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Protein

ABC transporter C family member 10

Gene

ABCC10

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Pump for glutathione S-conjugates.By similarity

Catalytic activityi

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi637 – 644ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1241 – 1248ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G59140-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter C family member 10 (EC:3.6.3.44)
Short name:
ABC transporter ABCC.10
Short name:
AtABCC10
Alternative name(s):
ATP-energized glutathione S-conjugate pump 14
Glutathione S-conjugate-transporting ATPase 14
Multidrug resistance-associated protein 14
Gene namesi
Name:ABCC10
Synonyms:MRP10, MRP14
Ordered Locus Names:At3g59140
ORF Names:F17J16.190
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G59140.
TAIRilocus:2077750. AT3G59140.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei23 – 43HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei58 – 78HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei87 – 107HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei124 – 144HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei147 – 167HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei290 – 310HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei312 – 332HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei415 – 435HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei511 – 531HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei889 – 909HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei925 – 945HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei993 – 1013HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1020 – 1040HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei1128 – 1148HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002260851 – 1453ABC transporter C family member 10Add BLAST1453

Proteomic databases

PaxDbiQ9LYS2.

PTM databases

iPTMnetiQ9LYS2.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

GenevisibleiQ9LYS2. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G59140.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LYS2.
SMRiQ9LYS2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 566ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST282
Domaini603 – 825ABC transporter 1PROSITE-ProRule annotationAdd BLAST223
Domaini886 – 1170ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST285
Domaini1207 – 1441ABC transporter 2PROSITE-ProRule annotationAdd BLAST235

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0054. Eukaryota.
COG1132. LUCA.
InParanoidiQ9LYS2.
OMAiYYFTGIN.
OrthoDBiEOG093600AY.

Family and domain databases

Gene3Di1.20.1560.10. 2 hits.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
SMARTiView protein in SMART
SM00382. AAA. 2 hits.
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9LYS2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIENYWTSFC GNHHTSSNCT VRFLQICFGI TLSFLTLCIC LFHKEPPKRI
60 70 80 90 100
HQFFCLRLVS ALFNGIIGSL DLVLGIWVLR ENHSKPLILW LVILIQGFTW
110 120 130 140 150
LFINLIICVR GTRIRKSSLR LLSIFSFFYG LVSSCLSVNN AVFGDELAVR
160 170 180 190 200
TILDVLLLPG SVLLLLSAYK GYRFDESGES SLYEPLNAGD SNGFSEKADF
210 220 230 240 250
DNRVSQFAKA GLFSTLSFWW LNSLIKRGNV KDLEEEDIPE LRKEERAETC
260 270 280 290 300
YSLFEENLIE QKRRLGSSCQ PSILKVTVLC VWRELLTSGF FAFMKIVAVS
310 320 330 340 350
AGPLLLNAFI LVAEGNASFR YEGLVLAVLL FFSKMIESLS QRQWYFRCRI
360 370 380 390 400
VGLRVRSLLT AAINKKQLRL NNSSRLIHSG SEIMNYATVD AYRIGEFPYW
410 420 430 440 450
FHQLWTTSFQ LLIALGILFH SVGVATFSAL AVIILTVLCN APIAKLQNKF
460 470 480 490 500
QSELMTSQDE RLKACNESLV NMKVLKLYAW ESHFKKVIEK LRNIELKSLK
510 520 530 540 550
AVQMRKAYNA VLFWSSPVFV SAATFATCYF LDIPLRASNV FTFVATLRLV
560 570 580 590 600
QDPVRMIPDV IGVTIQAKVA FSRIATFLEA PELQGGERRR KQRSEGNQNA
610 620 630 640 650
IIIKSASFSW EEKGSTKPNL RNVSLEVKFG EKVAVCGEVG SGKSTLLAAI
660 670 680 690 700
LGETPCVSGT IDFYGTIAYV SQTAWIQTGT IRDNILFGGV MDEHRYRETI
710 720 730 740 750
QKSSLDKDLE LLPDGDQTEI GERGVNLSGG QKQRIQLARA LYQDADIYLL
760 770 780 790 800
DDPFSAVDAH TASSLFQEYV MDALAGKAVL LVTHQVDFLP AFDSVLLMSD
810 820 830 840 850
GEITEADTYQ ELLARSRDFQ DLVNAHRETA GSERVVAVEN PTKPVKEINR
860 870 880 890 900
VISSQSKVLK PSRLIKQEER EKGDTGLRPY IQYMNQNKGY IFFFIASLAQ
910 920 930 940 950
VTFAVGQILQ NSWMAANVDN PQVSTLKLIL VYLLIGLCSV LCLMVRSVCV
960 970 980 990 1000
VIMCMKSSAS LFSQLLNSLF RAPMSFYDST PLGRILSRVS SDLSIVDLDV
1010 1020 1030 1040 1050
PFGLIFVVAS SVNTGCSLGV LAIVTWQVLF VSVPMVYLAF RLQKYYFQTA
1060 1070 1080 1090 1100
KELMRINGTT RSYVANHLAE SVAGAITIRA FDEEERFFKK SLTLIDTNAS
1110 1120 1130 1140 1150
PFFHSFAANE WLIQRLETVS AIVLASTAFC MILLPTGTFS SGFIGMALSY
1160 1170 1180 1190 1200
GLSLNMGLVY SVQNQCYLAN WIISVERLNQ YTHLTPEAPE VIEETRPPVN
1210 1220 1230 1240 1250
WPVTGRVEIS DLQIRYRRES PLVLKGISCT FEGGHKIGIV GRTGSGKTTL
1260 1270 1280 1290 1300
ISALFRLVEP VGGKIVVDGV DISKIGVHDL RSRFGIIPQD PTLFNGTVRF
1310 1320 1330 1340 1350
NLDPLCQHSD AEIWEVLGKC QLKEVVQEKE NGLDSLVVED GSNWSMGQRQ
1360 1370 1380 1390 1400
LFCLGRAVLR RSRVLVLDEA TASIDNATDL ILQKTIRREF ADCTVITVAH
1410 1420 1430 1440 1450
RIPTVMDCTM VLSISDGRIV EYDEPMKLMK DENSLFGKLV KEYWSHYNSA

DSR
Length:1,453
Mass (Da):162,813
Last modified:January 25, 2012 - v2
Checksum:iCB663426426A9970
GO

Sequence cautioni

Q9LYS2: The sequence CAB86942 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL163527 Genomic DNA. Translation: CAB86942.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE79882.1.
PIRiT47796.
RefSeqiNP_191473.2. NM_115776.4.
UniGeneiAt.34659.

Genome annotation databases

EnsemblPlantsiAT3G59140.1; AT3G59140.1; AT3G59140.
GeneIDi825083.
GrameneiAT3G59140.1; AT3G59140.1; AT3G59140.
KEGGiath:AT3G59140.

Similar proteinsi

Entry informationi

Entry nameiAB10C_ARATH
AccessioniPrimary (citable) accession number: Q9LYS2
Secondary accession number(s): F4J869
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 25, 2012
Last modified: October 25, 2017
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families