Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9MAA7

- GID1A_ARATH

UniProt

Q9MAA7 - GID1A_ARATH

Protein

Gibberellin receptor GID1A

Gene

GID1A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Functions as soluble gibberellin (GA) receptor. GA is an essential hormone that regulates growth and development in plants. Binds with high affinity the biologically active gibberellin GA4, but has no affinity for the biologically inactive GAs. In response to GA, interacts with specific DELLA proteins, known as repressors of GA-induced growth, and targets them for degradation via proteasome. Seems to be required for GA signaling that controls root growth, seed germination, stem elongation and flower development. Partially redundant with GID1B and GID1C.3 Publications

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei113 – 1131PROSITE-ProRule annotation
    Binding sitei127 – 1271Gibberellin1 Publication
    Active sitei191 – 1911PROSITE-ProRule annotation
    Binding sitei191 – 1911Gibberellin1 Publication
    Binding sitei238 – 2381Gibberellin; via carbonyl oxygen1 Publication
    Active sitei289 – 2891PROSITE-ProRule annotation
    Binding sitei320 – 3201Gibberellin; via amide nitrogen1 Publication

    GO - Molecular functioni

    1. gibberellin binding Source: UniProtKB
    2. hydrolase activity Source: UniProtKB-KW
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. floral organ morphogenesis Source: TAIR
    2. gibberellic acid mediated signaling pathway Source: UniProtKB-KW
    3. gibberellin mediated signaling pathway Source: TAIR
    4. positive regulation of gibberellic acid mediated signaling pathway Source: TAIR
    5. raffinose family oligosaccharide biosynthetic process Source: TAIR
    6. response to gibberellin Source: TAIR

    Keywords - Molecular functioni

    Hydrolase, Receptor

    Keywords - Biological processi

    Gibberellin signaling pathway

    Enzyme and pathway databases

    BioCyciARA:AT3G05120-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Gibberellin receptor GID1A (EC:3.-.-.-)
    Alternative name(s):
    AtCXE10
    Carboxylesterase 10
    GID1-like protein 1
    Protein GA INSENSITIVE DWARF 1A
    Short name:
    AtGID1A
    Gene namesi
    Name:GID1A
    Synonyms:CXE10, GID1L1
    Ordered Locus Names:At3g05120
    ORF Names:T12H1.8
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G05120.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: TAIR
    2. nucleus Source: TAIR

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    No visible phenotype under normal growth condition.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 345344Gibberellin receptor GID1APRO_0000071558Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ9MAA7.
    PRIDEiQ9MAA7.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    GenevestigatoriQ9MAA7.

    Interactioni

    Subunit structurei

    Interacts (via N-terminus) with the DELLA proteins GAI, RGA, RGL1, RGL2 and RGL3 (via N-terminus) in a GA-dependent manner.4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GAIQ9LQT86EBI-963597,EBI-963606
    GID2Q9STX33EBI-963597,EBI-619033
    RGAQ9SLH37EBI-963597,EBI-963624
    RGL2Q8GXW13EBI-963597,EBI-963665

    Protein-protein interaction databases

    BioGridi5009. 5 interactions.
    DIPiDIP-37659N.
    IntActiQ9MAA7. 5 interactions.
    STRINGi3702.AT3G05120.1-P.

    Structurei

    Secondary structure

    1
    345
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi10 – 134
    Helixi18 – 3417
    Helixi43 – 497
    Beta strandi63 – 719
    Turni72 – 754
    Beta strandi76 – 838
    Beta strandi103 – 1053
    Beta strandi107 – 1126
    Turni116 – 1183
    Helixi125 – 13814
    Beta strandi140 – 1456
    Turni150 – 1523
    Helixi157 – 17014
    Helixi173 – 1753
    Turni178 – 1803
    Beta strandi184 – 1907
    Helixi193 – 20513
    Turni206 – 2083
    Beta strandi213 – 2186
    Helixi228 – 2336
    Turni234 – 2363
    Helixi241 – 25111
    Turni261 – 2633
    Beta strandi280 – 2867
    Helixi292 – 30413
    Beta strandi309 – 3146
    Turni319 – 3224
    Beta strandi323 – 3253
    Helixi328 – 34215

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ZSHX-ray1.80A1-344[»]
    2ZSIX-ray1.80A1-344[»]
    DisProtiDP00723.
    ProteinModelPortaliQ9MAA7.
    SMRiQ9MAA7. Positions 6-344.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9MAA7.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni115 – 1162Gibberellin binding

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi113 – 1153Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity

    Sequence similaritiesi

    Belongs to the 'GDXG' lipolytic enzyme family.Curated

    Phylogenomic databases

    eggNOGiCOG0657.
    HOGENOMiHOG000152323.
    InParanoidiQ9MAA7.
    KOiK14493.
    OMAiWERQDEL.
    PhylomeDBiQ9MAA7.

