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Q9M9H6

- CK1_ARATH

UniProt

Q9M9H6 - CK1_ARATH

Protein

Probable choline kinase 1

Gene

CK1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Involved in phospholipid biosynthesis. Catalyzes the first step in phosphatidylcholine biosynthesis By similarity.By similarity

    Catalytic activityi

    ATP + choline = ADP + phosphocholine.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei73 – 731ATPBy similarity
    Binding sitei210 – 2101ATPBy similarity
    Binding sitei227 – 2271ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. choline kinase activity Source: TAIR

    GO - Biological processi

    1. CDP-choline pathway Source: GOC
    2. response to wounding Source: TAIR

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G71697-MONOMER.
    UniPathwayiUPA00753; UER00737.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable choline kinase 1 (EC:2.7.1.32)
    Short name:
    AtCK1
    Gene namesi
    Name:CK1
    Synonyms:CK
    Ordered Locus Names:At1g71697
    ORF Names:F14O23.8, F26A9.3
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G71697.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 346346Probable choline kinase 1PRO_0000423346Add
    BLAST

    Proteomic databases

    PRIDEiQ9M9H6.

    Expressioni

    Tissue specificityi

    Expressed in roots. Expressed at low levels in cauline leaves and flowers.1 Publication

    Inductioni

    By wounding, and salt and osmotic stresses.2 Publications

    Gene expression databases

    ArrayExpressiQ9M9H6.
    GenevestigatoriQ9M9H6.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G71697.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9M9H6.
    SMRiQ9M9H6. Positions 24-340.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the choline/ethanolamine kinase family.Curated

    Phylogenomic databases

    HOGENOMiHOG000041274.
    InParanoidiQ9M9H6.
    KOiK14156.
    OMAiEFDYMEY.
    PhylomeDBiQ9M9H6.

    Family and domain databases

    InterProiIPR026712. Cho/Etha_kinase.
    IPR007521. Choline_kin_N.
    IPR011009. Kinase-like_dom.
    [Graphical view]
    PANTHERiPTHR22603:SF32. PTHR22603:SF32. 1 hit.
    PfamiPF04428. Choline_kin_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9M9H6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIKTKTSLI PSCSSPEDLK RVLQTLGSSW GDVVEDLERL EVVPLKGAMT    50
    NEVYQINWPT LNGEDVHRKV LVRIYGDGVD LFFNRGDEIK TFECMSHHGY 100
    GPKLLGRFSD GRLEEFIHAR TLSADDLRVA ETSDFIAAKL REFHKLDMPG 150
    PKNVLLWERL RTWLKEAKNL ASPIEMDKYR LEGLENEINL LEERLTRDDQ 200
    EIGFCHNDLQ YGNVMIDEVT NAITIIDYEY SSFNPIAYDI ANHFCEMAAN 250
    YHSDTPHVLD YTLYPGEGER RRFISTYLGS TGNATSDKEV ERLLKDAESY 300
    TLANHIFWGL WGIISGHVNK IEFDYMEYAR QRFEQYWLRK PLLLEG 346
    Length:346
    Mass (Da):40,016
    Last modified:October 1, 2000 - v1
    Checksum:i3FABBAAAB09B5597
    GO

    Sequence cautioni

    The sequence AAG51828.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC012654 Genomic DNA. Translation: AAF43223.1.
    AC016163 Genomic DNA. Translation: AAG51828.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE35220.1.
    BT008311 mRNA. Translation: AAP37670.1.
    AK229787 mRNA. Translation: BAF01619.1.
    AK230407 mRNA. Translation: BAF02205.1.
    PIRiC96739.
    RefSeqiNP_177315.1. NM_105828.3.
    UniGeneiAt.43278.

    Genome annotation databases

    EnsemblPlantsiAT1G71697.1; AT1G71697.1; AT1G71697.
    GeneIDi843500.
    KEGGiath:AT1G71697.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC012654 Genomic DNA. Translation: AAF43223.1 .
    AC016163 Genomic DNA. Translation: AAG51828.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE35220.1 .
    BT008311 mRNA. Translation: AAP37670.1 .
    AK229787 mRNA. Translation: BAF01619.1 .
    AK230407 mRNA. Translation: BAF02205.1 .
    PIRi C96739.
    RefSeqi NP_177315.1. NM_105828.3.
    UniGenei At.43278.

    3D structure databases

    ProteinModelPortali Q9M9H6.
    SMRi Q9M9H6. Positions 24-340.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G71697.1-P.

    Proteomic databases

    PRIDEi Q9M9H6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G71697.1 ; AT1G71697.1 ; AT1G71697 .
    GeneIDi 843500.
    KEGGi ath:AT1G71697.

    Organism-specific databases

    TAIRi AT1G71697.

    Phylogenomic databases

    HOGENOMi HOG000041274.
    InParanoidi Q9M9H6.
    KOi K14156.
    OMAi EFDYMEY.
    PhylomeDBi Q9M9H6.

    Enzyme and pathway databases

    UniPathwayi UPA00753 ; UER00737 .
    BioCyci ARA:AT1G71697-MONOMER.

    Gene expression databases

    ArrayExpressi Q9M9H6.
    Genevestigatori Q9M9H6.

    Family and domain databases

    InterProi IPR026712. Cho/Etha_kinase.
    IPR007521. Choline_kin_N.
    IPR011009. Kinase-like_dom.
    [Graphical view ]
    PANTHERi PTHR22603:SF32. PTHR22603:SF32. 1 hit.
    Pfami PF04428. Choline_kin_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Jasmonic acid-dependent and -independent signaling pathways control wound-induced gene activation in Arabidopsis thaliana."
      Titarenko E., Rojo E., Leon J., Sanchez-Serrano J.J.
      Plant Physiol. 115:817-826(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, INDUCTION BY WOUNDING.
    6. "Regulation of phosphatidylcholine biosynthesis under salt stress involves choline kinases in Arabidopsis thaliana."
      Tasseva G., Richard L., Zachowski A.
      FEBS Lett. 566:115-120(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiCK1_ARATH
    AccessioniPrimary (citable) accession number: Q9M9H6
    Secondary accession number(s): Q9C9J3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 18, 2013
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3