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Protein

Phosphoinositide phospholipase C 7

Gene

PLC7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.By similarity1 Publication

Caution

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei118PROSITE-ProRule annotation1
Active sitei164PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Transducer
Biological processLipid degradation, Lipid metabolism

Enzyme and pathway databases

BioCyciARA:AT3G55940-MONOMER
BRENDAi3.1.4.11 399
ReactomeiR-ATH-112043 PLC beta mediated events
R-ATH-114604 GPVI-mediated activation cascade
R-ATH-1855204 Synthesis of IP3 and IP4 in the cytosol
R-ATH-202433 Generation of second messenger molecules
R-ATH-399997 Acetylcholine regulates insulin secretion
R-ATH-416476 G alpha (q) signalling events
R-ATH-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
R-ATH-5607764 CLEC7A (Dectin-1) signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide phospholipase C 7 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase PLC7
Short name:
AtPLC10
Short name:
AtPLC7
Short name:
PI-PLC7
Gene namesi
Name:PLC7
Synonyms:PLC10
Ordered Locus Names:At3g55940
ORF Names:F27K19.120
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G55940
TAIRilocus:2082018 AT3G55940

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003241321 – 584Phosphoinositide phospholipase C 7Add BLAST584

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei287PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9LY51
PRIDEiQ9LY51

PTM databases

iPTMnetiQ9LY51

Expressioni

Tissue specificityi

Expressed in leaves, roots, flowers and siliques.1 Publication

Gene expression databases

ExpressionAtlasiQ9LY51 baseline and differential
GenevisibleiQ9LY51 AT

Interactioni

Protein-protein interaction databases

BioGridi100761 interactor.
STRINGi3702.AT3G55940.1

Structurei

3D structure databases

ProteinModelPortaliQ9LY51
SMRiQ9LY51
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 102EF-hand-likeAdd BLAST77
Domaini103 – 248PI-PLC X-boxPROSITE-ProRule annotationAdd BLAST146
Domaini323 – 439PI-PLC Y-boxPROSITE-ProRule annotationAdd BLAST117
Domaini442 – 549C2PROSITE-ProRule annotationAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi258 – 312Asp-richAdd BLAST55

Phylogenomic databases

eggNOGiKOG0169 Eukaryota
ENOG410XPSW LUCA
HOGENOMiHOG000244119
InParanoidiQ9LY51
KOiK05857
OMAiHTHFDRY
OrthoDBiEOG0936050V
PhylomeDBiQ9LY51

Family and domain databases

Gene3Di2.60.40.1501 hit
3.20.20.1902 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011992 EF-hand-dom_pair
IPR001192 PI-PLC_fam
IPR017946 PLC-like_Pdiesterase_TIM-brl
IPR015359 PLC_EF-hand-like
IPR000909 PLipase_C_PInositol-sp_X_dom
IPR001711 PLipase_C_Pinositol-sp_Y
PANTHERiPTHR10336 PTHR10336, 1 hit
PfamiView protein in Pfam
PF00168 C2, 1 hit
PF09279 EF-hand_like, 1 hit
PF00388 PI-PLC-X, 1 hit
PF00387 PI-PLC-Y, 1 hit
PRINTSiPR00390 PHPHLIPASEC
SMARTiView protein in SMART
SM00239 C2, 1 hit
SM00148 PLCXc, 1 hit
SM00149 PLCYc, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF51695 SSF51695, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 1 hit
PS50007 PIPLC_X_DOMAIN, 1 hit
PS50008 PIPLC_Y_DOMAIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9LY51-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKQTYKVCF CFRRRYRHTV SVAPAEIKTL FDNYSDKGLM TTDLLLRFLI
60 70 80 90 100
DVQKQDKATK EEAQDIVNAS SSLLHRNGLH LDAFFKYLFA VTNSPLSSLE
110 120 130 140 150
VHQDMDAPLS HYFIYTGHNS YLTGNQLSSD CSELPIIEAL KKGVRVIELD
160 170 180 190 200
IWPNSDEDGI DVLHGRTLTS PVELIKCLRA IREHAFDVSD YPVVVTLEDH
210 220 230 240 250
LTPKLQAKVA EMVTDIFGEM LFTPPSGECL KEFPSPAFLK KRIMISTKPP
260 270 280 290 300
KEYKAATDDD LVKKGRDLGD KEVWGREVPS FIRRDRSVDK NDSNGDDDDD
310 320 330 340 350
DDDDDDDDDG DDKIKKNAPP EYKHLIAIEA GKPKGGITEC LKVDPDKVRR
360 370 380 390 400
LSLSEEQLEK ASEKYAKQIV RFTQRNLLRV YPKGTRITSS NYNPLIAWSH
410 420 430 440 450
GAQMVAFNMQ GLGRSLWVMQ GMFRGNGGCG YIKKPDLLLK SNAVFDPEAT
460 470 480 490 500
LPVKTTLRVT IYMGEGWYYD FPHTHFDRYS PPDFYTRVGI AGVPADTVMK
510 520 530 540 550
KTKTLEDNWI PAWDEVFEFP LTVPELALLR IEVHEYDMSE KDDFGGQICL
560 570 580
PVWELRQGIR AVPLRNQDGV KCRSVKLLVR LEFV
Note: No experimental confirmation available.
Length:584
Mass (Da):66,462
Last modified:October 1, 2000 - v1
Checksum:i16A8C5A402A8BA05
GO
Isoform 2 (identifier: Q9LY51-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-214: MVT → GNV
     215-584: Missing.

Note: No experimental confirmation available. Potentially inactive.
Show »
Length:214
Mass (Da):24,243
Checksum:i64CD6BEAD25205DB
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_032149212 – 214MVT → GNV in isoform 2. 1 Publication3
Alternative sequenceiVSP_032150215 – 584Missing in isoform 2. 1 PublicationAdd BLAST370

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL163832 Genomic DNA Translation: CAB87848.1
CP002686 Genomic DNA Translation: AEE79459.1
PIRiT49206
RefSeqiNP_191153.1, NM_115452.2 [Q9LY51-1]

Genome annotation databases

EnsemblPlantsiAT3G55940.1; AT3G55940.1; AT3G55940 [Q9LY51-1]
GeneIDi824760
GrameneiAT3G55940.1; AT3G55940.1; AT3G55940 [Q9LY51-1]
KEGGiath:AT3G55940

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPLCD7_ARATH
AccessioniPrimary (citable) accession number: Q9LY51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome