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Q9LZ86 (P2C66_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable protein phosphatase 2C 66

Short name=AtPP2C66
EC=3.1.3.16
Alternative name(s):
Protein POLTERGEIST-LIKE 2
Protein phosphatase 2C PLL2
Short name=PP2C PLL2
Gene names
Name:PLL2
Ordered Locus Names:At5g02400
ORF Names:T1E22.160
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length674 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity.

Subcellular location

Nucleus Potential.

Tissue specificity

Expressed at low level in seedlings, roots, leaves, stems, young inflorescences, flowers and siliques. Ref.3

Domain

The conserved PP2C phosphatase domain (244-663) is interrupted by an insertion of approximately 100 amino acids.

Disruption phenotype

No visible phenotype. Ref.3

Sequence similarities

Belongs to the PP2C family.

Contains 1 PP2C-like domain.

Ontologies

Keywords
   Cellular componentNucleus
   LigandMagnesium
Manganese
Metal-binding
   Molecular functionHydrolase
Protein phosphatase
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoprotein phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 674674Probable protein phosphatase 2C 66
PRO_0000301260

Regions

Domain322 – 637316PP2C-like

Sites

Metal binding2821Manganese 1 By similarity
Metal binding2821Manganese 2 By similarity
Metal binding2831Manganese 1; via carbonyl oxygen By similarity
Metal binding5931Manganese 2 By similarity
Metal binding6561Manganese 2 By similarity

Amino acid modifications

Modified residue1251Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9LZ86 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: CA2DE97E69791B0D

FASTA67474,838
        10         20         30         40         50         60 
MGNGVTTLTG CCTGTLAGEI SRRYDVSLVH DGLGHSFCYI RPDLPGVVLP SPESPLRSDH 

        70         80         90        100        110        120 
IQETTFRSIS GASVSANPST ALSGALSSDS DCPYSSAVSA SAFESSGNFA SLPLQPVPRG 

       130        140        150        160        170        180 
STWQSGPIVN ESGLGSAPFE RRFLSGPIES GLYSGPIEST KKTEKEKPKK IRKKPKSKKN 

       190        200        210        220        230        240 
FLTFKTLFAN LISNNNKPRL KKSVIEPING SDSSDSGRLH HEPVITSSRS NENPKSDLEE 

       250        260        270        280        290        300 
EDEKQSMNSV LDVQWAQGKA GEDRVHVVVS EDNGWVFVGI YDGFSGPDAP DYLLNNLYTA 

       310        320        330        340        350        360 
VQKELNGLLW NDEKLRSLGE NGMTKTGKCS DEEDPESGKE NCPVINNDDA VASGARNQAK 

       370        380        390        400        410        420 
SLKWRCEWEK KSNNKTKSDN RCDQKGSNST TTNHKDVLKA LLQALRKTED AYLELADQMV 

       430        440        450        460        470        480 
KENPELALMG SCVLVTLMKG EDVYVMNVGD SRAVLGRKPN LATGRKRQKE LERIREDSSL 

       490        500        510        520        530        540 
EDKEILMNGA MRNTLVPLQL NMEHSTRIEE EVRRIKKEHP DDDCAVENDR VKGYLKVTRA 

       550        560        570        580        590        600 
FGAGFLKQPK WNDALLEMFR IDYIGTSPYI TCSPSLCHHK LTSRDKFLIL SSDGLYEYFS 

       610        620        630        640        650        660 
NQEAIFEVES FISAFPEGDP AQHLIQEVLL RAANKFGMDF HELLEIPQGD RRRYHDDVSV 

       670 
IVISLEGRIW RSSM 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K. expand/collapse author list , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"POL and related phosphatases are dosage-sensitive regulators of meristem and organ development in Arabidopsis."
Song S.-K., Clark S.E.
Dev. Biol. 285:272-284(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, GENE FAMILY, NOMENCLATURE, DISRUPTION PHENOTYPE.
[4]"Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL162874 Genomic DNA. Translation: CAB85545.1.
CP002688 Genomic DNA. Translation: AED90468.1.
PIRT48261.
RefSeqNP_195860.1. NM_120318.1.
UniGeneAt.54686.

3D structure databases

ProteinModelPortalQ9LZ86.
SMRQ9LZ86. Positions 396-669.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT5G02400.1-P.

Proteomic databases

PRIDEQ9LZ86.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT5G02400.1; AT5G02400.1; AT5G02400.
GeneID830937.
KEGGath:AT5G02400.

Organism-specific databases

TAIRAT5G02400.

Phylogenomic databases

eggNOGNOG289757.
HOGENOMHOG000239375.
InParanoidQ9LZ86.
OMACAVENDR.
PhylomeDBQ9LZ86.
ProtClustDBCLSN2685134.

Enzyme and pathway databases

BioCycARA:AT5G02400-MONOMER.

Gene expression databases

GenevestigatorQ9LZ86.

Family and domain databases

Gene3D3.60.40.10. 3 hits.
InterProIPR001932. PP2C-like_dom.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERPTHR13832. PTHR13832. 1 hit.
PfamPF00481. PP2C. 1 hit.
[Graphical view]
SMARTSM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMSSF81606. SSF81606. 3 hits.
ProtoNetSearch...

Entry information

Entry nameP2C66_ARATH
AccessionPrimary (citable) accession number: Q9LZ86
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names