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Protein

Translationally controlled tumor protein 2

Gene

TCTP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates proliferation. Induces whole plant regeneration when expressed in heterologous systems (PubMed:26191065, PubMed:26237533). Involved in root growth and lateral root development, with a probable role in cell reprogramming (PubMed:25566280). The long-distance transport of TCTP RNA and/or protein in plants may have an important role in regulation of growth and development (Probable).1 Publication3 Publications

Miscellaneous

In a heterologous system, TCTP2 mRNA and protein are capable of moving long distance in both directions with a tendency for movment from source to sink tissue (PubMed:25566280, PubMed:26237533). In heterografts, the long-distance transport of TCTP2 is necessary but not sufficient to induce emergence of adventitious aerial roots in close proximity to the graft (PubMed:26237533).2 Publications

Caution

Was initially thought to be a pseudogene.1 Publication

GO - Biological processi

  • developmental process Source: TAIR
  • regulation of cell proliferation Source: TAIR

Names & Taxonomyi

Protein namesi
Recommended name:
Translationally controlled tumor protein 21 Publication
Short name:
AtTCTP21 Publication
Gene namesi
Name:TCTP21 Publication
Ordered Locus Names:At3g05540Imported
ORF Names:F18C1.20Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G05540
TAIRilocus:2078052 AT3G05540

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Seedling lethality at the early rosette stage when homozygous.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi35N → WVTVGAVDVNIGAN: Loss of regeneration capacity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004347271 – 156Translationally controlled tumor protein 2Add BLAST156

Expressioni

Tissue specificityi

Expressed in stems, cauline leaves, minor veins of rosette leaves, roots, lateral root primordia, vascular tissues of petioles and inflorescences, base of siliques, papillae and ovules. Not detected in root meristems, anthers or seeds (PubMed:26191065). Expressed in stomata, trichomes and root cortex (PubMed:26191065, PubMed:26237533).2 Publications

Gene expression databases

ExpressionAtlasiQ9M9V9 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliQ9M9V9
SMRiQ9M9V9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 156TCTPPROSITE-ProRule annotationAdd BLAST156

Sequence similaritiesi

Belongs to the TCTP family.PROSITE-ProRule annotation

Phylogenomic databases

InParanoidiF4J8E4
OrthoDBiEOG09360P0R
PhylomeDBiQ9M9V9

Family and domain databases

Gene3Di2.170.150.10, 1 hit
InterProiView protein in InterPro
IPR011057 Mss4-like_sf
IPR011323 Mss4/transl-control_tumor
IPR034737 TCTP
IPR018103 Translation_control_tumour_CS
IPR018105 Translational_control_tumour_p
PANTHERiPTHR11991 PTHR11991, 1 hit
PfamiView protein in Pfam
PF00838 TCTP, 1 hit
PRINTSiPR01653 TCTPROTEIN
SUPFAMiSSF51316 SSF51316, 1 hit
PROSITEiView protein in PROSITE
PS01003 TCTP_2, 1 hit
PS51797 TCTP_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q9M9V9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVYQDILTG DELLSDSFPY KEIENGMLWE VEGKNPSGEE GGEDEGVDDQ
60 70 80 90 100
AVKVVDIIDT FRLQEQPSFD KKQFVMFMKR YIKQLSPKLD SENQELFKKH
110 120 130 140 150
IESATKFLMS KLKDFQFFVG ESMEGEEGSL VFAYYREGAT DPTFLYLAYG

LKEIKC
Length:156
Mass (Da):18,016
Last modified:October 1, 2000 - v1
Checksum:i9C547B2EABC66A5D
GO

Sequence cautioni

The sequence AEE74255 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
KR261461 mRNA Translation: AKP17134.1
AC011620 Genomic DNA Translation: AAF26143.1
CP002686 Genomic DNA Translation: AEE74255.1 Sequence problems.
RefSeqiNP_187205.4, NM_111427.4
UniGeneiAt.53191

Genome annotation databases

GeneIDi819719
KEGGiath:AT3G05540

Similar proteinsi

Entry informationi

Entry nameiTCTP2_ARATH
AccessioniPrimary (citable) accession number: Q9M9V9
Secondary accession number(s): F4J8E4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 11, 2015
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health