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Q9MAA7

- GID1A_ARATH

UniProt

Q9MAA7 - GID1A_ARATH

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Protein

Gibberellin receptor GID1A

Gene
GID1A, CXE10, GID1L1, At3g05120, T12H1.8
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Functions as soluble gibberellin (GA) receptor. GA is an essential hormone that regulates growth and development in plants. Binds with high affinity the biologically active gibberellin GA4, but has no affinity for the biologically inactive GAs. In response to GA, interacts with specific DELLA proteins, known as repressors of GA-induced growth, and targets them for degradation via proteasome. Seems to be required for GA signaling that controls root growth, seed germination, stem elongation and flower development. Partially redundant with GID1B and GID1C.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei113 – 1131 Reviewed prediction
Binding sitei127 – 1271Gibberellin
Active sitei191 – 1911 By similarity
Binding sitei191 – 1911Gibberellin
Binding sitei238 – 2381Gibberellin; via carbonyl oxygen
Active sitei289 – 2891 By similarity
Binding sitei320 – 3201Gibberellin; via amide nitrogen

GO - Molecular functioni

  1. gibberellin binding Source: UniProtKB
  2. hydrolase activity Source: UniProtKB-KW
  3. protein binding Source: UniProtKB

GO - Biological processi

  1. floral organ morphogenesis Source: TAIR
  2. gibberellic acid mediated signaling pathway Source: UniProtKB-KW
  3. gibberellin mediated signaling pathway Source: TAIR
  4. positive regulation of gibberellic acid mediated signaling pathway Source: TAIR
  5. raffinose family oligosaccharide biosynthetic process Source: TAIR
  6. response to gibberellin Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Receptor

Keywords - Biological processi

Gibberellin signaling pathway

Enzyme and pathway databases

BioCyciARA:AT3G05120-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Gibberellin receptor GID1A (EC:3.-.-.-)
Alternative name(s):
AtCXE10
Carboxylesterase 10
GID1-like protein 1
Protein GA INSENSITIVE DWARF 1A
Short name:
AtGID1A
Gene namesi
Name:GID1A
Synonyms:CXE10, GID1L1
Ordered Locus Names:At3g05120
ORF Names:T12H1.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G05120.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: TAIR
  2. nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth condition.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 345344Gibberellin receptor GID1APRO_0000071558Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9MAA7.
PRIDEiQ9MAA7.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

GenevestigatoriQ9MAA7.

Interactioni

Subunit structurei

Interacts (via N-terminus) with the DELLA proteins GAI, RGA, RGL1, RGL2 and RGL3 (via N-terminus) in a GA-dependent manner.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GAIQ9LQT86EBI-963597,EBI-963606
GID2Q9STX33EBI-963597,EBI-619033
RGAQ9SLH37EBI-963597,EBI-963624
RGL2Q8GXW13EBI-963597,EBI-963665

Protein-protein interaction databases

BioGridi5009. 5 interactions.
DIPiDIP-37659N.
IntActiQ9MAA7. 5 interactions.
STRINGi3702.AT3G05120.1-P.

Structurei

Secondary structure

1
345
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi10 – 134
Helixi18 – 3417
Helixi43 – 497
Beta strandi63 – 719
Turni72 – 754
Beta strandi76 – 838
Beta strandi103 – 1053
Beta strandi107 – 1126
Turni116 – 1183
Helixi125 – 13814
Beta strandi140 – 1456
Turni150 – 1523
Helixi157 – 17014
Helixi173 – 1753
Turni178 – 1803
Beta strandi184 – 1907
Helixi193 – 20513
Turni206 – 2083
Beta strandi213 – 2186
Helixi228 – 2336
Turni234 – 2363
Helixi241 – 25111
Turni261 – 2633
Beta strandi280 – 2867
Helixi292 – 30413
Beta strandi309 – 3146
Turni319 – 3224
Beta strandi323 – 3253
Helixi328 – 34215

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ZSHX-ray1.80A1-344[»]
2ZSIX-ray1.80A1-344[»]
DisProtiDP00723.
ProteinModelPortaliQ9MAA7.
SMRiQ9MAA7. Positions 6-344.

Miscellaneous databases

EvolutionaryTraceiQ9MAA7.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni115 – 1162Gibberellin binding

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi113 – 1153Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion hole By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0657.
HOGENOMiHOG000152323.
InParanoidiQ9MAA7.
KOiK14493.
OMAiWERQDEL.
PhylomeDBiQ9MAA7.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR002168. Lipase_GDXG_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01173. LIPASE_GDXG_HIS. 1 hit.
PS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9MAA7-1 [UniParc]FASTAAdd to Basket

