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Protein

Probable thylakoidal processing peptidase 2, chloroplastic

Gene

TPP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Cleaves the thylakoid-transfer domain from a chloroplast protein.By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei214By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Protein family/group databases

MEROPSiS26.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable thylakoidal processing peptidase 2, chloroplastic (EC:3.4.21.89)
Alternative name(s):
Signal peptidase I-2
Gene namesi
Name:TPP2
Ordered Locus Names:At1g06870
ORF Names:F4H5.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G06870.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 367Lumenal, thylakoidSequence analysisAdd BLAST162

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Membrane, Plastid, Thylakoid

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1932907.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000310735? – 367Probable thylakoidal processing peptidase 2, chloroplastic
Transit peptidei1 – 68ChloroplastSequence analysisAdd BLAST68
Transit peptidei69 – ?ThylakoidSequence analysis

Proteomic databases

PaxDbiQ9M9Z2.

PTM databases

iPTMnetiQ9M9Z2.

Expressioni

Gene expression databases

GenevisibleiQ9M9Z2. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G06870.1.

Structurei

3D structure databases

ProteinModelPortaliQ9M9Z2.
SMRiQ9M9Z2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0171. Eukaryota.
COG0681. LUCA.
HOGENOMiHOG000243179.
InParanoidiQ9M9Z2.
KOiK03100.
OMAiSSMYSTI.
OrthoDBiEOG09360HO1.
PhylomeDBiQ9M9Z2.

Family and domain databases

Gene3Di2.10.109.10. 2 hits.
InterProiIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR015927. Peptidase_S24_S26A/B/C.
IPR019533. Peptidase_S26.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 1 hit.
PfamiPF10502. Peptidase_S26. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9M9Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRVTFTYS SYVARSIASS AGTRVGTGDV RSCFETWVRP RFCGHNQIPD
60 70 80 90 100
IVDKSPGSNT WGPSSGPRAR PASSMYSTIA REILEEGCKS PLVLGMISLM
110 120 130 140 150
NLTGAPQFSG MTGLGISPFK TSSVIPFLRG SKWMPCSIPA TLSTDIAEVD
160 170 180 190 200
RGGKVCDPKV KLELSDKVSN GGNGWVNKLL NICSEDAKAA FTAVTVSLLF
210 220 230 240 250
RSALAEPKSI PSTSMLPTLD VGDRVIAEKV SYFFRKPEVS DIVIFKAPPI
260 270 280 290 300
LVEHGYSCAD VFIKRIVASE GDWVEVCDGK LLVNDTVQAE DFVLEPIDYE
310 320 330 340 350
MEPMFVPEGY VFVLGDNRNK SFDSHNWGPL PIKNIIGRSV FRYWPPSKVS
360
DIIHHEQVSQ KRAVDVS
Length:367
Mass (Da):40,150
Last modified:October 1, 2000 - v1
Checksum:iBE18813DE031BBAE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111M → V in AAM62715 (Ref. 3) Curated1
Sequence conflicti196V → F in AAM62715 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011001 Genomic DNA. Translation: AAF63136.1.
CP002684 Genomic DNA. Translation: AEE28047.1.
AY085489 mRNA. Translation: AAM62715.1.
BT024745 mRNA. Translation: ABD59083.1.
PIRiE86203.
RefSeqiNP_172171.1. NM_100563.4.
UniGeneiAt.23784.

Genome annotation databases

EnsemblPlantsiAT1G06870.1; AT1G06870.1; AT1G06870.
GeneIDi837198.
GrameneiAT1G06870.1; AT1G06870.1; AT1G06870.
KEGGiath:AT1G06870.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011001 Genomic DNA. Translation: AAF63136.1.
CP002684 Genomic DNA. Translation: AEE28047.1.
AY085489 mRNA. Translation: AAM62715.1.
BT024745 mRNA. Translation: ABD59083.1.
PIRiE86203.
RefSeqiNP_172171.1. NM_100563.4.
UniGeneiAt.23784.

3D structure databases

ProteinModelPortaliQ9M9Z2.
SMRiQ9M9Z2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G06870.1.

Chemistry databases

ChEMBLiCHEMBL1932907.

Protein family/group databases

MEROPSiS26.A01.

PTM databases

iPTMnetiQ9M9Z2.

Proteomic databases

PaxDbiQ9M9Z2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G06870.1; AT1G06870.1; AT1G06870.
GeneIDi837198.
GrameneiAT1G06870.1; AT1G06870.1; AT1G06870.
KEGGiath:AT1G06870.

Organism-specific databases

TAIRiAT1G06870.

Phylogenomic databases

eggNOGiKOG0171. Eukaryota.
COG0681. LUCA.
HOGENOMiHOG000243179.
InParanoidiQ9M9Z2.
KOiK03100.
OMAiSSMYSTI.
OrthoDBiEOG09360HO1.
PhylomeDBiQ9M9Z2.

Miscellaneous databases

PROiQ9M9Z2.

Gene expression databases

GenevisibleiQ9M9Z2. AT.

Family and domain databases

Gene3Di2.10.109.10. 2 hits.
InterProiIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR015927. Peptidase_S24_S26A/B/C.
IPR019533. Peptidase_S26.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 1 hit.
PfamiPF10502. Peptidase_S26. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTPP2_ARATH
AccessioniPrimary (citable) accession number: Q9M9Z2
Secondary accession number(s): Q8LEC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.