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Q9LZU4

- CRK4_ARATH

UniProt

Q9LZU4 - CRK4_ARATH

Protein

Cysteine-rich receptor-like protein kinase 4

Gene

CRK4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei379 – 3791ATPPROSITE-ProRule annotation
    Active sitei476 – 4761Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi357 – 3659ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein serine/threonine kinase activity Source: UniProtKB-KW

    GO - Biological processi

    1. defense response to bacterium Source: TAIR
    2. programmed cell death Source: TAIR
    3. response to salicylic acid Source: TAIR

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT3G45860-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine-rich receptor-like protein kinase 4 (EC:2.7.11.-)
    Short name:
    Cysteine-rich RLK4
    Gene namesi
    Name:CRK4
    Ordered Locus Names:At3g45860
    ORF Names:F16L2_70
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G45860.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 676660Cysteine-rich receptor-like protein kinase 4PRO_0000295051Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9LZU4.

    Expressioni

    Inductioni

    By salicylic acid (SA) or by a bacterial pathogen infection.1 Publication

    Gene expression databases

    GenevestigatoriQ9LZU4.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT3G45860.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LZU4.
    SMRiQ9LZU4. Positions 306-626.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini17 – 287271ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini309 – 676368CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei288 – 30821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 135105Gnk2-homologous 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini146 – 246101Gnk2-homologous 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini351 – 631281Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CRK subfamily.PROSITE-ProRule annotation
    Contains 2 Gnk2-homologous domains.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    HOGENOMiHOG000116550.
    InParanoidiQ9LZU4.
    OMAiNYRINEV.
    PhylomeDBiQ9LZU4.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR013320. ConA-like_subgrp.
    IPR002902. GNK2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF07714. Pkinase_Tyr. 1 hit.
    PF01657. Stress-antifung. 2 hits.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51473. GNK2. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9LZU4-1 [UniParc]FASTAAdd to Basket

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    MSFFWLFPFL LHLSFADSLS PLSAPVQNFI HLNHSCPSSI LTYSRNSTYF    50
    TNLKTLLSSL SSRNASYSTG FQTATAGQAP DRVTGLFLCR GDVSQEVCRN 100
    CVAFSVKETL YWCPYNKEVV LYYDECMLRY SHRNILSTVT YDGSAILLNG 150
    ANISSSNQNQ VDEFRDLVSS TLNLAAVEAA NSSKKFYTRK VITPQPLYLL 200
    VQCTPDLTRQ DCLRCLQKSI KGMSLYRIGG RFFYPSCNSR YENYSFYNET 250
    ATRSSSPPSL PPRSTPQQQL KLAPPPLISE RGKGRNSSVI IVVVVPIIAL 300
    LLLFVAFFSL RAKKTRTNYE REPLTEESDD ITTAGSLQFD FKAIEAATNK 350
    FCETNKLGQG GFGEVYKGIF PSGVQVAVKR LSKTSGQGER EFANEVIVVA 400
    KLQHRNLVRL LGFCLERDER ILVYEFVPNK SLDYFIFDST MQSLLDWTRR 450
    YKIIGGIARG ILYLHQDSRL TIIHRDLKAG NILLGDDMNA KIADFGMARI 500
    FGMDQTEANT RRIVGTYGYM SPEYAMYGQF SMKSDVYSFG VLVLEIISGK 550
    KNSNVYQMDG TSAGNLVTYT WRLWSNGSPL ELVDPSFRDN YRINEVSRCI 600
    HIALLCVQEE AEDRPTMSAI VQMLTTSSIA LAVPQRPGFF FRSSKHEQVG 650
    LVDRLSINTS ALCSVDDASI TNVTPR 676
    Length:676
    Mass (Da):75,923
    Last modified:October 1, 2000 - v1
    Checksum:i46DB72413084CC89
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL162459 Genomic DNA. Translation: CAB82810.1.
    CP002686 Genomic DNA. Translation: AEE78083.1.
    PIRiT47526.
    RefSeqiNP_190172.1. NM_114455.1.
    UniGeneiAt.35982.

    Genome annotation databases

    EnsemblPlantsiAT3G45860.1; AT3G45860.1; AT3G45860.
    GeneIDi823729.
    KEGGiath:AT3G45860.

    Cross-referencesi

    Web resourcesi

    PlantP kinase Classification PPC

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL162459 Genomic DNA. Translation: CAB82810.1 .
    CP002686 Genomic DNA. Translation: AEE78083.1 .
    PIRi T47526.
    RefSeqi NP_190172.1. NM_114455.1.
    UniGenei At.35982.

    3D structure databases

    ProteinModelPortali Q9LZU4.
    SMRi Q9LZU4. Positions 306-626.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT3G45860.1-P.

    Proteomic databases

    PRIDEi Q9LZU4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G45860.1 ; AT3G45860.1 ; AT3G45860 .
    GeneIDi 823729.
    KEGGi ath:AT3G45860.

    Organism-specific databases

    GeneFarmi 642. 92.
    TAIRi AT3G45860.

    Phylogenomic databases

    eggNOGi COG0515.
    HOGENOMi HOG000116550.
    InParanoidi Q9LZU4.
    OMAi NYRINEV.
    PhylomeDBi Q9LZU4.

    Enzyme and pathway databases

    BioCyci ARA:AT3G45860-MONOMER.

    Gene expression databases

    Genevestigatori Q9LZU4.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR013320. ConA-like_subgrp.
    IPR002902. GNK2.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF07714. Pkinase_Tyr. 1 hit.
    PF01657. Stress-antifung. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51473. GNK2. 2 hits.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "A superfamily of proteins with novel cysteine-rich repeats."
      Chen Z.
      Plant Physiol. 126:473-476(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE.
    4. "Activation of hypersensitive cell death by pathogen-induced receptor-like protein kinases from Arabidopsis."
      Chen K., Fan B., Du L., Chen Z.
      Plant Mol. Biol. 56:271-283(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiCRK4_ARATH
    AccessioniPrimary (citable) accession number: Q9LZU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3