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Protein

Ataxin-3 homolog

Gene

At3g54130

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Interacts with key regulators of transcription and represses transcription. Acts as a histone-binding protein that regulates transcription. Acts as a deubiquitinating enzyme (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei20NucleophilePROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1
Active sitei141PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processTranscription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-ATH-5689877 Josephin domain DUBs

Protein family/group databases

MEROPSiC86.A01

Names & Taxonomyi

Protein namesi
Recommended name:
Ataxin-3 homolog (EC:3.4.19.12)
Alternative name(s):
MJD1a-like
Machado-Joseph disease-like protein
Gene namesi
Ordered Locus Names:At3g54130
ORF Names:F24B22.90
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G54130
TAIRilocus:2080330 AT3G54130

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000538361 – 280Ataxin-3 homologAdd BLAST280

Proteomic databases

PaxDbiQ9M391

PTM databases

iPTMnetiQ9M391

Expressioni

Gene expression databases

ExpressionAtlasiQ9M391 baseline and differential
GenevisibleiQ9M391 AT

Interactioni

Protein-protein interaction databases

BioGridi9897, 2 interactors
STRINGi3702.AT3G54130.1

Structurei

3D structure databases

ProteinModelPortaliQ9M391
SMRiQ9M391
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 187JosephinPROSITE-ProRule annotationAdd BLAST181
Domaini243 – 262UIMCuratedAdd BLAST20

Phylogenomic databases

eggNOGiKOG2935 Eukaryota
ENOG4111G4B LUCA
HOGENOMiHOG000006034
InParanoidiQ9M391
KOiK11863
OMAiMQAFICN
OrthoDBiEOG09360KCU
PhylomeDBiQ9M391

Family and domain databases

InterProiView protein in InterPro
IPR033865 Ataxin-3
IPR006155 Josephin
PANTHERiPTHR14159 PTHR14159, 1 hit
PfamiView protein in Pfam
PF02099 Josephin, 1 hit
SMARTiView protein in SMART
SM01246 Josephin, 1 hit
PROSITEiView protein in PROSITE
PS50957 JOSEPHIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9M391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERTSNGGML YHEVQESNLC AVHCVNTVLQ GPFFSEFDLA AVAADLDGKE
60 70 80 90 100
RQVMLEGAAV GGFAPGDFLA EESHNVSLGG DFSIQVLQKA LEVWDLQVIP
110 120 130 140 150
LNCPDAEPAQ IDPELESAFI CHLHDHWFCI RKVNGEWYNF DSLLAAPQHL
160 170 180 190 200
SKFYLSAFLD SLKGAGWSIF IVKGNFPQEC PMSSSSEASN SFGQWLSPED
210 220 230 240 250
AERIRKNTSS GSSARNKRSN DNVNQQRRNQ ALSREEVQAF SEMEDDDLKA
260 270 280
AIAASLLDAS AAEANLGAVG TSEKETEKQK
Length:280
Mass (Da):30,692
Last modified:October 1, 2000 - v1
Checksum:iF4A1C9A3F9A25A78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132957 Genomic DNA Translation: CAB70987.1
CP002686 Genomic DNA Translation: AEE79191.1
BT010762 mRNA Translation: AAR23732.1
BT010992 mRNA Translation: AAR24770.1
PIRiT47572
RefSeqiNP_190981.1, NM_115273.4
UniGeneiAt.926

Genome annotation databases

EnsemblPlantsiAT3G54130.1; AT3G54130.1; AT3G54130
GeneIDi824580
GrameneiAT3G54130.1; AT3G54130.1; AT3G54130
KEGGiath:AT3G54130

Similar proteinsi

Entry informationi

Entry nameiATX3H_ARATH
AccessioniPrimary (citable) accession number: Q9M391
Secondary accession number(s): Q53XG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health