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Protein

COMPASS-like H3K4 histone methylase component WDR5A

Gene

WDR5A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms multiple COMPASS-like complexes involved in histone methylation by interacting with different histone H3 'Lys-4' methyltransferases such as ATX1, SDG14 or SDG16 (PubMed:21423667). Binds to target loci chromatin, increasing H3K4 trimethylation and causing activation of the gene (PubMed:19567704). Upregulates FLC and MAF4 expression to delay flowering (PubMed:19567704).2 Publications

GO - Molecular functioni

  • histone binding Source: TAIR
  • methyltransferase activity Source: UniProtKB-KW

GO - Biological processi

  • vegetative to reproductive phase transition of meristem Source: TAIR

Keywordsi

Molecular functionMethyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-ATH-3214841 PKMTs methylate histone lysines
R-ATH-3214858 RMTs methylate histone arginines
R-ATH-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COMPASS-like H3K4 histone methylase component WDR5A1 Publication
Short name:
AtWDR5A1 Publication
Gene namesi
Name:WDR5A1 Publication
Ordered Locus Names:At3g49660Imported
ORF Names:T16K5.10Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G49660
TAIRilocus:2097435 AT3G49660

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004317821 – 317COMPASS-like H3K4 histone methylase component WDR5AAdd BLAST317

Proteomic databases

PaxDbiQ9M2Z2
PRIDEiQ9M2Z2

Expressioni

Tissue specificityi

Strongly expressed in developing embryos and endosperms (PubMed:21423667). Expressed in shoot and root apical regions, and in vasculature (PubMed:19567704).2 Publications

Gene expression databases

ExpressionAtlasiQ9M2Z2 baseline and differential
GenevisibleiQ9M2Z2 AT

Interactioni

Subunit structurei

Part of a complex composed of TRO, RBL and WDR5A (PubMed:21423667). This complex is formed during both vegetative and reproductive development (PubMed:21423667). Interacts with SDG14, SDG16, RBL, but not with TRO (PubMed:21423667). Interacts with ATX1 and K4-methylated H3 tails (PubMed:19567704).2 Publications

GO - Molecular functioni

  • histone binding Source: TAIR

Protein-protein interaction databases

STRINGi3702.AT3G49660.1

Structurei

3D structure databases

ProteinModelPortaliQ9M2Z2
SMRiQ9M2Z2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 61WD 1Sequence analysisAdd BLAST40
Repeati69 – 108WD 2Sequence analysisAdd BLAST40
Repeati111 – 152WD 3Sequence analysisAdd BLAST42
Repeati153 – 192WD 4Sequence analysisAdd BLAST40
Repeati196 – 235WD 5Sequence analysisAdd BLAST40
Repeati238 – 280WD 6Sequence analysisAdd BLAST43
Repeati283 – 317WD 7Sequence analysisAdd BLAST35

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0266 Eukaryota
ENOG410XP3K LUCA
HOGENOMiHOG000091642
KOiK14963
OMAiDNPICSH
OrthoDBiEOG09360H3N
PhylomeDBiQ9M2Z2

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 7 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 7 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 4 hits
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9M2Z2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEEIPATAS FTPYVHSQTL TSHNRAVSSV KFSSDGRLLA SASADKTIRT
60 70 80 90 100
YTINTINDPI AEPVQEFTGH ENGISDVAFS SDARFIVSAS DDKTLKLWDV
110 120 130 140 150
ETGSLIKTLI GHTNYAFCVN FNPQSNMIVS GSFDETVRIW DVTTGKCLKV
160 170 180 190 200
LPAHSDPVTA VDFNRDGSLI VSSSYDGLCR IWDSGTGHCV KTLIDDENPP
210 220 230 240 250
VSFVRFSPNG KFILVGTLDN TLRLWNISSA KFLKTYTGHV NAQYCISSAF
260 270 280 290 300
SVTNGKRIVS GSEDNCVHMW ELNSKKLLQK LEGHTETVMN VACHPTENLI
310
ASGSLDKTVR IWTQKKE
Length:317
Mass (Da):34,820
Last modified:October 1, 2000 - v1
Checksum:i70BED05EF6DB7DB0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132965 Genomic DNA Translation: CAB66904.1
CP002686 Genomic DNA Translation: AEE78573.1
PIRiT46032
RefSeqiNP_190535.1, NM_114826.4
UniGeneiAt.35578

Genome annotation databases

EnsemblPlantsiAT3G49660.1; AT3G49660.1; AT3G49660
GeneIDi824128
GrameneiAT3G49660.1; AT3G49660.1; AT3G49660
KEGGiath:AT3G49660

Similar proteinsi

Entry informationi

Entry nameiWDR5A_ARATH
AccessioniPrimary (citable) accession number: Q9M2Z2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 4, 2015
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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