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Q9M1K2

- PI5K4_ARATH

UniProt

Q9M1K2 - PI5K4_ARATH

Protein

Phosphatidylinositol 4-phosphate 5-kinase 4

Gene

PIP5K4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

    GO - Molecular functioni

    1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: TAIR
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. endocytosis Source: TAIR
    2. establishment of tissue polarity Source: TAIR
    3. phosphatidylinositol metabolic process Source: TAIR
    4. phosphatidylinositol phosphorylation Source: GOC
    5. plant-type cell wall modification Source: TAIR
    6. pollen germination Source: TAIR
    7. pollen tube growth Source: TAIR
    8. stomatal movement Source: TAIR

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT3G56960-MONOMER.
    ReactomeiREACT_187642. Synthesis of PIPs at the plasma membrane.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphatidylinositol 4-phosphate 5-kinase 4 (EC:2.7.1.68)
    Short name:
    AtPIP5K4
    Alternative name(s):
    1-phosphatidylinositol 4-phosphate kinase 4
    Diphosphoinositide kinase 4
    PtdIns(4)P-5-kinase 4
    Gene namesi
    Name:PIP5K4
    Ordered Locus Names:At3g56960
    ORF Names:F24I3.40
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G56960.

    Subcellular locationi

    GO - Cellular componenti

    1. apical plasma membrane Source: TAIR
    2. cytosol Source: TAIR
    3. plasma membrane Source: TAIR
    4. pollen tube Source: TAIR

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 779779Phosphatidylinositol 4-phosphate 5-kinase 4PRO_0000185476Add
    BLAST

    Proteomic databases

    PaxDbiQ9M1K2.
    PRIDEiQ9M1K2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9M1K2.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-8069801.
    STRINGi3702.AT3G56960.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9M1K2.
    SMRiQ9M1K2. Positions 396-640.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati77 – 9923MORN 1Add
    BLAST
    Repeati100 – 12223MORN 2Add
    BLAST
    Repeati123 – 14523MORN 3Add
    BLAST
    Repeati146 – 16823MORN 4Add
    BLAST
    Repeati169 – 19123MORN 5Add
    BLAST
    Repeati192 – 21423MORN 6Add
    BLAST
    Repeati215 – 23723MORN 7Add
    BLAST
    Repeati238 – 25922MORN 8Add
    BLAST
    Domaini382 – 775394PIPKPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni735 – 75622Activation loopBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 8 MORN repeats.Curated
    Contains 1 PIPK domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG4642.
    HOGENOMiHOG000193875.
    InParanoidiQ9M1K2.
    KOiK00889.
    OMAiKHGHGIK.
    PhylomeDBiQ9M1K2.

