Q9M591 (CRD1_ARATH) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 79.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase, chloroplastic Short name=Mg-protoporphyrin IX monomethyl ester oxidative cyclase EC=1.14.13.81 Alternative name(s): Copper response defect 1 protein Dicarboxylate diiron protein Short name=AtZIP | ||||||||
| Gene names |
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| Organism | Arabidopsis thaliana (Mouse-ear cress) | ||||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Protein attributes
| Sequence length | 409 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME). Ref.7 |
| Catalytic activity | Magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + H2O. Ref.7 131-hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADP+ + 2 H2O. Ref.7 131-oxo-magnesium-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = divinylprotochlorophyllide + NADP+ + 2 H2O. Ref.7 |
| Cofactor | Iron By similarity. |
| Pathway | |
| Subcellular location | Plastid › chloroplast inner membrane; Peripheral membrane protein. Plastid › chloroplast thylakoid membrane; Peripheral membrane protein Ref.7. |
| Sequence similarities | Belongs to the AcsF family. |
| Sequence caution | The sequence AAB18942.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Chlorophyll biosynthesis Photosynthesis |
| Cellular component | Chloroplast Membrane Plastid Plastid inner membrane Thylakoid |
| Coding sequence diversity | Alternative splicing |
| Domain | Transit peptide |
| Ligand | Iron Metal-binding NADP |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | chlorophyll biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW photosynthesisInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | chloroplast inner membrane Inferred from direct assay Ref.7. Source: TAIR chloroplast thylakoid membraneInferred from direct assay Ref.7. Source: TAIR |
| Molecular function | DNA binding Traceable author statement. Source: TAIR magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase activityInferred from mutant phenotype Ref.7. Source: TAIR transition metal ion bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 1 isoform produced by alternative splicing. [Select] Note: A number of isoforms are produced. According to EST sequences. | ||||||
| Isoform 1 (identifier: Q9M591-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 36 | 36 | Chloroplast Potential | ||||||
| Chain | 37 – 409 | 373 | Magnesium-protoporphyrin IX monomethyl ester [oxidative] cyclase, chloroplastic | PRO_0000000598 | |||||
Experimental info | |||||||||
| Sequence conflict | 14 | 1 | F → I in AAB18942. Ref.1 | ||||||
| Sequence conflict | 157 | 1 | L → S in AAB18942. Ref.1 | ||||||
| Sequence conflict | 216 – 219 | 4 | TYLS → RAAR in AAB51703. Ref.6 | ||||||
| Sequence conflict | 299 | 1 | C → W in AAF63476. Ref.2 | ||||||
| Sequence conflict | 310 – 312 | 3 | LNT → FKH in AAB51703. Ref.6 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "PNZIP is a novel mesophyll-specific cDNA that is regulated by phytochrome and the circadian rhythm and encodes a protein with a leucine zipper motif." Zheng C.C., Porat R., Lu P., O'Neill S.D. Plant Physiol. 116:27-35(1998) [PubMed: 9449833] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The Crd1 gene encodes a putative di-iron enzyme required for photosystem I accumulation in copper deficiency and hypoxia in Chlamydomonas reinhardtii." Moseley J.L., Quinn J., Eriksson M., Merchant S. EMBO J. 19:2139-2151(2000) [PubMed: 10811605] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana." Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. Tabata S.Nature 408:820-822(2000) [PubMed: 11130713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [4] | The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia. |
| [5] | "Cloning and characteristics of AT103 gene promoter." Liu N., Zheng C. Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-76. |
| [6] | "Isolation of molecular markers for salt stress responses in Arabidopsis thaliana." Pih K.T., Jang H.J., Kang S.G., Piao H.L., Hwang I. Mol. Cells 7:567-571(1997) [PubMed: 9339905] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 215-313. Strain: cv. Columbia. |
| [7] | "Arabidopsis CHL27, located in both envelope and thylakoid membranes, is required for the synthesis of protochlorophyllide." Tottey S., Block M.A., Allen M., Westergren T., Albrieux C., Scheller H.V., Merchant S., Jensen P.E. Proc. Natl. Acad. Sci. U.S.A. 100:16119-16124(2003) [PubMed: 14673103] [Abstract] Cited for: FUNCTION, ENZYME ACTIVITY, SUBCELLULAR LOCATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | U38232 mRNA. Translation: AAB18942.1. Different initiation. AF236101 mRNA. Translation: AAF63476.1. AL138655 Genomic DNA. Translation: CAB72164.1. CP002686 Genomic DNA. Translation: AEE79589.1. AY170319 Genomic DNA. Translation: AAO11785.1. U75599 mRNA. Translation: AAB51703.1. |
| IPI | IPI00517126. |
| PIR | T47754. |
| RefSeq | NP_191253.1. NM_115553.4. |
| UniGene | At.48778. At.70999. |
3D structure databases | |
| ProteinModelPortal | Q9M591. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9M591. |
Proteomic databases | |
| PRIDE | Q9M591. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblPlants | AT3G56940.1; AT3G56940.1; AT3G56940. |
| GeneID | 824861. |
| GenomeReviews | Gene locus AT3G56940 in contig BA000014_GR. |
| KEGG | ath:AT3G56940. |
| NMPDR | fig|3702.1.peg.17023. |
Organism-specific databases | |
| TAIR | At3g56940. |
Phylogenomic databases | |
| eggNOG | NOG10633. |
| GeneTree | EPGT00050000018409. |
| HOGENOM | HBG284843. |
| InParanoid | Q9M591. |
| OMA | HGDFFDA. |
| PhylomeDB | Q9M591. |
| ProtClustDB | PLN02508. |
Enzyme and pathway databases | |
| BioCyc | ARA:AT3G56940-MONOMER. MetaCyc:AT3G56940-MONOMER. |
Gene expression databases | |
| Genevestigator | Q9M591. |
| GermOnline | AT3G56940. Arabidopsis thaliana. |
Family and domain databases | |
| InterPro | IPR008434. AcsF. IPR012347. Ferritin-rel. IPR009078. Ferritin/RR-like. IPR003251. Rubrerythrin. [Graphical view] |
| Gene3D | G3DSA:1.20.1260.10. Ferritin_rel. 1 hit. |
| KO | K04035. |
| Pfam | PF02915. Rubrerythrin. 1 hit. [Graphical view] |
| SUPFAM | SSF47240. Ferritin/RR_like. 1 hit. |
| TIGRFAMs | TIGR02029. AcsF. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | CRD1_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q9M591 Secondary accession number(s): O04051 Q9M1K4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Plant Protein Annotation Program | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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