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Protein

Superoxide dismutase [Mn] 2, mitochondrial

Gene

MSD2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.By similarity

Catalytic activityi

2 superoxide + 2 H+ = O2 + H2O2.

Cofactori

Mn2+By similarityNote: Binds 1 Mn2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi60ManganeseBy similarity1
Metal bindingi108ManganeseBy similarity1
Metal bindingi197ManganeseBy similarity1
Metal bindingi201ManganeseBy similarity1

GO - Molecular functioni

GO - Biological processi

  • floral organ abscission Source: TAIR

Keywordsi

Molecular functionOxidoreductase
LigandManganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT3G56350-MONOMER
ReactomeiR-ATH-3299685 Detoxification of Reactive Oxygen Species

Names & Taxonomyi

Protein namesi
Recommended name:
Superoxide dismutase [Mn] 2, mitochondrial (EC:1.15.1.1)
Alternative name(s):
Protein MANGANESE SUPEROXIDE DISMUTASE 2
Short name:
AtMSD2
Gene namesi
Name:MSD2
Ordered Locus Names:At3g56350
ORF Names:F18O21_310
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G56350
TAIRilocus:2078356 AT3G56350

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_5000237373? – 241Superoxide dismutase [Mn] 2, mitochondrialSequence analysis
Transit peptidei1 – ?MitochondrionBy similarity

Proteomic databases

PaxDbiQ9LYK8
PRIDEiQ9LYK8
ProMEXiQ9LYK8

Expressioni

Gene expression databases

ExpressionAtlasiQ9LYK8 differential
GenevisibleiQ9LYK8 AT

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi10118, 1 interactor
STRINGi3702.AT3G56350.1

Structurei

3D structure databases

ProteinModelPortaliQ9LYK8
SMRiQ9LYK8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0876 Eukaryota
COG0605 LUCA
HOGENOMiHOG000013583
InParanoidiQ9LYK8
KOiK04564
OMAiYEGWKGE
OrthoDBiEOG09360K54
PhylomeDBiQ9LYK8

Family and domain databases

Gene3Di1.10.287.990, 1 hit
2.40.500.20, 1 hit
InterProiView protein in InterPro
IPR001189 Mn/Fe_SOD
IPR019833 Mn/Fe_SOD_BS
IPR019832 Mn/Fe_SOD_C
IPR019831 Mn/Fe_SOD_N
IPR036324 Mn/Fe_SOD_N_sf
IPR036314 SOD_C_sf
PfamiView protein in Pfam
PF02777 Sod_Fe_C, 1 hit
PF00081 Sod_Fe_N, 1 hit
PIRSFiPIRSF000349 SODismutase, 1 hit
PRINTSiPR01703 MNSODISMTASE
SUPFAMiSSF46609 SSF46609, 1 hit
SSF54719 SSF54719, 1 hit
PROSITEiView protein in PROSITE
PS00088 SOD_MN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LYK8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTTVIIIIF VAIFATTLHD ARGATMEPCL ESMKTASLPD LPYAYDALEP
60 70 80 90 100
AISEEIMRLH HQKHHQTYVT QYNKALNSLR SAMADGDHSS VVKLQSLIKF
110 120 130 140 150
NGGGHVNHAI FWKNLAPVHE GGGKPPHDPL ASAIDAHFGS LEGLIQKMNA
160 170 180 190 200
EGAAVQGSGW VWFGLDRELK RLVVETTANQ DPLVTKGSHL VPLIGIDVWE
210 220 230 240
HAYYPQYKNA RAEYLKNIWT VINWKYAADV FEKHTRDLDI N
Length:241
Mass (Da):26,892
Last modified:October 1, 2000 - v1
Checksum:i22E5F2FB84DD99D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY151395 mRNA Translation: AAN46857.1
AL163763 Genomic DNA Translation: CAB87434.1
CP002686 Genomic DNA Translation: AEE79512.1
BT004168 mRNA Translation: AAO42188.1
PIRiT47752
RefSeqiNP_191194.1, NM_115493.4
UniGeneiAt.34942

Genome annotation databases

EnsemblPlantsiAT3G56350.1; AT3G56350.1; AT3G56350
GeneIDi824802
GrameneiAT3G56350.1; AT3G56350.1; AT3G56350
KEGGiath:AT3G56350

Similar proteinsi

Entry informationi

Entry nameiSODM2_ARATH
AccessioniPrimary (citable) accession number: Q9LYK8
Secondary accession number(s): Q84W70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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