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Protein

Cell division control protein 48 homolog E

Gene

CDC48E

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably functions in cell division and growth processes. Interacts with certain SNAREs as part of specialized membrane fusion events where vesicles from the same organelle fuse (homotypic fusion) (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi248 – 2558ATPSequence analysis
Nucleotide bindingi521 – 5288ATPSequence analysis

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Protein transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-110320. Translesion Synthesis by POLH.
R-ATH-3371511. HSF1 activation.
R-ATH-5358346. Hedgehog ligand biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 48 homolog E
Short name:
AtCDC48e
Alternative name(s):
Transitional endoplasmic reticulum ATPase E
Gene namesi
Name:CDC48E
Ordered Locus Names:At5g03340
ORF Names:F12E4_70
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G03340.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasmcytoskeletonphragmoplast By similarity

  • Note: Primarily localized to the nucleus and, during cytokinesis, to the phragmoplast, a site where membrane vesicles are targeted in the deposition of new cell wall materials.By similarity

GO - Cellular componenti

  • cell wall Source: TAIR
  • cytoskeleton Source: UniProtKB-KW
  • cytosol Source: TAIR
  • Golgi apparatus Source: TAIR
  • nucleus Source: UniProtKB-SubCell
  • phragmoplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 810809Cell division control protein 48 homolog EPRO_0000084583Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei41 – 411PhosphoserineBy similarity

Post-translational modificationi

Ubiquitinated.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9LZF6.
PRIDEiQ9LZF6.

PTM databases

iPTMnetiQ9LZF6.

Expressioni

Gene expression databases

GenevisibleiQ9LZF6. AT.

Interactioni

Protein-protein interaction databases

BioGridi17146. 3 interactions.
IntActiQ9LZF6. 1 interaction.
STRINGi3702.AT5G03340.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LZF6.
SMRiQ9LZF6. Positions 21-767.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0730. Eukaryota.
COG0464. LUCA.
HOGENOMiHOG000223224.
InParanoidiQ9LZF6.
KOiK13525.
OMAiEIFDKPC.
PhylomeDBiQ9LZF6.

Family and domain databases

Gene3Di3.10.330.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR005938. AAA_ATPase_CDC48.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR004201. Cdc48_dom2.
IPR029067. CDC48_domain_2-like.
IPR003338. CDC4_N-term_subdom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
PF02359. CDC48_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM01072. CDC48_2. 1 hit.
SM01073. CDC48_N. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54585. SSF54585. 1 hit.
TIGRFAMsiTIGR01243. CDC48. 1 hit.
PROSITEiPS00674. AAA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LZF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNEPESSDS KTKKDFSTAI LERKKSPNRL VVDEAINDDN SVVSLHPTTM
60 70 80 90 100
EKLQLFRGDT ILIKGKKRKD TVCIALADET CEEPKIRMNK VVRSNLRVRL
110 120 130 140 150
GDVISVHQCP DVKYGKRVHI LPVDDTVEGV TGNLFDAYLK PYFLEAYRPV
160 170 180 190 200
RKGDLFLVRG GMRSVEFKVI ETDPAEYCVV APDTEIFCEG EPVKREDEER
210 220 230 240 250
LDEVGYDDVG GVRKQMAQIR ELVELPLRHP QLFKSIGVKP PKGILLYGPP
260 270 280 290 300
GSGKTLIARA VANETGAFFF CINGPEIMSK LAGESESNLR KAFEEAEKNA
310 320 330 340 350
PSIIFIDEID SIAPKREKTN GEVERRIVSQ LLTLMDGLKS RAHVIVMGAT
360 370 380 390 400
NRPNSIDPAL RRFGRFDREI DIGVPDEIGR LEVLRIHTKN MKLAEDVDLE
410 420 430 440 450
RISKDTHGYV GADLAALCTE AALQCIREKM DVIDLEDDSI DAEILNSMAV
460 470 480 490 500
SNEHFHTALG NSNPSALRET VVEVPNVSWE DIGGLENVKR ELQETVQYPV
510 520 530 540 550
EHPEKFEKFG MSPSKGVLFY GPPGCGKTLL AKAIANECQA NFISVKGPEL
560 570 580 590 600
LTMWFGESEA NVREIFDKAR QSAPCVLFFD ELDSIATQRG NSAGDAGGAA
610 620 630 640 650
DRVLNQLLTE MDGMNAKKTV FIIGATNRPD IIDSALLRPG RLDQLIYIPL
660 670 680 690 700
PDEDSRLNIF KACLRKSPVA KDVDVTALAK YTQGFSGADI TEICQRACKY
710 720 730 740 750
AIRENIEKDI ENERRRSQNP EAMEEDMVDD EVSEIRAAHF EESMKYARRS
760 770 780 790 800
VSDADIRKYQ AFAQTLQQSR GFGSEFRFDS TAGVGRTTGV AAADPFATSA
810
AAADDDDLYS
Length:810
Mass (Da):89,958
Last modified:February 1, 2003 - v2
Checksum:i1E8D08C6C5FA5F68
GO

