Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2

Gene

At3g08590

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.By similarity

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic (GAPC2), Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic (GAPC1)
  2. Phosphoglycerate kinase 3, cytosolic (PGK3)
  3. Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2 (At3g08590), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1 (PGM1)
  4. Enolase 1, chloroplastic (ENO1), Cytosolic enolase 3 (ENO3), Bifunctional enolase 2/transcriptional activator (ENO2)
  5. Pyruvate kinase (AXX17_At5g51800), Pyruvate kinase (AXX17_At3g24740), Pyruvate kinase (AXX17_At5g63250), Pyruvate kinase (AXX17_At3g50280), Pyruvate kinase (AXX17_ATUG04870), Pyruvate kinase (MAH20.13), Pyruvate kinase (MCD7.8), Pyruvate kinase (MBK5.16), Pyruvate kinase (F1I16_60), Pyruvate kinase (At3g25960), Pyruvate kinase (AXX17_At3g50440), Plastidial pyruvate kinase 3, chloroplastic (PKP3), Pyruvate kinase (At3g52990), Pyruvate kinase (AXX17_At5g08490), Pyruvate kinase (AXX17_At5g55530), Pyruvate kinase (AXX17_At3g28070), Pyruvate kinase (At2g36580), Pyruvate kinase (AXX17_At3g47400), Pyruvate kinase, Probable pyruvate kinase, cytosolic isozyme (At4g26390), Pyruvate kinase (F8J2_160), Pyruvate kinase (At3g52990), Pyruvate kinase (AXX17_At3g03460), Plastidial pyruvate kinase 2 (PKP2), Pyruvate kinase (AXX17_At2g33300), Pyruvate kinase (At3g04050), Pyruvate kinase (AXX17_At4g30430), Pyruvate kinase (F1I16_220), Plastidial pyruvate kinase 1, chloroplastic (PKP1), Pyruvate kinase (AXX17_At1g33230), Pyruvate kinase (At5g63680), Pyruvate kinase, Plastidial pyruvate kinase 4, chloroplastic (PKP4)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29Manganese 2By similarity1
Active sitei82Phosphoserine intermediateBy similarity1
Metal bindingi82Manganese 2By similarity1
Binding sitei141SubstrateBy similarity1
Binding sitei207SubstrateBy similarity1
Binding sitei214SubstrateBy similarity1
Binding sitei362SubstrateBy similarity1
Metal bindingi431Manganese 1By similarity1
Metal bindingi435Manganese 1By similarity1
Metal bindingi472Manganese 2By similarity1
Metal bindingi473Manganese 2By similarity1
Metal bindingi502Manganese 1By similarity1

GO - Molecular functioni

  • 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Source: TAIR
  • manganese ion binding Source: InterPro

GO - Biological processi

  • glucose catabolic process Source: InterPro
  • glycolytic process Source: UniProtKB-UniPathway
  • pollen development Source: TAIR
  • response to cadmium ion Source: TAIR
  • stomatal movement Source: TAIR

Keywordsi

Molecular functionIsomerase
Biological processGlycolysis
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT3G08590-MONOMER
BRENDAi5.4.2.12 399
UniPathwayiUPA00109; UER00186

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2 (EC:5.4.2.12)
Short name:
BPG-independent PGAM 2
Short name:
Phosphoglyceromutase 2
Alternative name(s):
PGAM-I 2
Gene namesi
Ordered Locus Names:At3g08590
ORF Names:F17O14.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G08590
TAIRilocus:2077793 AT3G08590

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002121092 – 560Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9M9K1
PRIDEiQ9M9K1

PTM databases

iPTMnetiQ9M9K1

Expressioni

Gene expression databases

ExpressionAtlasiQ9M9K1 baseline and differential
GenevisibleiQ9M9K1 AT

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi5341, 2 interactors
STRINGi3702.AT3G08590.1

