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Q9LYB4

- GPX5_ARATH

UniProt

Q9LYB4 - GPX5_ARATH

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Protein

Probable glutathione peroxidase 5

Gene

GPX5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May constitute a glutathione peroxidase-like protective system against oxidative stresses.By similarity

Catalytic activityi

2 glutathione + H2O2 = glutathione disulfide + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei46 – 461By similarity

GO - Molecular functioni

  1. glutathione peroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. embryo development ending in seed dormancy Source: TAIR
  2. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Stress response

Enzyme and pathway databases

BioCyciARA:AT3G63080-MONOMER.

Protein family/group databases

PeroxiBasei2475. AtGPx05.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutathione peroxidase 5 (EC:1.11.1.9)
Gene namesi
Name:GPX5
Ordered Locus Names:At3g63080
ORF Names:T20O10_180
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G63080.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: TAIR
  2. plasma membrane Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed
Chaini2 – 173172Probable glutathione peroxidase 5PRO_0000066639Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycine1 Publication

Keywords - PTMi

Lipoprotein, Myristate

Proteomic databases

PaxDbiQ9LYB4.
PRIDEiQ9LYB4.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Inductioni

By salt stress, osmotic stress and metals. Down-regulated by abscisic acid (ABA).1 Publication

Gene expression databases

GenevestigatoriQ9LYB4.

Interactioni

Protein-protein interaction databases

BioGridi10797. 1 interaction.
IntActiQ9LYB4. 1 interaction.
STRINGi3702.AT3G63080.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LYB4.
SMRiQ9LYB4. Positions 12-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glutathione peroxidase family.Curated

Phylogenomic databases

eggNOGiCOG0386.
HOGENOMiHOG000277054.
InParanoidiQ9LYB4.
KOiK00432.
OMAiCGFTESN.
PhylomeDBiQ9LYB4.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11592. PTHR11592. 1 hit.
PfamiPF00255. GSHPx. 1 hit.
[Graphical view]
PIRSFiPIRSF000303. Glutathion_perox. 1 hit.
PRINTSiPR01011. GLUTPROXDASE.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LYB4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGASSSSSVS EKSIHQFTVK DSSGKEVDLS VYQGKVLLVV NVASKCGFTE
60 70 80 90 100
SNYTQLTELY RKYKDQGFVV LAFPCNQFLS QEPGTSEEAH QFACTRFKAE
110 120 130 140 150
YPVFQKVRVN GQNAAPVYKF LKSKKPSFLG SRIKWNFTKF LVGKDGQVID
160 170
RYGTTVSPLS IQKDIEKALA QEL
Length:173
Mass (Da):19,327
Last modified:October 1, 2000 - v1
Checksum:iCE3F15979C150C65
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL163816 Genomic DNA. Translation: CAB87753.1.
CP002686 Genomic DNA. Translation: AEE80432.1.
BT003821 mRNA. Translation: AAO41874.1.
BT005137 mRNA. Translation: AAO50670.1.
AY085116 mRNA. Translation: AAM61670.1.
PIRiT48097.
RefSeqiNP_191867.1. NM_116173.3.
UniGeneiAt.34000.
At.43439.

Genome annotation databases

EnsemblPlantsiAT3G63080.1; AT3G63080.1; AT3G63080.
GeneIDi825483.
KEGGiath:AT3G63080.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL163816 Genomic DNA. Translation: CAB87753.1 .
CP002686 Genomic DNA. Translation: AEE80432.1 .
BT003821 mRNA. Translation: AAO41874.1 .
BT005137 mRNA. Translation: AAO50670.1 .
AY085116 mRNA. Translation: AAM61670.1 .
PIRi T48097.
RefSeqi NP_191867.1. NM_116173.3.
UniGenei At.34000.
At.43439.

3D structure databases

ProteinModelPortali Q9LYB4.
SMRi Q9LYB4. Positions 12-169.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 10797. 1 interaction.
IntActi Q9LYB4. 1 interaction.
STRINGi 3702.AT3G63080.1-P.

Protein family/group databases

PeroxiBasei 2475. AtGPx05.

Proteomic databases

PaxDbi Q9LYB4.
PRIDEi Q9LYB4.

Protocols and materials databases

DNASUi 825483.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G63080.1 ; AT3G63080.1 ; AT3G63080 .
GeneIDi 825483.
KEGGi ath:AT3G63080.

Organism-specific databases

GeneFarmi 2054. 163.
TAIRi AT3G63080.

Phylogenomic databases

eggNOGi COG0386.
HOGENOMi HOG000277054.
InParanoidi Q9LYB4.
KOi K00432.
OMAi CGFTESN.
PhylomeDBi Q9LYB4.

Enzyme and pathway databases

BioCyci ARA:AT3G63080-MONOMER.

Miscellaneous databases

PROi Q9LYB4.

Gene expression databases

Genevestigatori Q9LYB4.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR000889. Glutathione_peroxidase.
IPR029759. GPX_AS.
IPR029760. GPX_CS.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11592. PTHR11592. 1 hit.
Pfami PF00255. GSHPx. 1 hit.
[Graphical view ]
PIRSFi PIRSF000303. Glutathion_perox. 1 hit.
PRINTSi PR01011. GLUTPROXDASE.
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS00460. GLUTATHIONE_PEROXID_1. 1 hit.
PS00763. GLUTATHIONE_PEROXID_2. 1 hit.
PS51355. GLUTATHIONE_PEROXID_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Glutathione peroxidase genes in Arabidopsis are ubiquitous and regulated by abiotic stresses through diverse signaling pathways."
    Rodriguez Milla M.A., Maurer A., Rodriguez Huete A., Gustafson J.P.
    Plant J. 36:602-615(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE, TISSUE SPECIFICITY, INDUCTION.
  6. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: MYRISTOYLATION [LARGE SCALE ANALYSIS] AT GLY-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGPX5_ARATH
AccessioniPrimary (citable) accession number: Q9LYB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3