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Protein

Putative phosphatidylinositol 4-phosphate 5-kinase 11

Gene

PIP5K11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

  1. 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: TAIR
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. phosphatidylinositol phosphorylation Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT4G01190-MONOMER.
ReactomeiREACT_187642. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative phosphatidylinositol 4-phosphate 5-kinase 11 (EC:2.7.1.68)
Short name:
AtPIP5K11
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 11
Diphosphoinositide kinase 11
PtdIns(4)P-5-kinase 11
Gene namesi
Name:PIP5K11
Ordered Locus Names:At4g01190
ORF Names:F2N1.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 4

Organism-specific databases

TAIRiAT4G01190.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 401401Putative phosphatidylinositol 4-phosphate 5-kinase 11PRO_0000185483Add
BLAST

Proteomic databases

PRIDEiQ9M149.

Expressioni

Gene expression databases

GenevestigatoriQ9M149.

Interactioni

Protein-protein interaction databases

BioGridi13357. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9M149.
SMRiQ9M149. Positions 27-235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 390390PIPKPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni350 – 37122Activation loopBy similarityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi241 – 29353Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 PIPK domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG5253.
HOGENOMiHOG000193875.
InParanoidiQ9M149.
KOiK00889.
OMAiNRIRYST.
PhylomeDBiQ9M149.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9M149-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELRATVENR IRYSTKHIKH LPPGSITEFD WKDYCPVGFG LIQELEGIDH
60 70 80 90 100
DDYLLSICTD ETLKKISSGK IGNVFHISND NRFLIKILRK SEIKVTLEML
110 120 130 140 150
PRYYRHINYH RSSLFTRIFG AHSVKPLGGV KTYFAVMSNM LHSTIFVNKL
160 170 180 190 200
YDLKGSPKGR SNKKIEVRNT TVLKDIDFDF CFYVDPLARQ RIIKQTKLDC
210 220 230 240 250
ELLEEEGIMD YSLLVGLQSK GSCQGSLDGL NPVYGSFAPP SSFKSNSTKS
260 270 280 290 300
MKTASSSPDR SSVAMYSCSP DRDSVENEMS MTIQSVTSNS ASSETNILAT
310 320 330 340 350
TLSDLFHNSS NINFGMKIPA RARRVTRETG EEEWYNVVLY IGIVDTFQDY
360 370 380 390 400
GMKKRIEHCY KSIQYNSNSI STVHPKIYSS RFQDFVSNIF LPHDDDLSSK

Y
Length:401
Mass (Da):45,659
Last modified:October 1, 2000 - v1
Checksum:i8A12D10DA2DED4CA
GO

Sequence cautioni

The sequence AAB61030.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007269 Genomic DNA. Translation: AAB61030.1. Sequence problems.
AL161491 Genomic DNA. Translation: CAB80928.1.
CP002687 Genomic DNA. Translation: AEE81992.1.
PIRiF85015.
T01723.
RefSeqiNP_192028.1. NM_116349.1.
UniGeneiAt.54072.

Genome annotation databases

EnsemblPlantsiAT4G01190.1; AT4G01190.1; AT4G01190.
GeneIDi828066.
KEGGiath:AT4G01190.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF007269 Genomic DNA. Translation: AAB61030.1. Sequence problems.
AL161491 Genomic DNA. Translation: CAB80928.1.
CP002687 Genomic DNA. Translation: AEE81992.1.
PIRiF85015.
T01723.
RefSeqiNP_192028.1. NM_116349.1.
UniGeneiAt.54072.

3D structure databases

ProteinModelPortaliQ9M149.
SMRiQ9M149. Positions 27-235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi13357. 4 interactions.

Proteomic databases

PRIDEiQ9M149.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G01190.1; AT4G01190.1; AT4G01190.
GeneIDi828066.
KEGGiath:AT4G01190.

Organism-specific databases

TAIRiAT4G01190.

Phylogenomic databases

eggNOGiCOG5253.
HOGENOMiHOG000193875.
InParanoidiQ9M149.
KOiK00889.
OMAiNRIRYST.
PhylomeDBiQ9M149.

Enzyme and pathway databases

BioCyciARA:AT4G01190-MONOMER.
ReactomeiREACT_187642. Synthesis of PIPs at the plasma membrane.

Miscellaneous databases

PROiQ9M149.

Gene expression databases

GenevestigatoriQ9M149.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF01504. PIP5K. 1 hit.
[Graphical view]
SMARTiSM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C."
    Mueller-Roeber B., Pical C.
    Plant Physiol. 130:22-46(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiPI5KB_ARATH
AccessioniPrimary (citable) accession number: Q9M149
Secondary accession number(s): O04613
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.