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Q9MAQ3

- UBP11_ARATH

UniProt

Q9MAQ3 - UBP11_ARATH

Protein

Putative ubiquitin carboxyl-terminal hydrolase 11

Gene

UBP11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 2 (15 Jan 2008)
      Previous versions | rss
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    Functioni

    Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei310 – 3101NucleophilePROSITE-ProRule annotation
    Active sitei838 – 8381Proton acceptorPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ubiquitin-specific protease activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Enzyme and pathway databases

    BioCyciARA:AT1G32850-MONOMER.

    Protein family/group databases

    MEROPSiC19.A04.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative ubiquitin carboxyl-terminal hydrolase 11 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 11
    Short name:
    AtUBP11
    Ubiquitin thioesterase 11
    Ubiquitin-specific-processing protease 11
    Gene namesi
    Name:UBP11
    Ordered Locus Names:At1g32850
    ORF Names:F9L11.5
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G32850.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 892892Putative ubiquitin carboxyl-terminal hydrolase 11PRO_0000313038Add
    BLAST

    Proteomic databases

    PRIDEiQ9MAQ3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9MAQ3.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G32850.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9MAQ3.
    SMRiQ9MAQ3. Positions 27-225, 299-480, 626-885.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 132116DUSPPROSITE-ProRule annotationAdd
    BLAST
    Domaini301 – 880580USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 DUSP domain.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Phylogenomic databases

    eggNOGiCOG5560.
    HOGENOMiHOG000264375.
    InParanoidiQ9MAQ3.
    KOiK11835.
    OMAiRDTETED.
    PhylomeDBiQ9MAQ3.

    Family and domain databases

    Gene3Di3.30.2230.10. 1 hit.
    InterProiIPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view]
    PfamiPF06337. DUSP. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view]
    SMARTiSM00695. DUSP. 1 hit.
    [Graphical view]
    SUPFAMiSSF143791. SSF143791. 1 hit.
    PROSITEiPS51283. DUSP. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9MAQ3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLITDSESI GVCESSYTPE EERRIVTELN NEAEADLKEG NLYFVISNRW    50
    YTRWQRFVGL LTEEFRSGEP SEVTRPGPID NHDIIDSESD ASDPQLRMML 100
    EEGVDYTLVQ QEVWRKLVKW YKGGPPVPRK LISQGFYTKS FSVEVYLLCL 150
    TLTDSRDEST TIIRLSKQAS IGQLYEMVCA GKGVAKEKAR IWDYFEKKKS 200
    VLLDPSSEQS VEEAGLQFNQ DILLEVDGSA SSQFVMSLAE NELAMVPLEP 250
    MRSDAMDIVR GGGTLSNGHS NGFKFSFFGR NTFKDDVSSR TFGKGEKRGL 300
    GGLQNLGNTC FMNSTLQCLA HTPPIVEYFL QDYRSDINAK NPLGMRGELA 350
    IAFGELLRKL WSSGQNTVAP RAFKTKLARF APQFSGYNQH DSQEMLAFLL 400
    DGLHEDLNKV KRKPYIEAKD SDGRPDDEVA EEKWKYHKAR NDSVIVDVFQ 450
    GQYKSTLVCP DCGKISITFD PFMYLSLPLP SSRTRSMTVT VFYGDGSHLP 500
    MPYTVTVPKD GSCRDLSNAL GTACCLDNDE SLLLAEVYDH KVFKYYENPR 550
    ELLNGIKDNE HIVAYRFKQM HKGPGKVKLE ILHGEQEKSS DRGPKCFGTP 600
    LVTYINKEPL SGTDIATSIS GLLSPLRRVH MSCVVNSGNE NGHVPDESSR 650
    SILSRDTETE DNDRELSLSL LRDYYSFNLQ PLESDSVVNP GSVTKVLVKW 700
    NEKEHEKYDS SYLNDLPKVH KNVLAKKTMQ EGISLFSCLE AFLAEEPLGP 750
    DDMWYCPGCK EHRQANKKLD LWKLPDILVF HLKRFTYSRY FKNKIDTLVN 800
    FHIHDLDLSK YVKNEDGQSY LYELYAISNH YGGLGGGHYT AYAKLMDETK 850
    WYNFDDSRVS AVNESEIKTS AAYVLFYQRV KSDSETSDMK MD 892
    Length:892
    Mass (Da):101,175
    Last modified:January 15, 2008 - v2
    Checksum:i8377D6A44BD26A67
    GO

    Sequence cautioni

    The sequence AAF31287.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006424 Genomic DNA. Translation: AAF31287.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE31532.1.
    PIRiC86453.
    RefSeqiNP_174562.2. NM_103019.2.
    UniGeneiAt.51891.

    Genome annotation databases

    EnsemblPlantsiAT1G32850.1; AT1G32850.1; AT1G32850.
    GeneIDi840179.
    KEGGiath:AT1G32850.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006424 Genomic DNA. Translation: AAF31287.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE31532.1 .
    PIRi C86453.
    RefSeqi NP_174562.2. NM_103019.2.
    UniGenei At.51891.

    3D structure databases

    ProteinModelPortali Q9MAQ3.
    SMRi Q9MAQ3. Positions 27-225, 299-480, 626-885.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G32850.1-P.

    Protein family/group databases

    MEROPSi C19.A04.

    Proteomic databases

    PRIDEi Q9MAQ3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G32850.1 ; AT1G32850.1 ; AT1G32850 .
    GeneIDi 840179.
    KEGGi ath:AT1G32850.

    Organism-specific databases

    TAIRi AT1G32850.

    Phylogenomic databases

    eggNOGi COG5560.
    HOGENOMi HOG000264375.
    InParanoidi Q9MAQ3.
    KOi K11835.
    OMAi RDTETED.
    PhylomeDBi Q9MAQ3.

    Enzyme and pathway databases

    BioCyci ARA:AT1G32850-MONOMER.

    Gene expression databases

    Genevestigatori Q9MAQ3.

    Family and domain databases

    Gene3Di 3.30.2230.10. 1 hit.
    InterProi IPR006615. Pept_C19_DUSP.
    IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    [Graphical view ]
    Pfami PF06337. DUSP. 1 hit.
    PF00443. UCH. 1 hit.
    [Graphical view ]
    SMARTi SM00695. DUSP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF143791. SSF143791. 1 hit.
    PROSITEi PS51283. DUSP. 1 hit.
    PS00972. USP_1. 1 hit.
    PS00973. USP_2. 1 hit.
    PS50235. USP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine."
      Yan N., Doelling J.H., Falbel T.G., Durski A.M., Vierstra R.D.
      Plant Physiol. 124:1828-1843(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE.

    Entry informationi

    Entry nameiUBP11_ARATH
    AccessioniPrimary (citable) accession number: Q9MAQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: January 15, 2008
    Last modified: October 1, 2014
    This is version 84 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3