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Protein

Probable protein phosphatase 2C 33

Gene

PPC6-1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi100Manganese 1By similarity1
Metal bindingi100Manganese 2By similarity1
Metal bindingi101Manganese 1; via carbonyl oxygenBy similarity1
Metal bindingi338Manganese 2By similarity1
Metal bindingi384Manganese 2By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 33 (EC:3.1.3.16)
Short name:
AtPP2C33
Alternative name(s):
AtPPC6;1
Gene namesi
Name:PPC6-1
Ordered Locus Names:At3g02750
ORF Names:F13E7.31
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G02750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003679601 – 492Probable protein phosphatase 2C 33Add BLAST492

PTM databases

iPTMnetiQ9M8R7.
SwissPalmiQ9M8R7.

Expressioni

Gene expression databases

GenevisibleiQ9M8R7. AT.

Interactioni

Protein-protein interaction databases

BioGridi6243. 1 interactor.
IntActiQ9M8R7. 1 interactor.
MINTiMINT-8390499.

Structurei

3D structure databases

ProteinModelPortaliQ9M8R7.
SMRiQ9M8R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 393PPM-type phosphatasePROSITE-ProRule annotationAdd BLAST330

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000233897.
InParanoidiQ9M8R7.
OMAiRREEPLN.
PhylomeDBiQ9M8R7.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR015655. PP2C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 2 hits.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9M8R7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGSCLSAESR SPRPGSPCSP AFSVRKRKNS KKRPGSRNSS FDYRREEPLN
60 70 80 90 100
QVPGRMFLNG STEVACIYTQ QGKKGPNQDA MVVWENFGSR TDTIFCGVFD
110 120 130 140 150
GHGPYGHMVA KRVRDNLPLK LSAYWEAKVP VEGVLKAITT DTVNNVTNIN
160 170 180 190 200
NPEDAAAAAA FVTAEEEPRT SADMEEENTE TQPELFQTLK ESFLKAFKVM
210 220 230 240 250
DRELKFHGSV DCFCSGTTAV TLIKQGQYLV VGNVGDSRAV MGTRDSENTL
260 270 280 290 300
VAVQLTVDLK PNLPAEAERI RKCRGRVFAL RDEPEVCRVW LPNCDSPGLA
310 320 330 340 350
MARAFGDFCL KDFGLISVPD VSFRQLTEKD EFIVLATDGI WDVLSNEDVV
360 370 380 390 400
AIVASAPSRS SAARALVESA VRAWRYKYPT SKVDDCAAVC LYLDSSNTNA
410 420 430 440 450
ISTASSISKL EDGEEEELKA TTEDDDASGP SGLGRSSTVR SGKEIALDES
460 470 480 490
ETEKLIKEAD NLDSEPGTEY SALEGVARVN TLLNLPRFVP GK
Length:492
Mass (Da):53,715
Last modified:October 1, 2000 - v1
Checksum:iD021BD5ACE735CF2
GO
Isoform 2 (identifier: Q9M8R7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     264-264: P → PGWIILCECMMLSCGCMMDPLIMFIGFFFIPSIELA

Note: May be due to an intron retention. No experimental confirmation available.
Show »
Length:527
Mass (Da):57,674
Checksum:iE6296601474665D8
GO

Sequence cautioni

The sequence BX824075 differs from that shown. Sequencing errors.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti41F → L in AAL32574 (PubMed:14593172).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_036766264P → PGWIILCECMMLSCGCMMDP LIMFIGFFFIPSIELA in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018363 Genomic DNA. Translation: AAF26985.1.
CP002686 Genomic DNA. Translation: AEE73854.1.
CP002686 Genomic DNA. Translation: AEE73855.1.
CP002686 Genomic DNA. Translation: AEE73856.1.
AY062496 mRNA. Translation: AAL32574.1.
BX824075 mRNA. No translation available.
BT020578 mRNA. Translation: AAW80851.1.
BT029026 mRNA. Translation: ABI93935.1.
AB079669 mRNA. Translation: BAB84698.1.
RefSeqiNP_001030624.1. NM_001035547.2. [Q9M8R7-1]
NP_001030625.1. NM_001035548.1. [Q9M8R7-2]
NP_186924.1. NM_111143.3. [Q9M8R7-1]
UniGeneiAt.22072.

Genome annotation databases

EnsemblPlantsiAT3G02750.1; AT3G02750.1; AT3G02750. [Q9M8R7-1]
AT3G02750.2; AT3G02750.2; AT3G02750. [Q9M8R7-1]
GeneIDi820909.
GrameneiAT3G02750.1; AT3G02750.1; AT3G02750.
AT3G02750.2; AT3G02750.2; AT3G02750.
KEGGiath:AT3G02750.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018363 Genomic DNA. Translation: AAF26985.1.
CP002686 Genomic DNA. Translation: AEE73854.1.
CP002686 Genomic DNA. Translation: AEE73855.1.
CP002686 Genomic DNA. Translation: AEE73856.1.
AY062496 mRNA. Translation: AAL32574.1.
BX824075 mRNA. No translation available.
BT020578 mRNA. Translation: AAW80851.1.
BT029026 mRNA. Translation: ABI93935.1.
AB079669 mRNA. Translation: BAB84698.1.
RefSeqiNP_001030624.1. NM_001035547.2. [Q9M8R7-1]
NP_001030625.1. NM_001035548.1. [Q9M8R7-2]
NP_186924.1. NM_111143.3. [Q9M8R7-1]
UniGeneiAt.22072.

3D structure databases

ProteinModelPortaliQ9M8R7.
SMRiQ9M8R7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi6243. 1 interactor.
IntActiQ9M8R7. 1 interactor.
MINTiMINT-8390499.

PTM databases

iPTMnetiQ9M8R7.
SwissPalmiQ9M8R7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G02750.1; AT3G02750.1; AT3G02750. [Q9M8R7-1]
AT3G02750.2; AT3G02750.2; AT3G02750. [Q9M8R7-1]
GeneIDi820909.
GrameneiAT3G02750.1; AT3G02750.1; AT3G02750.
AT3G02750.2; AT3G02750.2; AT3G02750.
KEGGiath:AT3G02750.

Organism-specific databases

TAIRiAT3G02750.

Phylogenomic databases

HOGENOMiHOG000233897.
InParanoidiQ9M8R7.
OMAiRREEPLN.
PhylomeDBiQ9M8R7.

Miscellaneous databases

PROiQ9M8R7.

Gene expression databases

GenevisibleiQ9M8R7. AT.

Family and domain databases

Gene3Di3.60.40.10. 2 hits.
InterProiIPR015655. PP2C.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 2 hits.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 2 hits.
PROSITEiPS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2C33_ARATH
AccessioniPrimary (citable) accession number: Q9M8R7
Secondary accession number(s): Q2V3Z1, Q8SBC3, Q8W4L2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.