Q9M5X6 (NLTP_PYRCO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Non-specific lipid-transfer protein Short name=LTP Alternative name(s): Allergen=Pyr c 3
Organism	Pyrus communis (Pear) (Pyrus domestica)
Taxonomic identifier	23211 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Rosales › Rosaceae › Amygdaloideae › Maleae › Pyrus

Protein attributes

Sequence length	115 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues By similarity.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the plant LTP family.

Ontologies

Keywords
Biological process	Transport
Disease	Allergen
Domain	Signal
Ligand	Lipid-binding
PTM	Disulfide bond
Gene Ontology (GO)
Biological_process	lipid transport Inferred from electronic annotation. Source: InterPro
Molecular_function	lipid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential
	Chain	25 – 115	91	Non-specific lipid-transfer protein		PRO_0000018404
Amino acid modifications
	Disulfide bond	27 ↔ 74		By similarity
	Disulfide bond	37 ↔ 51		By similarity
	Disulfide bond	52 ↔ 97		By similarity
	Disulfide bond	72 ↔ 111		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9M5X6 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 90543BD036AA8D65	FASTA	115	11,463
	10 20 30 40 50 60 MASSAVIKLA LVVALCMAVS VAHAITCSQV SANLAPCINY VRSGGAVPPA CCNGIKTING 70 80 90 100 110 LAKTTPDRQA ACNCLKNLAG SVSGVNPGNA ESLPGKCGVN VPYKISTSTN CATVK

References

[1]	"Cloning of a cDNA encoding a lipid transfer protein as a potential allergen from Pyrus communis." Scheurer S., Wangorsch A., Haustein D., Vieths S. Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF221503 mRNA. Translation: AAF26451.1.
3D structure databases
ProteinModelPortal	Q9M5X6.
SMR	Q9M5X6. Positions 25-115.
ModBase	Search...
Protein family/group databases
Allergome	1066. Pyr c 3. 3458. Pyr c 3.0101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR016140. Bifunc_inhib/LTP/seed_store. IPR000528. Plant_LTP. [Graphical view]
Pfam	PF00234. Tryp_alpha_amyl. 1 hit. [Graphical view]
PRINTS	PR00382. LIPIDTRNSFER.
SMART	SM00499. AAI. 1 hit. [Graphical view]
SUPFAM	SSF47699. Bifunc_inhib/LTP/seed_store. 1 hit.
PROSITE	PS00597. PLANT_LTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NLTP_PYRCO

Accession

Primary (citable) accession number: Q9M5X6

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	October 1, 2000
Last modified:	March 6, 2013
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program