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Protein

Probable choline kinase 1

Gene

CK1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in phospholipid biosynthesis. Catalyzes the first step in phosphatidylcholine biosynthesis (By similarity).By similarity

Catalytic activityi

ATP + choline = ADP + phosphocholine.

Pathwayi: phosphatidylcholine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphocholine from choline.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable choline kinase 2 (At1g74320), Probable choline kinase 3 (At4g09760), Probable choline kinase 1 (CK1)
This subpathway is part of the pathway phosphatidylcholine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphocholine from choline, the pathway phosphatidylcholine biosynthesis and in Phospholipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73ATPBy similarity1
Binding sitei210ATPBy similarity1
Binding sitei227ATPBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • choline kinase activity Source: TAIR

GO - Biological processi

  • response to wounding Source: TAIR

Keywordsi

Molecular functionKinase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G71697-MONOMER
ReactomeiR-ATH-1483191 Synthesis of PC
R-ATH-1483213 Synthesis of PE
UniPathwayiUPA00753; UER00737

Names & Taxonomyi

Protein namesi
Recommended name:
Probable choline kinase 1 (EC:2.7.1.32)
Short name:
AtCK1
Gene namesi
Name:CK1
Synonyms:CK
Ordered Locus Names:At1g71697
ORF Names:F14O23.8, F26A9.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G71697
TAIRilocus:2824546 AT1G71697

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004233461 – 346Probable choline kinase 1Add BLAST346

Proteomic databases

PaxDbiQ9M9H6
PRIDEiQ9M9H6

PTM databases

iPTMnetiQ9M9H6

Expressioni

Tissue specificityi

Expressed in roots. Expressed at low levels in cauline leaves and flowers.1 Publication

Inductioni

By wounding, and salt and osmotic stresses.2 Publications

Gene expression databases

ExpressionAtlasiQ9M9H6 baseline and differential
GenevisibleiQ9M9H6 AT

Interactioni

Protein-protein interaction databases

BioGridi28720, 1 interactor
STRINGi3702.AT1G71697.1

Structurei

3D structure databases

ProteinModelPortaliQ9M9H6
SMRiQ9M9H6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the choline/ethanolamine kinase family.Curated

Phylogenomic databases

eggNOGiKOG2686 Eukaryota
COG0510 LUCA
HOGENOMiHOG000041274
InParanoidiQ9M9H6
KOiK14156
OMAiPIAYDIT
OrthoDBiEOG09360D8L
PhylomeDBiQ9M9H6

Family and domain databases

InterProiView protein in InterPro
IPR007521 Choline_kin_N
IPR011009 Kinase-like_dom_sf
PfamiView protein in Pfam
PF04428 Choline_kin_N, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit

Sequencei

Sequence statusi: Complete.

Q9M9H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKTKTSLI PSCSSPEDLK RVLQTLGSSW GDVVEDLERL EVVPLKGAMT
60 70 80 90 100
NEVYQINWPT LNGEDVHRKV LVRIYGDGVD LFFNRGDEIK TFECMSHHGY
110 120 130 140 150
GPKLLGRFSD GRLEEFIHAR TLSADDLRVA ETSDFIAAKL REFHKLDMPG
160 170 180 190 200
PKNVLLWERL RTWLKEAKNL ASPIEMDKYR LEGLENEINL LEERLTRDDQ
210 220 230 240 250
EIGFCHNDLQ YGNVMIDEVT NAITIIDYEY SSFNPIAYDI ANHFCEMAAN
260 270 280 290 300
YHSDTPHVLD YTLYPGEGER RRFISTYLGS TGNATSDKEV ERLLKDAESY
310 320 330 340
TLANHIFWGL WGIISGHVNK IEFDYMEYAR QRFEQYWLRK PLLLEG
Length:346
Mass (Da):40,016
Last modified:October 1, 2000 - v1
Checksum:i3FABBAAAB09B5597
GO

Sequence cautioni

The sequence AAG51828 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC012654 Genomic DNA Translation: AAF43223.1
AC016163 Genomic DNA Translation: AAG51828.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE35220.1
BT008311 mRNA Translation: AAP37670.1
AK229787 mRNA Translation: BAF01619.1
AK230407 mRNA Translation: BAF02205.1
PIRiC96739
RefSeqiNP_177315.1, NM_105828.4
UniGeneiAt.43278

Genome annotation databases

EnsemblPlantsiAT1G71697.1; AT1G71697.1; AT1G71697
GeneIDi843500
GrameneiAT1G71697.1; AT1G71697.1; AT1G71697
KEGGiath:AT1G71697

Similar proteinsi

Entry informationi

Entry nameiCK1_ARATH
AccessioniPrimary (citable) accession number: Q9M9H6
Secondary accession number(s): Q9C9J3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health