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Protein

Gibberellin receptor GID1B

Gene

GID1B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as soluble gibberellin (GA) receptor. GA is an essential hormone that regulates growth and development in plants. Binds with high affinity the biologically active gibberellin GA4, but has no affinity for the biologically inactive GAs. In response to GA, interacts with specific DELLA proteins, known as repressors of GA-induced growth, and targets them for degradation via proteasome. Seems to be required for GA signaling that controls root growth, seed germination and flower development. May function as a dominant GA receptor at low GA concentrations in germination. Partially redundant with GID1A and GID1C.3 Publications

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei127 – 1271GibberellinBy similarity
Active sitei191 – 1911PROSITE-ProRule annotationBy similarity
Binding sitei191 – 1911GibberellinBy similarity
Active sitei289 – 2891PROSITE-ProRule annotationBy similarity
Binding sitei320 – 3201Gibberellin; via amide nitrogenBy similarity

GO - Molecular functioni

GO - Biological processi

  • floral organ morphogenesis Source: TAIR
  • gibberellic acid mediated signaling pathway Source: UniProtKB-KW
  • gibberellin mediated signaling pathway Source: TAIR
  • positive regulation of gibberellic acid mediated signaling pathway Source: TAIR
  • response to gibberellin Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Receptor

Keywords - Biological processi

Gibberellin signaling pathway

Enzyme and pathway databases

BioCyciARA:AT3G63010-MONOMER.

Protein family/group databases

ESTHERiarath-GID1B. Plant_carboxylesterase.

Names & Taxonomyi

Protein namesi
Recommended name:
Gibberellin receptor GID1B (EC:3.-.-.-)
Alternative name(s):
AtCXE14
Carboxylesterase 14
GID1-like protein 2
Protein GA INSENSITIVE DWARF 1B
Short name:
AtGID1B
Gene namesi
Name:GID1B
Synonyms:CXE14, GID1L2
Ordered Locus Names:At3g63010
ORF Names:T20O10.110
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G63010.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth condition.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 358357Gibberellin receptor GID1BPRO_0000071559Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9LYC1.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

GenevisibleiQ9LYC1. AT.

Interactioni

Subunit structurei

Interacts with the DELLA proteins GAI, RGA, RGL1, RGL2 and RGL3 in a GA-dependent manner.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
GAIQ9LQT84EBI-963686,EBI-963606
GID2Q9STX33EBI-963686,EBI-619033
RGAQ9SLH36EBI-963686,EBI-963624

Protein-protein interaction databases

BioGridi10790. 4 interactions.
DIPiDIP-37662N.
IntActiQ9LYC1. 5 interactions.
STRINGi3702.AT3G63010.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LYC1.
SMRiQ9LYC1. Positions 6-343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni115 – 1162Gibberellin bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi113 – 1153Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000152323.
InParanoidiQ9LYC1.
KOiK14493.
OMAiGVNFPKS.
PhylomeDBiQ9LYC1.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR002168. Lipase_GDXG_HIS_AS.
IPR033140. Lipase_GDXG_put_SER_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01173. LIPASE_GDXG_HIS. 1 hit.
PS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LYC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGGNEVNLN ECKRIVPLNT WVLISNFKLA YKVLRRPDGS FNRDLAEFLD
60 70 80 90 100
RKVPANSFPL DGVFSFDHVD STTNLLTRIY QPASLLHQTR HGTLELTKPL
110 120 130 140 150
STTEIVPVLI FFHGGSFTHS SANSAIYDTF CRRLVTICGV VVVSVDYRRS
160 170 180 190 200
PEHRYPCAYD DGWNALNWVK SRVWLQSGKD SNVYVYLAGD SSGGNIAHNV
210 220 230 240 250
AVRATNEGVK VLGNILLHPM FGGQERTQSE KTLDGKYFVT IQDRDWYWRA
260 270 280 290 300
YLPEGEDRDH PACNPFGPRG QSLKGVNFPK SLVVVAGLDL VQDWQLAYVD
310 320 330 340 350
GLKKTGLEVN LLYLKQATIG FYFLPNNDHF HCLMEELNKF VHSIEDSQSK

SSPVLLTP
Length:358
Mass (Da):40,300
Last modified:October 1, 2000 - v1
Checksum:i8D24F47BC40CE4D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL163816 Genomic DNA. Translation: CAB87746.1.
CP002686 Genomic DNA. Translation: AEE80423.1.
AK228182 mRNA. Translation: BAF00137.1.
BT028997 mRNA. Translation: ABI93906.1.
PIRiT48090.
RefSeqiNP_191860.1. NM_116166.4.
UniGeneiAt.47986.

