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Protein

Putative histone deacetylase 10

Gene

HDA10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Hydrolase, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Putative histone deacetylase 10 (EC:3.5.1.98)
Gene namesi
Name:HDA10
Ordered Locus Names:At3g44660
ORF Names:T18B22.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G44660.
TAIRilocus:2098105. AT3G44660.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002800891 – 142Putative histone deacetylase 10Add BLAST142

Proteomic databases

PaxDbiQ9M1N8.

Expressioni

Gene expression databases

GenevisibleiQ9M1N8. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G44660.1.

Structurei

3D structure databases

ProteinModelPortaliQ9M1N8.
SMRiQ9M1N8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 34Histone deacetylaseAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi100 – 140Asp-richAdd BLAST41

Sequence similaritiesi

Belongs to the histone deacetylase family.Curated

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
HOGENOMiHOG000112868.
InParanoidiQ9M1N8.
KOiK06067.
PhylomeDBiQ9M1N8.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9M1N8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFSMLFTGH AECGGYTKEN VARCWTVETG ILLDTELPNE IPENDYIKYF
60 70 80 90 100
APDFSLKIPG GHIENLNTKS YISSIKVQIL ENLRYIQHAP SVQMQEVPPD
110 120 130 140
FYIPDFDEDE QNPDVRVDQR SRDKQIQRDD EYFDGDNDND AS
Length:142
Mass (Da):16,384
Last modified:October 1, 2000 - v1
Checksum:iAF59CB486862C6A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL138652 Genomic DNA. Translation: CAB72468.1.
CP002686 Genomic DNA. Translation: AEE77927.1.
PIRiT47441.
RefSeqiNP_190052.1. NM_114334.1.
UniGeneiAt.53729.

Genome annotation databases

EnsemblPlantsiAT3G44660.1; AT3G44660.1; AT3G44660.
GeneIDi823592.
GrameneiAT3G44660.1; AT3G44660.1; AT3G44660.
KEGGiath:AT3G44660.

Similar proteinsi

Entry informationi

Entry nameiHDA10_ARATH
AccessioniPrimary (citable) accession number: Q9M1N8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 1, 2000
Last modified: September 27, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families