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Protein

ABC transporter G family member 40

Gene

ABCG40

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a general defense protein (By similarity). Functions as a pump to exclude Pb2+ ions and/or Pb2+-containing toxic compounds from the cytoplasm. Contributes to Pb2+ ions resistance. Confers some resistance to the terpene sclareol (PubMed:14526118, PubMed:15923333).By similarity2 Publications
Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi187 – 194ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi870 – 877ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • abscisic acid transport Source: TAIR
  • defense response to oomycetes Source: UniProtKB
  • drug transmembrane transport Source: TAIR
  • lead ion transport Source: TAIR
  • response to ethylene Source: TAIR
  • response to jasmonic acid Source: TAIR
  • response to ozone Source: TAIR
  • response to salicylic acid Source: TAIR
  • terpenoid transport Source: TAIR
Complete GO annotation...

Keywords - Biological processi

Plant defense, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Protein family/group databases

TCDBi3.A.1.205.10. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter G family member 401 Publication
Short name:
ABC transporter ABCG.401 Publication
Short name:
AtABCG401 Publication
Alternative name(s):
Pleiotropic drug resistance protein 122 Publications
Gene namesi
Name:ABCG401 Publication
Synonyms:PDR122 Publications, PDR91 Publication
Ordered Locus Names:At1g15520Imported
ORF Names:T16N11.3Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G15520.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei523 – 543HelicalSequence analysisAdd BLAST21
Transmembranei562 – 582HelicalSequence analysisAdd BLAST21
Transmembranei611 – 631HelicalSequence analysisAdd BLAST21
Transmembranei643 – 663HelicalSequence analysisAdd BLAST21
Transmembranei667 – 687HelicalSequence analysisAdd BLAST21
Transmembranei696 – 716HelicalSequence analysisAdd BLAST21
Transmembranei756 – 776HelicalSequence analysisAdd BLAST21
Transmembranei1174 – 1194HelicalSequence analysisAdd BLAST21
Transmembranei1207 – 1227HelicalSequence analysisAdd BLAST21
Transmembranei1257 – 1277HelicalSequence analysisAdd BLAST21
Transmembranei1284 – 1304HelicalSequence analysisAdd BLAST21
Transmembranei1314 – 1334HelicalSequence analysisAdd BLAST21
Transmembranei1341 – 1361HelicalSequence analysisAdd BLAST21
Transmembranei1395 – 1415HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Increased susceptibility to the oomycetes Phytophthora brassicae and Phytophthora capsici.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002346391 – 1423ABC transporter G family member 40Add BLAST1423

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei962PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9M9E1.
PRIDEiQ9M9E1.

PTM databases

iPTMnetiQ9M9E1.

Expressioni

Tissue specificityi

Ubiquitous with higher levels in leaves, stems and flowers.3 Publications

Inductioni

Circadian-regulation. Expression increase during the dark phase and decrease during the light phase. Induced by cycloheximide (CHX), sclareol, and heavy metals such as Pb2+ ions. ETR1-, EIN2-, JAR1-, NPR1- and EDS5-dependent induction by incompatible fungal pathogens (A.brassicicola), by compatible fungal pathogens (S.sclerotiorum and F.oxysporum), and by compatible bacterial pathogens (P.syringae pv tomato). Also induced by phytohormones such as salicylic acid (SA), methyl jasmonate (MeJA) and ethylene.3 Publications

Gene expression databases

GenevisibleiQ9M9E1. AT.

Interactioni

Subunit structurei

Interacts with LECRK91 and LECRK92.1 Publication

Protein-protein interaction databases

STRINGi3702.AT1G15520.1.

Structurei

3D structure databases

ProteinModelPortaliQ9M9E1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini154 – 427ABC transporter 1PROSITE-ProRule annotationAdd BLAST274
Domaini505 – 718ABC transmembrane type-2 1Sequence analysisAdd BLAST214
Domaini825 – 1077ABC transporter 2PROSITE-ProRule annotationAdd BLAST253
Domaini1150 – 1364ABC transmembrane type-2 2Sequence analysisAdd BLAST215

