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Protein

Laccase-13

Gene

LAC13

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi79Copper 1; type 2By similarity1
Metal bindingi81Copper 2; type 3By similarity1
Metal bindingi124Copper 2; type 3By similarity1
Metal bindingi126Copper 3; type 3By similarity1
Metal bindingi470Copper 4; type 1By similarity1
Metal bindingi473Copper 1; type 2By similarity1
Metal bindingi475Copper 3; type 3By similarity1
Metal bindingi532Copper 3; type 3By similarity1
Metal bindingi533Copper 4; type 1By similarity1
Metal bindingi534Copper 2; type 3By similarity1
Metal bindingi538Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G07130-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-13 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 13
Diphenol oxidase 13
Urishiol oxidase 13
Gene namesi
Name:LAC13
Ordered Locus Names:At5g07130
ORF Names:T28J14.70
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G07130.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000028364122 – 569Laccase-13Add BLAST548

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...)Sequence analysis1
Glycosylationi186N-linked (GlcNAc...)Sequence analysis1
Glycosylationi296N-linked (GlcNAc...)Sequence analysis1
Glycosylationi330N-linked (GlcNAc...)Sequence analysis1
Glycosylationi381N-linked (GlcNAc...)Sequence analysis1
Glycosylationi391N-linked (GlcNAc...)Sequence analysis1
Glycosylationi432N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9LYQ2.

Expressioni

Tissue specificityi

Mostly expressed in roots. Also detected in leaves, stems and flowers but not in siliques.1 Publication

Gene expression databases

GenevisibleiQ9LYQ2. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G07130.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LYQ2.
SMRiQ9LYQ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 145Plastocyanin-like 1Add BLAST117
Domaini157 – 308Plastocyanin-like 2Add BLAST152
Domaini418 – 553Plastocyanin-like 3Add BLAST136

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ9LYQ2.
KOiK05909.
OMAiDSHIFWG.
OrthoDBiEOG093605O6.
PhylomeDBiQ9LYQ2.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LYQ2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQLRPFFLL LAIFVASLVN AEVHFHEFVI QETPVKRLCR VHNSITVNGQ
60 70 80 90 100
FPGPTLEVRN GDSLVITAIN KARYNISLHW HGIRQMRNPW ADGPEYITQC
110 120 130 140 150
PIQPGGSYTY RFTMEDQEGT LWWHAHSRWL RATVYGALII RPPLSSPHYP
160 170 180 190 200
FPVIPKREIT LLLGEWWDRN PMDVLNLAQF TGAAPNISDA FTINGQPGDL
210 220 230 240 250
YRCSSQETLR FLVGSGEIVL LRVINSALNQ ELFFGVANHK LTVVAADASY
260 270 280 290 300
TKPFSTNVIM LGPGQTTDVL LTADQPPAHY YMAAHAYNSA NAAFDNTTTT
310 320 330 340 350
AILKYKDASC VTLQAKSQAR AIPAQLPGFN DTATAAAFTA QMKSPSKVKV
360 370 380 390 400
PLEIDENLFF TVGLGLFNCP TPNTQRCQGP NGTRFTASIN NVSFVFPKQN
410 420 430 440 450
SIMQAYYQGT PTGVFTTDFP PTPPVTFDYT GNVSRGLWQP TRGTKAYKLK
460 470 480 490 500
FNSQVQIILQ DTSIVTTENH PMHLHGYEFY VVGTGVGNFN PNTDTSSFNL
510 520 530 540 550
IDPPRRNTIG TPPGGWVAIR FVANNPGAWL MHCHIDSHIF WGLAMVFLVE
560
NGEGHLQSVQ SPPLDLPQC
Length:569
Mass (Da):63,145
Last modified:October 1, 2000 - v1
Checksum:iDB618A13E0E2881B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL163652 Genomic DNA. Translation: CAB87269.1.
CP002688 Genomic DNA. Translation: AED91113.1.
PIRiT48484.
RefSeqiNP_196330.3. NM_120795.5.
UniGeneiAt.5043.

Genome annotation databases

EnsemblPlantsiAT5G07130.1; AT5G07130.1; AT5G07130.
GeneIDi830604.
GrameneiAT5G07130.1; AT5G07130.1; AT5G07130.
KEGGiath:AT5G07130.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL163652 Genomic DNA. Translation: CAB87269.1.
CP002688 Genomic DNA. Translation: AED91113.1.
PIRiT48484.
RefSeqiNP_196330.3. NM_120795.5.
UniGeneiAt.5043.

3D structure databases

ProteinModelPortaliQ9LYQ2.
SMRiQ9LYQ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G07130.1.

Proteomic databases

PaxDbiQ9LYQ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G07130.1; AT5G07130.1; AT5G07130.
GeneIDi830604.
GrameneiAT5G07130.1; AT5G07130.1; AT5G07130.
KEGGiath:AT5G07130.

Organism-specific databases

TAIRiAT5G07130.

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ9LYQ2.
KOiK05909.
OMAiDSHIFWG.
OrthoDBiEOG093605O6.
PhylomeDBiQ9LYQ2.

Enzyme and pathway databases

BioCyciARA:AT5G07130-MONOMER.

Miscellaneous databases

PROiQ9LYQ2.

Gene expression databases

GenevisibleiQ9LYQ2. AT.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR033138. Cu_oxidase_CS.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 3 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00079. MULTICOPPER_OXIDASE1. 1 hit.
PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAC13_ARATH
AccessioniPrimary (citable) accession number: Q9LYQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.