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Protein

Gibberellin receptor GID1A

Gene

GID1A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as soluble gibberellin (GA) receptor. GA is an essential hormone that regulates growth and development in plants. Binds with high affinity the biologically active gibberellin GA4, but has no affinity for the biologically inactive GAs. In response to GA, interacts with specific DELLA proteins, known as repressors of GA-induced growth, and targets them for degradation via proteasome. Seems to be required for GA signaling that controls root growth, seed germination, stem elongation and flower development. Partially redundant with GID1B and GID1C.3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei127Gibberellin1 Publication1
Active sitei191PROSITE-ProRule annotationBy similarity1
Binding sitei191Gibberellin1 Publication1
Binding sitei238Gibberellin; via carbonyl oxygen1 Publication1
Active sitei289PROSITE-ProRule annotationBy similarity1
Binding sitei320Gibberellin; via amide nitrogen1 Publication1

GO - Molecular functioni

  • gibberellin binding Source: UniProtKB
  • hydrolase activity Source: UniProtKB-KW

GO - Biological processi

  • floral organ morphogenesis Source: TAIR
  • gibberellic acid mediated signaling pathway Source: UniProtKB-KW
  • gibberellin mediated signaling pathway Source: TAIR
  • metabolic process Source: InterPro
  • positive regulation of gibberellic acid mediated signaling pathway Source: TAIR
  • response to gibberellin Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Receptor

Keywords - Biological processi

Gibberellin signaling pathway

Enzyme and pathway databases

BioCyciARA:AT3G05120-MONOMER.

Protein family/group databases

ESTHERiarath-gid1. Plant_carboxylesterase.
MEROPSiS09.A10.

Names & Taxonomyi

Protein namesi
Recommended name:
Gibberellin receptor GID1A (EC:3.-.-.-)
Alternative name(s):
AtCXE10
Carboxylesterase 10
GID1-like protein 1
Protein GA INSENSITIVE DWARF 1A
Short name:
AtGID1A
Gene namesi
Name:GID1A
Synonyms:CXE10, GID1L1
Ordered Locus Names:At3g05120
ORF Names:T12H1.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G05120.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: TAIR
  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth condition.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000715582 – 345Gibberellin receptor GID1AAdd BLAST344

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9MAA7.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

GenevisibleiQ9MAA7. AT.

Interactioni

Subunit structurei

Interacts (via N-terminus) with the DELLA proteins GAI, RGA, RGL1, RGL2 and RGL3 (via N-terminus) in a GA-dependent manner.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GAIQ9LQT86EBI-963597,EBI-963606
GID2Q9STX33EBI-963597,EBI-619033
RGAQ9SLH37EBI-963597,EBI-963624
RGL2Q8GXW13EBI-963597,EBI-963665

Protein-protein interaction databases

BioGridi5009. 6 interactors.
DIPiDIP-37659N.
IntActiQ9MAA7. 5 interactors.
STRINGi3702.AT3G05120.1.

Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 13Combined sources4
Helixi18 – 34Combined sources17
Helixi43 – 49Combined sources7
Beta strandi63 – 71Combined sources9
Turni72 – 75Combined sources4
Beta strandi76 – 83Combined sources8
Beta strandi103 – 105Combined sources3
Beta strandi107 – 112Combined sources6
Turni116 – 118Combined sources3
Helixi125 – 138Combined sources14
Beta strandi140 – 145Combined sources6
Turni150 – 152Combined sources3
Helixi157 – 170Combined sources14
Helixi173 – 175Combined sources3
Turni178 – 180Combined sources3
Beta strandi184 – 190Combined sources7
Helixi193 – 205Combined sources13
Turni206 – 208Combined sources3
Beta strandi213 – 218Combined sources6
Helixi228 – 233Combined sources6
Turni234 – 236Combined sources3
Helixi241 – 251Combined sources11
Turni261 – 263Combined sources3
Beta strandi280 – 286Combined sources7
Helixi292 – 304Combined sources13
Beta strandi309 – 314Combined sources6
Turni319 – 322Combined sources4
Beta strandi323 – 325Combined sources3
Helixi328 – 342Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZSHX-ray1.80A1-344[»]
2ZSIX-ray1.80A1-344[»]
DisProtiDP00723.
ProteinModelPortaliQ9MAA7.
SMRiQ9MAA7.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9MAA7.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni115 – 116Gibberellin binding2

