Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9LYS2 (AB10C_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ABC transporter C family member 10
Short name=ABC transporter ABCC.10
Short name=AtABCC10
EC=3.6.3.44
Alternative name(s):
ATP-energized glutathione S-conjugate pump 14
Glutathione S-conjugate-transporting ATPase 14
Multidrug resistance-associated protein 14
Gene names
Name:ABCC10
Synonyms:MRP10, MRP14
Ordered Locus Names:At3g59140
ORF Names:F17J16.190
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length1453 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Pump for glutathione S-conjugates By similarity.

Catalytic activity

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Ubiquitous. Ref.5

Sequence similarities

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Sequence caution

The sequence CAB86942.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

vacuolar membrane

Inferred from direct assay. Source: TAIR

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

xenobiotic-transporting ATPase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14531453ABC transporter C family member 10
PRO_0000226085

Regions

Transmembrane23 – 4321Helical; Potential
Transmembrane58 – 7821Helical; Potential
Transmembrane87 – 10721Helical; Potential
Transmembrane124 – 14421Helical; Potential
Transmembrane147 – 16721Helical; Potential
Transmembrane290 – 31021Helical; Potential
Transmembrane312 – 33221Helical; Potential
Transmembrane415 – 43521Helical; Potential
Transmembrane511 – 53121Helical; Potential
Transmembrane889 – 90921Helical; Potential
Transmembrane925 – 94521Helical; Potential
Transmembrane993 – 101321Helical; Potential
Transmembrane1020 – 104021Helical; Potential
Transmembrane1128 – 114821Helical; Potential
Domain285 – 566282ABC transmembrane type-1 1
Domain603 – 825223ABC transporter 1
Domain886 – 1170285ABC transmembrane type-1 2
Domain1207 – 1441235ABC transporter 2
Nucleotide binding637 – 6448ATP 1 Potential
Nucleotide binding1241 – 12488ATP 2 Potential

Sequences

Sequence LengthMass (Da)Tools
Q9LYS2 [UniParc].

Last modified January 25, 2012. Version 2.
Checksum: CB663426426A9970

FASTA1,453162,813
        10         20         30         40         50         60 
MIENYWTSFC GNHHTSSNCT VRFLQICFGI TLSFLTLCIC LFHKEPPKRI HQFFCLRLVS 

        70         80         90        100        110        120 
ALFNGIIGSL DLVLGIWVLR ENHSKPLILW LVILIQGFTW LFINLIICVR GTRIRKSSLR 

       130        140        150        160        170        180 
LLSIFSFFYG LVSSCLSVNN AVFGDELAVR TILDVLLLPG SVLLLLSAYK GYRFDESGES 

       190        200        210        220        230        240 
SLYEPLNAGD SNGFSEKADF DNRVSQFAKA GLFSTLSFWW LNSLIKRGNV KDLEEEDIPE 

       250        260        270        280        290        300 
LRKEERAETC YSLFEENLIE QKRRLGSSCQ PSILKVTVLC VWRELLTSGF FAFMKIVAVS 

       310        320        330        340        350        360 
AGPLLLNAFI LVAEGNASFR YEGLVLAVLL FFSKMIESLS QRQWYFRCRI VGLRVRSLLT 

       370        380        390        400        410        420 
AAINKKQLRL NNSSRLIHSG SEIMNYATVD AYRIGEFPYW FHQLWTTSFQ LLIALGILFH 

       430        440        450        460        470        480 
SVGVATFSAL AVIILTVLCN APIAKLQNKF QSELMTSQDE RLKACNESLV NMKVLKLYAW 

       490        500        510        520        530        540 
ESHFKKVIEK LRNIELKSLK AVQMRKAYNA VLFWSSPVFV SAATFATCYF LDIPLRASNV 

       550        560        570        580        590        600 
FTFVATLRLV QDPVRMIPDV IGVTIQAKVA FSRIATFLEA PELQGGERRR KQRSEGNQNA 

       610        620        630        640        650        660 
IIIKSASFSW EEKGSTKPNL RNVSLEVKFG EKVAVCGEVG SGKSTLLAAI LGETPCVSGT 

       670        680        690        700        710        720 
IDFYGTIAYV SQTAWIQTGT IRDNILFGGV MDEHRYRETI QKSSLDKDLE LLPDGDQTEI 

       730        740        750        760        770        780 
GERGVNLSGG QKQRIQLARA LYQDADIYLL DDPFSAVDAH TASSLFQEYV MDALAGKAVL 

       790        800        810        820        830        840 
LVTHQVDFLP AFDSVLLMSD GEITEADTYQ ELLARSRDFQ DLVNAHRETA GSERVVAVEN 

