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Protein

ABC transporter C family member 14

Gene

ABCC14

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Pump for glutathione S-conjugates.By similarity

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi674 – 681ATP 18
Nucleotide bindingi1331 – 1338ATP 28

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G62700-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter C family member 14 (EC:3.6.3.44)
Short name:
ABC transporter ABCC.14
Short name:
AtABCC14
Alternative name(s):
ATP-energized glutathione S-conjugate pump 10
Glutathione S-conjugate-transporting ATPase 10
Multidrug resistance-associated protein 10
Gene namesi
Name:ABCC14
Synonyms:MRP10, MRP14
Ordered Locus Names:At3g62700
ORF Names:F26K9.130
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G62700.
TAIRilocus:2081755. AT3G62700.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei45 – 65HelicalAdd BLAST21
Transmembranei100 – 120HelicalAdd BLAST21
Transmembranei131 – 151HelicalAdd BLAST21
Transmembranei165 – 185HelicalAdd BLAST21
Transmembranei197 – 217HelicalAdd BLAST21
Transmembranei247 – 267HelicalAdd BLAST21
Transmembranei324 – 344HelicalAdd BLAST21
Transmembranei363 – 383HelicalAdd BLAST21
Transmembranei437 – 457HelicalAdd BLAST21
Transmembranei461 – 481HelicalAdd BLAST21
Transmembranei549 – 569HelicalAdd BLAST21
Transmembranei976 – 996HelicalAdd BLAST21
Transmembranei1015 – 1035HelicalAdd BLAST21
Transmembranei1088 – 1108HelicalAdd BLAST21
Transmembranei1112 – 1132HelicalAdd BLAST21
Transmembranei1209 – 1229HelicalAdd BLAST21
Transmembranei1238 – 1258HelicalAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002260811 – 1539ABC transporter C family member 14Add BLAST1539

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei894PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9LZJ5.
PRIDEiQ9LZJ5.

PTM databases

iPTMnetiQ9LZJ5.
SwissPalmiQ9LZJ5.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

GenevisibleiQ9LZJ5. AT.

Interactioni

Protein-protein interaction databases

BioGridi10758. 2 interactors.
MINTiMINT-8065758.
STRINGi3702.AT3G62700.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LZJ5.
SMRiQ9LZJ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini324 – 605ABC transmembrane type-1 1Add BLAST282
Domaini639 – 862ABC transporter 1Add BLAST224
Domaini980 – 1260ABC transmembrane type-1 2Add BLAST281
Domaini1297 – 1531ABC transporter 2Add BLAST235

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
InParanoidiQ9LZJ5.
OMAiQFLEQTH.
OrthoDBiEOG0936007A.
PhylomeDBiQ9LZJ5.