Sequence similaritiesi

Contains 2 ABC transmembrane type-2 domains.Sequence analysis
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0065. Eukaryota.
COG0842. LUCA.
HOGENOMiHOG000238051.
InParanoidiQ9M9E1.
OMAiITEPMAD.
OrthoDBiEOG09360089.
PhylomeDBiQ9M9E1.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR029481. ABC_trans_N.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
IPR013581. PDR_assoc.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF14510. ABC_trans_N. 1 hit.
PF08370. PDR_assoc. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9M9E1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGTSFHQAS NSMRRNSSVW KKDSGREIFS RSSREEDDEE ALRWAALEKL
60 70 80 90 100
PTFDRLRKGI LTASHAGGPI NEIDIQKLGF QDTKKLLERL IKVGDDEHEK
110 120 130 140 150
LLWKLKKRID RVGIDLPTIE VRFDHLKVEA EVHVGGRALP TFVNFISNFA
160 170 180 190 200
DKFLNTLHLV PNRKKKFTIL NDVSGIVKPG RMALLLGPPS SGKTTLLLAL
210 220 230 240 250
AGKLDQELKQ TGRVTYNGHG MNEFVPQRTA AYIGQNDVHI GEMTVRETFA
260 270 280 290 300
YAARFQGVGS RYDMLTELAR REKEANIKPD PDIDIFMKAM STAGEKTNVM
310 320 330 340 350
TDYILKILGL EVCADTMVGD DMLRGISGGQ KKRVTTGEML VGPSRALFMD
360 370 380 390 400
EISTGLDSST TYQIVNSLRN YVHIFNGTAL ISLLQPAPET FNLFDDIILI
410 420 430 440 450
AEGEIIYEGP RDHVVEFFET MGFKCPPRKG VADFLQEVTS KKDQMQYWAR
460 470 480 490 500
RDEPYRFIRV REFAEAFQSF HVGRRIGDEL ALPFDKTKSH PAALTTKKYG
510 520 530 540 550
VGIKELVKTS FSREYLLMKR NSFVYYFKFG QLLVMAFLTM TLFFRTEMQK
560 570 580 590 600
KTEVDGSLYT GALFFILMML MFNGMSELSM TIAKLPVFYK QRDLLFYPAW
610 620 630 640 650
VYSLPPWLLK IPISFMEAAL TTFITYYVIG FDPNVGRLFK QYILLVLMNQ
660 670 680 690 700
MASALFKMVA ALGRNMIVAN TFGAFAMLVF FALGGVVLSR DDIKKWWIWG
710 720 730 740 750
YWISPIMYGQ NAILANEFFG HSWSRAVENS SETLGVTFLK SRGFLPHAYW
760 770 780 790 800
YWIGTGALLG FVVLFNFGFT LALTFLNSLG KPQAVIAEEP ASDETELQSA
810 820 830 840 850
RSEGVVEAGA NKKRGMVLPF EPHSITFDNV VYSVDMPQEM IEQGTQEDRL
860 870 880 890 900
VLLKGVNGAF RPGVLTALMG VSGAGKTTLM DVLAGRKTGG YIDGNITISG
910 920 930 940 950
YPKNQQTFAR ISGYCEQTDI HSPHVTVYES LVYSAWLRLP KEVDKNKRKI
960 970 980 990 1000
FIEEVMELVE LTPLRQALVG LPGESGLSTE QRKRLTIAVE LVANPSIIFM
1010 1020 1030 1040 1050
DEPTSGLDAR AAAIVMRTVR NTVDTGRTVV CTIHQPSIDI FEAFDELFLL
1060 1070 1080 1090 1100
KRGGEEIYVG PLGHESTHLI NYFESIQGIN KITEGYNPAT WMLEVSTTSQ
1110 1120 1130 1140 1150
EAALGVDFAQ VYKNSELYKR NKELIKELSQ PAPGSKDLYF PTQYSQSFLT
1160 1170 1180 1190 1200
QCMASLWKQH WSYWRNPPYT AVRFLFTIGI ALMFGTMFWD LGGKTKTRQD
1210 1220 1230 1240 1250
LSNAMGSMYT AVLFLGLQNA ASVQPVVNVE RTVFYREQAA GMYSAMPYAF
1260 1270 1280 1290 1300
AQVFIEIPYV LVQAIVYGLI VYAMIGFEWT AVKFFWYLFF MYGSFLTFTF
1310 1320 1330 1340 1350
YGMMAVAMTP NHHIASVVSS AFYGIWNLFS GFLIPRPSMP VWWEWYYWLC
1360 1370 1380 1390 1400
PVAWTLYGLI ASQFGDITEP MADSNMSVKQ FIREFYGYRE GFLGVVAAMN
1410 1420
VIFPLLFAVI FAIGIKSFNF QKR
Length:1,423
Mass (Da):161,017
Last modified:October 1, 2000 - v1
Checksum:iB40CFF2797486D23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013453 Genomic DNA. Translation: AAF71978.1.
CP002684 Genomic DNA. Translation: AEE29332.1.
BK001011 Genomic DNA. Translation: DAA00880.1.
PIRiA86289.
RefSeqiNP_173005.1. NM_101421.3.
UniGeneiAt.49303.

Genome annotation databases

EnsemblPlantsiAT1G15520.1; AT1G15520.1; AT1G15520.
GeneIDi838122.
GrameneiAT1G15520.1; AT1G15520.1; AT1G15520.
KEGGiath:AT1G15520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013453 Genomic DNA. Translation: AAF71978.1.
CP002684 Genomic DNA. Translation: AEE29332.1.
BK001011 Genomic DNA. Translation: DAA00880.1.
PIRiA86289.
RefSeqiNP_173005.1. NM_101421.3.
UniGeneiAt.49303.

3D structure databases

ProteinModelPortaliQ9M9E1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT1G15520.1.

Protein family/group databases

TCDBi3.A.1.205.10. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiQ9M9E1.

Proteomic databases

PaxDbiQ9M9E1.
PRIDEiQ9M9E1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G15520.1; AT1G15520.1; AT1G15520.
GeneIDi838122.
GrameneiAT1G15520.1; AT1G15520.1; AT1G15520.
KEGGiath:AT1G15520.

Organism-specific databases

TAIRiAT1G15520.

Phylogenomic databases

eggNOGiKOG0065. Eukaryota.
COG0842. LUCA.
HOGENOMiHOG000238051.
InParanoidiQ9M9E1.
OMAiITEPMAD.
OrthoDBiEOG09360089.
PhylomeDBiQ9M9E1.

Miscellaneous databases

PROiQ9M9E1.

Gene expression databases

GenevisibleiQ9M9E1. AT.

Family and domain databases

Gene3Di3.40.50.300. 3 hits.
InterProiIPR003593. AAA+_ATPase.
IPR013525. ABC_2_trans.
IPR029481. ABC_trans_N.
IPR003439. ABC_transporter-like.
IPR027417. P-loop_NTPase.
IPR013581. PDR_assoc.
[Graphical view]
PfamiPF01061. ABC2_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
PF14510. ABC_trans_N. 1 hit.
PF08370. PDR_assoc. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAB40G_ARATH
AccessioniPrimary (citable) accession number: Q9M9E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: October 1, 2000
Last modified: October 5, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.