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Protein

Putative ubiquitin carboxyl-terminal hydrolase 11

Gene

UBP11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei310 – 3101NucleophilePROSITE-ProRule annotation
Active sitei838 – 8381Proton acceptorPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

BioCyciARA:AT1G32850-MONOMER.

Protein family/group databases

MEROPSiC19.A04.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ubiquitin carboxyl-terminal hydrolase 11 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 11
Short name:
AtUBP11
Ubiquitin thioesterase 11
Ubiquitin-specific-processing protease 11
Gene namesi
Name:UBP11
Ordered Locus Names:At1g32850
ORF Names:F9L11.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G32850.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 892892Putative ubiquitin carboxyl-terminal hydrolase 11PRO_0000313038Add
BLAST

Proteomic databases

PRIDEiQ9MAQ3.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G32850.1.

Structurei

3D structure databases

ProteinModelPortaliQ9MAQ3.
SMRiQ9MAQ3. Positions 27-225, 299-480, 626-885.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini17 – 132116DUSPPROSITE-ProRule annotationAdd
BLAST
Domaini301 – 880580USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 DUSP domain.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Phylogenomic databases

eggNOGiCOG5560.
HOGENOMiHOG000264375.
InParanoidiQ9MAQ3.
KOiK11835.
OMAiNHDIIDS.
PhylomeDBiQ9MAQ3.

Family and domain databases

Gene3Di3.30.2230.10. 1 hit.
InterProiIPR006615. Pept_C19_DUSP.
IPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF06337. DUSP. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTiSM00695. DUSP. 1 hit.
[Graphical view]
SUPFAMiSSF143791. SSF143791. 1 hit.
PROSITEiPS51283. DUSP. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9MAQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLITDSESI GVCESSYTPE EERRIVTELN NEAEADLKEG NLYFVISNRW
60 70 80 90 100
YTRWQRFVGL LTEEFRSGEP SEVTRPGPID NHDIIDSESD ASDPQLRMML
110 120 130 140 150
EEGVDYTLVQ QEVWRKLVKW YKGGPPVPRK LISQGFYTKS FSVEVYLLCL
160 170 180 190 200
TLTDSRDEST TIIRLSKQAS IGQLYEMVCA GKGVAKEKAR IWDYFEKKKS
210 220 230 240 250
VLLDPSSEQS VEEAGLQFNQ DILLEVDGSA SSQFVMSLAE NELAMVPLEP
260 270 280 290 300
MRSDAMDIVR GGGTLSNGHS NGFKFSFFGR NTFKDDVSSR TFGKGEKRGL
310 320 330 340 350
GGLQNLGNTC FMNSTLQCLA HTPPIVEYFL QDYRSDINAK NPLGMRGELA
360 370 380 390 400
IAFGELLRKL WSSGQNTVAP RAFKTKLARF APQFSGYNQH DSQEMLAFLL
410 420 430 440 450
DGLHEDLNKV KRKPYIEAKD SDGRPDDEVA EEKWKYHKAR NDSVIVDVFQ
460 470 480 490 500
GQYKSTLVCP DCGKISITFD PFMYLSLPLP SSRTRSMTVT VFYGDGSHLP
510 520 530 540 550
MPYTVTVPKD GSCRDLSNAL GTACCLDNDE SLLLAEVYDH KVFKYYENPR
560 570 580 590 600
ELLNGIKDNE HIVAYRFKQM HKGPGKVKLE ILHGEQEKSS DRGPKCFGTP
610 620 630 640 650
LVTYINKEPL SGTDIATSIS GLLSPLRRVH MSCVVNSGNE NGHVPDESSR
660 670 680 690 700
SILSRDTETE DNDRELSLSL LRDYYSFNLQ PLESDSVVNP GSVTKVLVKW
710 720 730 740 750
NEKEHEKYDS SYLNDLPKVH KNVLAKKTMQ EGISLFSCLE AFLAEEPLGP
760 770 780 790 800
DDMWYCPGCK EHRQANKKLD LWKLPDILVF HLKRFTYSRY FKNKIDTLVN
810 820 830 840 850
FHIHDLDLSK YVKNEDGQSY LYELYAISNH YGGLGGGHYT AYAKLMDETK
860 870 880 890
WYNFDDSRVS AVNESEIKTS AAYVLFYQRV KSDSETSDMK MD
Length:892
Mass (Da):101,175
Last modified:January 15, 2008 - v2
Checksum:i8377D6A44BD26A67
GO

Sequence cautioni

The sequence AAF31287.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006424 Genomic DNA. Translation: AAF31287.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE31532.1.
PIRiC86453.
RefSeqiNP_174562.2. NM_103019.2.
UniGeneiAt.51891.

Genome annotation databases

EnsemblPlantsiAT1G32850.1; AT1G32850.1; AT1G32850.
GeneIDi840179.
KEGGiath:AT1G32850.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006424 Genomic DNA. Translation: AAF31287.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE31532.1.
PIRiC86453.
RefSeqiNP_174562.2. NM_103019.2.
UniGeneiAt.51891.

3D structure databases

ProteinModelPortaliQ9MAQ3.
SMRiQ9MAQ3. Positions 27-225, 299-480, 626-885.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G32850.1.

Protein family/group databases

MEROPSiC19.A04.

Proteomic databases

PRIDEiQ9MAQ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G32850.1; AT1G32850.1; AT1G32850.
GeneIDi840179.
KEGGiath:AT1G32850.

Organism-specific databases

TAIRiAT1G32850.

Phylogenomic databases

eggNOGiCOG5560.
HOGENOMiHOG000264375.
InParanoidiQ9MAQ3.
KOiK11835.
OMAiNHDIIDS.
PhylomeDBiQ9MAQ3.

Enzyme and pathway databases

BioCyciARA:AT1G32850-MONOMER.

Miscellaneous databases

PROiQ9MAQ3.

Family and domain databases

Gene3Di3.30.2230.10. 1 hit.
InterProiIPR006615. Pept_C19_DUSP.
IPR001394. Peptidase_C19_UCH.
IPR018200. USP_CS.
IPR028889. USP_dom.
[Graphical view]
PfamiPF06337. DUSP. 1 hit.
PF00443. UCH. 1 hit.
[Graphical view]
SMARTiSM00695. DUSP. 1 hit.
[Graphical view]
SUPFAMiSSF143791. SSF143791. 1 hit.
PROSITEiPS51283. DUSP. 1 hit.
PS00972. USP_1. 1 hit.
PS00973. USP_2. 1 hit.
PS50235. USP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine."
    Yan N., Doelling J.H., Falbel T.G., Durski A.M., Vierstra R.D.
    Plant Physiol. 124:1828-1843(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE.

Entry informationi

Entry nameiUBP11_ARATH
AccessioniPrimary (citable) accession number: Q9MAQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: July 22, 2015
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.