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Protein

ABC transporter B family member 21

Gene

ABCB21

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi438 – 4458ATP 1PROSITE-ProRule annotation
Nucleotide bindingi1087 – 10948ATP 2PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G62150-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter B family member 21
Short name:
ABC transporter ABCB.21
Short name:
AtABCB21
Alternative name(s):
Multidrug resistance protein 17
P-glycoprotein 21
Gene namesi
Name:ABCB21
Synonyms:MDR17, PGP21
Ordered Locus Names:At3g62150
ORF Names:T17J13.110
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G62150.

Subcellular locationi

  • Membrane PROSITE-ProRule annotation; Multi-pass membrane protein PROSITE-ProRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei77 – 9721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei128 – 14821HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei205 – 22521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei227 – 24721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei307 – 32721HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei336 – 35621HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei731 – 75121HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei774 – 79421HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei865 – 88521HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei952 – 97221HelicalPROSITE-ProRule annotationAdd
BLAST
Transmembranei986 – 100621HelicalPROSITE-ProRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12961296ABC transporter B family member 21PRO_0000227928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi113 – 1131N-linked (GlcNAc...)Sequence analysis
Glycosylationi409 – 4091N-linked (GlcNAc...)Sequence analysis
Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence analysis
Glycosylationi519 – 5191N-linked (GlcNAc...)Sequence analysis
Glycosylationi590 – 5901N-linked (GlcNAc...)Sequence analysis
Modified residuei657 – 6571PhosphoserineCombined sources
Modified residuei660 – 6601PhosphoserineCombined sources
Modified residuei681 – 6811PhosphoserineBy similarity
Glycosylationi826 – 8261N-linked (GlcNAc...)Sequence analysis
Glycosylationi1141 – 11411N-linked (GlcNAc...)Sequence analysis
Glycosylationi1240 – 12401N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9M1Q9.
PRIDEiQ9M1Q9.

PTM databases

iPTMnetiQ9M1Q9.

Expressioni

Gene expression databases

GenevisibleiQ9M1Q9. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G62150.1.

Structurei

3D structure databases

ProteinModelPortaliQ9M1Q9.
SMRiQ9M1Q9. Positions 68-667, 729-1291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini80 – 368289ABC transmembrane type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini403 – 639237ABC transporter 1PROSITE-ProRule annotationAdd
BLAST
Domaini730 – 1017288ABC transmembrane type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini1052 – 1289238ABC transporter 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ9M1Q9.
KOiK05658.
OMAiIVIFCTY.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9M1Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVIESEEG LKVDSPNRAD AETSNSKIHE EDEKELKTES DLKEEKKKTE
60 70 80 90 100
KNKQEEDEKT KTVPFHKLFA FADSFDIILM ILGTIGAVGN GLGFPIMTIL
110 120 130 140 150
FGDVIDVFGQ NQNSSDVSDK IAKVALKFVY LGLGTLVAAL LQVSGWMISG
160 170 180 190 200
ERQAGRIRSL YLQTILRQDI AFFDVETNTG EVVGRMSGDT VLIQDAMGEK
210 220 230 240 250
VGKAIQLVST FIGGFVIAFT EGWLLTLVMV SSIPLLVMSG AALAIVISKM
260 270 280 290 300
ASRGQTSYAK AAVVVEQTVG SIRTVASFTG EKQAISNYNK HLVSAYRAGV
310 320 330 340 350
FEGASTGLGL GTLNIVIFCT YALAVWYGGK MILEKGYTGG QVLIIIFAVL
360 370 380 390 400
TGSMSLGQAS PCLSAFAAGQ AAAYKMFEAI KRKPEIDASD TTGKVLDDIR
410 420 430 440 450
GDIELNNVNF SYPARPEEQI FRGFSLSISS GSTVALVGQS GSGKSTVVSL
460 470 480 490 500
IERFYDPQSG EVRIDGINLK EFQLKWIRSK IGLVSQEPVL FTSSIKENIA
510 520 530 540 550
YGKENATVEE IRKATELANA SKFIDKLPQG LDTMVGEHGT QLSGGQKQRI
560 570 580 590 600
AVARAILKDP RILLLDEATS ALDAESERIV QEALDRIMVN RTTVVVAHRL
610 620 630 640 650
STVRNADMIA VIHQGKIVEK GSHSELLRDP EGAYSQLIRL QEDTKQTEDS
660 670 680 690 700
TDEQKLSMES MKRSSLRKSS LSRSLSKRSS SFSMFGFPAG IDTNNEAIPE
710 720 730 740 750
KDIKVSTPIK EKKVSFFRVA ALNKPEIPML ILGSIAAVLN GVILPIFGIL
760 770 780 790 800
ISSVIKAFFK PPEQLKSDTR FWAIIFMLLG VASMVVFPAQ TIFFSIAGCK
810 820 830 840 850
LVQRIRSMCF EKVVRMEVGW FDETENSSGA IGARLSADAA TVRGLVGDAL
860 870 880 890 900
AQTVQNLASV TAGLVIAFVA SWQLAFIVLA MLPLIGLNGY IYMKFMVGFS
910 920 930 940 950
ADAKRMYEEA SQVANDAVGS IRTVASFCAE EKVMKMYKKK CEGPMRTGIR
960 970 980 990 1000
QGIVSGIGFG VSFFVLFSSY AASFYAGARL VDDGKTTFDS VFRVFFALTM
1010 1020 1030 1040 1050
AAVAISQSSS LSPDSSKASN AAASIFAVID RESKIDPSDE SGRVLDNVKG
1060 1070 1080 1090 1100
DIELRHISFK YPSRPDVQIF QDLCLSIRAG KTIALVGESG SGKSTVIALL
1110 1120 1130 1140 1150
QRFYDPDSGQ ITLDGVEIKT LQLKWLRQQT GLVSQEPVLF NETIRANIAY
1160 1170 1180 1190 1200
GKGGDATETE IVSAAELSNA HGFISGLQQG YDTMVGERGV QLSGGQKQRV
1210 1220 1230 1240 1250
AIARAIVKDP KVLLLDEATS ALDAESERVV QDALDRVMVN RTTVVVAHRL
1260 1270 1280 1290
STIKNADVIA VVKNGVIVEK GKHETLINIK DGVYASLVQL HLSAST
Length:1,296
Mass (Da):140,334
Last modified:January 25, 2012 - v2
Checksum:iED16D162A767C3A6
GO

