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Protein

Ferritin-3, chloroplastic

Gene

FER3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi106Iron 1PROSITE-ProRule annotation1
Metal bindingi141Iron 1PROSITE-ProRule annotation1
Metal bindingi141Iron 2PROSITE-ProRule annotation1
Metal bindingi144Iron 1PROSITE-ProRule annotation1
Metal bindingi190Iron 2PROSITE-ProRule annotation1
Metal bindingi224Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • flower development Source: TAIR
  • intracellular sequestering of iron ion Source: GO_Central
  • iron ion homeostasis Source: TAIR
  • iron ion transport Source: TAIR
  • leaf development Source: TAIR
  • photosynthesis Source: TAIR
  • response to iron ion Source: TAIR
  • response to reactive oxygen species Source: TAIR

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT3G56090-MONOMER
ReactomeiR-ATH-6798695 Neutrophil degranulation
R-ATH-917937 Iron uptake and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin-3, chloroplastic (EC:1.16.3.1)
Gene namesi
Name:FER3
Ordered Locus Names:At3g56090
ORF Names:F18O21_50
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G56090
TAIRilocus:2078481 AT3G56090

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 49ChloroplastSequence analysisAdd BLAST49
ChainiPRO_000000885650 – 259Ferritin-3, chloroplasticAdd BLAST210

Proteomic databases

PaxDbiQ9LYN2
PRIDEiQ9LYN2

Expressioni

Inductioni

By iron overload treatment.1 Publication

Gene expression databases

ExpressionAtlasiQ9LYN2 baseline and differential
GenevisibleiQ9LYN2 AT

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).By similarity

Protein-protein interaction databases

BioGridi10091, 4 interactors
STRINGi3702.AT3G56090.1

Structurei

3D structure databases

ProteinModelPortaliQ9LYN2
SMRiQ9LYN2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini89 – 242Ferritin-like diironPROSITE-ProRule annotationAdd BLAST154

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 88Extension peptide (EP)Add BLAST39

Sequence similaritiesi

Belongs to the ferritin family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2332 Eukaryota
COG1528 LUCA
HOGENOMiHOG000223383
InParanoidiQ9LYN2
KOiK00522
OMAiYVFDKEH
OrthoDBiEOG09360PX4
PhylomeDBiQ9LYN2

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LYN2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLKAASTFS LLNIHGEKKD ISPLFSSSSS ISSPVSSGKS GNLSFPLRAS
60 70 80 90 100
KSSTTTTSTL SGVVFEPFEE VKKEMDLVPS GQQLSLARHL YSPECEAAVN
110 120 130 140 150
EQINVEYNVS YVYHALYAYF DRDNVALKGL AKFFKESSVE EREHAELLME
160 170 180 190 200
YQNKRGGRVK LQPMVLPQSE FDHPEKGDAL YAMELALSLE KLVNEKLLNL
210 220 230 240 250
HSVASKNDDV QLADFIESVF LNEQVEAIKK ISEYVSQLRR LGKGHGTWHF

DQELLGAAA
Length:259
Mass (Da):28,837
Last modified:October 1, 2000 - v1
Checksum:i7E06E16761C2FB1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312190 mRNA Translation: CAC85399.1
AL163763 Genomic DNA Translation: CAB87408.1
CP002686 Genomic DNA Translation: AEE79476.1
AY072221 mRNA Translation: AAL60042.1
AY122951 mRNA Translation: AAM67484.1
PIRiT47726
RefSeqiNP_191168.1, NM_115467.5
UniGeneiAt.20042
At.67841

Genome annotation databases

EnsemblPlantsiAT3G56090.1; AT3G56090.1; AT3G56090
GeneIDi824775
GrameneiAT3G56090.1; AT3G56090.1; AT3G56090
KEGGiath:AT3G56090

Similar proteinsi

Entry informationi

Entry nameiFRI3_ARATH
AccessioniPrimary (citable) accession number: Q9LYN2
Secondary accession number(s): Q8WHW6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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