Reviewed, UniProtKB/Swiss-Prot Q9M149 (PI5KB_ARATH)

Names and origin

Protein names

Recommended name:
    Putative phosphatidylinositol-4-phosphate 5-kinase 11
      Short name=AtPIP5K11
    EC=2.7.1.68
Alternative name(s):
    1-phosphatidylinositol-4-phosphate kinase 11
    PtdIns(4)P-5-kinase 11
    Diphosphoinositide kinase 11

Gene names

Name:	PIP5K11
Ordered Locus Names:	At4g01190
ORF Names:	F2N1.9

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	401 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Sequence similarities	Contains 1 PI5K domain.
Sequence caution	The sequence AAB61030.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphatidylinositol metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	1-phosphatidylinositol-4-phosphate 5-kinase activity Inferred from direct assay. Source: TAIR ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 401	401	Putative phosphatidylinositol-4-phosphate 5-kinase 11		PRO_0000185483
Regions
	Domain	55 – 390	336	PI5K
	Region	350 – 371	22	Activation loop By similarity
	Compositional bias	241 – 293	53	Ser-rich

Sequences

	Sequence		Length	Mass (Da)
	Q9M149-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 8A12D10DA2DED4CA	FASTA	401	45,659
	10 20 30 40 50 60 MELRATVENR IRYSTKHIKH LPPGSITEFD WKDYCPVGFG LIQELEGIDH DDYLLSICTD 70 80 90 100 110 120 ETLKKISSGK IGNVFHISND NRFLIKILRK SEIKVTLEML PRYYRHINYH RSSLFTRIFG 130 140 150 160 170 180 AHSVKPLGGV KTYFAVMSNM LHSTIFVNKL YDLKGSPKGR SNKKIEVRNT TVLKDIDFDF 190 200 210 220 230 240 CFYVDPLARQ RIIKQTKLDC ELLEEEGIMD YSLLVGLQSK GSCQGSLDGL NPVYGSFAPP 250 260 270 280 290 300 SSFKSNSTKS MKTASSSPDR SSVAMYSCSP DRDSVENEMS MTIQSVTSNS ASSETNILAT 310 320 330 340 350 360 TLSDLFHNSS NINFGMKIPA RARRVTRETG EEEWYNVVLY IGIVDTFQDY GMKKRIEHCY 370 380 390 400 KSIQYNSNSI STVHPKIYSS RFQDFVSNIF LPHDDDLSSK Y

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana." Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B. , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R. Nature 402:769-777(1999) [PubMed: 10617198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C." Mueller-Roeber B., Pical C. Plant Physiol. 130:22-46(2002) [PubMed: 12226484] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF007269 Genomic DNA. Translation: AAB61030.1. AL161491 Genomic DNA. Translation: CAB80928.1.
IPI	IPI00520391.
PIR	F85015. T01723.
RefSeq	NP_192028.1.
UniGene	At.54072
3D structure databases
HSSP	HSSP built from PDB template 1BO1 based on UniProtKB P78356.
ModBase	Search...
Genome annotation databases
GeneID	828066.
GenomeReviews	Gene locus AT4G01190 in contig CT486007_GR.
KEGG	ath:AT4G01190.
NMPDR	fig|3702.1.peg.17902.
Organism-specific databases
TAIR	At4g01190.
Phylogenomic databases
OMA	Q9M149. EMANGEL.
Enzyme and pathway databases
BRENDA	2.7.1.68. 302.
Gene expression databases
ArrayExpress	Q9M149.
GermOnline	AT4G01190. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR002498. PInositol-4-P-5-kinase_core. IPR016034. PInositol-4P-5-kinase_core_sub. [Graphical view]
PANTHER	PTHR23086. PIP5K. 1 hit.
Pfam	PF01504. PIP5K. 1 hit. [Graphical view]
SMART	SM00330. PIPKc. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PI5KB_ARATH

Accession

Primary (citable) accession number: Q9M149
Secondary accession number(s): O04613

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)