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Q9LZU4 (CRK4_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine-rich receptor-like protein kinase 4

Short name=Cysteine-rich RLK4
EC=2.7.11.-
Gene names
Name:CRK4
Ordered Locus Names:At3g45860
ORF Names:F16L2_70
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length676 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Induction

By salicylic acid (SA) or by a bacterial pathogen infection. Ref.4

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CRK subfamily.

Contains 2 Gnk2-homologous domains.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 676660Cysteine-rich receptor-like protein kinase 4
PRO_0000295051

Regions

Topological domain17 – 287271Extracellular Potential
Transmembrane288 – 30821Helical; Potential
Topological domain309 – 676368Cytoplasmic Potential
Domain31 – 135105Gnk2-homologous 1
Domain146 – 246101Gnk2-homologous 2
Domain351 – 631281Protein kinase
Nucleotide binding357 – 3659ATP By similarity

Sites

Active site4761Proton acceptor By similarity
Binding site3791ATP By similarity

Amino acid modifications

Glycosylation331N-linked (GlcNAc...) Potential
Glycosylation461N-linked (GlcNAc...) Potential
Glycosylation641N-linked (GlcNAc...) Potential
Glycosylation1521N-linked (GlcNAc...) Potential
Glycosylation1811N-linked (GlcNAc...) Potential
Glycosylation2431N-linked (GlcNAc...) Potential
Glycosylation2481N-linked (GlcNAc...) Potential
Glycosylation2861N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9LZU4 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 46DB72413084CC89

FASTA67675,923
        10         20         30         40         50         60 
MSFFWLFPFL LHLSFADSLS PLSAPVQNFI HLNHSCPSSI LTYSRNSTYF TNLKTLLSSL 

        70         80         90        100        110        120 
SSRNASYSTG FQTATAGQAP DRVTGLFLCR GDVSQEVCRN CVAFSVKETL YWCPYNKEVV 

       130        140        150        160        170        180 
LYYDECMLRY SHRNILSTVT YDGSAILLNG ANISSSNQNQ VDEFRDLVSS TLNLAAVEAA 

       190        200        210        220        230        240 
NSSKKFYTRK VITPQPLYLL VQCTPDLTRQ DCLRCLQKSI KGMSLYRIGG RFFYPSCNSR 

       250        260        270        280        290        300 
YENYSFYNET ATRSSSPPSL PPRSTPQQQL KLAPPPLISE RGKGRNSSVI IVVVVPIIAL 

       310        320        330        340        350        360 
LLLFVAFFSL RAKKTRTNYE REPLTEESDD ITTAGSLQFD FKAIEAATNK FCETNKLGQG 

       370        380        390        400        410        420 
GFGEVYKGIF PSGVQVAVKR LSKTSGQGER EFANEVIVVA KLQHRNLVRL LGFCLERDER 

       430        440        450        460        470        480 
ILVYEFVPNK SLDYFIFDST MQSLLDWTRR YKIIGGIARG ILYLHQDSRL TIIHRDLKAG 

       490        500        510        520        530        540 
NILLGDDMNA KIADFGMARI FGMDQTEANT RRIVGTYGYM SPEYAMYGQF SMKSDVYSFG 

       550        560        570        580        590        600 
VLVLEIISGK KNSNVYQMDG TSAGNLVTYT WRLWSNGSPL ELVDPSFRDN YRINEVSRCI 

       610        620        630        640        650        660 
HIALLCVQEE AEDRPTMSAI VQMLTTSSIA LAVPQRPGFF FRSSKHEQVG LVDRLSINTS 

       670 
ALCSVDDASI TNVTPR 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. expand/collapse author list , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"A superfamily of proteins with novel cysteine-rich repeats."
Chen Z.
Plant Physiol. 126:473-476(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE.
[4]"Activation of hypersensitive cell death by pathogen-induced receptor-like protein kinases from Arabidopsis."
Chen K., Fan B., Du L., Chen Z.
Plant Mol. Biol. 56:271-283(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL162459 Genomic DNA. Translation: CAB82810.1.
CP002686 Genomic DNA. Translation: AEE78083.1.
PIRT47526.
RefSeqNP_190172.1. NM_114455.1.
UniGeneAt.35982.

3D structure databases

ProteinModelPortalQ9LZU4.
SMRQ9LZU4. Positions 306-626.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT3G45860.1-P.

Proteomic databases

PRIDEQ9LZU4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G45860.1; AT3G45860.1; AT3G45860.
GeneID823729.
KEGGath:AT3G45860.

Organism-specific databases

GeneFarm642. 92.
TAIRAT3G45860.

Phylogenomic databases

eggNOGCOG0515.
HOGENOMHOG000116550.
InParanoidQ9LZU4.
OMANYRINEV.
PhylomeDBQ9LZU4.

Enzyme and pathway databases

BioCycARA:AT3G45860-MONOMER.

Gene expression databases

GenevestigatorQ9LZU4.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR013320. ConA-like_subgrp.
IPR002902. GNK2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF07714. Pkinase_Tyr. 1 hit.
PF01657. Stress-antifung. 2 hits.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51473. GNK2. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCRK4_ARATH
AccessionPrimary (citable) accession number: Q9LZU4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names