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MAASDEVNLI ESRTVVPLNT WVLISNFKVA YNILRRPDGT FNRHLAEYLD    50
RKVTANANPV DGVFSFDVLI DRRINLLSRV YRPAYADQEQ PPSILDLEKP 100
VDGDIVPVIL FFHGGSFAHS SANSAIYDTL CRRLVGLCKC VVVSVNYRRA 150
PENPYPCAYD DGWIALNWVN SRSWLKSKKD SKVHIFLAGD SSGGNIAHNV 200
ALRAGESGID VLGNILLNPM FGGNERTESE KSLDGKYFVT VRDRDWYWKA 250
FLPEGEDREH PACNPFSPRG KSLEGVSFPK SLVVVAGLDL IRDWQLAYAE 300
GLKKAGQEVK LMHLEKATVG FYLLPNNNHF HNVMDEISAF VNAEC 345
Length:345
Mass (Da):38,618
Last modified:October 1, 2000 - v1
Checksum:iFE1ED6E13BC1A48D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC009177 Genomic DNA. Translation: AAF27018.1.
CP002686 Genomic DNA. Translation: AEE74188.1.
AY136305 mRNA. Translation: AAM96971.1.
BT002605 mRNA. Translation: AAO00965.1.
RefSeqiNP_187163.1. NM_111384.3.
UniGeneiAt.18371.
At.74127.

Genome annotation databases

EnsemblPlantsiAT3G05120.1; AT3G05120.1; AT3G05120.
GeneIDi819674.
KEGGiath:AT3G05120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC009177 Genomic DNA. Translation: AAF27018.1 .
CP002686 Genomic DNA. Translation: AEE74188.1 .
AY136305 mRNA. Translation: AAM96971.1 .
BT002605 mRNA. Translation: AAO00965.1 .
RefSeqi NP_187163.1. NM_111384.3.
UniGenei At.18371.
At.74127.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2ZSH X-ray 1.80 A 1-344 [» ]
2ZSI X-ray 1.80 A 1-344 [» ]
DisProti DP00723.
ProteinModelPortali Q9MAA7.
SMRi Q9MAA7. Positions 6-344.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 5009. 5 interactions.
DIPi DIP-37659N.
IntActi Q9MAA7. 5 interactions.
STRINGi 3702.AT3G05120.1-P.

Proteomic databases

PaxDbi Q9MAA7.
PRIDEi Q9MAA7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G05120.1 ; AT3G05120.1 ; AT3G05120 .
GeneIDi 819674.
KEGGi ath:AT3G05120.

Organism-specific databases

TAIRi AT3G05120.

Phylogenomic databases

eggNOGi COG0657.
HOGENOMi HOG000152323.
InParanoidi Q9MAA7.
KOi K14493.
OMAi WERQDEL.
PhylomeDBi Q9MAA7.

Enzyme and pathway databases

BioCyci ARA:AT3G05120-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9MAA7.

Gene expression databases

Genevestigatori Q9MAA7.

Family and domain databases

Gene3Di 3.40.50.1820. 1 hit.
InterProi IPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR002168. Lipase_GDXG_AS.
[Graphical view ]
Pfami PF07859. Abhydrolase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF53474. SSF53474. 1 hit.
PROSITEi PS01173. LIPASE_GDXG_HIS. 1 hit.
PS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "The carboxylesterase gene family from Arabidopsis thaliana."
    Marshall S.D., Putterill J.J., Plummer K.M., Newcomb R.D.
    J. Mol. Evol. 57:487-500(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, GENE FAMILY.
  5. "Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis."
    Griffiths J., Murase K., Rieu I., Zentella R., Zhang Z.L., Powers S.J., Gong F., Phillips A.L., Hedden P., Sun T.P., Thomas S.G.
    Plant Cell 18:3399-3414(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GAI AND RGA, DISRUPTION PHENOTYPE.
  6. Cited for: FUNCTION, INTERACTION WITH GAI; RGA; RGL1; RGL2 AND RGL3.
  7. "Multiple loss-of-function of Arabidopsis gibberellin receptor AtGID1s completely shuts down a gibberellin signal."
    Iuchi S., Suzuki H., Kim Y.C., Iuchi A., Kuromori T., Ueguchi-Tanaka M., Asami T., Yamaguchi I., Matsuoka M., Kobayashi M., Nakajima M.
    Plant J. 50:958-966(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  8. "Differential expression and affinities of Arabidopsis gibberellin receptors can explain variation in phenotypes of multiple knock-out mutants."
    Suzuki H., Park S.-H., Okubo K., Kitamura J., Ueguchi-Tanaka M., Iuchi S., Katoh E., Kobayashi M., Yamaguchi I., Matsuoka M., Asami T., Nakajima M.
    Plant J. 60:48-55(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RGL2.
  9. "Gibberellin-induced DELLA recognition by the gibberellin receptor GID1."
    Murase K., Hirano Y., Sun T.P., Hakoshima T.
    Nature 456:459-463(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 1-344 IN COMPLEX WITH GIBBERELLIN AND GAI.

Entry informationi

Entry nameiGID1A_ARATH
AccessioniPrimary (citable) accession number: Q9MAA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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