Structurei

3D structure databases

ProteinModelPortaliQ9M9K1
SMRiQ9M9K1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni171 – 172Substrate bindingBy similarity2
Regioni287 – 290Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4513 Eukaryota
COG0696 LUCA
HOGENOMiHOG000223664
InParanoidiQ9M9K1
KOiK15633
OMAiVDKCIGR
OrthoDBiEOG093605CN
PhylomeDBiQ9M9K1

Family and domain databases

CDDicd16010 iPGM, 1 hit
Gene3Di3.40.1450.10, 1 hit
3.40.720.10, 2 hits
InterProiView protein in InterPro
IPR017849 Alkaline_Pase-like_a/b/a
IPR017850 Alkaline_phosphatase_core_sf
IPR011258 BPG-indep_PGM_N
IPR006124 Metalloenzyme
IPR036646 PGAM_B_sf
IPR005995 Pgm_bpd_ind
PANTHERiPTHR31637 PTHR31637, 1 hit
PfamiView protein in Pfam
PF06415 iPGM_N, 1 hit
PF01676 Metalloenzyme, 1 hit
PIRSFiPIRSF001492 IPGAM, 1 hit
SUPFAMiSSF53649 SSF53649, 2 hits
SSF64158 SSF64158, 1 hit
TIGRFAMsiTIGR01307 pgm_bpd_ind, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9M9K1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSGDVNWK LADHPKLPKG KTIGLIVLDG WGESDPDQYN CIHKAPTPAM
60 70 80 90 100
DSLKDGKPDT WRLIKAHGTA VGLPSEDDMG NSEVGHNALG AGRIYAQGAK
110 120 130 140 150
LVDLALASGK IYEDEGFKYI SQSFEKGTVH LIGLLSDGGV HSRLDQVQLL
160 170 180 190 200
LKGFAERGAK RIRVHILTDG RDVLDGSSVG FVETLEADLA ALRAKGVDAQ
210 220 230 240 250
VASGGGRMYV TMDRYENDWS VVKRGWDAQV LGEAPHKFKS ALEAVKTLRA
260 270 280 290 300
EPGANDQYLP SFVIVDDNGK AVGPIVDGDA VVTFNFRADR MVMHAKALEY
310 320 330 340 350
KDFDKFDRVR VPDIRYAGML QYDGELKLPS RYLVSPPLID RTSGEYLAHN
360 370 380 390 400
GVRTFACSET VKFGHVTFFW NGNRSGYFNE KLEEYVEIPS DSGISFNVQP
410 420 430 440 450
KMKALEIAEK ARDAILSGKF DQVRVNLPNG DMVGHTGDIE ATVVACEAAD
460 470 480 490 500
RAVRTILDAI EQVGGIYVVT ADHGNAEDMV KRDKSGKPAL DKEGNLQILT
510 520 530 540 550
SHTLKPVPIA IGGPGLSAGV RFRQDIETPG LANVAATVMN LHGFVAPSDY
560
ETSLIEVVEK
Length:560
Mass (Da):60,764
Last modified:October 1, 2000 - v1
Checksum:i4D5AC08074D7BB8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012562 Genomic DNA Translation: AAG51361.1
CP002686 Genomic DNA Translation: AEE74650.1
CP002686 Genomic DNA Translation: AEE74651.1
AY039969 mRNA Translation: AAK64146.1
AF424615 mRNA Translation: AAL11608.1
AY113910 mRNA Translation: AAM44958.1
RefSeqiNP_187471.1, NM_111693.3
NP_850542.1, NM_180211.2
UniGeneiAt.68440

Genome annotation databases

EnsemblPlantsiAT3G08590.1; AT3G08590.1; AT3G08590
AT3G08590.2; AT3G08590.2; AT3G08590
GeneIDi820006
GrameneiAT3G08590.1; AT3G08590.1; AT3G08590
AT3G08590.2; AT3G08590.2; AT3G08590
KEGGiath:AT3G08590

Similar proteinsi

Entry informationi

Entry nameiPMG2_ARATH
AccessioniPrimary (citable) accession number: Q9M9K1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health