Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable thylakoidal processing peptidase 2, chloroplastic

Gene

TPP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cleaves the thylakoid-transfer domain from a chloroplast protein.By similarity

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei214By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease

Protein family/group databases

MEROPSiS26.A01

Names & Taxonomyi

Protein namesi
Recommended name:
Probable thylakoidal processing peptidase 2, chloroplastic (EC:3.4.21.89)
Alternative name(s):
Signal peptidase I-2
Gene namesi
Name:TPP2
Ordered Locus Names:At1g06870
ORF Names:F4H5.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G06870
TAIRilocus:2033108 AT1G06870

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 367Lumenal, thylakoidSequence analysisAdd BLAST162

Keywords - Cellular componenti

Chloroplast, Membrane, Plastid, Thylakoid

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1932907

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000310735? – 367Probable thylakoidal processing peptidase 2, chloroplastic
Transit peptidei1 – 68ChloroplastSequence analysisAdd BLAST68
Transit peptidei69 – ?ThylakoidSequence analysis

Proteomic databases

PaxDbiQ9M9Z2

PTM databases

iPTMnetiQ9M9Z2

Expressioni

Gene expression databases

ExpressionAtlasiQ9M9Z2 baseline and differential
GenevisibleiQ9M9Z2 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G06870.1

Structurei

3D structure databases

ProteinModelPortaliQ9M9Z2
SMRiQ9M9Z2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0171 Eukaryota
COG0681 LUCA
HOGENOMiHOG000243179
InParanoidiQ9M9Z2
KOiK03100
OMAiDIIHHEQ
OrthoDBiEOG09360HO1
PhylomeDBiQ9M9Z2

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR000223 Pept_S26A_signal_pept_1
IPR019758 Pept_S26A_signal_pept_1_CS
IPR019756 Pept_S26A_signal_pept_1_Ser-AS
IPR019533 Peptidase_S26
PfamiView protein in Pfam
PF10502 Peptidase_S26, 1 hit
PRINTSiPR00727 LEADERPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02227 sigpep_I_bact, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit
PS00761 SPASE_I_3, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9M9Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRVTFTYS SYVARSIASS AGTRVGTGDV RSCFETWVRP RFCGHNQIPD
60 70 80 90 100
IVDKSPGSNT WGPSSGPRAR PASSMYSTIA REILEEGCKS PLVLGMISLM
110 120 130 140 150
NLTGAPQFSG MTGLGISPFK TSSVIPFLRG SKWMPCSIPA TLSTDIAEVD
160 170 180 190 200
RGGKVCDPKV KLELSDKVSN GGNGWVNKLL NICSEDAKAA FTAVTVSLLF
210 220 230 240 250
RSALAEPKSI PSTSMLPTLD VGDRVIAEKV SYFFRKPEVS DIVIFKAPPI
260 270 280 290 300
LVEHGYSCAD VFIKRIVASE GDWVEVCDGK LLVNDTVQAE DFVLEPIDYE
310 320 330 340 350
MEPMFVPEGY VFVLGDNRNK SFDSHNWGPL PIKNIIGRSV FRYWPPSKVS
360
DIIHHEQVSQ KRAVDVS
Length:367
Mass (Da):40,150
Last modified:October 1, 2000 - v1
Checksum:iBE18813DE031BBAE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti111M → V in AAM62715 (Ref. 3) Curated1
Sequence conflicti196V → F in AAM62715 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011001 Genomic DNA Translation: AAF63136.1
CP002684 Genomic DNA Translation: AEE28047.1
AY085489 mRNA Translation: AAM62715.1
BT024745 mRNA Translation: ABD59083.1
PIRiE86203
RefSeqiNP_172171.1, NM_100563.4
UniGeneiAt.23784

Genome annotation databases

EnsemblPlantsiAT1G06870.1; AT1G06870.1; AT1G06870
GeneIDi837198
GrameneiAT1G06870.1; AT1G06870.1; AT1G06870
KEGGiath:AT1G06870

Similar proteinsi

Entry informationi

Entry nameiTPP2_ARATH
AccessioniPrimary (citable) accession number: Q9M9Z2
Secondary accession number(s): Q8LEC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health