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Protein

Glutathione S-transferase L3

Gene

GSTL3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the glutathione-dependent reduction of S-glutathionylquercetin to quercetin.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • response to cadmium ion Source: TAIR
  • response to toxic substance Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Detoxification

Enzyme and pathway databases

ReactomeiREACT_301198. Glutathione conjugation.
REACT_304012. Vitamin C (ascorbate) metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase L3 (EC:2.5.1.18)
Short name:
AtGSTL3
Alternative name(s):
GST class-lambda member 3
Gene namesi
Name:GSTL3
Ordered Locus Names:At5g02790
ORF Names:F9G14.100
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G02790.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235Glutathione S-transferase L3PRO_0000413579Add
BLAST

Proteomic databases

PRIDEiQ9LZ06.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G02790.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LZ06.
SMRiQ9LZ06. Positions 9-235.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 10882GST N-terminalAdd
BLAST
Domaini86 – 230145GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni37 – 382Glutathione bindingBy similarity
Regioni65 – 662Glutathione bindingBy similarity
Regioni79 – 802Glutathione bindingBy similarity
Regioni92 – 932Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Lambda family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000239968.
InParanoidiQ9LZ06.
KOiK00799.
OMAiFRMIDIT.
PhylomeDBiQ9LZ06.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9LZ06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPSFIFVED RPAPLDATSD PPSLFDGTTR LYTSYVCPFA QRVWITRNFK
60 70 80 90 100
GLQEKIKLVP LDLGNRPAWY KEKVYPENKV PALEHNGKII GESLDLIKYL
110 120 130 140 150
DNTFEGPSLY PEDHAKREFG DELLKYTDTF VKTMYVSLKG DPSKETAPVL
160 170 180 190 200
DYLENALYKF DDGPFFLGQL SLVDIAYIPF IERFQTVLNE LFKCDITAER
210 220 230
PKLSAWIEEI NKSDGYAQTK MDPKEIVEVF KKKFM
Length:235
Mass (Da):27,090
Last modified:October 1, 2000 - v1
Checksum:i52713E37176B2EB6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti189 – 1891N → D in AAM61679 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162973 Genomic DNA. Translation: CAB86033.1.
CP002688 Genomic DNA. Translation: AED90518.1.
AY140069 mRNA. Translation: AAM98210.1.
BT002166 mRNA. Translation: AAN72177.1.
AK227162 mRNA. Translation: BAE99204.1.
AY085126 mRNA. Translation: AAM61679.1.
PIRiT48300.
RefSeqiNP_195899.1. NM_120357.5.
UniGeneiAt.33363.

Genome annotation databases

EnsemblPlantsiAT5G02790.1; AT5G02790.1; AT5G02790.
GeneIDi831798.
KEGGiath:AT5G02790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162973 Genomic DNA. Translation: CAB86033.1.
CP002688 Genomic DNA. Translation: AED90518.1.
AY140069 mRNA. Translation: AAM98210.1.
BT002166 mRNA. Translation: AAN72177.1.
AK227162 mRNA. Translation: BAE99204.1.
AY085126 mRNA. Translation: AAM61679.1.
PIRiT48300.
RefSeqiNP_195899.1. NM_120357.5.
UniGeneiAt.33363.

3D structure databases

ProteinModelPortaliQ9LZ06.
SMRiQ9LZ06. Positions 9-235.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G02790.1.

Proteomic databases

PRIDEiQ9LZ06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G02790.1; AT5G02790.1; AT5G02790.
GeneIDi831798.
KEGGiath:AT5G02790.

Organism-specific databases

TAIRiAT5G02790.

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000239968.
InParanoidiQ9LZ06.
KOiK00799.
OMAiFRMIDIT.
PhylomeDBiQ9LZ06.

Enzyme and pathway databases

ReactomeiREACT_301198. Glutathione conjugation.
REACT_304012. Vitamin C (ascorbate) metabolism.

Miscellaneous databases

PROiQ9LZ06.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Roles for stress-inducible lambda glutathione transferases in flavonoid metabolism in plants as identified by ligand fishing."
    Dixon D.P., Edwards R.
    J. Biol. Chem. 285:36322-36329(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGSTL3_ARATH
AccessioniPrimary (citable) accession number: Q9LZ06
Secondary accession number(s): Q8LF01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 1, 2000
Last modified: June 24, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.