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Protein
Submitted name:

Phosphoinositide-3-kinase, regulatory subunit 4, p150

Gene

At4g29380

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. protein serine/threonine kinase activity Source: GO_Central

GO - Biological processi

  1. late endosome to vacuole transport Source: GO_Central
  2. macroautophagy Source: GO_Central
  3. peroxisome degradation Source: GO_Central
  4. pollen development Source: TAIR
  5. pollen germination Source: TAIR
  6. protein phosphorylation Source: GO_Central
  7. protein targeting to vacuole Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

KinaseImported, Transferase

Enzyme and pathway databases

BioCyciARA:AT4G29380-MONOMER.
ReactomeiREACT_187640. Synthesis of PIPs at the late endosome membrane.
REACT_187646. Synthesis of PIPs at the Golgi membrane.
REACT_187647. Synthesis of PIPs at the early endosome membrane.

Names & Taxonomyi

Protein namesi
Submitted name:
Phosphoinositide-3-kinase, regulatory subunit 4, p150Imported
Submitted name:
Putative uncharacterized protein AT4g29380Imported
Gene namesi
Ordered Locus Names:At4g29380Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 4

Organism-specific databases

TAIRiAT4G29380.

Subcellular locationi

GO - Cellular componenti

  1. Cul4-RING E3 ubiquitin ligase complex Source: TAIR
  2. cytoplasm Source: TAIR
  3. late endosome Source: GO_Central
  4. nuclear pore Source: GO_Central
  5. nucleus-vacuole junction Source: GO_Central
  6. phosphatidylinositol 3-kinase complex, class III, type I Source: GO_Central
  7. phosphatidylinositol 3-kinase complex, class III, type II Source: GO_Central
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ9M0E5.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G29380.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9M0E5.
SMRiQ9M0E5. Positions 28-354, 1070-1321.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

RepeatUniRule annotation, WD repeatUniRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000030331.
KOiK08333.
OMAiYDEAHFE.
PhylomeDBiQ9M0E5.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
2.130.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR021133. HEAT_type_2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02985. HEAT. 1 hit.
PF00069. Pkinase. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50978. SSF50978. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9M0E5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNKIARTTQ VSATEYYLHD LPSSYNLVLK EVLGRGRFLK SIQCKHDEGL
60 70 80 90 100
VVVKVYFKRG DSIDLREYER RLVKIKDVFL SLEHPHVWPF QFWQETDKAA
110 120 130 140 150
YLVRQYFYSN LHDRLSTRPF LSLVEKKWLA FQLLLAVKQC HEKDICHGDI
160 170 180 190 200
KCENVLLTSW NWLYLADFAS FKPTYIPYDD PSDFSFFFDT RGQRLCYLAP
210 220 230 240 250
ERFYEHGGET QVAQDAPLKP SMDIFAVGCV IAELFLEGQP LFELAQLLAY
260 270 280 290 300
RRGQHDPSQH LEKIPDPGIR KMILHMIQLE PEARLSAEDY LQNYVGVVFP
310 320 330 340 350
NYFSPFLHTL YCCWNPLPSD MRVATCQGIF QEILKKMMEN KSGDEIGVDS
360 370 380 390 400
PVTSNPMNAS TVQETFANHK LNSSKDLIRN TVNSKDEIFY SISDALKKNR
410 420 430 440 450
HPFLKKITMD DLGTLMSLYD SRSDTYGTPF LPVEGNMRCE GMVLIASMLC
460 470 480 490 500
SCIRNIKLPH LRREAILLLR SCSLYIDDDD RLQRVLPYVV ALLSDPTAIV
510 520 530 540 550
RCAAMETLCD ILPLVRDFPP SDAKIFPEYI FPMLSMLPED TEESVRICYA
560 570 580 590 600
SNIAKLALTA YGFLIHSFQL SDVGVLNELN SQQISTTPAS ETPSHLQKAN
610 620 630 640 650
GNAQLQQLRK TIAEVVQELV MGPKQTPNVR RALLQDIGEL CFFFGQRQSN
660 670 680 690 700
DFLLPILPAF LNDRDEQLRS VFFEKIVYVC FFVGQRSVEE YLLPYIDQAL
710 720 730 740 750
SDQTEAVIVN ALECLSTLCK SSFLRKRALL QMIECVYPLL CYPSQWVRRA
760 770 780 790 800
VVTFIAASSE CLGAVDSYAF IAPVIRSYLS RLPASIASEE GLLSCLKPPV
810 820 830 840 850
TREVVYRIFE KTRNPEFMAK QRKMWYSSSP QSKDWESVDL FDKDAGELNS
860 870 880 890 900
VECRAEQKQS VEGKKQIKSA SKQPEVQGKY AEKDAKLRIP RNPRPNASNT
910 920 930 940 950
VELRDPVYPE KLQFSGFMAP YVSGANSFIE PENIPLYSFS MDKRAATNPP
960 970 980 990 1000
VASESSLQMN SLGMGSLSVP WMDSMSKSFN LASSVPVPKL ISGSFHVGTN
1010 1020 1030 1040 1050
PKQFYRVVHE PESRENDQIS SAISKFQDLG VSSSSKSASV TSEDASSPAD
1060 1070 1080 1090 1100
LVGEPSLSRT SVPDSGWKPR GVLVAHLQEH RSAVNDIATS SDHSFFVSAS
1110 1120 1130 1140 1150
DDSTVKVWDS RKLEKDISFR SRLTYHLEGS RGMCTTMLRN STQVVVGASD
1160 1170 1180 1190 1200
GVIHMFSIDH ISRGLGNVVE KYSGIVDIKK KDVKEGALVS LLNYTADSLS
1210 1220 1230 1240 1250
GPMVMYSTQN CGIHLWDTRS DLDAWTLKAN PEEGYVSSLV TSPCGNWFVS
1260 1270 1280 1290 1300
GSSRGVLTLW DLRFRVPVNS WQYPIICPIE KMCLCFLPPS VSVSTTMKPL
1310 1320 1330 1340 1350
IYVAAGCNEV SLWNAEGGSC HQVLRVANYE NETDVSEFQW KLPSNKVNPK
1360 1370 1380 1390 1400
PNHRQNMSSK YRIEELNEPP PRLPGIRSLL PLPGGDLLTG GTDLKIRRWD
1410 1420 1430 1440 1450
YSSPERSYCI CGPSLKGVGN DDFYELKTNT GVQFVQETKR RPLATKLTAK
1460 1470 1480 1490
AVLAAAATDT AGCHRDSVQS LASVKLNQRL LISSSRDGAI KVWK
Length:1,494
Mass (Da):168,124
Last modified:October 1, 2000 - v1
Checksum:i78D71855073E8BFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002687 Genomic DNA. Translation: AEE85624.1.
AL161574 Genomic DNA. Translation: CAB79696.1.
RefSeqiNP_194667.1. NM_119083.2.
UniGeneiAt.27874.

