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Protein

Protein S-acyltransferase 18

Gene

PAT18

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

S-acyltransferase involved in protein lipid modification.2 Publications

Catalytic activityi

Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei188S-palmitoyl cysteine intermediateBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.3.1.225. 399.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S-acyltransferase 18 (EC:2.3.1.225)
Alternative name(s):
Probable palmitoyltransferase At4g01730
Zinc finger DHHC domain-containing protein At4g01730
Gene namesi
Name:PAT18
Ordered Locus Names:At4g01730
ORF Names:T15B16.11
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRilocus:2133447. AT4G01730.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003636021 – 508Protein S-acyltransferase 18Add BLAST508

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9M115.
PRIDEiQ9M115.

Expressioni

Developmental stagei

Highly expressed during bolting.1 Publication

Gene expression databases

ExpressionAtlasiQ9M115. baseline and differential.
GenevisibleiQ9M115. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G01730.1.

Structurei

3D structure databases

SMRiQ9M115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 208DHHCPROSITE-ProRule annotationAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi456 – 461Poly-Ser6

Domaini

The DHHC domain is required for palmitoyltransferase activity.By similarity

Sequence similaritiesi

Belongs to the DHHC palmitoyltransferase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
HOGENOMiHOG000084071.
InParanoidiQ9M115.
KOiK20027.
OMAiGYILWRY.
OrthoDBiEOG09360CVM.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9M115-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTRRRHGWQR PLHPLQIVGA VIYSVLVAAF YVFLGFFLGN RIAVIALLSV
60 70 80 90 100
FSSVAVSVIV LFVRCTAIDP TDKTSAKKKR KDKSKGVLMK LRVKVVLSQV
110 120 130 140 150
VVRFFRRLER KILRNFLRRT YLDPWKSSVQ LEPLLPFPLV MKDDDSVTPD
160 170 180 190 200
PKEEDDISYC SLCDLEVKRS SKHCRTCNRC VEGFDHHCRW LNNCVGKKNY
210 220 230 240 250
TTFILLMVFV LLMLIIEGGT ALAVFVRCFV DKKGMEMELK RRLYVEFPQW
260 270 280 290 300
ALATISIILV LFTAYGSAAM GQLFLFHVVL IRKGMRTYDY ILAMKEENQF
310 320 330 340 350
TEVDPFDELD SSSDESSDFD SPERLRPTFI SKFMCRKANE NQQRLSIKIE
360 370 380 390 400
GDEQSPSSTL INKKPGFHVS INPWKLITLS SEKALQAAEK AKERLRKTKP
410 420 430 440 450
VSGTEENSLK PLPLETKFGL LLDPDNNNTV LQPSTTAAVK LQVSPGRFSS
460 470 480 490 500
PRRRFSGSSS STVPSPKQKY RTNFDLKLTE VSRELESYIS RQVLCSVIKQ

DGSEASPR
Length:508
Mass (Da):57,904
Last modified:February 22, 2012 - v2
Checksum:i173907C4BCBE9BCC
GO

Sequence cautioni

The sequence AAC72868 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB77743 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104919 Genomic DNA. Translation: AAC72868.1. Sequence problems.
AL161492 Genomic DNA. Translation: CAB77743.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE82070.1.
PIRiC85022.
T02002.
RefSeqiNP_192082.4. NM_116403.5.
UniGeneiAt.54087.

Genome annotation databases

EnsemblPlantsiAT4G01730.1; AT4G01730.1; AT4G01730.
GeneIDi826911.
GrameneiAT4G01730.1; AT4G01730.1; AT4G01730.
KEGGiath:AT4G01730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF104919 Genomic DNA. Translation: AAC72868.1. Sequence problems.
AL161492 Genomic DNA. Translation: CAB77743.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE82070.1.
PIRiC85022.
T02002.
RefSeqiNP_192082.4. NM_116403.5.
UniGeneiAt.54087.

3D structure databases

SMRiQ9M115.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G01730.1.

Proteomic databases

PaxDbiQ9M115.
PRIDEiQ9M115.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G01730.1; AT4G01730.1; AT4G01730.
GeneIDi826911.
GrameneiAT4G01730.1; AT4G01730.1; AT4G01730.
KEGGiath:AT4G01730.

Organism-specific databases

AraportiAT4G01730.
TAIRilocus:2133447. AT4G01730.

Phylogenomic databases

eggNOGiKOG1311. Eukaryota.
COG5273. LUCA.
HOGENOMiHOG000084071.
InParanoidiQ9M115.
KOiK20027.
OMAiGYILWRY.
OrthoDBiEOG09360CVM.

Enzyme and pathway databases

BRENDAi2.3.1.225. 399.

Miscellaneous databases

PROiPR:Q9M115.

Gene expression databases

ExpressionAtlasiQ9M115. baseline and differential.
GenevisibleiQ9M115. AT.

Family and domain databases

InterProiView protein in InterPro
IPR001594. Palmitoyltrfase_DHHC.
PfamiView protein in Pfam
PF01529. zf-DHHC. 1 hit.
PROSITEiView protein in PROSITE
PS50216. DHHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiZDH16_ARATH
AccessioniPrimary (citable) accession number: Q9M115
Secondary accession number(s): F4JG49, Q9ZSI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: February 22, 2012
Last modified: April 12, 2017
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.