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Q9M1C7 (AB9C_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ABC transporter C family member 9
Short name=ABC transporter ABCC.9
Short name=AtABCC9
EC=3.6.3.44
Alternative name(s):
ATP-energized glutathione S-conjugate pump 9
Glutathione S-conjugate-transporting ATPase 9
Multidrug resistance-associated protein 9
Gene names
Name:ABCC9
Synonyms:MRP9
Ordered Locus Names:At3g60160
ORF Names:T2O9.140
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length1506 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Pump for glutathione S-conjugates By similarity.

Catalytic activity

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Ubiquitous. Ref.5

Sequence similarities

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Sequence caution

The sequence CAB75931.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processresponse to nematode

Inferred from expression pattern. Source: TAIR

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasmodesma

Inferred from direct assay. Source: TAIR

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

xenobiotic-transporting ATPase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 15061506ABC transporter C family member 9
PRO_0000226080

Regions

Transmembrane37 – 5721Helical; Potential
Transmembrane84 – 10421Helical; Potential
Transmembrane116 – 13621Helical; Potential
Transmembrane150 – 17021Helical; Potential
Transmembrane179 – 19921Helical; Potential
Transmembrane315 – 33521Helical; Potential
Transmembrane350 – 37021Helical; Potential
Transmembrane427 – 44721Helical; Potential
Transmembrane452 – 47221Helical; Potential
Transmembrane541 – 56121Helical; Potential
Transmembrane567 – 58721Helical; Potential
Transmembrane934 – 95623Helical; Potential
Transmembrane976 – 99621Helical; Potential
Transmembrane1048 – 106821Helical; Potential
Transmembrane1167 – 118721Helical; Potential
Transmembrane1191 – 121121Helical; Potential
Domain314 – 596283ABC transmembrane type-1 1
Domain630 – 853224ABC transporter 1
Domain936 – 1218283ABC transmembrane type-1 2
Domain1257 – 1489233ABC transporter 2
Nucleotide binding665 – 6728ATP 1 Potential
Nucleotide binding1289 – 12968ATP 2 Potential

Sequences

Sequence LengthMass (Da)Tools
Q9M1C7 [UniParc].

Last modified January 25, 2012. Version 2.
Checksum: 704CBD1D9EB97DBD

FASTA1,506168,210
        10         20         30         40         50         60 
MFKPFGFAAE TGSHLLTTQW LQLGNSLCLK ERISIAMQVT FLAFFLIHLA LKWFGVVRNR 

        70         80         90        100        110        120 
GSNDVEEDLK KQSITVKQSF SYNISLLCSV SILGTHCFIL LLLFRDSVVS RCDSSVSVFS 

       130        140        150        160        170        180 
AEVSQSFSWL FVSVVVVKIR ERRLVKFPWM LRSWWLCSFI LSFSFDAHFI TAKHEPLEFQ 

       190        200        210        220        230        240 
DYADLTGLLA SLFLLAVSIR GKTGFHLLES SGNTEPLLLG DQTEQNKKDS YSSSSPYGNA 

       250        260        270        280        290        300 
TLFQRITFSW INPLFSLGYK RPLEKDDVPD IDVKDSARFC SHAFDQKLKT TKEKEGPGNA 

       310        320        330        340        350        360 
FFYNSVLRYV WRKAAINAVF AVVNASTAYI GPYLINDFVE FLSEKQSQSL NHGYLLALGF 

       370        380        390        400        410        420 
LTAKIVETVT QRQWIFGARQ LGLRLRAALI SHIYQKGLVL SSQSRQSHTS GEIINYMSVD 

       430        440        450        460        470        480 
VQRITDFIWY VNNIWMLPIQ IFSAIYILQK HLGLGALAAL VTTLMVMACN YPLTRLQRNY 

       490        500        510        520        530        540 
QSDIMNAKDD RMKATSEILK NMKILKLQAW DNQFLNKVKT LRKKEYDCLW KSLRLQAFTT 

       550        560        570        580        590        600 
FILWGAPSLI SVVTFVTCML MGVKLTAGAV LSALATFQML QSPIFGLPDL LSALVQSKVS 

       610        620        630        640        650        660 
ADRIASYLQQ SETQKDAVEY CSKDHTELSV EIENGAFSWE PESSRPTLDD IELKVKSGMK 

       670        680        690        700        710        720 
VAVCGAVGSG KSSLLSSILG EIQKLKGTVR VSGKQAYVPQ SPWILSGTIR DNILFGSMYE 

       730        740        750        760        770        780 
SEKYERTVKA CALIKDFELF SNGDLTEIGE RGINMSGGQK QRIQIARAVY QNADIYLLDD 

       790        800        810        820        830        840 
PFSAVDAHTG RELFEDCLMG ILKDKTVLYV THQVEFLPAA DLILVMQNGR VMQAGKFEEL 

