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Protein

Fructose-1,6-bisphosphatase, cytosolic

Gene

At1g43670

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate.

Cofactori

Mg2+By similarityNote: Binds 3 Mg2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi71Magnesium 1By similarity1
Metal bindingi100Magnesium 1By similarity1
Metal bindingi100Magnesium 2By similarity1
Metal bindingi121Magnesium 2By similarity1
Metal bindingi121Magnesium 3By similarity1
Metal bindingi123Magnesium 2; via carbonyl oxygenBy similarity1
Metal bindingi124Magnesium 3By similarity1
Binding sitei215SubstrateBy similarity1
Binding sitei247SubstrateBy similarity1
Binding sitei267SubstrateBy similarity1
Binding sitei277SubstrateBy similarity1
Metal bindingi283Magnesium 3By similarity1

GO - Molecular functioni

  • fructose 1,6-bisphosphate 1-phosphatase activity Source: TAIR
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • fructose 1,6-bisphosphate metabolic process Source: TAIR
  • fructose 6-phosphate metabolic process Source: GO_Central
  • fructose catabolic process Source: InterPro
  • fructose metabolic process Source: GO_Central
  • gluconeogenesis Source: GO_Central
  • photosynthesis Source: TAIR
  • response to abscisic acid Source: TAIR
  • response to fructose Source: TAIR
  • starch catabolic process Source: TAIR
  • sucrose biosynthetic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT1G43670-MONOMER.
MetaCyc:AT1G43670-MONOMER.
ReactomeiR-ATH-70263. Gluconeogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-1,6-bisphosphatase, cytosolic (EC:3.1.3.11)
Short name:
FBPase
Alternative name(s):
D-fructose-1,6-bisphosphate 1-phosphohydrolase
Gene namesi
Ordered Locus Names:At1g43670
ORF Names:F2J6.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G43670.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: TAIR
  • cytosol Source: TAIR
  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002005121 – 341Fructose-1,6-bisphosphatase, cytosolicAdd BLAST341

Proteomic databases

PaxDbiQ9MA79.
PRIDEiQ9MA79.

Expressioni

Gene expression databases

GenevisibleiQ9MA79. AT.

Interactioni

Protein-protein interaction databases

BioGridi26178. 1 interactor.
IntActiQ9MA79. 1 interactor.
STRINGi3702.AT1G43670.1.

Structurei

3D structure databases

ProteinModelPortaliQ9MA79.
SMRiQ9MA79.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni124 – 127Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the FBPase class 1 family.Curated

Phylogenomic databases

eggNOGiKOG1458. Eukaryota.
COG0158. LUCA.
HOGENOMiHOG000191265.
InParanoidiQ9MA79.
KOiK03841.
OMAiFNYIAAK.
OrthoDBiEOG09360EJ7.
PhylomeDBiQ9MA79.

Family and domain databases

CDDicd00354. FBPase. 1 hit.
HAMAPiMF_01855. FBPase_class1. 1 hit.
InterProiIPR000146. FBPase_class-1.
IPR033391. FBPase_N.
IPR028343. FBPtase.
IPR020548. Fructose_bisphosphatase_AS.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.
PROSITEiPS00124. FBPASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9MA79-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDHAADAHRT DLMTITRFVL NEQSKYPESR GDFTILLSHI VLGCKFVCSA
60 70 80 90 100
VNKAGLAKLI GLAGETNIQG EEQKKLDVLS NDVFVNALVS SGRTSVLVSE
110 120 130 140 150
EDEEATFVEP SKRGKYCVVF DPLDGSSNID CGVSIGTIFG IYTLDHTDEP
160 170 180 190 200
TTADVLKPGN EMVAAGYCMY GSSCMLVLST GTGVHGFTLD PSLGEFILTH
210 220 230 240 250
PDIKIPNKGN IYSVNEGNAQ NWDGPTTKYV EKCKFPKDGS PAKSLRYVGS
260 270 280 290 300
MVADVHRTLL YGGIFLYPAD KKSPNGKLRV LYEVFPMSFL MEQAGGQAFT
310 320 330 340
GKKRALDLVP EKIHERSPIF LGSYDDVEEI KALYAEEEKK N
Length:341
Mass (Da):37,287
Last modified:October 1, 2000 - v1
Checksum:i00F18CD8588DADDA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009526 Genomic DNA. Translation: AAF63117.1.
CP002684 Genomic DNA. Translation: AEE31985.1.
BT000470 mRNA. Translation: AAN17447.1.
BT008732 mRNA. Translation: AAP42745.1.
PIRiH96499.
RefSeqiNP_175032.1. NM_103492.5.
UniGeneiAt.12074.
At.23691.

Genome annotation databases

EnsemblPlantsiAT1G43670.1; AT1G43670.1; AT1G43670.
GeneIDi840953.
GrameneiAT1G43670.1; AT1G43670.1; AT1G43670.
KEGGiath:AT1G43670.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009526 Genomic DNA. Translation: AAF63117.1.
CP002684 Genomic DNA. Translation: AEE31985.1.
BT000470 mRNA. Translation: AAN17447.1.
BT008732 mRNA. Translation: AAP42745.1.
PIRiH96499.
RefSeqiNP_175032.1. NM_103492.5.
UniGeneiAt.12074.
At.23691.

3D structure databases

ProteinModelPortaliQ9MA79.
SMRiQ9MA79.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi26178. 1 interactor.
IntActiQ9MA79. 1 interactor.
STRINGi3702.AT1G43670.1.

Proteomic databases

PaxDbiQ9MA79.
PRIDEiQ9MA79.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G43670.1; AT1G43670.1; AT1G43670.
GeneIDi840953.
GrameneiAT1G43670.1; AT1G43670.1; AT1G43670.
KEGGiath:AT1G43670.

Organism-specific databases

TAIRiAT1G43670.

Phylogenomic databases

eggNOGiKOG1458. Eukaryota.
COG0158. LUCA.
HOGENOMiHOG000191265.
InParanoidiQ9MA79.
KOiK03841.
OMAiFNYIAAK.
OrthoDBiEOG09360EJ7.
PhylomeDBiQ9MA79.

Enzyme and pathway databases

BioCyciARA:AT1G43670-MONOMER.
MetaCyc:AT1G43670-MONOMER.
ReactomeiR-ATH-70263. Gluconeogenesis.

Miscellaneous databases

PROiQ9MA79.

Gene expression databases

GenevisibleiQ9MA79. AT.

Family and domain databases

CDDicd00354. FBPase. 1 hit.
HAMAPiMF_01855. FBPase_class1. 1 hit.
InterProiIPR000146. FBPase_class-1.
IPR033391. FBPase_N.
IPR028343. FBPtase.
IPR020548. Fructose_bisphosphatase_AS.
[Graphical view]
PANTHERiPTHR11556. PTHR11556. 1 hit.
PfamiPF00316. FBPase. 1 hit.
[Graphical view]
PIRSFiPIRSF500210. FBPtase. 1 hit.
PIRSF000904. FBPtase_SBPase. 1 hit.
PRINTSiPR00115. F16BPHPHTASE.
PROSITEiPS00124. FBPASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiF16P2_ARATH
AccessioniPrimary (citable) accession number: Q9MA79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

In plants there are two FBPase isozymes: one in the cytosol and the other in the chloroplast.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.