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Q9M391 (ATX3H_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ataxin-3 homolog

EC=3.4.19.12
Alternative name(s):
MJD1a-like
Machado-Joseph disease-like protein
Gene names
Ordered Locus Names:At3g54130
ORF Names:F24B22.90
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 1 Josephin domain.

Contains 1 UIM (ubiquitin-interacting motif) repeat.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280Ataxin-3 homolog
PRO_0000053836

Regions

Domain7 – 187181Josephin
Repeat243 – 26220UIM

Sites

Active site201Nucleophile By similarity
Active site1261Proton acceptor By similarity
Active site1411 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9M391 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F4A1C9A3F9A25A78

FASTA28030,692
        10         20         30         40         50         60 
MERTSNGGML YHEVQESNLC AVHCVNTVLQ GPFFSEFDLA AVAADLDGKE RQVMLEGAAV 

        70         80         90        100        110        120 
GGFAPGDFLA EESHNVSLGG DFSIQVLQKA LEVWDLQVIP LNCPDAEPAQ IDPELESAFI 

       130        140        150        160        170        180 
CHLHDHWFCI RKVNGEWYNF DSLLAAPQHL SKFYLSAFLD SLKGAGWSIF IVKGNFPQEC 

       190        200        210        220        230        240 
PMSSSSEASN SFGQWLSPED AERIRKNTSS GSSARNKRSN DNVNQQRRNQ ALSREEVQAF 

       250        260        270        280 
SEMEDDDLKA AIAASLLDAS AAEANLGAVG TSEKETEKQK 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. expand/collapse author list , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Arabidopsis ORF clones."
Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Structural modeling of ataxin-3 reveals distant homology to adaptins."
Albrecht M., Hoffmann D., Evert B.O., Schmitt I., Wuellner U., Lengauer T.
Proteins 50:355-370(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: 3D-STRUCTURE MODELING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL132957 Genomic DNA. Translation: CAB70987.1.
CP002686 Genomic DNA. Translation: AEE79191.1.
BT010762 mRNA. Translation: AAR23732.1.
BT010992 mRNA. Translation: AAR24770.1.
PIRT47572.
RefSeqNP_190981.1. NM_115273.3.
UniGeneAt.926.

3D structure databases

ProteinModelPortalQ9M391.
SMRQ9M391. Positions 10-177.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-8065588.

Protein family/group databases

MEROPSC86.A01.

Proteomic databases

PaxDbQ9M391.
PRIDEQ9M391.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G54130.1; AT3G54130.1; AT3G54130.
GeneID824580.
KEGGath:AT3G54130.

Organism-specific databases

TAIRAT3G54130.

Phylogenomic databases

eggNOGNOG327234.
HOGENOMHOG000006034.
InParanoidQ9M391.
KOK11863.
OMALMDTGGP.
PhylomeDBQ9M391.

Enzyme and pathway databases

BioCycARA:AT3G54130-MONOMER.

Gene expression databases

GenevestigatorQ9M391.

Family and domain databases

InterProIPR006155. Josephin.
[Graphical view]
PfamPF02099. Josephin. 1 hit.
[Graphical view]
PRINTSPR01233. JOSEPHIN.
PROSITEPS50957. JOSEPHIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9M391.

Entry information

Entry nameATX3H_ARATH
AccessionPrimary (citable) accession number: Q9M391
Secondary accession number(s): Q53XG9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names