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Q9LZU4

- CRK4_ARATH

UniProt

Q9LZU4 - CRK4_ARATH

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Protein

Cysteine-rich receptor-like protein kinase 4

Gene

CRK4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei379 – 3791ATPPROSITE-ProRule annotation
Active sitei476 – 4761Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi357 – 3659ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW

GO - Biological processi

  1. defense response to bacterium Source: TAIR
  2. programmed cell death Source: TAIR
  3. response to salicylic acid Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G45860-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich receptor-like protein kinase 4 (EC:2.7.11.-)
Short name:
Cysteine-rich RLK4
Gene namesi
Name:CRK4
Ordered Locus Names:At3g45860
ORF Names:F16L2_70
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G45860.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 676660Cysteine-rich receptor-like protein kinase 4PRO_0000295051Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence Analysis
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence Analysis
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi248 – 2481N-linked (GlcNAc...)Sequence Analysis
Glycosylationi286 – 2861N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9LZU4.

Expressioni

Inductioni

By salicylic acid (SA) or by a bacterial pathogen infection.1 Publication

Gene expression databases

GenevestigatoriQ9LZU4.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G45860.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LZU4.
SMRiQ9LZU4. Positions 308-630.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini17 – 287271ExtracellularSequence AnalysisAdd
BLAST
Topological domaini309 – 676368CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei288 – 30821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 135105Gnk2-homologous 1PROSITE-ProRule annotationAdd
BLAST
Domaini146 – 246101Gnk2-homologous 2PROSITE-ProRule annotationAdd
BLAST
Domaini351 – 631281Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CRK subfamily.PROSITE-ProRule annotation
Contains 2 Gnk2-homologous domains.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000116550.
InParanoidiQ9LZU4.
OMAiNYRINEV.
PhylomeDBiQ9LZU4.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR002902. GNK2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF07714. Pkinase_Tyr. 1 hit.
PF01657. Stress-antifung. 2 hits.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51473. GNK2. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LZU4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFFWLFPFL LHLSFADSLS PLSAPVQNFI HLNHSCPSSI LTYSRNSTYF
60 70 80 90 100
TNLKTLLSSL SSRNASYSTG FQTATAGQAP DRVTGLFLCR GDVSQEVCRN
110 120 130 140 150
CVAFSVKETL YWCPYNKEVV LYYDECMLRY SHRNILSTVT YDGSAILLNG
160 170 180 190 200
ANISSSNQNQ VDEFRDLVSS TLNLAAVEAA NSSKKFYTRK VITPQPLYLL
210 220 230 240 250
VQCTPDLTRQ DCLRCLQKSI KGMSLYRIGG RFFYPSCNSR YENYSFYNET
260 270 280 290 300
ATRSSSPPSL PPRSTPQQQL KLAPPPLISE RGKGRNSSVI IVVVVPIIAL
310 320 330 340 350
LLLFVAFFSL RAKKTRTNYE REPLTEESDD ITTAGSLQFD FKAIEAATNK
360 370 380 390 400
FCETNKLGQG GFGEVYKGIF PSGVQVAVKR LSKTSGQGER EFANEVIVVA
410 420 430 440 450
KLQHRNLVRL LGFCLERDER ILVYEFVPNK SLDYFIFDST MQSLLDWTRR
460 470 480 490 500
YKIIGGIARG ILYLHQDSRL TIIHRDLKAG NILLGDDMNA KIADFGMARI
510 520 530 540 550
FGMDQTEANT RRIVGTYGYM SPEYAMYGQF SMKSDVYSFG VLVLEIISGK
560 570 580 590 600
KNSNVYQMDG TSAGNLVTYT WRLWSNGSPL ELVDPSFRDN YRINEVSRCI
610 620 630 640 650
HIALLCVQEE AEDRPTMSAI VQMLTTSSIA LAVPQRPGFF FRSSKHEQVG
660 670
LVDRLSINTS ALCSVDDASI TNVTPR
Length:676
Mass (Da):75,923
Last modified:October 1, 2000 - v1
Checksum:i46DB72413084CC89
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL162459 Genomic DNA. Translation: CAB82810.1.
CP002686 Genomic DNA. Translation: AEE78083.1.
PIRiT47526.
RefSeqiNP_190172.1. NM_114455.1.
UniGeneiAt.35982.

Genome annotation databases

EnsemblPlantsiAT3G45860.1; AT3G45860.1; AT3G45860.
GeneIDi823729.
KEGGiath:AT3G45860.

Cross-referencesi

Web resourcesi

PlantP kinase Classification PPC

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL162459 Genomic DNA. Translation: CAB82810.1 .
CP002686 Genomic DNA. Translation: AEE78083.1 .
PIRi T47526.
RefSeqi NP_190172.1. NM_114455.1.
UniGenei At.35982.

3D structure databases

ProteinModelPortali Q9LZU4.
SMRi Q9LZU4. Positions 308-630.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT3G45860.1-P.

Proteomic databases

PRIDEi Q9LZU4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G45860.1 ; AT3G45860.1 ; AT3G45860 .
GeneIDi 823729.
KEGGi ath:AT3G45860.

Organism-specific databases

GeneFarmi 642. 92.
TAIRi AT3G45860.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000116550.
InParanoidi Q9LZU4.
OMAi NYRINEV.
PhylomeDBi Q9LZU4.

Enzyme and pathway databases

BioCyci ARA:AT3G45860-MONOMER.

Gene expression databases

Genevestigatori Q9LZU4.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR013320. ConA-like_dom.
IPR002902. GNK2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF07714. Pkinase_Tyr. 1 hit.
PF01657. Stress-antifung. 2 hits.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51473. GNK2. 2 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "A superfamily of proteins with novel cysteine-rich repeats."
    Chen Z.
    Plant Physiol. 126:473-476(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE.
  4. "Activation of hypersensitive cell death by pathogen-induced receptor-like protein kinases from Arabidopsis."
    Chen K., Fan B., Du L., Chen Z.
    Plant Mol. Biol. 56:271-283(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.

Entry informationi

Entry nameiCRK4_ARATH
AccessioniPrimary (citable) accession number: Q9LZU4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3