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Protein

Putative calcium-transporting ATPase 11, plasma membrane-type

Gene

ACA11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol out of the cell or into organelles.By similarity

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).

Enzyme regulationi

Activated by calmodulin.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei4514-aspartylphosphate intermediateBy similarity1
Metal bindingi746MagnesiumBy similarity1
Metal bindingi750MagnesiumBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • calcium-transporting ATPase activity Source: TAIR
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • anion homeostasis Source: TAIR
  • defense response to bacterium Source: TAIR
  • negative regulation of programmed cell death Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Calcium, Calmodulin-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G57330-MONOMER.
ReactomeiR-ATH-418359. Reduction of cytosolic Ca++ levels.
R-ATH-5578775. Ion homeostasis.
R-ATH-936837. Ion transport by P-type ATPases.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative calcium-transporting ATPase 11, plasma membrane-type (EC:3.6.3.8)
Alternative name(s):
Ca(2+)-ATPase isoform 11
Gene namesi
Name:ACA11
Ordered Locus Names:At3g57330
ORF Names:F28O9.180
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G57330.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 157CytoplasmicSequence analysisAdd BLAST157
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Topological domaini179 – 196LumenalSequence analysisAdd BLAST18
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 345CytoplasmicSequence analysisAdd BLAST128
Transmembranei346 – 365HelicalSequence analysisAdd BLAST20
Topological domaini366 – 395LumenalSequence analysisAdd BLAST30
Transmembranei396 – 413HelicalSequence analysisAdd BLAST18
Topological domaini414 – 801CytoplasmicSequence analysisAdd BLAST388
Transmembranei802 – 820HelicalSequence analysisAdd BLAST19
Topological domaini821 – 831LumenalSequence analysisAdd BLAST11
Transmembranei832 – 852HelicalSequence analysisAdd BLAST21
Topological domaini853 – 872CytoplasmicSequence analysisAdd BLAST20
Transmembranei873 – 895HelicalSequence analysisAdd BLAST23
Topological domaini896 – 907LumenalSequence analysisAdd BLAST12
Transmembranei908 – 929HelicalSequence analysisAdd BLAST22
Topological domaini930 – 947CytoplasmicSequence analysisAdd BLAST18
Transmembranei948 – 969HelicalSequence analysisAdd BLAST22
Topological domaini970 – 979LumenalSequence analysis10
Transmembranei980 – 1001HelicalSequence analysisAdd BLAST22
Topological domaini1002 – 1025CytoplasmicSequence analysisAdd BLAST24

GO - Cellular componenti

  • chloroplast Source: TAIR
  • Golgi apparatus Source: TAIR
  • integral component of plasma membrane Source: GO_Central
  • plant-type vacuole membrane Source: TAIR
  • plasma membrane Source: TAIR
  • vacuolar membrane Source: TAIR
  • vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000464171 – 1025Putative calcium-transporting ATPase 11, plasma membrane-typeAdd BLAST1025

Proteomic databases

PaxDbiQ9M2L4.
PRIDEiQ9M2L4.

PTM databases

iPTMnetiQ9M2L4.
SwissPalmiQ9M2L4.

Expressioni

Gene expression databases

GenevisibleiQ9M2L4. AT.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CAM4P258542EBI-7522268,EBI-1235664

Protein-protein interaction databases

IntActiQ9M2L4. 1 interactor.
MINTiMINT-5162127.
STRINGi3702.AT3G57330.1.

Structurei

3D structure databases

ProteinModelPortaliQ9M2L4.
SMRiQ9M2L4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 30Interaction with calmodulinCuratedAdd BLAST12

