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Q9M9L7

- LONM4_ARATH

UniProt

Q9M9L7 - LONM4_ARATH

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Protein

Lon protease homolog 4, chloroplastic/mitochondrial

Gene
LON4, At3g05790, F10A16.8
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Protein inferred from homologyi

Functioni

ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei846 – 8461 By similarity
Active sitei889 – 8891 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi456 – 4638ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: RefGenome
  2. ATP-dependent peptidase activity Source: RefGenome
  3. mitochondrial light strand promoter anti-sense binding Source: RefGenome
  4. sequence-specific DNA binding Source: UniProtKB-HAMAP
  5. serine-type endopeptidase activity Source: RefGenome
  6. single-stranded DNA binding Source: RefGenome
  7. single-stranded RNA binding Source: RefGenome

GO - Biological processi

  1. ATP catabolic process Source: RefGenome
  2. cellular response to oxidative stress Source: RefGenome
  3. chaperone-mediated protein complex assembly Source: RefGenome
  4. misfolded or incompletely synthesized protein catabolic process Source: RefGenome
  5. mitochondrion organization Source: RefGenome
  6. oxidation-dependent protein catabolic process Source: RefGenome
  7. protein homooligomerization Source: RefGenome
  8. regulation of mitochondrial DNA replication Source: UniProtKB-HAMAP
  9. response to hypoxia Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G05790-MONOMER.

Protein family/group databases

MEROPSiS16.A02.

Names & Taxonomyi

Protein namesi
Recommended name:
Lon protease homolog 4, chloroplastic/mitochondrial (EC:3.4.21.-)
Short name:
AtLon4
Gene namesi
Name:LON4
Ordered Locus Names:At3g05790
ORF Names:F10A16.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G05790.

Subcellular locationi

Mitochondrion matrix. Plastidchloroplast thylakoid membrane; Peripheral membrane protein; Stromal side 1 Publication

GO - Cellular componenti

  1. chloroplast Source: TAIR
  2. chloroplast thylakoid membrane Source: UniProtKB-SubCell
  3. mitochondrial nucleoid Source: RefGenome
  4. mitochondrion Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Membrane, Mitochondrion, Plastid, Thylakoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 942Lon protease homolog 4, chloroplastic/mitochondrialUniRule annotationPRO_0000045425
Transit peptidei1 – ?Chloroplast and mitochondrion Reviewed prediction

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei54 – 541Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9M9L7.
PRIDEiQ9M9L7.

Expressioni

Gene expression databases

GenevestigatoriQ9M9L7.

Interactioni

Subunit structurei

Homohexamer or homoheptamer. Organized in a ring with a central cavity By similarity.

Protein-protein interaction databases

STRINGi3702.AT3G05790.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9M9L7.
SMRiQ9M9L7. Positions 354-662, 725-938.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini79 – 299221LonAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase S16 family.
Contains 1 Lon domain.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0466.
HOGENOMiHOG000261409.
InParanoidiQ9M9L7.
KOiK08675.
OMAiGMRRFRI.
PhylomeDBiQ9M9L7.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_03120. lonm_euk.
InterProiIPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR027503. Lonm_euk.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10046. PTHR10046. 1 hit.
PfamiPF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view]
PIRSFiPIRSF001174. Lon_proteas. 1 hit.
SMARTiSM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00763. lon. 1 hit.
PROSITEiPS01046. LON_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9M9L7-1 [UniParc]FASTAAdd to Basket