       850        860        870        880        890        900 
PTKPVKEINR VISSQSKVLK PSRLIKQEER EKGDTGLRPY IQYMNQNKGY IFFFIASLAQ 

       910        920        930        940        950        960 
VTFAVGQILQ NSWMAANVDN PQVSTLKLIL VYLLIGLCSV LCLMVRSVCV VIMCMKSSAS 

       970        980        990       1000       1010       1020 
LFSQLLNSLF RAPMSFYDST PLGRILSRVS SDLSIVDLDV PFGLIFVVAS SVNTGCSLGV 

      1030       1040       1050       1060       1070       1080 
LAIVTWQVLF VSVPMVYLAF RLQKYYFQTA KELMRINGTT RSYVANHLAE SVAGAITIRA 

      1090       1100       1110       1120       1130       1140 
FDEEERFFKK SLTLIDTNAS PFFHSFAANE WLIQRLETVS AIVLASTAFC MILLPTGTFS 

      1150       1160       1170       1180       1190       1200 
SGFIGMALSY GLSLNMGLVY SVQNQCYLAN WIISVERLNQ YTHLTPEAPE VIEETRPPVN 

      1210       1220       1230       1240       1250       1260 
WPVTGRVEIS DLQIRYRRES PLVLKGISCT FEGGHKIGIV GRTGSGKTTL ISALFRLVEP 

      1270       1280       1290       1300       1310       1320 
VGGKIVVDGV DISKIGVHDL RSRFGIIPQD PTLFNGTVRF NLDPLCQHSD AEIWEVLGKC 

      1330       1340       1350       1360       1370       1380 
QLKEVVQEKE NGLDSLVVED GSNWSMGQRQ LFCLGRAVLR RSRVLVLDEA TASIDNATDL 

      1390       1400       1410       1420       1430       1440 
ILQKTIRREF ADCTVITVAH RIPTVMDCTM VLSISDGRIV EYDEPMKLMK DENSLFGKLV 

      1450 
KEYWSHYNSA DSR

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. expand/collapse author list , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
Nature 408:820-822(2000) [PubMed: 11130713] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"The Arabidopsis thaliana ABC protein superfamily, a complete inventory."
Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.
J. Biol. Chem. 276:30231-30244(2001) [PubMed: 11346655] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[4]"Multifunctionality of plant ABC transporters -- more than just detoxifiers."
Martinoia E., Klein M., Geisler M., Bovet L., Forestier C., Kolukisaoglu H.U., Mueller-Roeber B., Schulz B.
Planta 214:345-355(2002) [PubMed: 11855639] [Abstract]
Cited for: GENE FAMILY.
[5]"Family business: the multidrug-resistance related protein (MRP) ABC transporter genes in Arabidopsis thaliana."
Kolukisaoglu U.H., Bovet L., Klein M., Eggmann T., Geisler M., Wanke D., Martinoia E., Schulz B.
Planta 216:107-119(2002) [PubMed: 12430019] [Abstract]
Cited for: TISSUE SPECIFICITY.
[6]"Plant ABC proteins - a unified nomenclature and updated inventory."
Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M., Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A., Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.
Trends Plant Sci. 13:151-159(2008) [PubMed: 18299247] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AL163527 Genomic DNA. Translation: CAB86942.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE79882.1.
IPIIPI00539087.
PIRT47796.

3D structure databases

ProteinModelPortalQ9LYS2.
SMRQ9LYS2. Positions 210-763, 813-1380.
ModBaseSearch...

Proteomic databases

PRIDEQ9LYS2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G59140.1; AT3G59140.1; AT3G59140.
GenomeReviewsGene locus AT3G59140 in contig BA000014_GR.

Organism-specific databases

TAIRAt3g59140.

Phylogenomic databases

eggNOGKOG0054.
GeneTreeEPGT00070000028299.
HOGENOMHBG758042.
InParanoidQ9LYS2.
PhylomeDBQ9LYS2.

Gene expression databases

GenevestigatorQ9LYS2.
GermOnlineAT3G59140. Arabidopsis thaliana.

Family and domain databases

InterProIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
IPR001140. ABC_transptr_TM_dom.
IPR011527. ABC_transptrTM_dom_typ1.
IPR003593. ATPase_AAA+_core.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF90123. ABC_TM_1. 2 hits.
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAB10C_ARATH
AccessionPrimary (citable) accession number: Q9LYS2
Secondary accession number(s): F4J869
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: January 25, 2012
Last modified: January 25, 2012
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents