Q9M7M8 (PROF5_HEVBR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Profilin-5 Alternative name(s): Pollen allergen Hev b 8.0203 Allergen=Hev b 8.0203
Organism	Hevea brasiliensis (Para rubber tree) (Siphonia brasiliensis)
Taxonomic identifier	3981 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Malpighiales › Euphorbiaceae › Crotonoideae › Micrandreae › Hevea

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG By similarity.
Subunit structure	Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio.
Subcellular location	Cytoplasm › cytoskeleton By similarity.
Allergenic properties	Causes an allergic reaction in human. Involved in latex allergic reactions.
Sequence similarities	Belongs to the profilin family.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Disease	Allergen
Ligand	Actin-binding
Gene Ontology (GO)
Biological_process	actin cytoskeleton organization Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW cytoskeleton Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 131	130	Profilin-5		PRO_0000199637

Sequences

	Sequence		Length	Mass (Da)
	Q9M7M8 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: DE35F4AA7AB269A7	FASTA	131	14,009
	10 20 30 40 50 60 MSWQTYVDDH LMCDIDGHRL TAAAIIGHDG SVWAQSSGFP QFKSDEVAAV MKDFDEPGSL 70 80 90 100 110 120 APTGLHLGGT KYMVIQGEPG AVIRGKKGSG GITVKKTGQA LIIGIYDEPL TPGQCNMIVE 130 RLGDYLLEQG M

References

[1]	"Characterization of new isoforms of the latex allergen, Hev b 8." Beezhold D.H., Hickey V.L., Kostyal D.A., Sussman G.L. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF119367 mRNA. Translation: AAF34343.1.
3D structure databases
ProteinModelPortal	Q9M7M8.
SMR	Q9M7M8. Positions 2-131.
ModBase	Search...
Protein family/group databases
Allergome	397. Hev b 8. 402. Hev b 8.0203.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR027310. Profilin_CS. IPR005455. Profilin_eukaryotes/bac. [Graphical view]
PANTHER	PTHR11604. PTHR11604. 1 hit.
Pfam	PF00235. Profilin. 1 hit. [Graphical view]
PRINTS	PR00392. PROFILIN. PR01640. PROFILINPLNT.
SMART	SM00392. PROF. 1 hit. [Graphical view]
SUPFAM	SSF55770. Profilin. 1 hit.
PROSITE	PS00414. PROFILIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PROF5_HEVBR

Accession

Primary (citable) accession number: Q9M7M8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	October 1, 2000
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program