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Q9LYQ2

- LAC13_ARATH

UniProt

Q9LYQ2 - LAC13_ARATH

Protein

Laccase-13

Gene

LAC13

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Lignin degradation and detoxification of lignin-derived products.By similarity

    Catalytic activityi

    4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

    Cofactori

    Binds 4 copper ions per monomer.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi79 – 791Copper 1; type 2By similarity
    Metal bindingi81 – 811Copper 2; type 3By similarity
    Metal bindingi124 – 1241Copper 2; type 3By similarity
    Metal bindingi126 – 1261Copper 3; type 3By similarity
    Metal bindingi470 – 4701Copper 4; type 1By similarity
    Metal bindingi473 – 4731Copper 1; type 2By similarity
    Metal bindingi475 – 4751Copper 3; type 3By similarity
    Metal bindingi532 – 5321Copper 3; type 3By similarity
    Metal bindingi533 – 5331Copper 4; type 1By similarity
    Metal bindingi534 – 5341Copper 2; type 3By similarity
    Metal bindingi538 – 5381Copper 4; type 1By similarity

    GO - Molecular functioni

    1. copper ion binding Source: InterPro
    2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lignin catabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Lignin degradation

    Keywords - Ligandi

    Copper, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT5G07130-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Laccase-13 (EC:1.10.3.2)
    Alternative name(s):
    Benzenediol:oxygen oxidoreductase 13
    Diphenol oxidase 13
    Urishiol oxidase 13
    Gene namesi
    Name:LAC13
    Ordered Locus Names:At5g07130
    ORF Names:T28J14.70
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G07130.

    Subcellular locationi

    GO - Cellular componenti

    1. apoplast Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Apoplast, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 569548Laccase-13PRO_0000283641Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Expressioni

    Tissue specificityi

    Mostly expressed in roots. Also detected in leaves, stems and flowers but not in siliques.1 Publication

    Gene expression databases

    GenevestigatoriQ9LYQ2.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT5G07130.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LYQ2.
    SMRiQ9LYQ2. Positions 39-548.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 145117Plastocyanin-like 1Add
    BLAST
    Domaini157 – 308152Plastocyanin-like 2Add
    BLAST
    Domaini418 – 553136Plastocyanin-like 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the multicopper oxidase family.Curated
    Contains 3 plastocyanin-like domains.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG2132.
    HOGENOMiHOG000241916.
    InParanoidiQ9LYQ2.
    OMAiKNALNER.
    PhylomeDBiQ9LYQ2.

    Family and domain databases

    Gene3Di2.60.40.420. 3 hits.
    InterProiIPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view]
    PfamiPF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF49503. SSF49503. 3 hits.
    TIGRFAMsiTIGR03389. laccase. 1 hit.
    PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9LYQ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEQLRPFFLL LAIFVASLVN AEVHFHEFVI QETPVKRLCR VHNSITVNGQ    50
    FPGPTLEVRN GDSLVITAIN KARYNISLHW HGIRQMRNPW ADGPEYITQC 100
    PIQPGGSYTY RFTMEDQEGT LWWHAHSRWL RATVYGALII RPPLSSPHYP 150
    FPVIPKREIT LLLGEWWDRN PMDVLNLAQF TGAAPNISDA FTINGQPGDL 200
    YRCSSQETLR FLVGSGEIVL LRVINSALNQ ELFFGVANHK LTVVAADASY 250
    TKPFSTNVIM LGPGQTTDVL LTADQPPAHY YMAAHAYNSA NAAFDNTTTT 300
    AILKYKDASC VTLQAKSQAR AIPAQLPGFN DTATAAAFTA QMKSPSKVKV 350
    PLEIDENLFF TVGLGLFNCP TPNTQRCQGP NGTRFTASIN NVSFVFPKQN 400
    SIMQAYYQGT PTGVFTTDFP PTPPVTFDYT GNVSRGLWQP TRGTKAYKLK 450
    FNSQVQIILQ DTSIVTTENH PMHLHGYEFY VVGTGVGNFN PNTDTSSFNL 500
    IDPPRRNTIG TPPGGWVAIR FVANNPGAWL MHCHIDSHIF WGLAMVFLVE 550
    NGEGHLQSVQ SPPLDLPQC 569
    Length:569
    Mass (Da):63,145
    Last modified:October 1, 2000 - v1
    Checksum:iDB618A13E0E2881B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL163652 Genomic DNA. Translation: CAB87269.1.
    CP002688 Genomic DNA. Translation: AED91113.1.
    PIRiT48484.
    RefSeqiNP_196330.3. NM_120795.4.
    UniGeneiAt.5043.

    Genome annotation databases

    EnsemblPlantsiAT5G07130.1; AT5G07130.1; AT5G07130.
    GeneIDi830604.
    KEGGiath:AT5G07130.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL163652 Genomic DNA. Translation: CAB87269.1 .
    CP002688 Genomic DNA. Translation: AED91113.1 .
    PIRi T48484.
    RefSeqi NP_196330.3. NM_120795.4.
    UniGenei At.5043.

    3D structure databases

    ProteinModelPortali Q9LYQ2.
    SMRi Q9LYQ2. Positions 39-548.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT5G07130.1-P.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G07130.1 ; AT5G07130.1 ; AT5G07130 .
    GeneIDi 830604.
    KEGGi ath:AT5G07130.

    Organism-specific databases

    TAIRi AT5G07130.

    Phylogenomic databases

    eggNOGi COG2132.
    HOGENOMi HOG000241916.
    InParanoidi Q9LYQ2.
    OMAi KNALNER.
    PhylomeDBi Q9LYQ2.

    Enzyme and pathway databases

    BioCyci ARA:AT5G07130-MONOMER.

    Gene expression databases

    Genevestigatori Q9LYQ2.

    Family and domain databases

    Gene3Di 2.60.40.420. 3 hits.
    InterProi IPR001117. Cu-oxidase.
    IPR011706. Cu-oxidase_2.
    IPR011707. Cu-oxidase_3.
    IPR002355. Cu_oxidase_Cu_BS.
    IPR008972. Cupredoxin.
    IPR017761. Laccase.
    [Graphical view ]
    Pfami PF00394. Cu-oxidase. 1 hit.
    PF07731. Cu-oxidase_2. 1 hit.
    PF07732. Cu-oxidase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49503. SSF49503. 3 hits.
    TIGRFAMsi TIGR03389. laccase. 1 hit.
    PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
    PS00080. MULTICOPPER_OXIDASE2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
      Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
      , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
      Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
      Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
      J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiLAC13_ARATH
    AccessioniPrimary (citable) accession number: Q9LYQ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3