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Q9M9H6

- CK1_ARATH

UniProt

Q9M9H6 - CK1_ARATH

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Protein

Probable choline kinase 1

Gene

CK1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Involved in phospholipid biosynthesis. Catalyzes the first step in phosphatidylcholine biosynthesis (By similarity).By similarity

Catalytic activityi

ATP + choline = ADP + phosphocholine.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei73 – 731ATPBy similarity
Binding sitei210 – 2101ATPBy similarity
Binding sitei227 – 2271ATPBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. choline kinase activity Source: TAIR

GO - Biological processi

  1. CDP-choline pathway Source: GOC
  2. response to wounding Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G71697-MONOMER.
ReactomeiREACT_187678. Synthesis of PE.
REACT_190860. Synthesis of PC.
UniPathwayiUPA00753; UER00737.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable choline kinase 1 (EC:2.7.1.32)
Short name:
AtCK1
Gene namesi
Name:CK1
Synonyms:CK
Ordered Locus Names:At1g71697
ORF Names:F14O23.8, F26A9.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 1

Organism-specific databases

TAIRiAT1G71697.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 346346Probable choline kinase 1PRO_0000423346Add
BLAST

Proteomic databases

PRIDEiQ9M9H6.

Expressioni

Tissue specificityi

Expressed in roots. Expressed at low levels in cauline leaves and flowers.1 Publication

Inductioni

By wounding, and salt and osmotic stresses.2 Publications

Gene expression databases

GenevestigatoriQ9M9H6.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G71697.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9M9H6.
SMRiQ9M9H6. Positions 24-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the choline/ethanolamine kinase family.Curated

Phylogenomic databases

HOGENOMiHOG000041274.
InParanoidiQ9M9H6.
KOiK14156.
OMAiEFDYMEY.
PhylomeDBiQ9M9H6.

Family and domain databases

InterProiIPR026712. Cho/Etha_kinase.
IPR007521. Choline_kin_N.
IPR011009. Kinase-like_dom.
[Graphical view]
PANTHERiPTHR22603:SF32. PTHR22603:SF32. 1 hit.
PfamiPF04428. Choline_kin_N. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9M9H6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIKTKTSLI PSCSSPEDLK RVLQTLGSSW GDVVEDLERL EVVPLKGAMT
60 70 80 90 100
NEVYQINWPT LNGEDVHRKV LVRIYGDGVD LFFNRGDEIK TFECMSHHGY
110 120 130 140 150
GPKLLGRFSD GRLEEFIHAR TLSADDLRVA ETSDFIAAKL REFHKLDMPG
160 170 180 190 200
PKNVLLWERL RTWLKEAKNL ASPIEMDKYR LEGLENEINL LEERLTRDDQ
210 220 230 240 250
EIGFCHNDLQ YGNVMIDEVT NAITIIDYEY SSFNPIAYDI ANHFCEMAAN
260 270 280 290 300
YHSDTPHVLD YTLYPGEGER RRFISTYLGS TGNATSDKEV ERLLKDAESY
310 320 330 340
TLANHIFWGL WGIISGHVNK IEFDYMEYAR QRFEQYWLRK PLLLEG
Length:346
Mass (Da):40,016
Last modified:October 1, 2000 - v1
Checksum:i3FABBAAAB09B5597
GO

Sequence cautioni

The sequence AAG51828.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012654 Genomic DNA. Translation: AAF43223.1.
AC016163 Genomic DNA. Translation: AAG51828.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE35220.1.
BT008311 mRNA. Translation: AAP37670.1.
AK229787 mRNA. Translation: BAF01619.1.
AK230407 mRNA. Translation: BAF02205.1.
PIRiC96739.
RefSeqiNP_177315.1. NM_105828.3.
UniGeneiAt.43278.

Genome annotation databases

EnsemblPlantsiAT1G71697.1; AT1G71697.1; AT1G71697.
GeneIDi843500.
KEGGiath:AT1G71697.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012654 Genomic DNA. Translation: AAF43223.1 .
AC016163 Genomic DNA. Translation: AAG51828.1 . Sequence problems.
CP002684 Genomic DNA. Translation: AEE35220.1 .
BT008311 mRNA. Translation: AAP37670.1 .
AK229787 mRNA. Translation: BAF01619.1 .
AK230407 mRNA. Translation: BAF02205.1 .
PIRi C96739.
RefSeqi NP_177315.1. NM_105828.3.
UniGenei At.43278.

3D structure databases

ProteinModelPortali Q9M9H6.
SMRi Q9M9H6. Positions 24-340.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT1G71697.1-P.

Proteomic databases

PRIDEi Q9M9H6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT1G71697.1 ; AT1G71697.1 ; AT1G71697 .
GeneIDi 843500.
KEGGi ath:AT1G71697.

Organism-specific databases

TAIRi AT1G71697.

Phylogenomic databases

HOGENOMi HOG000041274.
InParanoidi Q9M9H6.
KOi K14156.
OMAi EFDYMEY.
PhylomeDBi Q9M9H6.

Enzyme and pathway databases

UniPathwayi UPA00753 ; UER00737 .
BioCyci ARA:AT1G71697-MONOMER.
Reactomei REACT_187678. Synthesis of PE.
REACT_190860. Synthesis of PC.

Gene expression databases

Genevestigatori Q9M9H6.

Family and domain databases

InterProi IPR026712. Cho/Etha_kinase.
IPR007521. Choline_kin_N.
IPR011009. Kinase-like_dom.
[Graphical view ]
PANTHERi PTHR22603:SF32. PTHR22603:SF32. 1 hit.
Pfami PF04428. Choline_kin_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
    Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
    , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
    Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Jasmonic acid-dependent and -independent signaling pathways control wound-induced gene activation in Arabidopsis thaliana."
    Titarenko E., Rojo E., Leon J., Sanchez-Serrano J.J.
    Plant Physiol. 115:817-826(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, INDUCTION BY WOUNDING.
  6. "Regulation of phosphatidylcholine biosynthesis under salt stress involves choline kinases in Arabidopsis thaliana."
    Tasseva G., Richard L., Zachowski A.
    FEBS Lett. 566:115-120(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiCK1_ARATH
AccessioniPrimary (citable) accession number: Q9M9H6
Secondary accession number(s): Q9C9J3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3