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Q9M8R7

- P2C33_ARATH

UniProt

Q9M8R7 - P2C33_ARATH

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Protein

Probable protein phosphatase 2C 33

Gene

PPC6-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi100 – 1001Manganese 1By similarity
Metal bindingi100 – 1001Manganese 2By similarity
Metal bindingi101 – 1011Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi338 – 3381Manganese 2By similarity
Metal bindingi384 – 3841Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. phosphoprotein phosphatase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:GQT-2832-MONOMER.
ARA:GQT-940-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 33 (EC:3.1.3.16)
Short name:
AtPP2C33
Alternative name(s):
AtPPC6;1
Gene namesi
Name:PPC6-1
Ordered Locus Names:At3g02750
ORF Names:F13E7.31
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G02750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Probable protein phosphatase 2C 33PRO_0000367960Add
BLAST

Proteomic databases

PaxDbiQ9M8R7.
PRIDEiQ9M8R7.

Expressioni

Gene expression databases

GenevestigatoriQ9M8R7.

Interactioni

Protein-protein interaction databases

BioGridi6243. 1 interaction.
IntActiQ9M8R7. 1 interaction.
MINTiMINT-8390499.

Structurei

3D structure databases

ProteinModelPortaliQ9M8R7.
SMRiQ9M8R7. Positions 71-352.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini187 – 353167PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233897.
InParanoidiQ9M8R7.
OMAiNFGSRTD.
PhylomeDBiQ9M8R7.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9M8R7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSCLSAESR SPRPGSPCSP AFSVRKRKNS KKRPGSRNSS FDYRREEPLN
60 70 80 90 100
QVPGRMFLNG STEVACIYTQ QGKKGPNQDA MVVWENFGSR TDTIFCGVFD
110 120 130 140 150
GHGPYGHMVA KRVRDNLPLK LSAYWEAKVP VEGVLKAITT DTVNNVTNIN
160 170 180 190 200
NPEDAAAAAA FVTAEEEPRT SADMEEENTE TQPELFQTLK ESFLKAFKVM
210 220 230 240 250
DRELKFHGSV DCFCSGTTAV TLIKQGQYLV VGNVGDSRAV MGTRDSENTL
260 270 280 290 300
VAVQLTVDLK PNLPAEAERI RKCRGRVFAL RDEPEVCRVW LPNCDSPGLA
310 320 330 340 350
MARAFGDFCL KDFGLISVPD VSFRQLTEKD EFIVLATDGI WDVLSNEDVV
360 370 380 390 400
AIVASAPSRS SAARALVESA VRAWRYKYPT SKVDDCAAVC LYLDSSNTNA
410 420 430 440 450
ISTASSISKL EDGEEEELKA TTEDDDASGP SGLGRSSTVR SGKEIALDES
460 470 480 490
ETEKLIKEAD NLDSEPGTEY SALEGVARVN TLLNLPRFVP GK
Length:492
Mass (Da):53,715
Last modified:October 1, 2000 - v1
Checksum:iD021BD5ACE735CF2
GO
Isoform 2 (identifier: Q9M8R7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-264: P → PGWIILCECMMLSCGCMMDPLIMFIGFFFIPSIELA

Note: May be due to an intron retention. No experimental confirmation available.

Show »
Length:527
Mass (Da):57,674
Checksum:iE6296601474665D8
GO

Sequence cautioni

The sequence BX824075 differs from that shown. Reason: Sequencing errors.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411F → L in AAL32574. (PubMed:14593172)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei264 – 2641P → PGWIILCECMMLSCGCMMDP LIMFIGFFFIPSIELA in isoform 2. CuratedVSP_036766

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018363 Genomic DNA. Translation: AAF26985.1.
CP002686 Genomic DNA. Translation: AEE73854.1.
CP002686 Genomic DNA. Translation: AEE73855.1.
CP002686 Genomic DNA. Translation: AEE73856.1.
AY062496 mRNA. Translation: AAL32574.1.
BX824075 mRNA. No translation available.
BT020578 mRNA. Translation: AAW80851.1.
BT029026 mRNA. Translation: ABI93935.1.
AB079669 mRNA. Translation: BAB84698.1.
RefSeqiNP_001030624.1. NM_001035547.1. [Q9M8R7-1]
NP_001030625.1. NM_001035548.1. [Q9M8R7-2]
NP_186924.1. NM_111143.3. [Q9M8R7-1]
UniGeneiAt.22072.

Genome annotation databases

EnsemblPlantsiAT3G02750.1; AT3G02750.1; AT3G02750. [Q9M8R7-1]
AT3G02750.2; AT3G02750.2; AT3G02750. [Q9M8R7-1]
GeneIDi820909.
KEGGiath:AT3G02750.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018363 Genomic DNA. Translation: AAF26985.1 .
CP002686 Genomic DNA. Translation: AEE73854.1 .
CP002686 Genomic DNA. Translation: AEE73855.1 .
CP002686 Genomic DNA. Translation: AEE73856.1 .
AY062496 mRNA. Translation: AAL32574.1 .
BX824075 mRNA. No translation available.
BT020578 mRNA. Translation: AAW80851.1 .
BT029026 mRNA. Translation: ABI93935.1 .
AB079669 mRNA. Translation: BAB84698.1 .
RefSeqi NP_001030624.1. NM_001035547.1. [Q9M8R7-1 ]
NP_001030625.1. NM_001035548.1. [Q9M8R7-2 ]
NP_186924.1. NM_111143.3. [Q9M8R7-1 ]
UniGenei At.22072.

3D structure databases

ProteinModelPortali Q9M8R7.
SMRi Q9M8R7. Positions 71-352.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 6243. 1 interaction.
IntActi Q9M8R7. 1 interaction.
MINTi MINT-8390499.

Proteomic databases

PaxDbi Q9M8R7.
PRIDEi Q9M8R7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G02750.1 ; AT3G02750.1 ; AT3G02750 . [Q9M8R7-1 ]
AT3G02750.2 ; AT3G02750.2 ; AT3G02750 . [Q9M8R7-1 ]
GeneIDi 820909.
KEGGi ath:AT3G02750.

Organism-specific databases

TAIRi AT3G02750.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000233897.
InParanoidi Q9M8R7.
OMAi NFGSRTD.
PhylomeDBi Q9M8R7.

Enzyme and pathway databases

BioCyci ARA:GQT-2832-MONOMER.
ARA:GQT-940-MONOMER.

Gene expression databases

Genevestigatori Q9M8R7.

Family and domain databases

Gene3Di 3.60.40.10. 2 hits.
InterProi IPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Whole genome sequence comparisons and 'full-length' cDNA sequences: a combined approach to evaluate and improve Arabidopsis genome annotation."
    Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M., Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M., Weissenbach J., Salanoubat M.
    Genome Res. 14:406-413(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Arabidopsis ORF clones."
    Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  6. "Substrate specificity of type 2C protein phosphatases (PP2C) in Arabidopsis thaliana."
    Izumi S., Yamada M., Ohsato H., Miyazaki S., Bohnert H.J., Fukuhara T.
    Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 191-492.
  7. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  8. "Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks."
    Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A., Grossmann J., Gruissem W., Baginsky S.
    Plant Physiol. 150:889-903(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiP2C33_ARATH
AccessioniPrimary (citable) accession number: Q9M8R7
Secondary accession number(s): Q2V3Z1, Q8SBC3, Q8W4L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3