Reviewed, UniProtKB/Swiss-Prot Q9M9Q9 (PER5_ARATH)

Names and origin

Protein names

Recommended name:
    Peroxidase 5
      Short name=Atperox P5
    EC=1.11.1.7

Gene names

Name:	PER5
Synonyms:	P5
Ordered Locus Names:	At1g14550
ORF Names:	T5E21.5, F14L17.33

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	321 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.
Catalytic activity	Donor + H2O2 = oxidized donor + 2 H2O.
Cofactor	Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity. Binds 2 calcium ions per subunit By similarity.
Subcellular location	Secreted By similarity.
Miscellaneous	There are 73 peroxidase genes in A.thaliana.
Sequence similarities	Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.
Sequence caution	The sequence AAF63165.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Cellular component	Secreted
Domain	Signal
Ligand	Calcium Heme Iron Metal-binding
Molecular function	Oxidoreductase Peroxidase
PTM	Disulfide bond Glycoprotein Pyrrolidone carboxylic acid
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to oxidative stress Inferred from electronic annotation. Source: InterPro
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro peroxidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 321	297	Peroxidase 5		PRO_0000023671
Sites
	Active site	66	1	Proton acceptor By similarity
	Metal binding	67	1	Calcium 1 By similarity
	Metal binding	70	1	Calcium 1; via carbonyl oxygen By similarity
	Metal binding	72	1	Calcium 1; via carbonyl oxygen By similarity
	Metal binding	74	1	Calcium 1 By similarity
	Metal binding	76	1	Calcium 1 By similarity
	Metal binding	194	1	Iron (heme axial ligand) By similarity
	Metal binding	195	1	Calcium 2 By similarity
	Metal binding	240	1	Calcium 2 By similarity
	Metal binding	243	1	Calcium 2 By similarity
	Metal binding	248	1	Calcium 2 By similarity
	Binding site	164	1	Substrate; via carbonyl oxygen By similarity
	Site	62	1	Transition state stabilizer By similarity
Amino acid modifications
	Modified residue	25	1	Pyrrolidone carboxylic acid By similarity
	Glycosylation	211	1	N-linked (GlcNAc...) Potential
	Glycosylation	285	1	N-linked (GlcNAc...) Potential
	Disulfide bond	35 ↔ 115		By similarity
	Disulfide bond	68 ↔ 73		By similarity
	Disulfide bond	121 ↔ 317		By similarity
	Disulfide bond	201 ↔ 227		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9M9Q9-1 [UniParc]. Last modified November 25, 2002. Version 2. Checksum: C493FDCCCE8E26FE	FASTA	321	35,007
	10 20 30 40 50 60 MERFSLRFVL MMVSIILTSS ICQAQLSPTF YDQSCRNALS KIRSSVRTAI ARERRMAASL 70 80 90 100 110 120 IRMHFHDCFV HGCDASILLE GTSTIESERD ALPNFKSVRG FEVIDKAKSE VEKVCPGIVS 130 140 150 160 170 180 CADIIAVAAR DASEYVGGPK WAVKVGRRDS TAAFKALANS GELPGFKDTL DQLSGLFSKK 190 200 210 220 230 240 GLNTRDLVAL SGAHTIGQSQ CFLFRDRLYE NSSDIDAGFA STRKRRCPTV GGDGNLAALD 250 260 270 280 290 300 LVTPNSFDNN YYKNLMQKKG LLVTDQVLFG SGASTDGIVS EYSKNRSKFA ADFATAMIKM 310 320 GNIEPLTGSN GEIRKICSFV N

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Analysis and expression of the class III peroxidase large gene family in Arabidopsis thaliana." Tognolli M., Penel C., Greppin H., Simon P. Gene 288:129-138(2002) [PubMed: 12034502] [Abstract] Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE. Strain: cv. Columbia.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AC010657 Genomic DNA. Translation: AAF63165.1. Sequence problems. AC012188 Genomic DNA. Translation: AAF43956.1. Different initiation.
IPI	IPI00544334.
PIR	C86280.
RefSeq	NP_172907.1.
UniGene	At.51610
3D structure databases
HSSP	HSSP built from PDB template 1SCH based on UniProtKB P22195.
ModBase	Search...
Protein family/group databases
PeroxiBase	81. AtPrx05.
Genome annotation databases
GeneID	838017.
GenomeReviews	Gene locus AT1G14550 in contig CT485782_GR.
KEGG	ath:AT1G14550.
NMPDR	fig|3702.1.peg.1740.
Organism-specific databases
GeneFarm	1516. 61.
TAIR	At1g14550.
Phylogenomic databases
OMA	Q9M9Q9. TSTIESE.
Enzyme and pathway databases
BRENDA	1.11.1.7. 302.
Gene expression databases
ArrayExpress	Q9M9Q9.
GermOnline	AT1G14550. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR002016. Haem_peroxidase_pln/fun/bac. IPR000823. Peroxidase_pln. IPR019794. Peroxidases_AS. IPR019793. Peroxidases_heam-ligand_BS. [Graphical view]
Pfam	PF00141. peroxidase. 1 hit. [Graphical view]
PRINTS	PR00458. PEROXIDASE. PR00461. PLPEROXIDASE.
PROSITE	PS00435. PEROXIDASE_1. 1 hit. PS00436. PEROXIDASE_2. 1 hit. PS50873. PEROXIDASE_4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PER5_ARATH

Accession

Primary (citable) accession number: Q9M9Q9
Secondary accession number(s): Q9MA28

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 25, 2002
Last sequence update:	November 25, 2002
Last modified:	June 16, 2009
This is version 63 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)