EBI-8772960,EBI-1633418

Protein-protein interaction databases

BioGridi29354. 4 interactions.
IntActiQ9MAX3. 1 interaction.
STRINGi3702.AT1G78000.1.

Structurei

3D structure databases

ProteinModelPortaliQ9MAX3.
SMRiQ9MAX3. Positions 87-502, 519-644.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini522 – 645124STASPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 STAS domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
HOGENOMiHOG000199842.
InParanoidiQ9MAX3.
KOiK17470.
OMAiFWDMVST.
PhylomeDBiQ9MAX3.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR030314. High_sul_transp.
IPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 1 hit.
PTHR11814:SF65. PTHR11814:SF65. 1 hit.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9MAX3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRAHPVDG SPATDGGHVP MKPSPTRHKV GIPPKQNMFK DFMYTFKETF
60 70 80 90 100
FHDDPLRDFK DQPKSKQFML GLQSVFPVFD WGRNYTFKKF RGDLISGLTI
110 120 130 140 150
ASLCIPQDIG YAKLANLDPK YGLYSSFVPP LVYACMGSSR DIAIGPVAVV
160 170 180 190 200
SLLLGTLLRA EIDPNTSPDE YLRLAFTATF FAGITEAALG FFRLGFLIDF
210 220 230 240 250
LSHAAVVGFM GGAAITIALQ QLKGFLGIKK FTKKTDIISV LESVFKAAHH
260 270 280 290 300
GWNWQTILIG ASFLTFLLTS KIIGKKSKKL FWVPAIAPLI SVIVSTFFVY
310 320 330 340 350
ITRADKQGVQ IVKHLDQGIN PSSFHLIYFT GDNLAKGIRI GVVAGMVALT
360 370 380 390 400
EAVAIGRTFA AMKDYQIDGN KEMVALGMMN VVGSMSSCYV ATGSFSRSAV
410 420 430 440 450
NFMAGCQTAV SNIIMSIVVL LTLLFLTPLF KYTPNAILAA IIINAVIPLI
460 470 480 490 500
DIQAAILIFK VDKLDFIACI GAFFGVIFVS VEIGLLIAVS ISFAKILLQV
510 520 530 540 550
TRPRTAVLGN IPRTSVYRNI QQYPEATMVP GVLTIRVDSA IYFSNSNYVR
560 570 580 590 600
ERIQRWLHEE EEKVKAASLP RIQFLIIEMS PVTDIDTSGI HALEDLYKSL
610 620 630 640 650
QKRDIQLILA NPGPLVIGKL HLSHFADMLG QDNIYLTVAD AVEACCPKLS

NEV
Length:653
Mass (Da):71,707
Last modified:October 1, 2000 - v1
Checksum:iB019CADDD9ADED46
GO

Sequence cautioni

The sequence AAF17685.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042322 mRNA. Translation: BAA95484.1.
AC009243 Genomic DNA. Translation: AAF17685.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE36055.1.
CP002684 Genomic DNA. Translation: AEE36056.1.
AK227518 mRNA. Translation: BAE99518.1.
PIRiD96809.
RefSeqiNP_565166.1. NM_106449.2.
NP_849899.1. NM_179568.1.
UniGeneiAt.10549.

Genome annotation databases

EnsemblPlantsiAT1G78000.1; AT1G78000.1; AT1G78000.
AT1G78000.2; AT1G78000.2; AT1G78000.
GeneIDi844135.
GrameneiAT1G78000.1; AT1G78000.1; AT1G78000.
AT1G78000.2; AT1G78000.2; AT1G78000.
KEGGiath:AT1G78000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB042322 mRNA. Translation: BAA95484.1.
AC009243 Genomic DNA. Translation: AAF17685.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE36055.1.
CP002684 Genomic DNA. Translation: AEE36056.1.
AK227518 mRNA. Translation: BAE99518.1.
PIRiD96809.
RefSeqiNP_565166.1. NM_106449.2.
NP_849899.1. NM_179568.1.
UniGeneiAt.10549.

3D structure databases

ProteinModelPortaliQ9MAX3.
SMRiQ9MAX3. Positions 87-502, 519-644.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi29354. 4 interactions.
IntActiQ9MAX3. 1 interaction.
STRINGi3702.AT1G78000.1.

Protein family/group databases

TCDBi2.A.53.1.6. the sulfate permease (sulp) family.

PTM databases

iPTMnetiQ9MAX3.

Proteomic databases

PaxDbiQ9MAX3.
PRIDEiQ9MAX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G78000.1; AT1G78000.1; AT1G78000.
AT1G78000.2; AT1G78000.2; AT1G78000.
GeneIDi844135.
GrameneiAT1G78000.1; AT1G78000.1; AT1G78000.
AT1G78000.2; AT1G78000.2; AT1G78000.
KEGGiath:AT1G78000.

Organism-specific databases

TAIRiAT1G78000.

Phylogenomic databases

eggNOGiKOG0236. Eukaryota.
COG0659. LUCA.
HOGENOMiHOG000199842.
InParanoidiQ9MAX3.
KOiK17470.
OMAiFWDMVST.
PhylomeDBiQ9MAX3.

Miscellaneous databases

PROiQ9MAX3.

Gene expression databases

GenevisibleiQ9MAX3. AT.

Family and domain databases

Gene3Di3.30.750.24. 1 hit.
InterProiIPR030314. High_sul_transp.
IPR018045. S04_transporter_CS.
IPR011547. SLC26A/SulP_dom.
IPR001902. SLC26A/SulP_fam.
IPR002645. STAS_dom.
[Graphical view]
PANTHERiPTHR11814. PTHR11814. 1 hit.
PTHR11814:SF65. PTHR11814:SF65. 1 hit.
PfamiPF01740. STAS. 1 hit.
PF00916. Sulfate_transp. 1 hit.
[Graphical view]
SUPFAMiSSF52091. SSF52091. 1 hit.
TIGRFAMsiTIGR00815. sulP. 1 hit.
PROSITEiPS01130. SLC26A. 1 hit.
PS50801. STAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two distinct high-affinity sulfate transporters with different inducibilities mediate uptake of sulfate in Arabidopsis roots."
    Yoshimoto N., Takahashi H., Smith F.W., Yamaya T., Saito K.
    Plant J. 29:465-473(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION.
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Selenate-resistant mutants of Arabidopsis thaliana identify Sultr1;2, a sulfate transporter required for efficient transport of sulfate into roots."
    Shibagaki N., Rose A., McDermott J.P., Fujiwara T., Hayashi H., Yoneyama T., Davies J.P.
    Plant J. 29:475-486(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTANTS SEL1.
  6. "An Arabidopsis thaliana high-affinity molybdate transporter required for efficient uptake of molybdate from soil."
    Tomatsu H., Takano J., Takahashi H., Watanabe-Takahashi A., Shibagaki N., Fujiwara T.
    Proc. Natl. Acad. Sci. U.S.A. 104:18807-18812(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: cv. Columbia.
  7. "Binding of cysteine synthase to the STAS domain of sulfate transporter and its regulatory consequences."
    Shibagaki N., Grossman A.R.
    J. Biol. Chem. 285:25094-25102(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: HOMODIMERIZATION, INTERACTION WITH OASA1, ENZYME REGULATION.

Entry informationi

Entry nameiSUT12_ARATH
AccessioniPrimary (citable) accession number: Q9MAX3
Secondary accession number(s): Q0WTN0, Q9SH00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: October 1, 2000
Last modified: February 17, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Sel1 mutations in the gene lead to the resistance of the plant to selenate, a toxic analog of sulfate.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.