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Protein

Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2

Gene

At3g08590

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.By similarity

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.

Cofactori

Mn2+By similarityNote: Binds 2 manganese ions per subunit.By similarity

Pathwayi: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase GAPC2, cytosolic (GAPC2), Glyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic (GAPC1)
  2. Phosphoglycerate kinase 3, cytosolic (PGK3)
  3. Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2 (At3g08590), 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 1 (PGM1)
  4. Enolase 1, chloroplastic (ENO1), Cytosolic enolase 3 (ENO3), Bifunctional enolase 2/transcriptional activator (ENO2)
  5. Pyruvate kinase (AXX17_At5g51800), Pyruvate kinase (AXX17_At3g24740), Pyruvate kinase (AXX17_At3g50280), Pyruvate kinase (AXX17_ATUG04870), Pyruvate kinase (At5g08570), Pyruvate kinase (At5g56350), Pyruvate kinase (At3g25960), Pyruvate kinase (At5g63680), Pyruvate kinase (F1I16_60), Pyruvate kinase (AXX17_At3g50440), Plastidial pyruvate kinase 3, chloroplastic (PKP3), Pyruvate kinase (At3g52990), Pyruvate kinase (AXX17_At3g28070), Pyruvate kinase (At2g36580), Pyruvate kinase (AXX17_At3g47400), Pyruvate kinase, Probable pyruvate kinase, cytosolic isozyme (At4g26390), Pyruvate kinase (F8J2_160), Pyruvate kinase (At3g52990), Pyruvate kinase (AXX17_At3g03460), Plastidial pyruvate kinase 2 (PKP2), Pyruvate kinase (T11I18.16), Pyruvate kinase (AXX17_At4g30430), Pyruvate kinase (F1I16_220), Plastidial pyruvate kinase 1, chloroplastic (PKP1), Pyruvate kinase (AXX17_At1g33230), Pyruvate kinase (At5g63680), Pyruvate kinase, Plastidial pyruvate kinase 4, chloroplastic (PKP4)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi29Manganese 2By similarity1
Active sitei82Phosphoserine intermediateBy similarity1
Metal bindingi82Manganese 2By similarity1
Binding sitei141SubstrateBy similarity1
Binding sitei207SubstrateBy similarity1
Binding sitei214SubstrateBy similarity1
Binding sitei362SubstrateBy similarity1
Metal bindingi431Manganese 1By similarity1
Metal bindingi435Manganese 1By similarity1
Metal bindingi472Manganese 2By similarity1
Metal bindingi473Manganese 2By similarity1
Metal bindingi502Manganese 1By similarity1

GO - Molecular functioni

  • 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Source: TAIR
  • manganese ion binding Source: InterPro

GO - Biological processi

  • glucose catabolic process Source: InterPro
  • glycolytic process Source: UniProtKB-UniPathway
  • pollen development Source: TAIR
  • response to cadmium ion Source: TAIR
  • stomatal movement Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT3G08590-MONOMER.
BRENDAi5.4.2.12. 399.
UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2 (EC:5.4.2.12)
Short name:
BPG-independent PGAM 2
Short name:
Phosphoglyceromutase 2
Alternative name(s):
PGAM-I 2
Gene namesi
Ordered Locus Names:At3g08590
ORF Names:F17O14.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G08590.

Subcellular locationi

GO - Cellular componenti

  • apoplast Source: TAIR
  • cytosol Source: TAIR
  • plasmodesma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002121092 – 560Probable 2,3-bisphosphoglycerate-independent phosphoglycerate mutase 2Add BLAST559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylglycineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9M9K1.
PRIDEiQ9M9K1.

PTM databases

iPTMnetiQ9M9K1.

Expressioni

Gene expression databases

ExpressionAtlasiQ9M9K1. baseline and differential.
GenevisibleiQ9M9K1. AT.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

BioGridi5341. 2 interactors.
STRINGi3702.AT3G08590.1.

