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Protein

Lon protease homolog 4, chloroplastic/mitochondrial

Gene

LON4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.UniRule annotation

Miscellaneous

This protein may be expected to contain an N-terminal transit peptide but none has been predicted.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei846UniRule annotation1
Active sitei889UniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi456 – 463ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Hydrolase, Protease, Serine protease
LigandATP-binding, Nucleotide-binding

Protein family/group databases

MEROPSiS16.A02.

Names & Taxonomyi

Protein namesi
Recommended name:
Lon protease homolog 4, chloroplastic/mitochondrial (EC:3.4.21.-UniRule annotation)
Short name:
AtLon4
Gene namesi
Name:LON4
Ordered Locus Names:At3g05790
ORF Names:F10A16.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G05790.
TAIRilocus:2074469. AT3G05790.

Subcellular locationi

GO - Cellular componenti

  • chloroplast Source: TAIR
  • chloroplast thylakoid membrane Source: UniProtKB-SubCell
  • mitochondrial matrix Source: GO_Central
  • mitochondrion Source: TAIR

Keywords - Cellular componenti

Chloroplast, Membrane, Mitochondrion, Plastid, Thylakoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000454251 – 942Lon protease homolog 4, chloroplastic/mitochondrialAdd BLAST942

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9M9L7.

Expressioni

Gene expression databases

ExpressionAtlasiQ9M9L7. baseline and differential.
GenevisibleiQ9M9L7. AT.

Interactioni

Subunit structurei

Homohexamer or homoheptamer. Organized in a ring with a central cavity.UniRule annotation

Protein-protein interaction databases

STRINGi3702.AT3G05790.1.

Structurei

3D structure databases

ProteinModelPortaliQ9M9L7.
SMRiQ9M9L7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 299Lon N-terminalPROSITE-ProRule annotationAdd BLAST221
Domaini756 – 940Lon proteolyticPROSITE-ProRule annotationAdd BLAST185

Sequence similaritiesi

Belongs to the peptidase S16 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG2004. Eukaryota.
COG0466. LUCA.
HOGENOMiHOG000261409.
InParanoidiQ9M9L7.
KOiK08675.
OMAiGANKHEN.
OrthoDBiEOG093602OP.
PhylomeDBiQ9M9L7.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
HAMAPiMF_03120. lonm_euk. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR004815. Lon_bac/euk-typ.
IPR008269. Lon_proteolytic.
IPR027065. Lon_Prtase.
IPR003111. Lon_substr-bd.
IPR027503. Lonm_euk.
IPR027417. P-loop_NTPase.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
PANTHERiPTHR43718. PTHR43718. 1 hit.
PfamiView protein in Pfam
PF00004. AAA. 1 hit.
PF05362. Lon_C. 1 hit.
PF02190. LON_substr_bdg. 1 hit.
PIRSFiPIRSF001174. Lon_proteas. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiView protein in PROSITE
PS51787. LON_N. 1 hit.
PS51786. LON_PROTEOLYTIC. 1 hit.
PS01046. LON_SER. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9M9L7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKFLTPTAY ASHHVTPATR FRSTPVKNLL FKQLTLLTGW NRSSYELGRR
60 70 80 90 100
SFSSDLDSDT KSSTTTVSAK PHLDDCLTVI ALPLPHKPLI PGFYMPIYVK
110 120 130 140 150
DPKVLAALQE SRRQQAPYAG AFLLKDDASS DSSSSSETEN ILEKLKGKEL
160 170 180 190 200
INRIHEVGTL AQISSIQGEQ VILIGHRQLR ITEMVSESED PLTVKVDHLK
210 220 230 240 250
DKPYDKDDDV IKATYFQVMS TLRDVLKTTS LWRDHVRTYT QACSLHIWHC
260 270 280 290 300
LRHIGEFNYP KLADFGAGIS GANKHQNQGV LEELDVHKRL ELTLELVKKE
310 320 330 340 350
VEINKIQESI AKAVEEKFSG DRRRIILKEQ INAIKKELGG ETDSKSALSE
360 370 380 390 400
KFRGRIDPIK DKIPGHVLKV IEEELKKLQL LETSSSEFDV TCNYLDWLTV
410 420 430 440 450
LPWGNFSDEN FNVLRAEKIL DEDHYGLSDV KERILEFIAV GGLRGTSQGK
460 470 480 490 500
IICLSGPTGV GKTSIGRSIA RALDRKFFRF SVGGLSDVAE IKGHRRTYIG
510 520 530 540 550
AMPGKMVQCL KNVGTENPLV LIDEIDKLGV RGHHGDPASA MLELLDPEQN
560 570 580 590 600
ANFLDHYLDV PIDLSKVLFV CTANVTDTIP GPLLDRMEVI TLSGYITDEK
610 620 630 640 650
MHIARDYLEK TARRDCGIKP EQVDVSDAAF LSLIEHYCRE AGVRNLQKQI
660 670 680 690 700
EKIFRKIALK LVRKAASTEV PRISDDVTTD TEETKSLAKT DLESPETSAE
710 720 730 740 750
GSTVLTDELA TGDPTESTTE QSGEVAETVE KYMIDESNLS DYVGKPVFQE
760 770 780 790 800
EKIYEQTPVG VVMGLAWTSM GGSTLYIETT FVEEGEGKGG LHITGRLGDV
810 820 830 840 850
MKESAEIAHT VARRIMLEKE PENKLFANSK LHLHVPAGAT PKDGPSAGCT
860 870 880 890 900
MITSLLSLAL KKPVRKDLAM TGEVTLTGRI LAIGGVKEKT IAARRSQVKV
910 920 930 940
IIFPEANRRD FDELARNVKE GLEVHFVDEY EQIFELAFGY DH
Length:942
Mass (Da):104,925
Last modified:October 1, 2000 - v1
Checksum:i90F3238714F4C52E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012393 Genomic DNA. Translation: AAF26081.1.
CP002686 Genomic DNA. Translation: AEE74297.1.
RefSeqiNP_566259.1. NM_111453.1.
UniGeneiAt.53196.

Genome annotation databases

EnsemblPlantsiAT3G05790.1; AT3G05790.1; AT3G05790.
GeneIDi819748.
GrameneiAT3G05790.1; AT3G05790.1; AT3G05790.
KEGGiath:AT3G05790.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLONM4_ARATH
AccessioniPrimary (citable) accession number: Q9M9L7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2000
Last modified: July 5, 2017
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families