Q9MAQ3 (UBP11_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative ubiquitin carboxyl-terminal hydrolase 11
EC=3.4.19.12

Alternative name(s):
Deubiquitinating enzyme 11
Short name=AtUBP11
Ubiquitin thioesterase 11
Ubiquitin-specific-processing protease 11

Gene names

Name:	UBP11
Ordered Locus Names:	At1g32850
ORF Names:	F9L11.5

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	892 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.
Catalytic activity	Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
Sequence similarities	Belongs to the peptidase C19 family. Contains 1 DUSP domain.
Sequence caution	The sequence AAF31287.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Ubl conjugation pathway
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ubiquitin-dependent protein catabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW ubiquitin thiolesterase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 892	892	Putative ubiquitin carboxyl-terminal hydrolase 11		PRO_0000313038
Regions
	Domain	17 – 132	116	DUSP
Sites
	Active site	310	1	Nucleophile By similarity
	Active site	838	1	Proton acceptor By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9MAQ3 [UniParc]. Last modified January 15, 2008. Version 2. Checksum: 8377D6A44BD26A67	FASTA	892	101,175
	10 20 30 40 50 60 MTLITDSESI GVCESSYTPE EERRIVTELN NEAEADLKEG NLYFVISNRW YTRWQRFVGL 70 80 90 100 110 120 LTEEFRSGEP SEVTRPGPID NHDIIDSESD ASDPQLRMML EEGVDYTLVQ QEVWRKLVKW 130 140 150 160 170 180 YKGGPPVPRK LISQGFYTKS FSVEVYLLCL TLTDSRDEST TIIRLSKQAS IGQLYEMVCA 190 200 210 220 230 240 GKGVAKEKAR IWDYFEKKKS VLLDPSSEQS VEEAGLQFNQ DILLEVDGSA SSQFVMSLAE 250 260 270 280 290 300 NELAMVPLEP MRSDAMDIVR GGGTLSNGHS NGFKFSFFGR NTFKDDVSSR TFGKGEKRGL 310 320 330 340 350 360 GGLQNLGNTC FMNSTLQCLA HTPPIVEYFL QDYRSDINAK NPLGMRGELA IAFGELLRKL 370 380 390 400 410 420 WSSGQNTVAP RAFKTKLARF APQFSGYNQH DSQEMLAFLL DGLHEDLNKV KRKPYIEAKD 430 440 450 460 470 480 SDGRPDDEVA EEKWKYHKAR NDSVIVDVFQ GQYKSTLVCP DCGKISITFD PFMYLSLPLP 490 500 510 520 530 540 SSRTRSMTVT VFYGDGSHLP MPYTVTVPKD GSCRDLSNAL GTACCLDNDE SLLLAEVYDH 550 560 570 580 590 600 KVFKYYENPR ELLNGIKDNE HIVAYRFKQM HKGPGKVKLE ILHGEQEKSS DRGPKCFGTP 610 620 630 640 650 660 LVTYINKEPL SGTDIATSIS GLLSPLRRVH MSCVVNSGNE NGHVPDESSR SILSRDTETE 670 680 690 700 710 720 DNDRELSLSL LRDYYSFNLQ PLESDSVVNP GSVTKVLVKW NEKEHEKYDS SYLNDLPKVH 730 740 750 760 770 780 KNVLAKKTMQ EGISLFSCLE AFLAEEPLGP DDMWYCPGCK EHRQANKKLD LWKLPDILVF 790 800 810 820 830 840 HLKRFTYSRY FKNKIDTLVN FHIHDLDLSK YVKNEDGQSY LYELYAISNH YGGLGGGHYT 850 860 870 880 890 AYAKLMDETK WYNFDDSRVS AVNESEIKTS AAYVLFYQRV KSDSETSDMK MD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine." Yan N., Doelling J.H., Falbel T.G., Durski A.M., Vierstra R.D. Plant Physiol. 124:1828-1843(2000) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC006424 Genomic DNA. Translation: AAF31287.1. Sequence problems. CP002684 Genomic DNA. Translation: AEE31532.1.
IPI	IPI00534425.
PIR	C86453.
RefSeq	NP_174562.2. NM_103019.2.
UniGene	At.51891.
3D structure databases
HSSP	HSSP built from PDB template 2GFO based on UniProtKB P40818.
ProteinModelPortal	Q9MAQ3.
SMR	Q9MAQ3. Positions 27-225, 299-480, 626-885.
ModBase	Search...
Protein-protein interaction databases
STRING	3702.AT1G32850.1-P.
Protein family/group databases
MEROPS	C19.A04.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G32850.1; AT1G32850.1; AT1G32850.
GeneID	840179.
KEGG	ath:AT1G32850.
Organism-specific databases
TAIR	At1g32850.
Phylogenomic databases
eggNOG	COG5560.
HOGENOM	HOG000264375.
InParanoid	Q9MAQ3.
KO	K11835.
OMA	HCSASEC.
PhylomeDB	Q9MAQ3.
ProtClustDB	CLSN2689389.
Gene expression databases
Genevestigator	Q9MAQ3.
Family and domain databases
InterPro	IPR006615. Pept_C19_DUSP. IPR018200. Pept_C19ubi-hydrolase_C_CS. IPR001394. Peptidase_C19. [Graphical view]
Pfam	PF06337. DUSP. 1 hit. PF00443. UCH. 1 hit. [Graphical view]
SMART	SM00695. DUSP. 1 hit. [Graphical view]
PROSITE	PS51283. DUSP. 1 hit. PS00972. UCH_2_1. 1 hit. PS00973. UCH_2_2. 1 hit. PS50235. UCH_2_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

UBP11_ARATH

Accession

Primary (citable) accession number: Q9MAQ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	January 15, 2008
Last modified:	May 1, 2013
This is version 70 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program