Sequence cautioni

The sequence CAB83290.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162751 Genomic DNA. Translation: CAB83290.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED90587.1.
AK117125 mRNA. Translation: BAC41803.1.
AK118571 mRNA. Translation: BAC43171.1.
BT006485 mRNA. Translation: AAP21293.1.
RefSeqiNP_568114.1. NM_120412.2.
UniGeneiAt.33291.

Genome annotation databases

EnsemblPlantsiAT5G03340.1; AT5G03340.1; AT5G03340.
GeneIDi831870.
GrameneiAT5G03340.1; AT5G03340.1; AT5G03340.
KEGGiath:AT5G03340.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162751 Genomic DNA. Translation: CAB83290.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED90587.1.
AK117125 mRNA. Translation: BAC41803.1.
AK118571 mRNA. Translation: BAC43171.1.
BT006485 mRNA. Translation: AAP21293.1.
RefSeqiNP_568114.1. NM_120412.2.
UniGeneiAt.33291.

3D structure databases

ProteinModelPortaliQ9LZF6.
SMRiQ9LZF6. Positions 21-767.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi17146. 3 interactions.
IntActiQ9LZF6. 1 interaction.
STRINGi3702.AT5G03340.1.

PTM databases

iPTMnetiQ9LZF6.

Proteomic databases

PaxDbiQ9LZF6.
PRIDEiQ9LZF6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G03340.1; AT5G03340.1; AT5G03340.
GeneIDi831870.
GrameneiAT5G03340.1; AT5G03340.1; AT5G03340.
KEGGiath:AT5G03340.

Organism-specific databases

TAIRiAT5G03340.

Phylogenomic databases

eggNOGiKOG0730. Eukaryota.
COG0464. LUCA.
HOGENOMiHOG000223224.
InParanoidiQ9LZF6.
KOiK13525.
OMAiEIFDKPC.
PhylomeDBiQ9LZF6.

Enzyme and pathway databases

ReactomeiR-ATH-110320. Translesion Synthesis by POLH.
R-ATH-3371511. HSF1 activation.
R-ATH-5358346. Hedgehog ligand biogenesis.

Miscellaneous databases

PROiQ9LZF6.

Gene expression databases

GenevisibleiQ9LZF6. AT.

Family and domain databases

Gene3Di3.10.330.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR005938. AAA_ATPase_CDC48.
IPR009010. Asp_de-COase-like_dom.
IPR003959. ATPase_AAA_core.
IPR003960. ATPase_AAA_CS.
IPR004201. Cdc48_dom2.
IPR029067. CDC48_domain_2-like.
IPR003338. CDC4_N-term_subdom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00004. AAA. 2 hits.
PF02933. CDC48_2. 1 hit.
PF02359. CDC48_N. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
SM01072. CDC48_2. 1 hit.
SM01073. CDC48_N. 1 hit.
[Graphical view]
SUPFAMiSSF50692. SSF50692. 1 hit.
SSF52540. SSF52540. 2 hits.
SSF54585. SSF54585. 1 hit.
TIGRFAMsiTIGR01243. CDC48. 1 hit.
PROSITEiPS00674. AAA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Tandem affinity purification and mass spectrometric analysis of ubiquitylated proteins in Arabidopsis."
    Saracco S.A., Hansson M., Scalf M., Walker J.M., Smith L.M., Vierstra R.D.
    Plant J. 59:344-358(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCD48E_ARATH
AccessioniPrimary (citable) accession number: Q9LZF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: February 17, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.