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Protein

ABC transporter B family member 21

Gene

ABCB21

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi438 – 445ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1087 – 1094ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • auxin efflux Source: TAIR
  • auxin influx Source: TAIR
  • basipetal auxin transport Source: GO_Central

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G62150-MONOMER
ReactomeiR-ATH-159418 Recycling of bile acids and salts
R-ATH-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-ATH-382556 ABC-family proteins mediated transport

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter B family member 21
Short name:
ABC transporter ABCB.21
Short name:
AtABCB21
Alternative name(s):
Multidrug resistance protein 17
P-glycoprotein 21
Gene namesi
Name:ABCB21
Synonyms:MDR17, PGP21
Ordered Locus Names:At3g62150
ORF Names:T17J13.110
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi

Organism-specific databases

AraportiAT3G62150
TAIRilocus:2097978 AT3G62150

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei77 – 97HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei128 – 148HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei205 – 225HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei227 – 247HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei307 – 327HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei336 – 356HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei731 – 751HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei774 – 794HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei865 – 885HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei952 – 972HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei986 – 1006HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002279281 – 1296ABC transporter B family member 21Add BLAST1296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi409N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi505N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi519N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi590N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei657PhosphoserineCombined sources1
Modified residuei660PhosphoserineCombined sources1
Glycosylationi826N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1141N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1240N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9M1Q9
PRIDEiQ9M1Q9

PTM databases

iPTMnetiQ9M1Q9

Expressioni

Gene expression databases

ExpressionAtlasiQ9M1Q9 baseline and differential
GenevisibleiQ9M1Q9 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G62150.1

Structurei

3D structure databases

ProteinModelPortaliQ9M1Q9
SMRiQ9M1Q9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini80 – 368ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST289
Domaini403 – 639ABC transporter 1PROSITE-ProRule annotationAdd BLAST237
Domaini730 – 1017ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST288
Domaini1052 – 1289ABC transporter 2PROSITE-ProRule annotationAdd BLAST238

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055 Eukaryota
COG1132 LUCA
InParanoidiQ9M1Q9
KOiK05658
OMAiGSAKTME
OrthoDBiEOG093600JM

Family and domain databases

Gene3Di1.20.1560.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q9M1Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVIESEEG LKVDSPNRAD AETSNSKIHE EDEKELKTES DLKEEKKKTE
60 70 80 90 100
KNKQEEDEKT KTVPFHKLFA FADSFDIILM ILGTIGAVGN GLGFPIMTIL
110 120 130 140 150
FGDVIDVFGQ NQNSSDVSDK IAKVALKFVY LGLGTLVAAL LQVSGWMISG
160 170 180 190 200
ERQAGRIRSL YLQTILRQDI AFFDVETNTG EVVGRMSGDT VLIQDAMGEK
210 220 230 240 250
VGKAIQLVST FIGGFVIAFT EGWLLTLVMV SSIPLLVMSG AALAIVISKM
260 270 280 290 300
ASRGQTSYAK AAVVVEQTVG SIRTVASFTG EKQAISNYNK HLVSAYRAGV
310 320 330 340 350
FEGASTGLGL GTLNIVIFCT YALAVWYGGK MILEKGYTGG QVLIIIFAVL
360 370 380 390 400
TGSMSLGQAS PCLSAFAAGQ AAAYKMFEAI KRKPEIDASD TTGKVLDDIR
410 420 430 440 450
GDIELNNVNF SYPARPEEQI FRGFSLSISS GSTVALVGQS GSGKSTVVSL
460 470 480 490 500
IERFYDPQSG EVRIDGINLK EFQLKWIRSK IGLVSQEPVL FTSSIKENIA
510 520 530 540 550
YGKENATVEE IRKATELANA SKFIDKLPQG LDTMVGEHGT QLSGGQKQRI
560 570 580 590 600
AVARAILKDP RILLLDEATS ALDAESERIV QEALDRIMVN RTTVVVAHRL
610 620 630 640 650
STVRNADMIA VIHQGKIVEK GSHSELLRDP EGAYSQLIRL QEDTKQTEDS
660 670 680 690 700
TDEQKLSMES MKRSSLRKSS LSRSLSKRSS SFSMFGFPAG IDTNNEAIPE
710 720 730 740 750
KDIKVSTPIK EKKVSFFRVA ALNKPEIPML ILGSIAAVLN GVILPIFGIL
760 770 780 790 800
ISSVIKAFFK PPEQLKSDTR FWAIIFMLLG VASMVVFPAQ TIFFSIAGCK
810 820 830 840 850
LVQRIRSMCF EKVVRMEVGW FDETENSSGA IGARLSADAA TVRGLVGDAL
860 870 880 890 900
AQTVQNLASV TAGLVIAFVA SWQLAFIVLA MLPLIGLNGY IYMKFMVGFS
910 920 930 940 950
ADAKRMYEEA SQVANDAVGS IRTVASFCAE EKVMKMYKKK CEGPMRTGIR
960 970 980 990 1000
QGIVSGIGFG VSFFVLFSSY AASFYAGARL VDDGKTTFDS VFRVFFALTM
1010 1020 1030 1040 1050
AAVAISQSSS LSPDSSKASN AAASIFAVID RESKIDPSDE SGRVLDNVKG
1060 1070 1080 1090 1100
DIELRHISFK YPSRPDVQIF QDLCLSIRAG KTIALVGESG SGKSTVIALL
1110 1120 1130 1140 1150
QRFYDPDSGQ ITLDGVEIKT LQLKWLRQQT GLVSQEPVLF NETIRANIAY
1160 1170 1180 1190 1200
GKGGDATETE IVSAAELSNA HGFISGLQQG YDTMVGERGV QLSGGQKQRV
1210 1220 1230 1240 1250
AIARAIVKDP KVLLLDEATS ALDAESERVV QDALDRVMVN RTTVVVAHRL
1260 1270 1280 1290
STIKNADVIA VVKNGVIVEK GKHETLINIK DGVYASLVQL HLSAST
Length:1,296
Mass (Da):140,334
Last modified:January 25, 2012 - v2
Checksum:iED16D162A767C3A6
GO

Sequence cautioni

The sequence CAB71875 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138651 Genomic DNA Translation: CAB71875.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE80316.1
CP002686 Genomic DNA Translation: ANM65205.1
CP002686 Genomic DNA Translation: ANM65206.1
PIRiT48007
RefSeqiNP_001327192.1, NM_001340143.1
NP_001327193.1, NM_001340142.1
NP_191774.2, NM_116080.3
UniGeneiAt.34174

Genome annotation databases

EnsemblPlantsiAT3G62150.1; AT3G62150.1; AT3G62150
AT3G62150.2; AT3G62150.2; AT3G62150
AT3G62150.3; AT3G62150.3; AT3G62150
GeneIDi825388
GrameneiAT3G62150.1; AT3G62150.1; AT3G62150
AT3G62150.2; AT3G62150.2; AT3G62150
AT3G62150.3; AT3G62150.3; AT3G62150
KEGGiath:AT3G62150

Similar proteinsi

Entry informationi

Entry nameiAB21B_ARATH
AccessioniPrimary (citable) accession number: Q9M1Q9
Secondary accession number(s): A0A1I9LRJ8, F4IX45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: January 25, 2012
Last modified: April 25, 2018
This is version 130 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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