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi113 – 115Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity3

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000152323.
InParanoidiQ9MAA7.
KOiK14493.
OMAiVMDEISA.
OrthoDBiEOG09360EOQ.
PhylomeDBiQ9MAA7.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR002168. Lipase_GDXG_HIS_AS.
IPR033140. Lipase_GDXG_put_SER_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01173. LIPASE_GDXG_HIS. 1 hit.
PS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9MAA7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASDEVNLI ESRTVVPLNT WVLISNFKVA YNILRRPDGT FNRHLAEYLD
60 70 80 90 100
RKVTANANPV DGVFSFDVLI DRRINLLSRV YRPAYADQEQ PPSILDLEKP
110 120 130 140 150
VDGDIVPVIL FFHGGSFAHS SANSAIYDTL CRRLVGLCKC VVVSVNYRRA
160 170 180 190 200
PENPYPCAYD DGWIALNWVN SRSWLKSKKD SKVHIFLAGD SSGGNIAHNV
210 220 230 240 250
ALRAGESGID VLGNILLNPM FGGNERTESE KSLDGKYFVT VRDRDWYWKA
260 270 280 290 300
FLPEGEDREH PACNPFSPRG KSLEGVSFPK SLVVVAGLDL IRDWQLAYAE
310 320 330 340
GLKKAGQEVK LMHLEKATVG FYLLPNNNHF HNVMDEISAF VNAEC
Length:345
Mass (Da):38,618
Last modified:October 1, 2000 - v1
Checksum:iFE1ED6E13BC1A48D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009177 Genomic DNA. Translation: AAF27018.1.
CP002686 Genomic DNA. Translation: AEE74188.1.
AY136305 mRNA. Translation: AAM96971.1.
BT002605 mRNA. Translation: AAO00965.1.
RefSeqiNP_187163.1. NM_111384.4.
UniGeneiAt.18371.
At.74127.

Genome annotation databases

EnsemblPlantsiAT3G05120.1; AT3G05120.1; AT3G05120.
GeneIDi819674.
GrameneiAT3G05120.1; AT3G05120.1; AT3G05120.
KEGGiath:AT3G05120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009177 Genomic DNA. Translation: AAF27018.1.
CP002686 Genomic DNA. Translation: AEE74188.1.
AY136305 mRNA. Translation: AAM96971.1.
BT002605 mRNA. Translation: AAO00965.1.
RefSeqiNP_187163.1. NM_111384.4.
UniGeneiAt.18371.
At.74127.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZSHX-ray1.80A1-344[»]
2ZSIX-ray1.80A1-344[»]
DisProtiDP00723.
ProteinModelPortaliQ9MAA7.
SMRiQ9MAA7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi5009. 6 interactors.
DIPiDIP-37659N.
IntActiQ9MAA7. 5 interactors.
STRINGi3702.AT3G05120.1.

Protein family/group databases

ESTHERiarath-gid1. Plant_carboxylesterase.
MEROPSiS09.A10.

Proteomic databases

PaxDbiQ9MAA7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G05120.1; AT3G05120.1; AT3G05120.
GeneIDi819674.
GrameneiAT3G05120.1; AT3G05120.1; AT3G05120.
KEGGiath:AT3G05120.

Organism-specific databases

TAIRiAT3G05120.

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000152323.
InParanoidiQ9MAA7.
KOiK14493.
OMAiVMDEISA.
OrthoDBiEOG09360EOQ.
PhylomeDBiQ9MAA7.

Enzyme and pathway databases

BioCyciARA:AT3G05120-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9MAA7.
PROiQ9MAA7.

Gene expression databases

GenevisibleiQ9MAA7. AT.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR002168. Lipase_GDXG_HIS_AS.
IPR033140. Lipase_GDXG_put_SER_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01173. LIPASE_GDXG_HIS. 1 hit.
PS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGID1A_ARATH
AccessioniPrimary (citable) accession number: Q9MAA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.