Sequence cautioni

The sequence CAB71875.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138651 Genomic DNA. Translation: CAB71875.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE80316.1.
PIRiT48007.
RefSeqiNP_191774.2. NM_116080.2.
UniGeneiAt.34174.

Genome annotation databases

EnsemblPlantsiAT3G62150.1; AT3G62150.1; AT3G62150.
GeneIDi825388.
GrameneiAT3G62150.1; AT3G62150.1; AT3G62150.
KEGGiath:AT3G62150.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138651 Genomic DNA. Translation: CAB71875.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE80316.1.
PIRiT48007.
RefSeqiNP_191774.2. NM_116080.2.
UniGeneiAt.34174.

3D structure databases

ProteinModelPortaliQ9M1Q9.
SMRiQ9M1Q9. Positions 68-667, 729-1291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G62150.1.

PTM databases

iPTMnetiQ9M1Q9.

Proteomic databases

PaxDbiQ9M1Q9.
PRIDEiQ9M1Q9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G62150.1; AT3G62150.1; AT3G62150.
GeneIDi825388.
GrameneiAT3G62150.1; AT3G62150.1; AT3G62150.
KEGGiath:AT3G62150.

Organism-specific databases

TAIRiAT3G62150.

Phylogenomic databases

eggNOGiKOG0055. Eukaryota.
COG1132. LUCA.
InParanoidiQ9M1Q9.
KOiK05658.
OMAiIVIFCTY.

Enzyme and pathway databases

BioCyciARA:AT3G62150-MONOMER.

Miscellaneous databases

PROiQ9M1Q9.

Gene expression databases

GenevisibleiQ9M1Q9. AT.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "The Arabidopsis thaliana ABC protein superfamily, a complete inventory."
    Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.
    J. Biol. Chem. 276:30231-30244(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  4. "Phosphoproteomics of the Arabidopsis plasma membrane and a new phosphorylation site database."
    Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.
    Plant Cell 16:2394-2405(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-657 AND SER-660, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: GENE FAMILY, NOMENCLATURE.
  6. "Large-scale Arabidopsis phosphoproteome profiling reveals novel chloroplast kinase substrates and phosphorylation networks."
    Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A., Grossmann J., Gruissem W., Baginsky S.
    Plant Physiol. 150:889-903(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAB21B_ARATH
AccessioniPrimary (citable) accession number: Q9M1Q9
Secondary accession number(s): F4IX45
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: January 25, 2012
Last modified: July 6, 2016
This is version 115 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.