Genome annotation databases

EnsemblPlantsiAT4G29380.1; AT4G29380.1; AT4G29380.
GeneIDi829059.
KEGGiath:AT4G29380.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002687 Genomic DNA. Translation: AEE85624.1.
AL161574 Genomic DNA. Translation: CAB79696.1.
RefSeqiNP_194667.1. NM_119083.2.
UniGeneiAt.27874.

3D structure databases

ProteinModelPortaliQ9M0E5.
SMRiQ9M0E5. Positions 28-354, 1070-1321.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT4G29380.1-P.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G29380.1; AT4G29380.1; AT4G29380.
GeneIDi829059.
KEGGiath:AT4G29380.

Organism-specific databases

TAIRiAT4G29380.

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000030331.
KOiK08333.
OMAiYDEAHFE.
PhylomeDBiQ9M0E5.

Enzyme and pathway databases

BioCyciARA:AT4G29380-MONOMER.
ReactomeiREACT_187640. Synthesis of PIPs at the late endosome membrane.
REACT_187646. Synthesis of PIPs at the Golgi membrane.
REACT_187647. Synthesis of PIPs at the early endosome membrane.

Miscellaneous databases

PROiQ9M0E5.

Gene expression databases

GenevestigatoriQ9M0E5.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
2.130.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000357. HEAT.
IPR021133. HEAT_type_2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02985. HEAT. 1 hit.
PF00069. Pkinase. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
SSF50978. SSF50978. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50077. HEAT_REPEAT. 2 hits.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
    EU, CSHL and WU Arabidopsis Sequencing Project
    Mayer K., Schuller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Dusterhoft A., Stiekema W., Entian K.D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
    , Mache R., Muller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portatelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.A., McCullagh B., Bilham L., Robben J., Van der Schueren J., Grymonprez B., Chuang Y.J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirske W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Kotter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., Van Montagu M., Rogers J., Cronin A., Quail M., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Blocker H., Scharfe M., Grimm M., Lohnert T.H., Dose S., de Haan M., Maarse A., Schafer M., Muller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Mundlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Montfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sehkon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffmann J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M., Martienssen R., McCombie W.R.
    Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. ColumbiaImported.
  2. Lennard N., Quail M., Harris B., Rajandream M.A., Barrell B.G., Mewes H.W., Lemcke K., Mayer K.F.X.
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. EU Arabidopsis sequencing project
    Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. TAIR10
    Swarbreck D., Lamesch P., Wilks C., Huala E.
    Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  5. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. ColumbiaImported.

Entry informationi

Entry nameiQ9M0E5_ARATH
AccessioniPrimary (citable) accession number: Q9M0E5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.