       850        860        870        880        890        900 
LKQNIGFEVL VGAHNEALDS ILSIEKSSRN FKEGSKDDTA SIAESLQTHC DSEHNISTEN 

       910        920        930        940        950        960 
KKKEAKLVQD EETEKGVIGK EVYLAYLTTV KGGLLVPFII LAQSCFQMLQ IASNYWMAWT 

       970        980        990       1000       1010       1020 
APPTAESIPK LGMGRILLVY ALLAAGSSLC VLARTILVAI GGLSTAETFF SRMLCSIFRA 

      1030       1040       1050       1060       1070       1080 
PMSFFDSTPT GRILNRASTD QSVLDLEMAV KLGWCAFSII QIVGTIFVMS QVAWQVCVIF 

      1090       1100       1110       1120       1130       1140 
IPVAVACVFY QRYYTPTARE LSRMSGVERA PILHHFAESL AGATTIRAFD QRDRFISSNL 

      1150       1160       1170       1180       1190       1200 
VLIDSHSRPW FHVASAMEWL SFRLNLLSHF VFAFSLVLLV TLPEGVINPS IAGLGVTYGL 

      1210       1220       1230       1240       1250       1260 
SLNVLQATVI WNICNAENKM ISVERILQYS KIPSEAPLVI DGHRPLDNWP NVGSIVFRDL 

      1270       1280       1290       1300       1310       1320 
QVRYAEHFPA VLKNITCEFP GGKKIGVVGR TGSGKSTLIQ ALFRIVEPSQ GTIVIDNVDI 

      1330       1340       1350       1360       1370       1380 
TKIGLHDLRS RLGIIPQDPA LFDGTIRLNL DPLAQYTDHE IWEAIDKCQL GDVIRAKDER 

      1390       1400       1410       1420       1430       1440 
LDATVVENGE NWSVGQRQLV CLGRVLLKKS NILVLDEATA SVDSATDGVI QKIINQEFKD 

      1450       1460       1470       1480       1490       1500 
RTVVTIAHRI HTVIESDLVL VLSDGRIAEF DSPAKLLQRE DSFFSKLIKE YSLRSNHFAG 


SNDLLS

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. expand/collapse author list , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
Nature 408:820-822(2000) [PubMed: 11130713] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"The Arabidopsis thaliana ABC protein superfamily, a complete inventory."
Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.
J. Biol. Chem. 276:30231-30244(2001) [PubMed: 11346655] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[4]"Multifunctionality of plant ABC transporters -- more than just detoxifiers."
Martinoia E., Klein M., Geisler M., Bovet L., Forestier C., Kolukisaoglu H.U., Mueller-Roeber B., Schulz B.
Planta 214:345-355(2002) [PubMed: 11855639] [Abstract]
Cited for: GENE FAMILY.
[5]"Family business: the multidrug-resistance related protein (MRP) ABC transporter genes in Arabidopsis thaliana."
Kolukisaoglu U.H., Bovet L., Klein M., Eggmann T., Geisler M., Wanke D., Martinoia E., Schulz B.
Planta 216:107-119(2002) [PubMed: 12430019] [Abstract]
Cited for: TISSUE SPECIFICITY.
[6]"Plant ABC proteins - a unified nomenclature and updated inventory."
Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M., Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A., Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.
Trends Plant Sci. 13:151-159(2008) [PubMed: 18299247] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL138658 Genomic DNA. Translation: CAB75931.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE80019.1.
IPIIPI00519552.
IPI01020062.
PIRT47840.

3D structure databases

ProteinModelPortalQ9M1C7.
SMRQ9M1C7. Positions 303-855, 920-1475.
ModBaseSearch...

Proteomic databases

PRIDEQ9M1C7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G60160.1; AT3G60160.1; AT3G60160.
GenomeReviewsGene locus AT3G60160 in contig BA000014_GR.
NMPDRfig|3702.1.peg.17377.

Organism-specific databases

TAIRAt3g60160.

Phylogenomic databases

eggNOGKOG0054.
HOGENOMHBG758042.
InParanoidQ9M1C7.
OMASHARREK.
PhylomeDBQ9M1C7.
ProtClustDBCLSN2685033.

Gene expression databases

GenevestigatorQ9M1C7.
GermOnlineAT3G60160. Arabidopsis thaliana.

Family and domain databases

InterProIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
IPR001140. ABC_transptr_TM_dom.
IPR011527. ABC_transptrTM_dom_typ1.
IPR003593. ATPase_AAA+_core.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF90123. ABC_TM_1. 2 hits.
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAB9C_ARATH
AccessionPrimary (citable) accession number: Q9M1C7
Secondary accession number(s): F4JAM7
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 25, 2012
Last modified: January 25, 2012
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents