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Q9M1D3

- CISY5_ARATH

UniProt

Q9M1D3 - CISY5_ARATH

Protein

Citrate synthase 5, mitochondrial

Gene

CSY5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (22 Feb 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei300 – 3001PROSITE-ProRule annotation
    Active sitei346 – 3461PROSITE-ProRule annotation
    Active sitei401 – 4011PROSITE-ProRule annotation

    GO - Molecular functioni

    1. citrate (Si)-synthase activity Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    BioCyciARA:AT3G60100-MONOMER.
    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase 5, mitochondrial (EC:2.3.3.16)
    Gene namesi
    Name:CSY5
    Ordered Locus Names:At3g60100
    ORF Names:T2O9.80
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G60100.

    Subcellular locationi

    Mitochondrion matrix 1 Publication

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell
    2. mitochondrion Source: TAIR

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 2525MitochondrionSequence AnalysisAdd
    BLAST
    Chaini26 – 464439Citrate synthase 5, mitochondrialPRO_0000005485Add
    BLAST

    Proteomic databases

    PaxDbiQ9M1D3.
    PRIDEiQ9M1D3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9M1D3.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT3G60100.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9M1D3.
    SMRiQ9M1D3. Positions 36-460.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0372.
    HOGENOMiHOG000130831.
    InParanoidiQ9M1D3.
    KOiK01647.
    OMAiEAHRPRI.

    Family and domain databases

    Gene3Di1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR010109. Citrate_synthase_euk.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    TIGRFAMsiTIGR01793. cit_synth_euk. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9M1D3-1 [UniParc]FASTAAdd to Basket

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    MVFFRSVSAI SRLRSRAVQQ SSLSNSVRWL HSSELDLKSQ MQEIIPEQQD    50
    RLKKLKSEQG KVPVGNITVD MVLGGMRGMT GLLWETSLLD ADEGIRFRGM 100
    SIPECQKILP SAESGEEPLP ESLLWLLLTG KVPTKEQANA LSTELAHRAA 150
    VPAIDALPST AHPMTQFASG VMALQVQSEF QKAYEQGDIS KSKYWEPTFE 200
    DALNLIARVP VVASYVYRRM YKDGSIIPLD DSLDYGANFS HMLGFDSPQM 250
    KELMRLYVTI HSDHEGGNVS AHAGHLVGSA LSDPYLSFAA ALNGLAGPLH 300
    GLANQEVLLW IKLVVEECGE SISKEQLKDY VWKTLNSGKV VPGYGHGVLR 350
    KTDPRYICQR EFALKHLPDD PLFQLVSKLY EVVPPILTEL GKVKNPWPNV 400
    DAHSGVLLNY YGLTEARYYT VLFGVSRSLG ICSQLIWDRA LGLPLERPKS 450
    VNMDWLDNFT RLNR 464
    Length:464
    Mass (Da):51,724
    Last modified:February 22, 2012 - v2
    Checksum:i2D2AE88A6AA29BB2
    GO

    Sequence cautioni

    The sequence CAB75925.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL138658 Genomic DNA. Translation: CAB75925.1. Sequence problems.
    CP002686 Genomic DNA. Translation: AEE80011.1.
    PIRiT47834.
    RefSeqiNP_191569.2. NM_115873.3.
    UniGeneiAt.70776.

    Genome annotation databases

    EnsemblPlantsiAT3G60100.1; AT3G60100.1; AT3G60100.
    GeneIDi825180.
    KEGGiath:AT3G60100.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL138658 Genomic DNA. Translation: CAB75925.1 . Sequence problems.
    CP002686 Genomic DNA. Translation: AEE80011.1 .
    PIRi T47834.
    RefSeqi NP_191569.2. NM_115873.3.
    UniGenei At.70776.

    3D structure databases

    ProteinModelPortali Q9M1D3.
    SMRi Q9M1D3. Positions 36-460.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT3G60100.1-P.

    Proteomic databases

    PaxDbi Q9M1D3.
    PRIDEi Q9M1D3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G60100.1 ; AT3G60100.1 ; AT3G60100 .
    GeneIDi 825180.
    KEGGi ath:AT3G60100.

    Organism-specific databases

    GeneFarmi 4305.
    TAIRi AT3G60100.

    Phylogenomic databases

    eggNOGi COG0372.
    HOGENOMi HOG000130831.
    InParanoidi Q9M1D3.
    KOi K01647.
    OMAi EAHRPRI.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .
    BioCyci ARA:AT3G60100-MONOMER.

    Gene expression databases

    Genevestigatori Q9M1D3.

    Family and domain databases

    Gene3Di 1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR010109. Citrate_synthase_euk.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    TIGRFAMsi TIGR01793. cit_synth_euk. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
      Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
      Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Strain: cv. Landsberg erecta.

    Entry informationi

    Entry nameiCISY5_ARATH
    AccessioniPrimary (citable) accession number: Q9M1D3
    Secondary accession number(s): F4JAL9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: February 22, 2012
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3