Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9M9L7

- LONM4_ARATH

UniProt

Q9M9L7 - LONM4_ARATH

Protein

Lon protease homolog 4, chloroplastic/mitochondrial

Gene

LON4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei846 – 8461UniRule annotation
    Active sitei889 – 8891UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi456 – 4638ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: RefGenome
    2. ATP-dependent peptidase activity Source: RefGenome
    3. mitochondrial light strand promoter anti-sense binding Source: RefGenome
    4. sequence-specific DNA binding Source: UniProtKB-HAMAP
    5. serine-type endopeptidase activity Source: RefGenome
    6. single-stranded DNA binding Source: RefGenome
    7. single-stranded RNA binding Source: RefGenome

    GO - Biological processi

    1. ATP catabolic process Source: RefGenome
    2. cellular response to oxidative stress Source: RefGenome
    3. chaperone-mediated protein complex assembly Source: RefGenome
    4. misfolded or incompletely synthesized protein catabolic process Source: RefGenome
    5. mitochondrion organization Source: RefGenome
    6. oxidation-dependent protein catabolic process Source: RefGenome
    7. protein homooligomerization Source: RefGenome
    8. regulation of mitochondrial DNA replication Source: UniProtKB-HAMAP
    9. response to hypoxia Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Ligandi

    ATP-binding, DNA-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT3G05790-MONOMER.

    Protein family/group databases

    MEROPSiS16.A02.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lon protease homolog 4, chloroplastic/mitochondrial (EC:3.4.21.-UniRule annotation)
    Short name:
    AtLon4
    Gene namesi
    Name:LON4
    Ordered Locus Names:At3g05790
    ORF Names:F10A16.8
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G05790.

    Subcellular locationi

    Mitochondrion matrix 1 PublicationUniRule annotation. Plastidchloroplast thylakoid membrane 1 Publication; Peripheral membrane protein 1 Publication; Stromal side 1 Publication

    GO - Cellular componenti

    1. chloroplast Source: TAIR
    2. chloroplast thylakoid membrane Source: UniProtKB-SubCell
    3. mitochondrial nucleoid Source: RefGenome
    4. mitochondrion Source: TAIR

    Keywords - Cellular componenti

    Chloroplast, Membrane, Mitochondrion, Plastid, Thylakoid

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 942Lon protease homolog 4, chloroplastic/mitochondrialPRO_0000045425
    Transit peptidei1 – ?Chloroplast and mitochondrionSequence Analysis

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei54 – 541PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9M9L7.
    PRIDEiQ9M9L7.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9M9L7.

    Interactioni

    Subunit structurei

    Homohexamer or homoheptamer. Organized in a ring with a central cavity.UniRule annotation

    Protein-protein interaction databases

    STRINGi3702.AT3G05790.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9M9L7.
    SMRiQ9M9L7. Positions 354-662, 725-938.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini79 – 299221LonUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S16 family.UniRule annotation
    Contains 1 Lon domain.UniRule annotation

