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Q9M1K2

- PI5K4_ARATH

UniProt

Q9M1K2 - PI5K4_ARATH

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Protein

Phosphatidylinositol 4-phosphate 5-kinase 4

Gene
PIP5K4, At3g56960, F24I3.40
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Protein predictedi

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: TAIR
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. endocytosis Source: TAIR
  2. establishment of tissue polarity Source: TAIR
  3. phosphatidylinositol metabolic process Source: TAIR
  4. phosphatidylinositol phosphorylation Source: GOC
  5. plant-type cell wall modification Source: TAIR
  6. pollen germination Source: TAIR
  7. pollen tube growth Source: TAIR
  8. stomatal movement Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G56960-MONOMER.
ReactomeiREACT_187642. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 4 (EC:2.7.1.68)
Short name:
AtPIP5K4
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 4
Diphosphoinositide kinase 4
PtdIns(4)P-5-kinase 4
Gene namesi
Name:PIP5K4
Ordered Locus Names:At3g56960
ORF Names:F24I3.40
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G56960.

Subcellular locationi

GO - Cellular componenti

  1. apical plasma membrane Source: TAIR
  2. cytosol Source: TAIR
  3. plasma membrane Source: TAIR
  4. pollen tube Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 779779Phosphatidylinositol 4-phosphate 5-kinase 4PRO_0000185476Add
BLAST

Proteomic databases

PaxDbiQ9M1K2.
PRIDEiQ9M1K2.

Expressioni

Gene expression databases

GenevestigatoriQ9M1K2.

Interactioni

Protein-protein interaction databases

MINTiMINT-8069801.
STRINGi3702.AT3G56960.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9M1K2.
SMRiQ9M1K2. Positions 396-640.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati77 – 9923MORN 1Add
BLAST
Repeati100 – 12223MORN 2Add
BLAST
Repeati123 – 14523MORN 3Add
BLAST
Repeati146 – 16823MORN 4Add
BLAST
Repeati169 – 19123MORN 5Add
BLAST
Repeati192 – 21423MORN 6Add
BLAST
Repeati215 – 23723MORN 7Add
BLAST
Repeati238 – 25922MORN 8Add
BLAST
Domaini382 – 775394PIPKAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni735 – 75622Activation loop By similarityAdd
BLAST

Sequence similaritiesi

Contains 8 MORN repeats.
Contains 1 PIPK domain.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG4642.
HOGENOMiHOG000193875.
InParanoidiQ9M1K2.
KOiK00889.
OMAiKHGHGIK.
PhylomeDBiQ9M1K2.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 7 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9M1K2-1 [UniParc]FASTAAdd to Basket

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MSKEQSCVLK AWEVTVRKTQ QAKKRANSIF GTVSVAPQTD DDATTTTEEN    50
DDETSTNRSS IGELYHAERI LPNGDYYTGQ WYDSFPHGHG KYLWTDGCMY 100
IGDWYNGKTM GRGKFGWPSG ATYEGEFKSG YMDGVGLYTG PSGDTYKGQW 150
VMNLKHGHGI KRFANGDVYD GEWRRGLQEA QGKYQWRDGS YYMGEWKNAT 200
ICGKGTFIWT DGNRYDGFWD DGFPRGNGTF KWADGSFYVG HWSNDPEEMN 250
GTYYPSGDDG SPEWDPKDVF TNLSEYKICS GERVPVLPSQ KKLSVWNSSK 300
RVEKPRRMSV DGRVSVGVDR AFEKMNMWGT ESGEGAADID STTRRDLDAE 350
MMRLEAEGFI QSLRPSPAPM RLPRAGRKQG ETISKGHRNY ELMLNLQLGI 400
RHAVGKQAPV VSLDLKHSAF DPKEKVWTRF PPEGTKYTPP HQSSEFKWKD 450
YCPLVFRSLR KLFKVDPADY MLSICGNDAL RELSSPGKSG SFFYLTNDDR 500
YMIKTMKKSE TKVLLRMLAA YYNHVRAFEN TLVIRFYGLH CVKLTGPIQK 550
KVRFVIMGNL FCSEYSIHRR FDLKGSSLGR TTDKPESEIN SNTILKDLDL 600
NFIFRLQKAW YQEFIRQVDK DCEFLEQERI MDYSLLVGIH FREASVAGEL 650
IPSGARTPIG EFEDESAPRL SRADVDQLLS DPTRWASIRL GGNMPARAER 700
TMRRSDCEFQ LVGEPTGEYY EVVMIFGIID ILQDYDISKK LEHAYKSIQY 750
DPTSISAVDP RLYSRRFRDF IFKVFTEDN 779
Length:779
Mass (Da):89,238
Last modified:October 1, 2000 - v1
Checksum:iFAEB3BF1603C18B0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL138655 Genomic DNA. Translation: CAB72166.1.
CP002686 Genomic DNA. Translation: AEE79593.1.
PIRiT47756.
RefSeqiNP_191255.1. NM_115555.1.
UniGeneiAt.53961.

Genome annotation databases

EnsemblPlantsiAT3G56960.1; AT3G56960.1; AT3G56960.
GeneIDi824863.
KEGGiath:AT3G56960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL138655 Genomic DNA. Translation: CAB72166.1 .
CP002686 Genomic DNA. Translation: AEE79593.1 .
PIRi T47756.
RefSeqi NP_191255.1. NM_115555.1.
UniGenei At.53961.

3D structure databases

ProteinModelPortali Q9M1K2.
SMRi Q9M1K2. Positions 396-640.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-8069801.
STRINGi 3702.AT3G56960.1-P.

Proteomic databases

PaxDbi Q9M1K2.
PRIDEi Q9M1K2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G56960.1 ; AT3G56960.1 ; AT3G56960 .
GeneIDi 824863.
KEGGi ath:AT3G56960.

Organism-specific databases

TAIRi AT3G56960.

Phylogenomic databases

eggNOGi COG4642.
HOGENOMi HOG000193875.
InParanoidi Q9M1K2.
KOi K00889.
OMAi KHGHGIK.
PhylomeDBi Q9M1K2.

Enzyme and pathway databases

BioCyci ARA:AT3G56960-MONOMER.
Reactomei REACT_187642. Synthesis of PIPs at the plasma membrane.

Gene expression databases

Genevestigatori Q9M1K2.

Family and domain databases

Gene3Di 3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProi IPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view ]
PANTHERi PTHR23086. PTHR23086. 1 hit.
Pfami PF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view ]
PIRSFi PIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTi SM00698. MORN. 7 hits.
SM00330. PIPKc. 1 hit.
[Graphical view ]
PROSITEi PS51455. PIPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C."
    Mueller-Roeber B., Pical C.
    Plant Physiol. 130:22-46(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiPI5K4_ARATH
AccessioniPrimary (citable) accession number: Q9M1K2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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