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Q9LYQ2

- LAC13_ARATH

UniProt

Q9LYQ2 - LAC13_ARATH

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Protein

Laccase-13

Gene

LAC13

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi79 – 791Copper 1; type 2By similarity
Metal bindingi81 – 811Copper 2; type 3By similarity
Metal bindingi124 – 1241Copper 2; type 3By similarity
Metal bindingi126 – 1261Copper 3; type 3By similarity
Metal bindingi470 – 4701Copper 4; type 1By similarity
Metal bindingi473 – 4731Copper 1; type 2By similarity
Metal bindingi475 – 4751Copper 3; type 3By similarity
Metal bindingi532 – 5321Copper 3; type 3By similarity
Metal bindingi533 – 5331Copper 4; type 1By similarity
Metal bindingi534 – 5341Copper 2; type 3By similarity
Metal bindingi538 – 5381Copper 4; type 1By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G07130-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-13 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 13
Diphenol oxidase 13
Urishiol oxidase 13
Gene namesi
Name:LAC13
Ordered Locus Names:At5g07130
ORF Names:T28J14.70
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G07130.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 569548Laccase-13PRO_0000283641Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi75 – 751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi296 – 2961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi330 – 3301N-linked (GlcNAc...)Sequence Analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi391 – 3911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi432 – 4321N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Mostly expressed in roots. Also detected in leaves, stems and flowers but not in siliques.1 Publication

Gene expression databases

GenevestigatoriQ9LYQ2.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G07130.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LYQ2.
SMRiQ9LYQ2. Positions 39-548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 145117Plastocyanin-like 1Add
BLAST
Domaini157 – 308152Plastocyanin-like 2Add
BLAST
Domaini418 – 553136Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ9LYQ2.
OMAiKNALNER.
PhylomeDBiQ9LYQ2.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LYQ2 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEQLRPFFLL LAIFVASLVN AEVHFHEFVI QETPVKRLCR VHNSITVNGQ
60 70 80 90 100
FPGPTLEVRN GDSLVITAIN KARYNISLHW HGIRQMRNPW ADGPEYITQC
110 120 130 140 150
PIQPGGSYTY RFTMEDQEGT LWWHAHSRWL RATVYGALII RPPLSSPHYP
160 170 180 190 200
FPVIPKREIT LLLGEWWDRN PMDVLNLAQF TGAAPNISDA FTINGQPGDL
210 220 230 240 250
YRCSSQETLR FLVGSGEIVL LRVINSALNQ ELFFGVANHK LTVVAADASY
260 270 280 290 300
TKPFSTNVIM LGPGQTTDVL LTADQPPAHY YMAAHAYNSA NAAFDNTTTT
310 320 330 340 350
AILKYKDASC VTLQAKSQAR AIPAQLPGFN DTATAAAFTA QMKSPSKVKV
360 370 380 390 400
PLEIDENLFF TVGLGLFNCP TPNTQRCQGP NGTRFTASIN NVSFVFPKQN
410 420 430 440 450
SIMQAYYQGT PTGVFTTDFP PTPPVTFDYT GNVSRGLWQP TRGTKAYKLK
460 470 480 490 500
FNSQVQIILQ DTSIVTTENH PMHLHGYEFY VVGTGVGNFN PNTDTSSFNL
510 520 530 540 550
IDPPRRNTIG TPPGGWVAIR FVANNPGAWL MHCHIDSHIF WGLAMVFLVE
560
NGEGHLQSVQ SPPLDLPQC
Length:569
Mass (Da):63,145
Last modified:October 1, 2000 - v1
Checksum:iDB618A13E0E2881B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL163652 Genomic DNA. Translation: CAB87269.1.
CP002688 Genomic DNA. Translation: AED91113.1.
PIRiT48484.
RefSeqiNP_196330.3. NM_120795.4.
UniGeneiAt.5043.

Genome annotation databases

EnsemblPlantsiAT5G07130.1; AT5G07130.1; AT5G07130.
GeneIDi830604.
KEGGiath:AT5G07130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL163652 Genomic DNA. Translation: CAB87269.1 .
CP002688 Genomic DNA. Translation: AED91113.1 .
PIRi T48484.
RefSeqi NP_196330.3. NM_120795.4.
UniGenei At.5043.

3D structure databases

ProteinModelPortali Q9LYQ2.
SMRi Q9LYQ2. Positions 39-548.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT5G07130.1-P.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G07130.1 ; AT5G07130.1 ; AT5G07130 .
GeneIDi 830604.
KEGGi ath:AT5G07130.

Organism-specific databases

TAIRi AT5G07130.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000241916.
InParanoidi Q9LYQ2.
OMAi KNALNER.
PhylomeDBi Q9LYQ2.

Enzyme and pathway databases

BioCyci ARA:AT5G07130-MONOMER.

Gene expression databases

Genevestigatori Q9LYQ2.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 3 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
PROSITEi PS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
    Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
    J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAC13_ARATH
AccessioniPrimary (citable) accession number: Q9LYQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3