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Protein

Probable arabinose 5-phosphate isomerase

Gene

SETH3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P).By similarity

Catalytic activityi

D-arabinose 5-phosphate = D-ribulose 5-phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei78Catalytically relevantBy similarity1
Binding sitei107SubstrateBy similarity1
Sitei130Catalytically relevantBy similarity1
Sitei171Catalytically relevantBy similarity1
Sitei212Catalytically relevantBy similarity1
Binding sitei295SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 80ATPSequence analysis6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Lipopolysaccharide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G54690-MONOMER.
MetaCyc:AT3G54690-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable arabinose 5-phosphate isomerase (EC:5.3.1.13)
Short name:
API
Alternative name(s):
CBS domain-containing protein CBSSIS1
Gene namesi
Name:SETH3
Synonyms:CBSSIS1
Ordered Locus Names:At3g54690
ORF Names:T5N23_50
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G54690.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004122261 – 350Probable arabinose 5-phosphate isomeraseAdd BLAST350

Proteomic databases

PaxDbiQ9M1T1.

Expressioni

Gene expression databases

GenevisibleiQ9M1T1. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G54690.1.

Structurei

3D structure databases

ProteinModelPortaliQ9M1T1.
SMRiQ9M1T1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 203SISPROSITE-ProRule annotationAdd BLAST144
Domaini229 – 288CBS 1PROSITE-ProRule annotationAdd BLAST60
Domaini297 – 350CBS 2PROSITE-ProRule annotationAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 95Substrate bindingBy similarity2
Regioni133 – 142Substrate bindingBy similarity10
Regioni167 – 169Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the SIS family. GutQ/KpsF subfamily.Curated
Contains 2 CBS domains.PROSITE-ProRule annotation
Contains 1 SIS domain.PROSITE-ProRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

eggNOGiENOG410IFJQ. Eukaryota.
COG0517. LUCA.
COG0794. LUCA.
HOGENOMiHOG000264729.
InParanoidiQ9M1T1.
KOiK06041.
OMAiADFAKFH.
OrthoDBiEOG09360FF1.
PhylomeDBiQ9M1T1.

Family and domain databases

InterProiIPR000644. CBS_dom.
IPR004800. KdsD/KpsF-type.
IPR001347. SIS.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF01380. SIS. 1 hit.
[Graphical view]
PIRSFiPIRSF004692. KdsD_KpsF. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00393. kpsF. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS51464. SIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9M1T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGSLPPPSLD FSSIDHNSLK NGGSSHQEIS HDNLLNLFKS QQDLLNHFFK
60 70 80 90 100
HLDLSQTLDF SRILLSTTGT VFFTGVGKSA FVANKVSQTL VSLSFRSSFL
110 120 130 140 150
SPLDALHGDI GALSPRDVLV FFSKSGATEE LLRLVPCARA KGAFLVSLTS
160 170 180 190 200
VSGNPLAGVC DMNVHLPLQR ELCPFNLAPV TSTAIQMVFG DTIAVALMAA
210 220 230 240 250
RNLSKEEYAA NHPAGRIGKS LIFKVKDVMK KQEELPVCKE GDLIMDQLVE
260 270 280 290 300
LTSKGCGCLL VVDEHSRLIG TFTDGDLRRT LKASGEAIFK LSVGEMCNRK
310 320 330 340 350
PRTIGPETMA VEAMKKMESP PSPVQFLPVV NEDNTLIGIV TLHGLVSAGL
Length:350
Mass (Da):37,749
Last modified:October 1, 2000 - v1
Checksum:i6926AA514F33E2A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138650 Genomic DNA. Translation: CAB77589.1.
CP002686 Genomic DNA. Translation: AEE79267.1.
AK227009 mRNA. Translation: BAE99073.1.
PIRiT47628.
RefSeqiNP_191029.1. NM_115326.5.
UniGeneiAt.1210.

Genome annotation databases

EnsemblPlantsiAT3G54690.1; AT3G54690.1; AT3G54690.
GeneIDi824634.
GrameneiAT3G54690.1; AT3G54690.1; AT3G54690.
KEGGiath:AT3G54690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138650 Genomic DNA. Translation: CAB77589.1.
CP002686 Genomic DNA. Translation: AEE79267.1.
AK227009 mRNA. Translation: BAE99073.1.
PIRiT47628.
RefSeqiNP_191029.1. NM_115326.5.
UniGeneiAt.1210.

3D structure databases

ProteinModelPortaliQ9M1T1.
SMRiQ9M1T1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G54690.1.

Proteomic databases

PaxDbiQ9M1T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G54690.1; AT3G54690.1; AT3G54690.
GeneIDi824634.
GrameneiAT3G54690.1; AT3G54690.1; AT3G54690.
KEGGiath:AT3G54690.

Organism-specific databases

TAIRiAT3G54690.

Phylogenomic databases

eggNOGiENOG410IFJQ. Eukaryota.
COG0517. LUCA.
COG0794. LUCA.
HOGENOMiHOG000264729.
InParanoidiQ9M1T1.
KOiK06041.
OMAiADFAKFH.
OrthoDBiEOG09360FF1.
PhylomeDBiQ9M1T1.

Enzyme and pathway databases

BioCyciARA:AT3G54690-MONOMER.
MetaCyc:AT3G54690-MONOMER.

Miscellaneous databases

PROiQ9M1T1.

Gene expression databases

GenevisibleiQ9M1T1. AT.

Family and domain databases

InterProiIPR000644. CBS_dom.
IPR004800. KdsD/KpsF-type.
IPR001347. SIS.
[Graphical view]
PfamiPF00571. CBS. 2 hits.
PF01380. SIS. 1 hit.
[Graphical view]
PIRSFiPIRSF004692. KdsD_KpsF. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00393. kpsF. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS51464. SIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSETH3_ARATH
AccessioniPrimary (citable) accession number: Q9M1T1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.