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Q9M391

- ATX3H_ARATH

UniProt

Q9M391 - ATX3H_ARATH

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Protein
Ataxin-3 homolog
Gene
At3g54130, F24B22.90
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei20 – 201Nucleophile By similarity
Active sitei126 – 1261Proton acceptor By similarity
Active sitei141 – 1411 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. omega peptidase activity Source: InterPro

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

BioCyciARA:AT3G54130-MONOMER.

Protein family/group databases

MEROPSiC86.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
Ataxin-3 homolog (EC:3.4.19.12)
Alternative name(s):
MJD1a-like
Machado-Joseph disease-like protein
Gene namesi
Ordered Locus Names:At3g54130
ORF Names:F24B22.90
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G54130.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Ataxin-3 homolog
PRO_0000053836Add
BLAST

Proteomic databases

PaxDbiQ9M391.
PRIDEiQ9M391.

Expressioni

Gene expression databases

GenevestigatoriQ9M391.

Interactioni

Protein-protein interaction databases

MINTiMINT-8065588.

Structurei

3D structure databases

ProteinModelPortaliQ9M391.
SMRiQ9M391. Positions 10-177.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 187181Josephin
Add
BLAST
Repeati243 – 26220UIM
Add
BLAST

Sequence similaritiesi

Contains 1 Josephin domain.

Phylogenomic databases

eggNOGiNOG327234.
HOGENOMiHOG000006034.
InParanoidiQ9M391.
KOiK11863.
OMAiLMDTGGP.
PhylomeDBiQ9M391.

Family and domain databases

InterProiIPR006155. Josephin.
[Graphical view]
PfamiPF02099. Josephin. 1 hit.
[Graphical view]
PRINTSiPR01233. JOSEPHIN.
PROSITEiPS50957. JOSEPHIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9M391-1 [UniParc]FASTAAdd to Basket

« Hide

MERTSNGGML YHEVQESNLC AVHCVNTVLQ GPFFSEFDLA AVAADLDGKE    50
RQVMLEGAAV GGFAPGDFLA EESHNVSLGG DFSIQVLQKA LEVWDLQVIP 100
LNCPDAEPAQ IDPELESAFI CHLHDHWFCI RKVNGEWYNF DSLLAAPQHL 150
SKFYLSAFLD SLKGAGWSIF IVKGNFPQEC PMSSSSEASN SFGQWLSPED 200
AERIRKNTSS GSSARNKRSN DNVNQQRRNQ ALSREEVQAF SEMEDDDLKA 250
AIAASLLDAS AAEANLGAVG TSEKETEKQK 280
Length:280
Mass (Da):30,692
Last modified:October 1, 2000 - v1
Checksum:iF4A1C9A3F9A25A78
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL132957 Genomic DNA. Translation: CAB70987.1.
CP002686 Genomic DNA. Translation: AEE79191.1.
BT010762 mRNA. Translation: AAR23732.1.
BT010992 mRNA. Translation: AAR24770.1.
PIRiT47572.
RefSeqiNP_190981.1. NM_115273.3.
UniGeneiAt.926.

Genome annotation databases

EnsemblPlantsiAT3G54130.1; AT3G54130.1; AT3G54130.
GeneIDi824580.
KEGGiath:AT3G54130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL132957 Genomic DNA. Translation: CAB70987.1 .
CP002686 Genomic DNA. Translation: AEE79191.1 .
BT010762 mRNA. Translation: AAR23732.1 .
BT010992 mRNA. Translation: AAR24770.1 .
PIRi T47572.
RefSeqi NP_190981.1. NM_115273.3.
UniGenei At.926.

3D structure databases

ProteinModelPortali Q9M391.
SMRi Q9M391. Positions 10-177.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-8065588.

Protein family/group databases

MEROPSi C86.A01.

Proteomic databases

PaxDbi Q9M391.
PRIDEi Q9M391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G54130.1 ; AT3G54130.1 ; AT3G54130 .
GeneIDi 824580.
KEGGi ath:AT3G54130.

Organism-specific databases

TAIRi AT3G54130.

Phylogenomic databases

eggNOGi NOG327234.
HOGENOMi HOG000006034.
InParanoidi Q9M391.
KOi K11863.
OMAi LMDTGGP.
PhylomeDBi Q9M391.

Enzyme and pathway databases

BioCyci ARA:AT3G54130-MONOMER.

Miscellaneous databases

PROi Q9M391.

Gene expression databases

Genevestigatori Q9M391.

Family and domain databases

InterProi IPR006155. Josephin.
[Graphical view ]
Pfami PF02099. Josephin. 1 hit.
[Graphical view ]
PRINTSi PR01233. JOSEPHIN.
PROSITEi PS50957. JOSEPHIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Arabidopsis ORF clones."
    Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Structural modeling of ataxin-3 reveals distant homology to adaptins."
    Albrecht M., Hoffmann D., Evert B.O., Schmitt I., Wuellner U., Lengauer T.
    Proteins 50:355-370(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING.

Entry informationi

Entry nameiATX3H_ARATH
AccessioniPrimary (citable) accession number: Q9M391
Secondary accession number(s): Q53XG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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