    Family and domain databases

    Gene3Di3.40.50.1820. 1 hit.
    InterProiIPR029058. AB_hydrolase.
    IPR013094. AB_hydrolase_3.
    IPR002168. Lipase_GDXG_AS.
    [Graphical view]
    PfamiPF07859. Abhydrolase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF53474. SSF53474. 1 hit.
    PROSITEiPS01173. LIPASE_GDXG_HIS. 1 hit.
    PS01174. LIPASE_GDXG_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9MAA7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAASDEVNLI ESRTVVPLNT WVLISNFKVA YNILRRPDGT FNRHLAEYLD    50
    RKVTANANPV DGVFSFDVLI DRRINLLSRV YRPAYADQEQ PPSILDLEKP 100
    VDGDIVPVIL FFHGGSFAHS SANSAIYDTL CRRLVGLCKC VVVSVNYRRA 150
    PENPYPCAYD DGWIALNWVN SRSWLKSKKD SKVHIFLAGD SSGGNIAHNV 200
    ALRAGESGID VLGNILLNPM FGGNERTESE KSLDGKYFVT VRDRDWYWKA 250
    FLPEGEDREH PACNPFSPRG KSLEGVSFPK SLVVVAGLDL IRDWQLAYAE 300
    GLKKAGQEVK LMHLEKATVG FYLLPNNNHF HNVMDEISAF VNAEC 345
    Length:345
    Mass (Da):38,618
    Last modified:October 1, 2000 - v1
    Checksum:iFE1ED6E13BC1A48D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009177 Genomic DNA. Translation: AAF27018.1.
    CP002686 Genomic DNA. Translation: AEE74188.1.
    AY136305 mRNA. Translation: AAM96971.1.
    BT002605 mRNA. Translation: AAO00965.1.
    RefSeqiNP_187163.1. NM_111384.3.
    UniGeneiAt.18371.
    At.74127.

    Genome annotation databases

    EnsemblPlantsiAT3G05120.1; AT3G05120.1; AT3G05120.
    GeneIDi819674.
    KEGGiath:AT3G05120.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009177 Genomic DNA. Translation: AAF27018.1 .
    CP002686 Genomic DNA. Translation: AEE74188.1 .
    AY136305 mRNA. Translation: AAM96971.1 .
    BT002605 mRNA. Translation: AAO00965.1 .
    RefSeqi NP_187163.1. NM_111384.3.
    UniGenei At.18371.
    At.74127.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ZSH X-ray 1.80 A 1-344 [» ]
    2ZSI X-ray 1.80 A 1-344 [» ]
    DisProti DP00723.
    ProteinModelPortali Q9MAA7.
    SMRi Q9MAA7. Positions 6-344.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 5009. 5 interactions.
    DIPi DIP-37659N.
    IntActi Q9MAA7. 5 interactions.
    STRINGi 3702.AT3G05120.1-P.

    Proteomic databases

    PaxDbi Q9MAA7.
    PRIDEi Q9MAA7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G05120.1 ; AT3G05120.1 ; AT3G05120 .
    GeneIDi 819674.
    KEGGi ath:AT3G05120.

    Organism-specific databases

    TAIRi AT3G05120.

    Phylogenomic databases

    eggNOGi COG0657.
    HOGENOMi HOG000152323.
    InParanoidi Q9MAA7.
    KOi K14493.
    OMAi WERQDEL.
    PhylomeDBi Q9MAA7.

    Enzyme and pathway databases

    BioCyci ARA:AT3G05120-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9MAA7.

    Gene expression databases

    Genevestigatori Q9MAA7.

    Family and domain databases

    Gene3Di 3.40.50.1820. 1 hit.
    InterProi IPR029058. AB_hydrolase.
    IPR013094. AB_hydrolase_3.
    IPR002168. Lipase_GDXG_AS.
    [Graphical view ]
    Pfami PF07859. Abhydrolase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53474. SSF53474. 1 hit.
    PROSITEi PS01173. LIPASE_GDXG_HIS. 1 hit.
    PS01174. LIPASE_GDXG_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "The carboxylesterase gene family from Arabidopsis thaliana."
      Marshall S.D., Putterill J.J., Plummer K.M., Newcomb R.D.
      J. Mol. Evol. 57:487-500(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, GENE FAMILY.
    5. "Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis."
      Griffiths J., Murase K., Rieu I., Zentella R., Zhang Z.L., Powers S.J., Gong F., Phillips A.L., Hedden P., Sun T.P., Thomas S.G.
      Plant Cell 18:3399-3414(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH GAI AND RGA, DISRUPTION PHENOTYPE.
    6. Cited for: FUNCTION, INTERACTION WITH GAI; RGA; RGL1; RGL2 AND RGL3.
    7. "Multiple loss-of-function of Arabidopsis gibberellin receptor AtGID1s completely shuts down a gibberellin signal."
      Iuchi S., Suzuki H., Kim Y.C., Iuchi A., Kuromori T., Ueguchi-Tanaka M., Asami T., Yamaguchi I., Matsuoka M., Kobayashi M., Nakajima M.
      Plant J. 50:958-966(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, DISRUPTION PHENOTYPE.
    8. "Differential expression and affinities of Arabidopsis gibberellin receptors can explain variation in phenotypes of multiple knock-out mutants."
      Suzuki H., Park S.-H., Okubo K., Kitamura J., Ueguchi-Tanaka M., Iuchi S., Katoh E., Kobayashi M., Yamaguchi I., Matsuoka M., Asami T., Nakajima M.
      Plant J. 60:48-55(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RGL2.
    9. "Gibberellin-induced DELLA recognition by the gibberellin receptor GID1."
      Murase K., Hirano Y., Sun T.P., Hakoshima T.
      Nature 456:459-463(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 1-344 IN COMPLEX WITH GIBBERELLIN AND GAI.

    Entry informationi

    Entry nameiGID1A_ARATH
    AccessioniPrimary (citable) accession number: Q9MAA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 93 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3