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Protein

COMPASS-like H3K4 histone methylase component WDR5A

Gene

WDR5A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Forms multiple COMPASS-like complexes involved in histone methylation by interacting with different histone H3 'Lys-4' methyltransferases such as ATX1, SDG14 or SDG16 (PubMed:21423667). Binds to target loci chromatin, increasing H3K4 trimethylation and causing activation of the gene (PubMed:19567704). Upregulates FLC and MAF4 expression to delay flowering (PubMed:19567704).2 Publications

GO - Molecular functioni

  • histone binding Source: TAIR
  • methyltransferase activity Source: UniProtKB-KW

GO - Biological processi

  • vegetative to reproductive phase transition of meristem Source: TAIR

Keywordsi

Molecular functionMethyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
COMPASS-like H3K4 histone methylase component WDR5A1 Publication
Short name:
AtWDR5A1 Publication
Gene namesi
Name:WDR5A1 Publication
Ordered Locus Names:At3g49660Imported
ORF Names:T16K5.10Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRilocus:2097435. AT3G49660.

Subcellular locationi

  • Nucleus 2 Publications

GO - Cellular componenti

  • nucleus Source: TAIR
  • Set1C/COMPASS complex Source: TAIR

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004317821 – 317COMPASS-like H3K4 histone methylase component WDR5AAdd BLAST317

Proteomic databases

PaxDbiQ9M2Z2.

Expressioni

Tissue specificityi

Strongly expressed in developing embryos and endosperms (PubMed:21423667). Expressed in shoot and root apical regions, and in vasculature (PubMed:19567704).2 Publications

Gene expression databases

ExpressionAtlasiQ9M2Z2. baseline and differential.
GenevisibleiQ9M2Z2. AT.

Interactioni

Subunit structurei

Part of a complex composed of TRO, RBL and WDR5A (PubMed:21423667). This complex is formed during both vegetative and reproductive development (PubMed:21423667). Interacts with SDG14, SDG16, RBL, but not with TRO (PubMed:21423667). Interacts with ATX1 and K4-methylated H3 tails (PubMed:19567704).2 Publications

GO - Molecular functioni

  • histone binding Source: TAIR

Protein-protein interaction databases

STRINGi3702.AT3G49660.1.

Structurei

3D structure databases

ProteinModelPortaliQ9M2Z2.
SMRiQ9M2Z2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 61WD 1Sequence analysisAdd BLAST40
Repeati69 – 108WD 2Sequence analysisAdd BLAST40
Repeati111 – 152WD 3Sequence analysisAdd BLAST42
Repeati153 – 192WD 4Sequence analysisAdd BLAST40
Repeati196 – 235WD 5Sequence analysisAdd BLAST40
Repeati238 – 280WD 6Sequence analysisAdd BLAST43
Repeati283 – 317WD 7Sequence analysisAdd BLAST35

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
HOGENOMiHOG000091642.
KOiK14963.
OMAiYTGHRNE.
OrthoDBiEOG09360H3N.
PhylomeDBiQ9M2Z2.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF00400. WD40. 7 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00320. WD40. 7 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9M2Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEIPATAS FTPYVHSQTL TSHNRAVSSV KFSSDGRLLA SASADKTIRT
60 70 80 90 100
YTINTINDPI AEPVQEFTGH ENGISDVAFS SDARFIVSAS DDKTLKLWDV
110 120 130 140 150
ETGSLIKTLI GHTNYAFCVN FNPQSNMIVS GSFDETVRIW DVTTGKCLKV
160 170 180 190 200
LPAHSDPVTA VDFNRDGSLI VSSSYDGLCR IWDSGTGHCV KTLIDDENPP
210 220 230 240 250
VSFVRFSPNG KFILVGTLDN TLRLWNISSA KFLKTYTGHV NAQYCISSAF
260 270 280 290 300
SVTNGKRIVS GSEDNCVHMW ELNSKKLLQK LEGHTETVMN VACHPTENLI
310
ASGSLDKTVR IWTQKKE
Length:317
Mass (Da):34,820
Last modified:October 1, 2000 - v1
Checksum:i70BED05EF6DB7DB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132965 Genomic DNA. Translation: CAB66904.1.
CP002686 Genomic DNA. Translation: AEE78573.1.
PIRiT46032.
RefSeqiNP_190535.1. NM_114826.4.
UniGeneiAt.35578.

Genome annotation databases

EnsemblPlantsiAT3G49660.1; AT3G49660.1; AT3G49660.
GeneIDi824128.
GrameneiAT3G49660.1; AT3G49660.1; AT3G49660.
KEGGiath:AT3G49660.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132965 Genomic DNA. Translation: CAB66904.1.
CP002686 Genomic DNA. Translation: AEE78573.1.
PIRiT46032.
RefSeqiNP_190535.1. NM_114826.4.
UniGeneiAt.35578.

3D structure databases

ProteinModelPortaliQ9M2Z2.
SMRiQ9M2Z2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G49660.1.

Proteomic databases

PaxDbiQ9M2Z2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G49660.1; AT3G49660.1; AT3G49660.
GeneIDi824128.
GrameneiAT3G49660.1; AT3G49660.1; AT3G49660.
KEGGiath:AT3G49660.

Organism-specific databases

AraportiAT3G49660.
TAIRilocus:2097435. AT3G49660.

Phylogenomic databases

eggNOGiKOG0266. Eukaryota.
ENOG410XP3K. LUCA.
HOGENOMiHOG000091642.
KOiK14963.
OMAiYTGHRNE.
OrthoDBiEOG09360H3N.
PhylomeDBiQ9M2Z2.

Miscellaneous databases

PROiQ9M2Z2.

Gene expression databases

ExpressionAtlasiQ9M2Z2. baseline and differential.
GenevisibleiQ9M2Z2. AT.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiView protein in InterPro
IPR020472. G-protein_beta_WD-40_rep.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
PfamiView protein in Pfam
PF00400. WD40. 7 hits.
PRINTSiPR00320. GPROTEINBRPT.
SMARTiView protein in SMART
SM00320. WD40. 7 hits.
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiView protein in PROSITE
PS00678. WD_REPEATS_1. 4 hits.
PS50082. WD_REPEATS_2. 7 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiWDR5A_ARATH
AccessioniPrimary (citable) accession number: Q9M2Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 4, 2015
Last sequence update: October 1, 2000
Last modified: February 15, 2017
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.