    Family and domain databases

    Gene3Di3.30.800.10. 1 hit.
    3.30.810.10. 2 hits.
    InterProiIPR003409. MORN.
    IPR017163. PIno-4-P-5_kinase_pln.
    IPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view]
    PANTHERiPTHR23086. PTHR23086. 1 hit.
    PfamiPF02493. MORN. 8 hits.
    PF01504. PIP5K. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
    SMARTiSM00698. MORN. 7 hits.
    SM00330. PIPKc. 1 hit.
    [Graphical view]
    PROSITEiPS51455. PIPK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9M1K2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKEQSCVLK AWEVTVRKTQ QAKKRANSIF GTVSVAPQTD DDATTTTEEN    50
    DDETSTNRSS IGELYHAERI LPNGDYYTGQ WYDSFPHGHG KYLWTDGCMY 100
    IGDWYNGKTM GRGKFGWPSG ATYEGEFKSG YMDGVGLYTG PSGDTYKGQW 150
    VMNLKHGHGI KRFANGDVYD GEWRRGLQEA QGKYQWRDGS YYMGEWKNAT 200
    ICGKGTFIWT DGNRYDGFWD DGFPRGNGTF KWADGSFYVG HWSNDPEEMN 250
    GTYYPSGDDG SPEWDPKDVF TNLSEYKICS GERVPVLPSQ KKLSVWNSSK 300
    RVEKPRRMSV DGRVSVGVDR AFEKMNMWGT ESGEGAADID STTRRDLDAE 350
    MMRLEAEGFI QSLRPSPAPM RLPRAGRKQG ETISKGHRNY ELMLNLQLGI 400
    RHAVGKQAPV VSLDLKHSAF DPKEKVWTRF PPEGTKYTPP HQSSEFKWKD 450
    YCPLVFRSLR KLFKVDPADY MLSICGNDAL RELSSPGKSG SFFYLTNDDR 500
    YMIKTMKKSE TKVLLRMLAA YYNHVRAFEN TLVIRFYGLH CVKLTGPIQK 550
    KVRFVIMGNL FCSEYSIHRR FDLKGSSLGR TTDKPESEIN SNTILKDLDL 600
    NFIFRLQKAW YQEFIRQVDK DCEFLEQERI MDYSLLVGIH FREASVAGEL 650
    IPSGARTPIG EFEDESAPRL SRADVDQLLS DPTRWASIRL GGNMPARAER 700
    TMRRSDCEFQ LVGEPTGEYY EVVMIFGIID ILQDYDISKK LEHAYKSIQY 750
    DPTSISAVDP RLYSRRFRDF IFKVFTEDN 779
    Length:779
    Mass (Da):89,238
    Last modified:October 1, 2000 - v1
    Checksum:iFAEB3BF1603C18B0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL138655 Genomic DNA. Translation: CAB72166.1.
    CP002686 Genomic DNA. Translation: AEE79593.1.
    PIRiT47756.
    RefSeqiNP_191255.1. NM_115555.1.
    UniGeneiAt.53961.

    Genome annotation databases

    EnsemblPlantsiAT3G56960.1; AT3G56960.1; AT3G56960.
    GeneIDi824863.
    KEGGiath:AT3G56960.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL138655 Genomic DNA. Translation: CAB72166.1 .
    CP002686 Genomic DNA. Translation: AEE79593.1 .
    PIRi T47756.
    RefSeqi NP_191255.1. NM_115555.1.
    UniGenei At.53961.

    3D structure databases

    ProteinModelPortali Q9M1K2.
    SMRi Q9M1K2. Positions 396-640.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-8069801.
    STRINGi 3702.AT3G56960.1-P.

    Proteomic databases

    PaxDbi Q9M1K2.
    PRIDEi Q9M1K2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G56960.1 ; AT3G56960.1 ; AT3G56960 .
    GeneIDi 824863.
    KEGGi ath:AT3G56960.

    Organism-specific databases

    TAIRi AT3G56960.

    Phylogenomic databases

    eggNOGi COG4642.
    HOGENOMi HOG000193875.
    InParanoidi Q9M1K2.
    KOi K00889.
    OMAi KHGHGIK.
    PhylomeDBi Q9M1K2.

    Enzyme and pathway databases

    BioCyci ARA:AT3G56960-MONOMER.
    Reactomei REACT_187642. Synthesis of PIPs at the plasma membrane.

    Gene expression databases

    Genevestigatori Q9M1K2.

    Family and domain databases

    Gene3Di 3.30.800.10. 1 hit.
    3.30.810.10. 2 hits.
    InterProi IPR003409. MORN.
    IPR017163. PIno-4-P-5_kinase_pln.
    IPR023610. PInositol-4-P-5-kinase.
    IPR027483. PInositol-4-P-5-kinase_C.
    IPR002498. PInositol-4-P-5-kinase_core.
    IPR027484. PInositol-4-P-5-kinase_N.
    IPR016034. PInositol-4P-5-kinase_core_sub.
    [Graphical view ]
    PANTHERi PTHR23086. PTHR23086. 1 hit.
    Pfami PF02493. MORN. 8 hits.
    PF01504. PIP5K. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037274. PIP5K_plant_prd. 1 hit.
    SMARTi SM00698. MORN. 7 hits.
    SM00330. PIPKc. 1 hit.
    [Graphical view ]
    PROSITEi PS51455. PIPK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C."
      Mueller-Roeber B., Pical C.
      Plant Physiol. 130:22-46(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiPI5K4_ARATH
    AccessioniPrimary (citable) accession number: Q9M1K2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3