Family and domain databases

Gene3Di1.20.1560.10. 2 hits.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9LZJ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRWLSSTWLS DLSCSSSSVI EPSSSLPAPI QWLRFILLSP CPQRLLSSTV
60 70 80 90 100
DVLFLLILFF FAIQKLCSSS SSRTNGEADI TKPLLGRRTR TRTTGLFKTT
110 120 130 140 150
VVVTIVLSFC SLVLCVSAFF TTRTKLKLVD TLFWLIHAVT NVVIAVLVLH
160 170 180 190 200
LKRFASPSHP LTLRIYWVFN FVVTTLFTVS GILHLLSDDP AAASLRADDV
210 220 230 240 250
ASFISFPLTA VLLLVSIKGS TGVVVTTSNV TAPAKSNDVV VEKSENVSLY
260 270 280 290 300
ASASFISKTF WLWMNPLLRK GYKSPLNLDQ VPTLSPEHRA EKLATLFESK
310 320 330 340 350
WPKPQENSRN PVRTTLIRCF WKEIAFTAVL AIIRLSVIYV GPVLIQSFVD
360 370 380 390 400
FTSGKRSSPS QGYYLVLILL IAKFVEVLST HQFNFNSQKL GMLIRSTLIT
410 420 430 440 450
ALYKKGLKLT GSARQNHGVG QIVNYMAVDA QQLSDMMLQL HAIWLMPLQV
460 470 480 490 500
AAAIVLLYNT LGPSVVTTVI GLTGIFVFIL LGTKRNNRYQ FSLMMNRDSR
510 520 530 540 550
MKATNEMLNY MRVIKFQAWE DHFNERILKF REMEFGWLSK FLYSIAGNII
560 570 580 590 600
VLWSTPVLIS ALTFTTAVFL GVKLDAGTVF TTTTIFKILQ EPIRTFPQSM
610 620 630 640 650
ISLSQAMISL GRLDAYMMSR ELSEETVERS QGCDGNVAVE IKDGSFSWDD
660 670 680 690 700
EDDEPAIENI NFEVKKGELA AIVGTVGSGK SSLLASVLGE MHKLSGKVRV
710 720 730 740 750
CGTTAYVAQT SWIQNGTVQD NILFGLPMNR SKYNEVLKVC CLEKDMQIME
760 770 780 790 800
FGDQTEIGER GINLSGGQKQ RIQLARAVYQ ESDVYLLDDV FSAVDAHTGS
810 820 830 840 850
DIFKKCVRGA LKGKTILLVT HQVDFLHNVD RILVMRDGMI VQSGKYDELV
860 870 880 890 900
SSGLDFGELV AAHETSMELV EAGSASATAA NVPMASPITQ RSISIESPRQ
910 920 930 940 950
PKSPKVHRTT SMESPRVLRT TSMESPRLSE LNDESIKSFL GSNIPEDGSR
960 970 980 990 1000
LIKEEEREVG QVSFQVYKLY STEAYGWWGM ILVVFFSVAW QASLMASDYW
1010 1020 1030 1040 1050
LAYETSAKNE VSFDATVFIR VYVIIAAVSI VLVCLRAFYV THLGLKTAQI
1060 1070 1080 1090 1100
FFKQILNSLV HAPMSFFDTT PSGRILSRAS TDQTNVDIFI PFMIGLVATM
1110 1120 1130 1140 1150
YTTLLSIFIV TCQYAWPTVF FIIPLGWLNI WYRGYYLASS RELTRLDSIT
1160 1170 1180 1190 1200
KAPVIHHFSE SIAGVMTIRA FKKQPMFRQE NVKRVNANLR MDFHNNGSNE
1210 1220 1230 1240 1250
WLGFRLELIG SWVLCISALF MVMLPSNIIK PENVGLSLSY GLSLNGVLFW
1260 1270 1280 1290 1300
AIYLSCFIEN KMVSVERIKQ FTDIPAEAKW EIKESRPPPN WPYKGNIRLE
1310 1320 1330 1340 1350
DVKVRYRPNT PLVLKGLTID IKGGEKIGVV GRTGSGKSTL IQVLFRLVEP
1360 1370 1380 1390 1400
SGGKIIIDGI DICTLGLHDL RSRFGIIPQE PVLFEGTVRS NIDPTEKYSD
1410 1420 1430 1440 1450
EEIWKSLERC QLKDVVASKP EKLDSLVADN GENWSVGQRQ LLCLGRVMLK
1460 1470 1480 1490 1500
RSRILFLDEA TASVDSQTDA MIQKIIREDF SDCTIISIAH RIPTVMDCDR
1510 1520 1530
VLVIDAGKAK EYDSPVRLLE RQSLFAALVQ EYALRSAGI
Length:1,539
Mass (Da):172,137
Last modified:October 1, 2000 - v1
Checksum:iBF953EC320330648
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162651 Genomic DNA. Translation: CAB83120.1.
CP002686 Genomic DNA. Translation: AEE80381.1.
PIRiT48059.
RefSeqiNP_191829.1. NM_116135.3.
UniGeneiAt.4827.

Genome annotation databases

EnsemblPlantsiAT3G62700.1; AT3G62700.1; AT3G62700.
GeneIDi825444.
GrameneiAT3G62700.1; AT3G62700.1; AT3G62700.
KEGGiath:AT3G62700.

Similar proteinsi

Entry informationi

Entry nameiAB14C_ARATH
AccessioniPrimary (citable) accession number: Q9LZJ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families