« Hide

MLKFLTPTAY ASHHVTPATR FRSTPVKNLL FKQLTLLTGW NRSSYELGRR    50
SFSSDLDSDT KSSTTTVSAK PHLDDCLTVI ALPLPHKPLI PGFYMPIYVK 100
DPKVLAALQE SRRQQAPYAG AFLLKDDASS DSSSSSETEN ILEKLKGKEL 150
INRIHEVGTL AQISSIQGEQ VILIGHRQLR ITEMVSESED PLTVKVDHLK 200
DKPYDKDDDV IKATYFQVMS TLRDVLKTTS LWRDHVRTYT QACSLHIWHC 250
LRHIGEFNYP KLADFGAGIS GANKHQNQGV LEELDVHKRL ELTLELVKKE 300
VEINKIQESI AKAVEEKFSG DRRRIILKEQ INAIKKELGG ETDSKSALSE 350
KFRGRIDPIK DKIPGHVLKV IEEELKKLQL LETSSSEFDV TCNYLDWLTV 400
LPWGNFSDEN FNVLRAEKIL DEDHYGLSDV KERILEFIAV GGLRGTSQGK 450
IICLSGPTGV GKTSIGRSIA RALDRKFFRF SVGGLSDVAE IKGHRRTYIG 500
AMPGKMVQCL KNVGTENPLV LIDEIDKLGV RGHHGDPASA MLELLDPEQN 550
ANFLDHYLDV PIDLSKVLFV CTANVTDTIP GPLLDRMEVI TLSGYITDEK 600
MHIARDYLEK TARRDCGIKP EQVDVSDAAF LSLIEHYCRE AGVRNLQKQI 650
EKIFRKIALK LVRKAASTEV PRISDDVTTD TEETKSLAKT DLESPETSAE 700
GSTVLTDELA TGDPTESTTE QSGEVAETVE KYMIDESNLS DYVGKPVFQE 750
EKIYEQTPVG VVMGLAWTSM GGSTLYIETT FVEEGEGKGG LHITGRLGDV 800
MKESAEIAHT VARRIMLEKE PENKLFANSK LHLHVPAGAT PKDGPSAGCT 850
MITSLLSLAL KKPVRKDLAM TGEVTLTGRI LAIGGVKEKT IAARRSQVKV 900
IIFPEANRRD FDELARNVKE GLEVHFVDEY EQIFELAFGY DH 942
Length:942
Mass (Da):104,925
Last modified:October 1, 2000 - v1
Checksum:i90F3238714F4C52E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC012393 Genomic DNA. Translation: AAF26081.1.
CP002686 Genomic DNA. Translation: AEE74297.1.
RefSeqiNP_566259.1. NM_111453.1.
UniGeneiAt.53196.

Genome annotation databases

EnsemblPlantsiAT3G05790.1; AT3G05790.1; AT3G05790.
GeneIDi819748.
KEGGiath:AT3G05790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC012393 Genomic DNA. Translation: AAF26081.1 .
CP002686 Genomic DNA. Translation: AEE74297.1 .
RefSeqi NP_566259.1. NM_111453.1.
UniGenei At.53196.

3D structure databases

ProteinModelPortali Q9M9L7.
SMRi Q9M9L7. Positions 354-662, 725-938.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT3G05790.1-P.

Protein family/group databases

MEROPSi S16.A02.

Proteomic databases

PaxDbi Q9M9L7.
PRIDEi Q9M9L7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G05790.1 ; AT3G05790.1 ; AT3G05790 .
GeneIDi 819748.
KEGGi ath:AT3G05790.

Organism-specific databases

GeneFarmi 1770. 137.
TAIRi AT3G05790.

Phylogenomic databases

eggNOGi COG0466.
HOGENOMi HOG000261409.
InParanoidi Q9M9L7.
KOi K08675.
OMAi GMRRFRI.
PhylomeDBi Q9M9L7.

Enzyme and pathway databases

BioCyci ARA:AT3G05790-MONOMER.

Gene expression databases

Genevestigatori Q9M9L7.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_03120. lonm_euk.
InterProi IPR003593. AAA+_ATPase.
IPR003959. ATPase_AAA_core.
IPR004815. Lon_bac/euk-typ.
IPR027065. Lon_Prtase.
IPR027503. Lonm_euk.
IPR027417. P-loop_NTPase.
IPR008269. Pept_S16_C.
IPR003111. Pept_S16_N.
IPR008268. Peptidase_S16_AS.
IPR015947. PUA-like_domain.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view ]
PANTHERi PTHR10046. PTHR10046. 1 hit.
Pfami PF00004. AAA. 1 hit.
PF02190. LON. 1 hit.
PF05362. Lon_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF001174. Lon_proteas. 1 hit.
SMARTi SM00382. AAA. 1 hit.
SM00464. LON. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsi TIGR00763. lon. 1 hit.
PROSITEi PS01046. LON_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Multiple intracellular locations of Lon protease in Arabidopsis: evidence for the localization of AtLon4 to chloroplasts."
    Ostersetzer O., Kato Y., Adam Z., Sakamoto W.
    Plant Cell Physiol. 48:881-885(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiLONM4_ARATH
AccessioniPrimary (citable) accession number: Q9M9L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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