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Protein

Proliferating cellular nuclear antigen 1

Gene

PCNA

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi61 – 80Sequence analysisAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processDNA replication

Enzyme and pathway databases

ReactomeiR-ATH-110312 Translesion synthesis by REV1
R-ATH-110314 Recognition of DNA damage by PCNA-containing replication complex
R-ATH-110320 Translesion Synthesis by POLH
R-ATH-174411 Polymerase switching on the C-strand of the telomere
R-ATH-174414 Processive synthesis on the C-strand of the telomere
R-ATH-174417 Telomere C-strand (Lagging Strand) Synthesis
R-ATH-174437 Removal of the Flap Intermediate from the C-strand
R-ATH-4615885 SUMOylation of DNA replication proteins
R-ATH-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
R-ATH-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-ATH-5655862 Translesion synthesis by POLK
R-ATH-5656121 Translesion synthesis by POLI
R-ATH-5656169 Termination of translesion DNA synthesis
R-ATH-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-ATH-5696400 Dual Incision in GG-NER
R-ATH-6782135 Dual incision in TC-NER
R-ATH-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-ATH-69091 Polymerase switching
R-ATH-69166 Removal of the Flap Intermediate
R-ATH-69183 Processive synthesis on the lagging strand

Names & Taxonomyi

Protein namesi
Recommended name:
Proliferating cellular nuclear antigen 1
Short name:
PCNA 1
Gene namesi
Name:PCNA
Synonyms:PCNA1
Ordered Locus Names:At1g07370
ORF Names:F22G5.29
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G07370
TAIRilocus:2025062 AT1G07370

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001491771 – 263Proliferating cellular nuclear antigen 1Add BLAST263

Proteomic databases

PaxDbiQ9M7Q7
PRIDEiQ9M7Q7

PTM databases

iPTMnetiQ9M7Q7

Expressioni

Gene expression databases

ExpressionAtlasiQ9M7Q7 baseline and differential
GenevisibleiQ9M7Q7 AT

Interactioni

Subunit structurei

Homo- and heterotrimer. Interacts with POLH, ATXR5 and ATXR6.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
POLHQ8H2D52EBI-1810458,EBI-1810451

Protein-protein interaction databases

BioGridi22490, 18 interactors
IntActiQ9M7Q7, 7 interactors
STRINGi3702.AT1G07370.1

Structurei

Secondary structure

1263
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Helixi10 – 19Combined sources10
Turni20 – 22Combined sources3
Beta strandi24 – 31Combined sources8
Beta strandi34 – 40Combined sources7
Beta strandi44 – 53Combined sources10
Helixi54 – 56Combined sources3
Beta strandi57 – 64Combined sources8
Beta strandi66 – 71Combined sources6
Helixi72 – 80Combined sources9
Beta strandi87 – 92Combined sources6
Beta strandi97 – 104Combined sources8
Beta strandi111 – 117Combined sources7
Beta strandi134 – 140Combined sources7
Helixi141 – 152Combined sources12
Beta strandi156 – 163Combined sources8
Beta strandi166 – 173Combined sources8
Beta strandi176 – 182Combined sources7
Helixi191 – 193Combined sources3
Beta strandi196 – 201Combined sources6
Beta strandi203 – 208Combined sources6
Helixi209 – 215Combined sources7
Helixi216 – 221Combined sources6
Beta strandi223 – 229Combined sources7
Beta strandi235 – 241Combined sources7
Turni242 – 244Combined sources3
Beta strandi245 – 251Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZVVX-ray2.00A/B1-256[»]
ProteinModelPortaliQ9M7Q7
SMRiQ9M7Q7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9M7Q7

Family & Domainsi

Sequence similaritiesi

Belongs to the PCNA family.Curated

Phylogenomic databases

eggNOGiKOG1636 Eukaryota
COG0592 LUCA
HOGENOMiHOG000211098
InParanoidiQ9M7Q7
KOiK04802
OMAiSDGFDKY
OrthoDBiEOG09360IU7
PhylomeDBiQ9M7Q7

Family and domain databases

HAMAPiMF_00317 DNApol_clamp_arch, 1 hit
InterProiView protein in InterPro
IPR000730 Pr_cel_nuc_antig
IPR022649 Pr_cel_nuc_antig_C
IPR022659 Pr_cel_nuc_antig_CS
IPR022648 Pr_cel_nuc_antig_N
PANTHERiPTHR11352:SF0 PTHR11352:SF0, 1 hit
PfamiView protein in Pfam
PF02747 PCNA_C, 1 hit
PF00705 PCNA_N, 1 hit
PRINTSiPR00339 PCNACYCLIN
TIGRFAMsiTIGR00590 pcna, 1 hit
PROSITEiView protein in PROSITE
PS01251 PCNA_1, 1 hit
PS00293 PCNA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9M7Q7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLELRLVQGS LLKKVLESIK DLVNDANFDC SSTGFSLQAM DSSHVALVSL
60 70 80 90 100
LLRSEGFEHY RCDRNLSMGM NLGNMSKMLK CAGNDDIITI KADDGGDTVT
110 120 130 140 150
FMFESPTQDK IADFEMKLMD IDSEHLGIPD AEYHSIVRMP SNEFSRICKD
160 170 180 190 200
LSSIGDTVVI SVTKEGVKFS TAGDIGTANI VLRQNTTVDK PEDAIVIEMK
210 220 230 240 250
EPVSLSFALR YMNSFTKATP LSDTVTISLS SELPVVVEYK VAEMGYIRYY
260
LAPKIEEEED TNP
Length:263
Mass (Da):29,122
Last modified:February 21, 2001 - v2
Checksum:iDA63C0F637CDB5D7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti48V → A in AAF40018 (Ref. 1) Curated1
Sequence conflicti48V → A in ABU25233 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083220 mRNA Translation: AAF40018.1
EU072917 mRNA Translation: ABU25233.1
AC022464 Genomic DNA Translation: AAF79566.1
CP002684 Genomic DNA Translation: AEE28115.1
AF462821 mRNA Translation: AAL58911.1
AY098969 mRNA Translation: AAM19979.1
AY086852 mRNA Translation: AAM63900.1
RefSeqiNP_172217.1, NM_100611.4
UniGeneiAt.11997

Genome annotation databases

EnsemblPlantsiAT1G07370.1; AT1G07370.1; AT1G07370
GeneIDi837249
GrameneiAT1G07370.1; AT1G07370.1; AT1G07370
KEGGiath:AT1G07370

Similar proteinsi

Entry informationi

Entry nameiPCNA1_ARATH
AccessioniPrimary (citable) accession number: Q9M7Q7
Secondary accession number(s): A7UIK5, Q9LNV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: February 21, 2001
Last modified: May 23, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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