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Protein

Lon protease homolog 3, mitochondrial

Gene

LON3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.UniRule annotation

Catalytic activityi

Hydrolysis of proteins in presence of ATP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei828UniRule annotation1
Active sitei871UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi447 – 454ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Hydrolase, Protease, Serine protease
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPSiS16.A03

Names & Taxonomyi

Protein namesi
Recommended name:
Lon protease homolog 3, mitochondrial (EC:3.4.21.53UniRule annotation)
Gene namesi
Name:LON3
Ordered Locus Names:At3g05780
ORF Names:F10A16.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G05780
TAIRilocus:2074454 AT3G05780

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 63MitochondrionUniRule annotationAdd BLAST63
ChainiPRO_000004542464 – 924Lon protease homolog 3, mitochondrialAdd BLAST861

Proteomic databases

PaxDbiQ9M9L8
PRIDEiQ9M9L8

Expressioni

Gene expression databases

ExpressionAtlasiQ9M9L8 baseline and differential
GenevisibleiQ9M9L8 AT

Interactioni

Subunit structurei

Homohexamer or homoheptamer. Organized in a ring with a central cavity.UniRule annotation

Protein-protein interaction databases

STRINGi3702.AT3G05780.1

Structurei

3D structure databases

ProteinModelPortaliQ9M9L8
SMRiQ9M9L8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini112 – 323Lon N-terminalPROSITE-ProRule annotationAdd BLAST212
Domaini738 – 922Lon proteolyticPROSITE-ProRule annotationAdd BLAST185

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2004 Eukaryota
COG0466 LUCA
HOGENOMiHOG000261409
InParanoidiQ9M9L8
KOiK08675
OMAiTESKTKQ
OrthoDBiEOG09360001
PhylomeDBiQ9M9L8

Family and domain databases

Gene3Di3.30.230.10, 1 hit
HAMAPiMF_03120 lonm_euk, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR004815 Lon_bac/euk-typ
IPR008269 Lon_proteolytic
IPR027065 Lon_Prtase
IPR003111 Lon_substr-bd
IPR027503 Lonm_euk
IPR027417 P-loop_NTPase
IPR008268 Peptidase_S16_AS
IPR015947 PUA-like_sf
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PANTHERiPTHR43718 PTHR43718, 1 hit
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF05362 Lon_C, 1 hit
PF02190 LON_substr_bdg, 1 hit
PIRSFiPIRSF001174 Lon_proteas, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00464 LON, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54211 SSF54211, 1 hit
SSF88697 SSF88697, 2 hits
TIGRFAMsiTIGR00763 lon, 1 hit
PROSITEiView protein in PROSITE
PS51787 LON_N, 1 hit
PS51786 LON_PROTEOLYTIC, 1 hit
PS01046 LON_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9M9L8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPKRFNTSG FDTTLRLPSY YGFLHLTQSL TLNSRVFYGA RHVTPPAIRI
60 70 80 90 100
GSNPVQSLLL FRAPTQLTGW NRSSRDLLGR RVSFSDRSDG VDLLSSSPIL
110 120 130 140 150
STNPNLDDSL TVIALPLPHK PLIPGFYMPI HVKDPKVLAA LQESTRQQSP
160 170 180 190 200
YVGAFLLKDC ASTDSSSRSE TEDNVVEKFK VKGKPKKKRR KELLNRIHQV
210 220 230 240 250
GTLAQISSIQ GEQVILVGRR RLIIEEMVSE DPLTVRVDHL KDKPYDKDNA
260 270 280 290 300
VIKASYVEVI STLREVLKTN SLWRDQDIGD FSYQHLADFG AGISGANKHK
310 320 330 340 350
NQGVLTELDV HKRLELTLEL VKKQVEINKI KETDDGSSLS AKIRVRIDTK
360 370 380 390 400
RDKIPKHVIK VMEEEFTKLE MLEENYSDFD LTYNYLHWLT VLPWGNFSYE
410 420 430 440 450
NFDVLRAKKI LDEDHYGLSD VKERILEFIA VGRLRGTSQG KIICLSGPPG
460 470 480 490 500
VGKTSIGRSI ARALDRKFFR FSVGGLSDVA EIKGHCQTYV GAMPGKMVQC
510 520 530 540 550
LKSVGTANPL ILFDEIDKLG RCHTGDPASA LLEVMDPEQN AKFLDHFLNV
560 570 580 590 600
TIDLSKVLFV CTANVIEMIP GPLLDRMEVI DLSGYVTDEK MHIARDYLVK
610 620 630 640 650
KTCRDCGIKP EHVDLSDAAL LSLIENYCRE AGVRNLQKQI EKIYRKVALE
660 670 680 690 700
LVRQGAVSFD VTDTKDTKSL AKTDSEVKRM KVADIMKILE SATGDSTESK
710 720 730 740 750
TKQSGLVAKT FEKVMIDESN LADYVGKPVF QEEKIYEQTP VGVVMGLAWT
760 770 780 790 800
SMGGSTLYIE TTFVEEGLGK GGLHITGQLG DVMKESAQIA HTVARRIMFE
810 820 830 840 850
KEPENLFFAN SKLHLHVPEG ATPKDGPSAG CTMITSFLSL AMKKLVRKDL
860 870 880 890 900
AMTGEVTLTG RILPIGGVKE KTIAARRSQI KTIIFPEANR RDFEELAENM
910 920
KEGLDVHFVD EYEKIFDLAF NYDH
Length:924
Mass (Da):103,476
Last modified:October 1, 2000 - v1
Checksum:iDF6BCA96ECF99C65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012393 Genomic DNA Translation: AAF26080.1
CP002686 Genomic DNA Translation: AEE74296.1
RefSeqiNP_566258.1, NM_111452.1
UniGeneiAt.53195

Genome annotation databases

EnsemblPlantsiAT3G05780.1; AT3G05780.1; AT3G05780
GeneIDi819747
GrameneiAT3G05780.1; AT3G05780.1; AT3G05780
KEGGiath:AT3G05780

Similar proteinsi

Entry informationi

Entry nameiLONM3_ARATH
AccessioniPrimary (citable) accession number: Q9M9L8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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