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0466.
    HOGENOMiHOG000261409.
    InParanoidiQ9M9L7.
    KOiK08675.
    OMAiGMRRFRI.
    PhylomeDBiQ9M9L7.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_03120. lonm_euk.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR004815. Lon_bac/euk-typ.
    IPR027065. Lon_Prtase.
    IPR027503. Lonm_euk.
    IPR027417. P-loop_NTPase.
    IPR008269. Pept_S16_C.
    IPR003111. Pept_S16_N.
    IPR008268. Peptidase_S16_AS.
    IPR015947. PUA-like_domain.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PANTHERiPTHR10046. PTHR10046. 1 hit.
    PfamiPF00004. AAA. 1 hit.
    PF02190. LON. 1 hit.
    PF05362. Lon_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001174. Lon_proteas. 1 hit.
    SMARTiSM00382. AAA. 1 hit.
    SM00464. LON. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsiTIGR00763. lon. 1 hit.
    PROSITEiPS01046. LON_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9M9L7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKFLTPTAY ASHHVTPATR FRSTPVKNLL FKQLTLLTGW NRSSYELGRR    50
    SFSSDLDSDT KSSTTTVSAK PHLDDCLTVI ALPLPHKPLI PGFYMPIYVK 100
    DPKVLAALQE SRRQQAPYAG AFLLKDDASS DSSSSSETEN ILEKLKGKEL 150
    INRIHEVGTL AQISSIQGEQ VILIGHRQLR ITEMVSESED PLTVKVDHLK 200
    DKPYDKDDDV IKATYFQVMS TLRDVLKTTS LWRDHVRTYT QACSLHIWHC 250
    LRHIGEFNYP KLADFGAGIS GANKHQNQGV LEELDVHKRL ELTLELVKKE 300
    VEINKIQESI AKAVEEKFSG DRRRIILKEQ INAIKKELGG ETDSKSALSE 350
    KFRGRIDPIK DKIPGHVLKV IEEELKKLQL LETSSSEFDV TCNYLDWLTV 400
    LPWGNFSDEN FNVLRAEKIL DEDHYGLSDV KERILEFIAV GGLRGTSQGK 450
    IICLSGPTGV GKTSIGRSIA RALDRKFFRF SVGGLSDVAE IKGHRRTYIG 500
    AMPGKMVQCL KNVGTENPLV LIDEIDKLGV RGHHGDPASA MLELLDPEQN 550
    ANFLDHYLDV PIDLSKVLFV CTANVTDTIP GPLLDRMEVI TLSGYITDEK 600
    MHIARDYLEK TARRDCGIKP EQVDVSDAAF LSLIEHYCRE AGVRNLQKQI 650
    EKIFRKIALK LVRKAASTEV PRISDDVTTD TEETKSLAKT DLESPETSAE 700
    GSTVLTDELA TGDPTESTTE QSGEVAETVE KYMIDESNLS DYVGKPVFQE 750
    EKIYEQTPVG VVMGLAWTSM GGSTLYIETT FVEEGEGKGG LHITGRLGDV 800
    MKESAEIAHT VARRIMLEKE PENKLFANSK LHLHVPAGAT PKDGPSAGCT 850
    MITSLLSLAL KKPVRKDLAM TGEVTLTGRI LAIGGVKEKT IAARRSQVKV 900
    IIFPEANRRD FDELARNVKE GLEVHFVDEY EQIFELAFGY DH 942
    Length:942
    Mass (Da):104,925
    Last modified:October 1, 2000 - v1
    Checksum:i90F3238714F4C52E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC012393 Genomic DNA. Translation: AAF26081.1.
    CP002686 Genomic DNA. Translation: AEE74297.1.
    RefSeqiNP_566259.1. NM_111453.1.
    UniGeneiAt.53196.

    Genome annotation databases

    EnsemblPlantsiAT3G05790.1; AT3G05790.1; AT3G05790.
    GeneIDi819748.
    KEGGiath:AT3G05790.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC012393 Genomic DNA. Translation: AAF26081.1 .
    CP002686 Genomic DNA. Translation: AEE74297.1 .
    RefSeqi NP_566259.1. NM_111453.1.
    UniGenei At.53196.

    3D structure databases

    ProteinModelPortali Q9M9L7.
    SMRi Q9M9L7. Positions 354-662, 725-938.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT3G05790.1-P.

    Protein family/group databases

    MEROPSi S16.A02.

    Proteomic databases

    PaxDbi Q9M9L7.
    PRIDEi Q9M9L7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G05790.1 ; AT3G05790.1 ; AT3G05790 .
    GeneIDi 819748.
    KEGGi ath:AT3G05790.

    Organism-specific databases

    GeneFarmi 1770. 137.
    TAIRi AT3G05790.

    Phylogenomic databases

    eggNOGi COG0466.
    HOGENOMi HOG000261409.
    InParanoidi Q9M9L7.
    KOi K08675.
    OMAi GMRRFRI.
    PhylomeDBi Q9M9L7.

    Enzyme and pathway databases

    BioCyci ARA:AT3G05790-MONOMER.

    Gene expression databases

    Genevestigatori Q9M9L7.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_03120. lonm_euk.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR004815. Lon_bac/euk-typ.
    IPR027065. Lon_Prtase.
    IPR027503. Lonm_euk.
    IPR027417. P-loop_NTPase.
    IPR008269. Pept_S16_C.
    IPR003111. Pept_S16_N.
    IPR008268. Peptidase_S16_AS.
    IPR015947. PUA-like_domain.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    PANTHERi PTHR10046. PTHR10046. 1 hit.
    Pfami PF00004. AAA. 1 hit.
    PF02190. LON. 1 hit.
    PF05362. Lon_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001174. Lon_proteas. 1 hit.
    SMARTi SM00382. AAA. 1 hit.
    SM00464. LON. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsi TIGR00763. lon. 1 hit.
    PROSITEi PS01046. LON_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Multiple intracellular locations of Lon protease in Arabidopsis: evidence for the localization of AtLon4 to chloroplasts."
      Ostersetzer O., Kato Y., Adam Z., Sakamoto W.
      Plant Cell Physiol. 48:881-885(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiLONM4_ARATH
    AccessioniPrimary (citable) accession number: Q9M9L7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 10, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3