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Protein

Serine/threonine-protein phosphatase PP1 isozyme 9

Gene

TOPP9

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi66Manganese 1By similarity1
Metal bindingi68Manganese 1By similarity1
Metal bindingi94Manganese 1By similarity1
Metal bindingi94Manganese 2By similarity1
Metal bindingi126Manganese 2By similarity1
Active sitei127Proton donorBy similarity1
Metal bindingi175Manganese 2By similarity1
Metal bindingi250Manganese 2By similarity1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • protein serine/threonine phosphatase activity Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase PP1 isozyme 9 (EC:3.1.3.16)
Gene namesi
Name:TOPP9
Ordered Locus Names:At3g05580
ORF Names:F18C1.15
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G05580.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003089872 – 318Serine/threonine-protein phosphatase PP1 isozyme 9Add BLAST317

Proteomic databases

PaxDbiQ9M9W3.

Expressioni

Gene expression databases

GenevisibleiQ9M9W3. AT.

Interactioni

Protein-protein interaction databases

BioGridi5059. 3 interactors.
IntActiQ9M9W3. 2 interactors.
STRINGi3702.AT3G05580.1.

Structurei

3D structure databases

ProteinModelPortaliQ9M9W3.
SMRiQ9M9W3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPP phosphatase family. PP-1 subfamily.Curated

Phylogenomic databases

eggNOGiENOG410IN81. Eukaryota.
ENOG410YCEC. LUCA.
HOGENOMiHOG000172697.
InParanoidiQ9M9W3.
KOiK06269.
OMAiNNICIRA.
OrthoDBiEOG09360G9F.
PhylomeDBiQ9M9W3.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9M9W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMTSMEGMME MGVLDDIIRR LLEGKGGKQV QLSEVEIRQL CVNARQIFLS
60 70 80 90 100
QPNLLELHAP IRICGDIHGQ YQDLLRLFEY GGYPPSANYL FLGDYVDRGK
110 120 130 140 150
QSLETICLLL AYKIRYPSKI FLLRGNHEDA KINRIYGFYD ECKRRFNVRL
160 170 180 190 200
WKIFTDCFNC LPVAALIDEK ILCMHGGLSP ELENLGQIRE IQRPTEIPDN
210 220 230 240 250
GLLCDLLWSD PDQKNEGWTD SDRGISCTFG ADVVADFLDK NDLDLICRGH
260 270 280 290 300
QVVEDGYEFF AKRRLVTIFS APNYGGEFDN AGALLSVDQS LVCSFEILKP
310
APASSTNPLK KVPKMGKS
Length:318
Mass (Da):36,001
Last modified:October 1, 2000 - v1
Checksum:i548C712D728C099D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011620 Genomic DNA. Translation: AAF26139.1.
CP002686 Genomic DNA. Translation: AEE74262.1.
BT010532 mRNA. Translation: AAQ65155.1.
AK175443 mRNA. Translation: BAD43206.1.
RefSeqiNP_187209.1. NM_111431.4.
UniGeneiAt.40648.

Genome annotation databases

EnsemblPlantsiAT3G05580.1; AT3G05580.1; AT3G05580.
GeneIDi819724.
GrameneiAT3G05580.1; AT3G05580.1; AT3G05580.
KEGGiath:AT3G05580.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011620 Genomic DNA. Translation: AAF26139.1.
CP002686 Genomic DNA. Translation: AEE74262.1.
BT010532 mRNA. Translation: AAQ65155.1.
AK175443 mRNA. Translation: BAD43206.1.
RefSeqiNP_187209.1. NM_111431.4.
UniGeneiAt.40648.

3D structure databases

ProteinModelPortaliQ9M9W3.
SMRiQ9M9W3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi5059. 3 interactors.
IntActiQ9M9W3. 2 interactors.
STRINGi3702.AT3G05580.1.

Proteomic databases

PaxDbiQ9M9W3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G05580.1; AT3G05580.1; AT3G05580.
GeneIDi819724.
GrameneiAT3G05580.1; AT3G05580.1; AT3G05580.
KEGGiath:AT3G05580.

Organism-specific databases

TAIRiAT3G05580.

Phylogenomic databases

eggNOGiENOG410IN81. Eukaryota.
ENOG410YCEC. LUCA.
HOGENOMiHOG000172697.
InParanoidiQ9M9W3.
KOiK06269.
OMAiNNICIRA.
OrthoDBiEOG09360G9F.
PhylomeDBiQ9M9W3.

Miscellaneous databases

PROiQ9M9W3.

Gene expression databases

GenevisibleiQ9M9W3. AT.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
IPR006186. Ser/Thr-sp_prot-phosphatase.
IPR031675. STPPase_N.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
PF16891. STPPase_N. 1 hit.
[Graphical view]
PRINTSiPR00114. STPHPHTASE.
SMARTiSM00156. PP2Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
PROSITEiPS00125. SER_THR_PHOSPHATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPP19_ARATH
AccessioniPrimary (citable) accession number: Q9M9W3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.