Structurei

3D structure databases

ProteinModelPortaliQ9M9K1.
SMRiQ9M9K1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni171 – 172Substrate bindingBy similarity2
Regioni287 – 290Substrate bindingBy similarity4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4513. Eukaryota.
COG0696. LUCA.
HOGENOMiHOG000223664.
InParanoidiQ9M9K1.
KOiK15633.
OMAiGWGESDP.
OrthoDBiEOG093605CN.
PhylomeDBiQ9M9K1.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9M9K1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSSGDVNWK LADHPKLPKG KTIGLIVLDG WGESDPDQYN CIHKAPTPAM
60 70 80 90 100
DSLKDGKPDT WRLIKAHGTA VGLPSEDDMG NSEVGHNALG AGRIYAQGAK
110 120 130 140 150
LVDLALASGK IYEDEGFKYI SQSFEKGTVH LIGLLSDGGV HSRLDQVQLL
160 170 180 190 200
LKGFAERGAK RIRVHILTDG RDVLDGSSVG FVETLEADLA ALRAKGVDAQ
210 220 230 240 250
VASGGGRMYV TMDRYENDWS VVKRGWDAQV LGEAPHKFKS ALEAVKTLRA
260 270 280 290 300
EPGANDQYLP SFVIVDDNGK AVGPIVDGDA VVTFNFRADR MVMHAKALEY
310 320 330 340 350
KDFDKFDRVR VPDIRYAGML QYDGELKLPS RYLVSPPLID RTSGEYLAHN
360 370 380 390 400
GVRTFACSET VKFGHVTFFW NGNRSGYFNE KLEEYVEIPS DSGISFNVQP
410 420 430 440 450
KMKALEIAEK ARDAILSGKF DQVRVNLPNG DMVGHTGDIE ATVVACEAAD
460 470 480 490 500
RAVRTILDAI EQVGGIYVVT ADHGNAEDMV KRDKSGKPAL DKEGNLQILT
510 520 530 540 550
SHTLKPVPIA IGGPGLSAGV RFRQDIETPG LANVAATVMN LHGFVAPSDY
560
ETSLIEVVEK
Length:560
Mass (Da):60,764
Last modified:October 1, 2000 - v1
Checksum:i4D5AC08074D7BB8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012562 Genomic DNA. Translation: AAG51361.1.
CP002686 Genomic DNA. Translation: AEE74650.1.
CP002686 Genomic DNA. Translation: AEE74651.1.
AY039969 mRNA. Translation: AAK64146.1.
AF424615 mRNA. Translation: AAL11608.1.
AY113910 mRNA. Translation: AAM44958.1.
RefSeqiNP_187471.1. NM_111693.3.
NP_850542.1. NM_180211.2.
UniGeneiAt.68440.

Genome annotation databases

EnsemblPlantsiAT3G08590.1; AT3G08590.1; AT3G08590.
AT3G08590.2; AT3G08590.2; AT3G08590.
GeneIDi820006.
GrameneiAT3G08590.1; AT3G08590.1; AT3G08590.
AT3G08590.2; AT3G08590.2; AT3G08590.
KEGGiath:AT3G08590.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012562 Genomic DNA. Translation: AAG51361.1.
CP002686 Genomic DNA. Translation: AEE74650.1.
CP002686 Genomic DNA. Translation: AEE74651.1.
AY039969 mRNA. Translation: AAK64146.1.
AF424615 mRNA. Translation: AAL11608.1.
AY113910 mRNA. Translation: AAM44958.1.
RefSeqiNP_187471.1. NM_111693.3.
NP_850542.1. NM_180211.2.
UniGeneiAt.68440.

3D structure databases

ProteinModelPortaliQ9M9K1.
SMRiQ9M9K1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi5341. 2 interactors.
STRINGi3702.AT3G08590.1.

PTM databases

iPTMnetiQ9M9K1.

Proteomic databases

PaxDbiQ9M9K1.
PRIDEiQ9M9K1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G08590.1; AT3G08590.1; AT3G08590.
AT3G08590.2; AT3G08590.2; AT3G08590.
GeneIDi820006.
GrameneiAT3G08590.1; AT3G08590.1; AT3G08590.
AT3G08590.2; AT3G08590.2; AT3G08590.
KEGGiath:AT3G08590.

Organism-specific databases

TAIRiAT3G08590.

Phylogenomic databases

eggNOGiKOG4513. Eukaryota.
COG0696. LUCA.
HOGENOMiHOG000223664.
InParanoidiQ9M9K1.
KOiK15633.
OMAiGWGESDP.
OrthoDBiEOG093605CN.
PhylomeDBiQ9M9K1.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.
BioCyciARA:AT3G08590-MONOMER.
BRENDAi5.4.2.12. 399.

Miscellaneous databases

PROiQ9M9K1.

Gene expression databases

ExpressionAtlasiQ9M9K1. baseline and differential.
GenevisibleiQ9M9K1. AT.

Family and domain databases

Gene3Di3.40.1450.10. 1 hit.
3.40.720.10. 2 hits.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR011258. BPG-indep_PGM_N.
IPR006124. Metalloenzyme.
IPR005995. Pgm_bpd_ind.
[Graphical view]
PfamiPF06415. iPGM_N. 1 hit.
PF01676. Metalloenzyme. 1 hit.
[Graphical view]
PIRSFiPIRSF001492. IPGAM. 1 hit.
SUPFAMiSSF53649. SSF53649. 2 hits.
SSF64158. SSF64158. 1 hit.
TIGRFAMsiTIGR01307. pgm_bpd_ind. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPMG2_ARATH
AccessioniPrimary (citable) accession number: Q9M9K1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 130 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.