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Protein

Ataxin-3 homolog

Gene

At3g54130

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei20NucleophilePROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1
Active sitei141PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

BioCyciARA:AT3G54130-MONOMER.
ReactomeiR-ATH-5689877. Josephin domain DUBs.

Protein family/group databases

MEROPSiC86.A01.

Names & Taxonomyi

Protein namesi
Recommended name:
Ataxin-3 homolog (EC:3.4.19.12)
Alternative name(s):
MJD1a-like
Machado-Joseph disease-like protein
Gene namesi
Ordered Locus Names:At3g54130
ORF Names:F24B22.90
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G54130.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538361 – 280Ataxin-3 homologAdd BLAST280

Proteomic databases

PaxDbiQ9M391.

PTM databases

iPTMnetiQ9M391.

Expressioni

Gene expression databases

GenevisibleiQ9M391. AT.

Interactioni

Protein-protein interaction databases

BioGridi9897. 2 interactors.
MINTiMINT-8065588.
STRINGi3702.AT3G54130.1.

Structurei

3D structure databases

ProteinModelPortaliQ9M391.
SMRiQ9M391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 187JosephinPROSITE-ProRule annotationAdd BLAST181
Domaini243 – 262UIMCuratedAdd BLAST20

Sequence similaritiesi

Contains 1 Josephin domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG2935. Eukaryota.
ENOG4111G4B. LUCA.
HOGENOMiHOG000006034.
InParanoidiQ9M391.
KOiK11863.
OMAiRQVMLQG.
OrthoDBiEOG09360KCU.
PhylomeDBiQ9M391.

Family and domain databases

InterProiIPR033865. Ataxin-3.
IPR006155. Josephin.
[Graphical view]
PANTHERiPTHR14159. PTHR14159. 1 hit.
PfamiPF02099. Josephin. 1 hit.
[Graphical view]
SMARTiSM01246. Josephin. 1 hit.
[Graphical view]
PROSITEiPS50957. JOSEPHIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9M391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERTSNGGML YHEVQESNLC AVHCVNTVLQ GPFFSEFDLA AVAADLDGKE
60 70 80 90 100
RQVMLEGAAV GGFAPGDFLA EESHNVSLGG DFSIQVLQKA LEVWDLQVIP
110 120 130 140 150
LNCPDAEPAQ IDPELESAFI CHLHDHWFCI RKVNGEWYNF DSLLAAPQHL
160 170 180 190 200
SKFYLSAFLD SLKGAGWSIF IVKGNFPQEC PMSSSSEASN SFGQWLSPED
210 220 230 240 250
AERIRKNTSS GSSARNKRSN DNVNQQRRNQ ALSREEVQAF SEMEDDDLKA
260 270 280
AIAASLLDAS AAEANLGAVG TSEKETEKQK
Length:280
Mass (Da):30,692
Last modified:October 1, 2000 - v1
Checksum:iF4A1C9A3F9A25A78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132957 Genomic DNA. Translation: CAB70987.1.
CP002686 Genomic DNA. Translation: AEE79191.1.
BT010762 mRNA. Translation: AAR23732.1.
BT010992 mRNA. Translation: AAR24770.1.
PIRiT47572.
RefSeqiNP_190981.1. NM_115273.4.
UniGeneiAt.926.

Genome annotation databases

EnsemblPlantsiAT3G54130.1; AT3G54130.1; AT3G54130.
GeneIDi824580.
GrameneiAT3G54130.1; AT3G54130.1; AT3G54130.
KEGGiath:AT3G54130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132957 Genomic DNA. Translation: CAB70987.1.
CP002686 Genomic DNA. Translation: AEE79191.1.
BT010762 mRNA. Translation: AAR23732.1.
BT010992 mRNA. Translation: AAR24770.1.
PIRiT47572.
RefSeqiNP_190981.1. NM_115273.4.
UniGeneiAt.926.

3D structure databases

ProteinModelPortaliQ9M391.
SMRiQ9M391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi9897. 2 interactors.
MINTiMINT-8065588.
STRINGi3702.AT3G54130.1.

Protein family/group databases

MEROPSiC86.A01.

PTM databases

iPTMnetiQ9M391.

Proteomic databases

PaxDbiQ9M391.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G54130.1; AT3G54130.1; AT3G54130.
GeneIDi824580.
GrameneiAT3G54130.1; AT3G54130.1; AT3G54130.
KEGGiath:AT3G54130.

Organism-specific databases

TAIRiAT3G54130.

Phylogenomic databases

eggNOGiKOG2935. Eukaryota.
ENOG4111G4B. LUCA.
HOGENOMiHOG000006034.
InParanoidiQ9M391.
KOiK11863.
OMAiRQVMLQG.
OrthoDBiEOG09360KCU.
PhylomeDBiQ9M391.

Enzyme and pathway databases

BioCyciARA:AT3G54130-MONOMER.
ReactomeiR-ATH-5689877. Josephin domain DUBs.

Miscellaneous databases

PROiQ9M391.

Gene expression databases

GenevisibleiQ9M391. AT.

Family and domain databases

InterProiIPR033865. Ataxin-3.
IPR006155. Josephin.
[Graphical view]
PANTHERiPTHR14159. PTHR14159. 1 hit.
PfamiPF02099. Josephin. 1 hit.
[Graphical view]
SMARTiSM01246. Josephin. 1 hit.
[Graphical view]
PROSITEiPS50957. JOSEPHIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATX3H_ARATH
AccessioniPrimary (citable) accession number: Q9M391
Secondary accession number(s): Q53XG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.