Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dehydration-responsive element-binding protein 1A

Gene

DREB1A

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]CCGAC-3'. Binding to the C-repeat/DRE element mediates cold-inducible transcription. CBF/DREB1 factors play a key role in freezing tolerance and cold acclimation.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi50 – 107AP2/ERFPROSITE-ProRule annotationAdd BLAST58

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • DNA binding transcription factor activity Source: TAIR

GO - Biological processi

  • cold acclimation Source: TAIR
  • response to cold Source: TAIR
  • response to water deprivation Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding
Biological processStress response, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydration-responsive element-binding protein 1A1 Publication
Short name:
Protein DREB1A1 Publication
Alternative name(s):
C-repeat/dehydration-responsive element-binding factor 31 Publication
Short name:
C-repeat-binding factor 31 Publication
Short name:
CRT/DRE-binding factor 31 Publication
Cold resistance-related AP2 transcription factor
Gene namesi
Name:DREB1A1 Publication
Synonyms:CBF31 Publication, CRAP2, ERF0721 Publication
Ordered Locus Names:At4g25480Imported
ORF Names:M7J2.150Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G25480
TAIRilocus:2131849 AT4G25480

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi63V → A: Affects the binding to the CRT/DRE cis-element. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001125281 – 216Dehydration-responsive element-binding protein 1AAdd BLAST216

Proteomic databases

PaxDbiQ9M0L0

Expressioni

Inductioni

By cold stress. Positively regulated by the transcription factor ICE1. Subject to degradation by the 26S proteasome pathway in freezing conditions (PubMed:28344081).4 Publications

Gene expression databases

ExpressionAtlasiQ9M0L0 baseline and differential
GenevisibleiQ9M0L0 AT

Interactioni

Subunit structurei

Interacts with 14-3-3 proteins GRF1, GRF3, GRF5, GRF6, GRF7, GRF9 and GRF10 in the nucleus upon freezing.1 Publication

Protein-protein interaction databases

BioGridi13939, 3 interactors
STRINGi3702.AT4G25480.1

Structurei

3D structure databases

ProteinModelPortaliQ9M0L0
SMRiQ9M0L0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi35 – 47Nuclear localization signalSequence analysisAdd BLAST13

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi205 – 210Poly-Asp6

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IVY9 Eukaryota
ENOG410YK37 LUCA
InParanoidiQ9M0L0
KOiK09286
OMAiMNMEEAT
OrthoDBiEOG09360N5C
PhylomeDBiQ9M0L0

Family and domain databases

CDDicd00018 AP2, 1 hit
Gene3Di3.30.730.10, 1 hit
InterProiView protein in InterPro
IPR001471 AP2/ERF_dom
IPR036955 AP2/ERF_dom_sf
IPR016177 DNA-bd_dom_sf
PfamiView protein in Pfam
PF00847 AP2, 1 hit
PRINTSiPR00367 ETHRSPELEMNT
SMARTiView protein in SMART
SM00380 AP2, 1 hit
SUPFAMiSSF54171 SSF54171, 1 hit
PROSITEiView protein in PROSITE
PS51032 AP2_ERF, 1 hit

Sequencei

Sequence statusi: Complete.

Q9M0L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSFSAFSEM FGSDYESSVS SGGDYIPTLA SSCPKKPAGR KKFRETRHPI
60 70 80 90 100
YRGVRRRNSG KWVCEVREPN KKTRIWLGTF QTAEMAARAH DVAALALRGR
110 120 130 140 150
SACLNFADSA WRLRIPESTC AKDIQKAAAE AALAFQDEMC DATTDHGFDM
160 170 180 190 200
EETLVEAIYT AEQSENAFYM HDEAMFEMPS LLANMAEGML LPLPSVQWNH
210
NHEVDGDDDD VSLWSY
Length:216
Mass (Da):24,236
Last modified:May 24, 2004 - v2
Checksum:iC625E2D0FAE0FFFB
GO

Sequence cautioni

The sequence ABD72616 differs from that shown. Reason: Erroneous termination at position 152. Translated as Glu.Curated
The sequence CAA18178 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB81358 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146H → Y in BAA33434 (PubMed:9735350).Curated1
Sequence conflicti146H → Y in AAU93686 (Ref. 6) Curated1
Sequence conflicti146H → Y in ABD14412 (Ref. 7) Curated1
Sequence conflicti193L → P in ABD72616 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti2N → S in strain: cv. Cvi-1. 1 Publication1
Natural varianti19V → I in strain: cv. Cvi-1. 1 Publication1
Natural varianti142A → V in strain: cv. Cvi-1. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB007787 mRNA Translation: BAA33791.1
AB013815 Genomic DNA Translation: BAA33434.1
AF074602 mRNA Translation: AAD15977.1
AF076155 Genomic DNA Translation: AAC99370.1
AF062924 Genomic DNA Translation: AAC78646.1
AY667247 Genomic DNA Translation: AAV80414.1
AY691904 Genomic DNA Translation: AAU93686.1
DQ372533 Genomic DNA Translation: ABD14412.1
DQ415923 Genomic DNA Translation: ABD72616.1 Sequence problems.
AL022197 Genomic DNA Translation: CAA18178.1 Sequence problems.
AL161563 Genomic DNA Translation: CAB81358.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE85065.1
BT024594 mRNA Translation: ABD42992.1
PIRiD85294
JE0297
T05799
T51830
RefSeqiNP_567720.1, NM_118680.2
UniGeneiAt.231

Genome annotation databases

EnsemblPlantsiAT4G25480.1; AT4G25480.1; AT4G25480
GeneIDi828652
GrameneiAT4G25480.1; AT4G25480.1; AT4G25480
KEGGiath:AT4G25480

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDRE1A_ARATH
AccessioniPrimary (citable) accession number: Q9M0L0
Secondary accession number(s): O65612
, O82131, Q1ZZS0, Q2HII7, Q5QE70, Q5Y4C4, Q9SAZ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: May 24, 2004
Last modified: April 25, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health