Genome annotation databases

EnsemblPlantsiAT3G63010.1; AT3G63010.1; AT3G63010.
GeneIDi825476.
GrameneiAT3G63010.1; AT3G63010.1; AT3G63010.
KEGGiath:AT3G63010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL163816 Genomic DNA. Translation: CAB87746.1.
CP002686 Genomic DNA. Translation: AEE80423.1.
AK228182 mRNA. Translation: BAF00137.1.
BT028997 mRNA. Translation: ABI93906.1.
PIRiT48090.
RefSeqiNP_191860.1. NM_116166.4.
UniGeneiAt.47986.

3D structure databases

ProteinModelPortaliQ9LYC1.
SMRiQ9LYC1. Positions 6-343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi10790. 4 interactions.
DIPiDIP-37662N.
IntActiQ9LYC1. 5 interactions.
STRINGi3702.AT3G63010.1.

Protein family/group databases

ESTHERiarath-GID1B. Plant_carboxylesterase.

Proteomic databases

PaxDbiQ9LYC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G63010.1; AT3G63010.1; AT3G63010.
GeneIDi825476.
GrameneiAT3G63010.1; AT3G63010.1; AT3G63010.
KEGGiath:AT3G63010.

Organism-specific databases

TAIRiAT3G63010.

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000152323.
InParanoidiQ9LYC1.
KOiK14493.
OMAiGVNFPKS.
PhylomeDBiQ9LYC1.

Enzyme and pathway databases

BioCyciARA:AT3G63010-MONOMER.

Miscellaneous databases

PROiQ9LYC1.

Gene expression databases

GenevisibleiQ9LYC1. AT.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR002168. Lipase_GDXG_HIS_AS.
IPR033140. Lipase_GDXG_put_SER_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01173. LIPASE_GDXG_HIS. 1 hit.
PS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Arabidopsis ORF clones."
    Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.
    Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "The carboxylesterase gene family from Arabidopsis thaliana."
    Marshall S.D., Putterill J.J., Plummer K.M., Newcomb R.D.
    J. Mol. Evol. 57:487-500(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, GENE FAMILY.
  6. "Genetic characterization and functional analysis of the GID1 gibberellin receptors in Arabidopsis."
    Griffiths J., Murase K., Rieu I., Zentella R., Zhang Z.L., Powers S.J., Gong F., Phillips A.L., Hedden P., Sun T.P., Thomas S.G.
    Plant Cell 18:3399-3414(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH GAI AND RGA, DISRUPTION PHENOTYPE.
  7. Cited for: FUNCTION, INTERACTION WITH GAI; RGA; RGL1; RGL2 AND RGL3.
  8. "Multiple loss-of-function of Arabidopsis gibberellin receptor AtGID1s completely shuts down a gibberellin signal."
    Iuchi S., Suzuki H., Kim Y.C., Iuchi A., Kuromori T., Ueguchi-Tanaka M., Asami T., Yamaguchi I., Matsuoka M., Kobayashi M., Nakajima M.
    Plant J. 50:958-966(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  9. "Differential expression and affinities of Arabidopsis gibberellin receptors can explain variation in phenotypes of multiple knock-out mutants."
    Suzuki H., Park S.-H., Okubo K., Kitamura J., Ueguchi-Tanaka M., Iuchi S., Katoh E., Kobayashi M., Yamaguchi I., Matsuoka M., Asami T., Nakajima M.
    Plant J. 60:48-55(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RGL2.

Entry informationi

Entry nameiGID1B_ARATH
AccessioniPrimary (citable) accession number: Q9LYC1
Secondary accession number(s): Q0WRW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2000
Last modified: March 16, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.