Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9M391

- ATX3H_ARATH

UniProt

Q9M391 - ATX3H_ARATH

Protein

Ataxin-3 homolog

Gene

At3g54130

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei20 – 201NucleophilePROSITE-ProRule annotation
    Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation
    Active sitei141 – 1411PROSITE-ProRule annotation

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. omega peptidase activity Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Transcription, Transcription regulation, Ubl conjugation pathway

    Enzyme and pathway databases

    BioCyciARA:AT3G54130-MONOMER.

    Protein family/group databases

    MEROPSiC86.A01.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ataxin-3 homolog (EC:3.4.19.12)
    Alternative name(s):
    MJD1a-like
    Machado-Joseph disease-like protein
    Gene namesi
    Ordered Locus Names:At3g54130
    ORF Names:F24B22.90
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G54130.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 280280Ataxin-3 homologPRO_0000053836Add
    BLAST

    Proteomic databases

    PaxDbiQ9M391.
    PRIDEiQ9M391.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9M391.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-8065588.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9M391.
    SMRiQ9M391. Positions 10-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 187181JosephinPROSITE-ProRule annotationAdd
    BLAST
    Repeati243 – 26220UIMAdd
    BLAST

    Sequence similaritiesi

    Contains 1 Josephin domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG327234.
    HOGENOMiHOG000006034.
    InParanoidiQ9M391.
    KOiK11863.
    OMAiLMDTGGP.
    PhylomeDBiQ9M391.

    Family and domain databases

    InterProiIPR006155. Josephin.
    [Graphical view]
    PfamiPF02099. Josephin. 1 hit.
    [Graphical view]
    PRINTSiPR01233. JOSEPHIN.
    PROSITEiPS50957. JOSEPHIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9M391-1 [UniParc]FASTAAdd to Basket

    « Hide

    MERTSNGGML YHEVQESNLC AVHCVNTVLQ GPFFSEFDLA AVAADLDGKE    50
    RQVMLEGAAV GGFAPGDFLA EESHNVSLGG DFSIQVLQKA LEVWDLQVIP 100
    LNCPDAEPAQ IDPELESAFI CHLHDHWFCI RKVNGEWYNF DSLLAAPQHL 150
    SKFYLSAFLD SLKGAGWSIF IVKGNFPQEC PMSSSSEASN SFGQWLSPED 200
    AERIRKNTSS GSSARNKRSN DNVNQQRRNQ ALSREEVQAF SEMEDDDLKA 250
    AIAASLLDAS AAEANLGAVG TSEKETEKQK 280
    Length:280
    Mass (Da):30,692
    Last modified:October 1, 2000 - v1
    Checksum:iF4A1C9A3F9A25A78
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL132957 Genomic DNA. Translation: CAB70987.1.
    CP002686 Genomic DNA. Translation: AEE79191.1.
    BT010762 mRNA. Translation: AAR23732.1.
    BT010992 mRNA. Translation: AAR24770.1.
    PIRiT47572.
    RefSeqiNP_190981.1. NM_115273.3.
    UniGeneiAt.926.

    Genome annotation databases

    EnsemblPlantsiAT3G54130.1; AT3G54130.1; AT3G54130.
    GeneIDi824580.
    KEGGiath:AT3G54130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL132957 Genomic DNA. Translation: CAB70987.1 .
    CP002686 Genomic DNA. Translation: AEE79191.1 .
    BT010762 mRNA. Translation: AAR23732.1 .
    BT010992 mRNA. Translation: AAR24770.1 .
    PIRi T47572.
    RefSeqi NP_190981.1. NM_115273.3.
    UniGenei At.926.

    3D structure databases

    ProteinModelPortali Q9M391.
    SMRi Q9M391. Positions 10-177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-8065588.

    Protein family/group databases

    MEROPSi C86.A01.

    Proteomic databases

    PaxDbi Q9M391.
    PRIDEi Q9M391.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G54130.1 ; AT3G54130.1 ; AT3G54130 .
    GeneIDi 824580.
    KEGGi ath:AT3G54130.

    Organism-specific databases

    TAIRi AT3G54130.

    Phylogenomic databases

    eggNOGi NOG327234.
    HOGENOMi HOG000006034.
    InParanoidi Q9M391.
    KOi K11863.
    OMAi LMDTGGP.
    PhylomeDBi Q9M391.

    Enzyme and pathway databases

    BioCyci ARA:AT3G54130-MONOMER.

    Miscellaneous databases

    PROi Q9M391.

    Gene expression databases

    Genevestigatori Q9M391.

    Family and domain databases

    InterProi IPR006155. Josephin.
    [Graphical view ]
    Pfami PF02099. Josephin. 1 hit.
    [Graphical view ]
    PRINTSi PR01233. JOSEPHIN.
    PROSITEi PS50957. JOSEPHIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Arabidopsis ORF clones."
      Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Structural modeling of ataxin-3 reveals distant homology to adaptins."
      Albrecht M., Hoffmann D., Evert B.O., Schmitt I., Wuellner U., Lengauer T.
      Proteins 50:355-370(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: 3D-STRUCTURE MODELING.

    Entry informationi

    Entry nameiATX3H_ARATH
    AccessioniPrimary (citable) accession number: Q9M391
    Secondary accession number(s): Q53XG9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 25, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3