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Protein

Lon protease homolog 3, mitochondrial

Gene

LON3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei828 – 8281UniRule annotation
Active sitei871 – 8711UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi447 – 4548ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G05780-MONOMER.

Protein family/group databases

MEROPSiS16.A03.

Names & Taxonomyi

Protein namesi
Recommended name:
Lon protease homolog 3, mitochondrial (EC:3.4.21.-UniRule annotation)
Gene namesi
Name:LON3
Ordered Locus Names:At3g05780
ORF Names:F10A16.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G05780.

Subcellular locationi

  • Mitochondrion matrix UniRule annotation

GO - Cellular componenti

  • mitochondrial matrix Source: GO_Central
  • mitochondrion Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6363MitochondrionUniRule annotationAdd
BLAST
Chaini64 – 924861Lon protease homolog 3, mitochondrialPRO_0000045424Add
BLAST

Proteomic databases

PaxDbiQ9M9L8.
PRIDEiQ9M9L8.

PTM databases

iPTMnetiQ9M9L8.

Expressioni

Gene expression databases

GenevisibleiQ9M9L8. AT.

Interactioni

Subunit structurei

Homohexamer or homoheptamer. Organized in a ring with a central cavity.UniRule annotation

Protein-protein interaction databases

STRINGi3702.AT3G05780.1.

Structurei

3D structure databases

ProteinModelPortaliQ9M9L8.
SMRiQ9M9L8. Positions 354-920.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini112 – 323212Lon N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini738 – 922185Lon proteolyticPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation
Contains 1 Lon N-terminal domain.PROSITE-ProRule annotation
Contains 1 Lon proteolytic domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2004. Eukaryota.
COG0466. LUCA.
HOGENOMiHOG000261409.
InParanoidiQ9M9L8.
KOiK08675.
OMAiTESKTKQ.
PhylomeDBiQ9M9L8.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_03120. lonm_euk.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR003111. LON_substr-bd_dom.
IPR027503. Lonm_euk.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 3 hits.
PfamiPF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 2 hits.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9M9L8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMPKRFNTSG FDTTLRLPSY YGFLHLTQSL TLNSRVFYGA RHVTPPAIRI
60 70 80 90 100
GSNPVQSLLL FRAPTQLTGW NRSSRDLLGR RVSFSDRSDG VDLLSSSPIL
110 120 130 140 150
STNPNLDDSL TVIALPLPHK PLIPGFYMPI HVKDPKVLAA LQESTRQQSP
160 170 180 190 200
YVGAFLLKDC ASTDSSSRSE TEDNVVEKFK VKGKPKKKRR KELLNRIHQV
210 220 230 240 250
GTLAQISSIQ GEQVILVGRR RLIIEEMVSE DPLTVRVDHL KDKPYDKDNA
260 270 280 290 300
VIKASYVEVI STLREVLKTN SLWRDQDIGD FSYQHLADFG AGISGANKHK
310 320 330 340 350
NQGVLTELDV HKRLELTLEL VKKQVEINKI KETDDGSSLS AKIRVRIDTK
360 370 380 390 400
RDKIPKHVIK VMEEEFTKLE MLEENYSDFD LTYNYLHWLT VLPWGNFSYE
410 420 430 440 450
NFDVLRAKKI LDEDHYGLSD VKERILEFIA VGRLRGTSQG KIICLSGPPG
460 470 480 490 500
VGKTSIGRSI ARALDRKFFR FSVGGLSDVA EIKGHCQTYV GAMPGKMVQC
510 520 530 540 550
LKSVGTANPL ILFDEIDKLG RCHTGDPASA LLEVMDPEQN AKFLDHFLNV
560 570 580 590 600
TIDLSKVLFV CTANVIEMIP GPLLDRMEVI DLSGYVTDEK MHIARDYLVK
610 620 630 640 650
KTCRDCGIKP EHVDLSDAAL LSLIENYCRE AGVRNLQKQI EKIYRKVALE
660 670 680 690 700
LVRQGAVSFD VTDTKDTKSL AKTDSEVKRM KVADIMKILE SATGDSTESK
710 720 730 740 750
TKQSGLVAKT FEKVMIDESN LADYVGKPVF QEEKIYEQTP VGVVMGLAWT
760 770 780 790 800
SMGGSTLYIE TTFVEEGLGK GGLHITGQLG DVMKESAQIA HTVARRIMFE
810 820 830 840 850
KEPENLFFAN SKLHLHVPEG ATPKDGPSAG CTMITSFLSL AMKKLVRKDL
860 870 880 890 900
AMTGEVTLTG RILPIGGVKE KTIAARRSQI KTIIFPEANR RDFEELAENM
910 920
KEGLDVHFVD EYEKIFDLAF NYDH
Length:924
Mass (Da):103,476
Last modified:October 1, 2000 - v1
Checksum:iDF6BCA96ECF99C65
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012393 Genomic DNA. Translation: AAF26080.1.
CP002686 Genomic DNA. Translation: AEE74296.1.
RefSeqiNP_566258.1. NM_111452.1.
UniGeneiAt.53195.

Genome annotation databases

EnsemblPlantsiAT3G05780.1; AT3G05780.1; AT3G05780.
GeneIDi819747.
GrameneiAT3G05780.1; AT3G05780.1; AT3G05780.
KEGGiath:AT3G05780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012393 Genomic DNA. Translation: AAF26080.1.
CP002686 Genomic DNA. Translation: AEE74296.1.
RefSeqiNP_566258.1. NM_111452.1.
UniGeneiAt.53195.

3D structure databases

ProteinModelPortaliQ9M9L8.
SMRiQ9M9L8. Positions 354-920.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G05780.1.

Protein family/group databases

MEROPSiS16.A03.

PTM databases

iPTMnetiQ9M9L8.

Proteomic databases

PaxDbiQ9M9L8.
PRIDEiQ9M9L8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G05780.1; AT3G05780.1; AT3G05780.
GeneIDi819747.
GrameneiAT3G05780.1; AT3G05780.1; AT3G05780.
KEGGiath:AT3G05780.

Organism-specific databases

TAIRiAT3G05780.

Phylogenomic databases

eggNOGiKOG2004. Eukaryota.
COG0466. LUCA.
HOGENOMiHOG000261409.
InParanoidiQ9M9L8.
KOiK08675.
OMAiTESKTKQ.
PhylomeDBiQ9M9L8.

Enzyme and pathway databases

BioCyciARA:AT3G05780-MONOMER.

Miscellaneous databases

PROiQ9M9L8.

Gene expression databases

GenevisibleiQ9M9L8. AT.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_03120. lonm_euk.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR003111. LON_substr-bd_dom.
IPR027503. Lonm_euk.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 3 hits.
PfamiPF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 2 hits.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.

Entry informationi

Entry nameiLONM3_ARATH
AccessioniPrimary (citable) accession number: Q9M9L8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2000
Last modified: February 17, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.