Domaini

The N-terminus contains an autoinhibitory calmodulin-binding domain, which binds calmodulin in a calcium-dependent fashion.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0204. Eukaryota.
ENOG410XNNC. LUCA.
HOGENOMiHOG000265623.
InParanoidiQ9M2L4.
KOiK01537.
OMAiTAIAKCK.
OrthoDBiEOG09360106.
PhylomeDBiQ9M2L4.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR024750. Ca_ATPase_N_dom.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF12515. CaATP_NAI. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9M2L4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLLKDFEV ASKNPSLEAR QRWRSSVGLV KNRARRFRMI SNLDKLAENE
60 70 80 90 100
KKRCQIQEKI RVVFYVQKAA FQFIDAGARP EYKLTDEVKK AGFYVEADEL
110 120 130 140 150
ASMVRNHDTK SLTKIGGPEG IAQKVSVSLA EGVRSSELHI REKIYGENRY
160 170 180 190 200
TEKPARSFLT FVWEALQDIT LIILMVCAVV SIGVGVATEG FPKGMYDGTG
210 220 230 240 250
ILLSIILVVM VTAISDYKQS LQFRDLDREK KKIIIQVTRD GSRQEVSIHD
260 270 280 290 300
LVVGDVVHLS IGDQVPADGI FISGYNLEID ESSLSGESEP SHVNKEKPFL
310 320 330 340 350
LSGTKVQNGS AKMLVTTVGM RTEWGKLMDT LSEGGEDETP LQVKLNGVAT
360 370 380 390 400
IIGKIGLGFA VLTFVVLCIR FVVEKATAGS ITEWSSEDAL TLLDYFAIAV
410 420 430 440 450
TIIVVAVPEG LPLAVTLSLA FAMKQLMSDR ALVRHLAACE TMGSSTCICT
460 470 480 490 500
DKTGTLTTNH MVVNKVWICE NIKERQEENF QLNLSEQVKN ILIQAIFQNT
510 520 530 540 550
GSEVVKDKEG KTQILGSPTE RAILEFGLLL GGDVDTQRRE HKILKIEPFN
560 570 580 590 600
SDKKKMSVLT SHSGGKVRAF CKGASEIVLK MCEKVVDSNG ESVPLSEEKI
610 620 630 640 650
ASISDVIEGF ASEALRTLCL VYTDLDEAPR GDLPNGGYTL VAVVGIKDPV
660 670 680 690 700
RPGVREAVQT CQAAGITVRM VTGDNISTAK AIAKECGILT AGGVAIEGSD
710 720 730 740 750
FRNLPPHEMR AILPKIQVMA RSLPLDKHTL VNNLRKMGEV VAVTGDGTND
760 770 780 790 800
APALHEADIG LAMGIAGTEV AKENADVIIM DDNFATIVNV AKWGRAVYIN
810 820 830 840 850
IQKFVQFQLT VNVVALIINF VSACITGSAP LTAVQLLWVN MIMDTLGALA
860 870 880 890 900
LATEPPNEGL MKRQPIGRTA SFITRAMWRN IIGQSIYQLI VLGILNFAGK
910 920 930 940 950
QILNLNGPDS TIVLNTIIFN SFVFCQVFNE VNSREIEKIN VFEGMFKSWV
960 970 980 990 1000
FVAVMTATVG FQVIIVEFLG AFASTVPLSW QHWLLCILIG SVSMILAVGL
1010 1020
KCIPVESNRH HDGYELLPSG PSDSA
Length:1,025
Mass (Da):111,945
Last modified:October 1, 2000 - v1
Checksum:i5488C4046D7F308F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137080 Genomic DNA. Translation: CAB68139.1.
CP002686 Genomic DNA. Translation: AEE79642.1.
PIRiT45811.
RefSeqiNP_191292.1. NM_115593.7.
UniGeneiAt.34841.

Genome annotation databases

EnsemblPlantsiAT3G57330.1; AT3G57330.1; AT3G57330.
GeneIDi824900.
GrameneiAT3G57330.1; AT3G57330.1; AT3G57330.
KEGGiath:AT3G57330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137080 Genomic DNA. Translation: CAB68139.1.
CP002686 Genomic DNA. Translation: AEE79642.1.
PIRiT45811.
RefSeqiNP_191292.1. NM_115593.7.
UniGeneiAt.34841.

3D structure databases

ProteinModelPortaliQ9M2L4.
SMRiQ9M2L4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9M2L4. 1 interactor.
MINTiMINT-5162127.
STRINGi3702.AT3G57330.1.

PTM databases

iPTMnetiQ9M2L4.
SwissPalmiQ9M2L4.

Proteomic databases

PaxDbiQ9M2L4.
PRIDEiQ9M2L4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G57330.1; AT3G57330.1; AT3G57330.
GeneIDi824900.
GrameneiAT3G57330.1; AT3G57330.1; AT3G57330.
KEGGiath:AT3G57330.

Organism-specific databases

TAIRiAT3G57330.

Phylogenomic databases

eggNOGiKOG0204. Eukaryota.
ENOG410XNNC. LUCA.
HOGENOMiHOG000265623.
InParanoidiQ9M2L4.
KOiK01537.
OMAiTAIAKCK.
OrthoDBiEOG09360106.
PhylomeDBiQ9M2L4.

Enzyme and pathway databases

BioCyciARA:AT3G57330-MONOMER.
ReactomeiR-ATH-418359. Reduction of cytosolic Ca++ levels.
R-ATH-5578775. Ion homeostasis.
R-ATH-936837. Ion transport by P-type ATPases.

Miscellaneous databases

PROiQ9M2L4.

Gene expression databases

GenevisibleiQ9M2L4. AT.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR024750. Ca_ATPase_N_dom.
IPR023214. HAD-like_dom.
IPR006408. P-type_ATPase_IIB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF12515. CaATP_NAI. 1 hit.
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSiPR00120. HATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 2 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01517. ATPase-IIB_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACA11_ARATH
AccessioniPrimary (citable) accession number: Q9M2L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 137 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.