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Q9LYN2

- FRI3_ARATH

UniProt

Q9LYN2 - FRI3_ARATH

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Protein
Ferritin-3, chloroplastic
Gene
FER3, At3g56090, F18O21_50
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi106 – 1061Iron 1 By similarity
Metal bindingi141 – 1411Iron 1 By similarity
Metal bindingi141 – 1411Iron 2 By similarity
Metal bindingi144 – 1441Iron 1 By similarity
Metal bindingi190 – 1901Iron 2 By similarity
Metal bindingi224 – 2241Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. flower development Source: TAIR
  3. iron ion homeostasis Source: TAIR
  4. iron ion transport Source: TAIR
  5. leaf development Source: TAIR
  6. photosynthesis Source: TAIR
  7. response to iron ion Source: TAIR
  8. response to reactive oxygen species Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT3G56090-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin-3, chloroplastic (EC:1.16.3.1)
Gene namesi
Name:FER3
Ordered Locus Names:At3g56090
ORF Names:F18O21_50
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G56090.

Subcellular locationi

Plastidchloroplast By similarity

GO - Cellular componenti

  1. chloroplast Source: TAIR
  2. chloroplast envelope Source: TAIR
  3. chloroplast stroma Source: TAIR
  4. membrane Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4949Chloroplast Reviewed prediction
Add
BLAST
Chaini50 – 259210Ferritin-3, chloroplastic
PRO_0000008856Add
BLAST

Proteomic databases

PaxDbiQ9LYN2.
PRIDEiQ9LYN2.

Expressioni

Inductioni

By iron overload treatment.1 Publication

Gene expression databases

ArrayExpressiQ9LYN2.
GenevestigatoriQ9LYN2.

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited By similarity.

Protein-protein interaction databases

BioGridi10091. 1 interaction.
STRINGi3702.AT3G56090.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LYN2.
SMRiQ9LYN2. Positions 62-255.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 242154Ferritin-like diiron
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 8839Extension peptide (EP)
Add
BLAST

Sequence similaritiesi

Belongs to the ferritin family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1528.
HOGENOMiHOG000223383.
InParanoidiQ9LYN2.
KOiK00522.
OMAiTHIDYLT.
PhylomeDBiQ9LYN2.

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LYN2-1 [UniParc]FASTAAdd to Basket

« Hide

MLLKAASTFS LLNIHGEKKD ISPLFSSSSS ISSPVSSGKS GNLSFPLRAS    50
KSSTTTTSTL SGVVFEPFEE VKKEMDLVPS GQQLSLARHL YSPECEAAVN 100
EQINVEYNVS YVYHALYAYF DRDNVALKGL AKFFKESSVE EREHAELLME 150
YQNKRGGRVK LQPMVLPQSE FDHPEKGDAL YAMELALSLE KLVNEKLLNL 200
HSVASKNDDV QLADFIESVF LNEQVEAIKK ISEYVSQLRR LGKGHGTWHF 250
DQELLGAAA 259
Length:259
Mass (Da):28,837
Last modified:October 1, 2000 - v1
Checksum:i7E06E16761C2FB1B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ312190 mRNA. Translation: CAC85399.1.
AL163763 Genomic DNA. Translation: CAB87408.1.
CP002686 Genomic DNA. Translation: AEE79476.1.
AY072221 mRNA. Translation: AAL60042.1.
AY122951 mRNA. Translation: AAM67484.1.
PIRiT47726.
RefSeqiNP_191168.1. NM_115467.4.
UniGeneiAt.20042.
At.67841.

Genome annotation databases

EnsemblPlantsiAT3G56090.1; AT3G56090.1; AT3G56090.
GeneIDi824775.
KEGGiath:AT3G56090.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ312190 mRNA. Translation: CAC85399.1 .
AL163763 Genomic DNA. Translation: CAB87408.1 .
CP002686 Genomic DNA. Translation: AEE79476.1 .
AY072221 mRNA. Translation: AAL60042.1 .
AY122951 mRNA. Translation: AAM67484.1 .
PIRi T47726.
RefSeqi NP_191168.1. NM_115467.4.
UniGenei At.20042.
At.67841.

3D structure databases

ProteinModelPortali Q9LYN2.
SMRi Q9LYN2. Positions 62-255.
ModBasei Search...

Protein-protein interaction databases

BioGridi 10091. 1 interaction.
STRINGi 3702.AT3G56090.1-P.

Proteomic databases

PaxDbi Q9LYN2.
PRIDEi Q9LYN2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G56090.1 ; AT3G56090.1 ; AT3G56090 .
GeneIDi 824775.
KEGGi ath:AT3G56090.

Organism-specific databases

TAIRi AT3G56090.

Phylogenomic databases

eggNOGi COG1528.
HOGENOMi HOG000223383.
InParanoidi Q9LYN2.
KOi K00522.
OMAi THIDYLT.
PhylomeDBi Q9LYN2.

Enzyme and pathway databases

BioCyci ARA:AT3G56090-MONOMER.

Gene expression databases

ArrayExpressi Q9LYN2.
Genevestigatori Q9LYN2.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR014034. Ferritin_CS.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00204. FERRITIN_2. 1 hit.
PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and differential expression of the four members of the Arabidopsis thaliana ferritin gene family."
    Petit J.-M., Briat J.-F., Lobreaux S.
    Biochem. J. 359:575-582(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INDUCTION.
    Strain: cv. Columbia.
  2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.

Entry informationi

Entry nameiFRI3_ARATH
AccessioniPrimary (citable) accession number: Q9LYN2
Secondary accession number(s): Q8WHW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi