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Protein

Peptide methionine sulfoxide reductase A2

Gene

MRSA2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the reduction of methionine sulfoxide (MetSO) to methionine in proteins. Plays a protective role against oxidative stress by restoring activity to proteins that have been inactivated by methionine oxidation. Prevents cellular oxidative damage in long nights. MSRA family specifically reduces the MetSO S-enantiomer.1 Publication

Catalytic activityi

Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin.
L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin.

Enzyme regulationi

Activated during dark in short day conditions.1 Publication

GO - Molecular functioni

  • L-methionine:thioredoxin-disulfide S-oxidoreductase activity Source: UniProtKB
  • peptide-methionine (S)-S-oxide reductase activity Source: TAIR

GO - Biological processi

  • cellular protein modification process Source: TAIR
  • cellular response to oxidative stress Source: UniProtKB
  • protein repair Source: InterPro
  • response to karrikin Source: TAIR
  • response to oxidative stress Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciARA:AT5G07460-MONOMER.
ReactomeiR-ATH-5676934. Protein repair.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide methionine sulfoxide reductase A2 (EC:1.8.4.11)
Short name:
AtMSRA2
Alternative name(s):
Peptide-methionine (S)-S-oxide reductase
Short name:
Peptide Met(O) reductase
Protein-methionine-S-oxide reductase
Gene namesi
Name:MRSA2
Synonyms:PMSR2
Ordered Locus Names:At5g07460
ORF Names:T2I1.170
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G07460.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

In short day conditions, reduced growth and increased oxidative stress late in the dark period.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 218218Peptide methionine sulfoxide reductase A2PRO_0000395512Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei205 – 2051PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9LY15.
PRIDEiQ9LY15.

PTM databases

iPTMnetiQ9LY15.

Expressioni

Gene expression databases

GenevisibleiQ9LY15. AT.

Interactioni

Protein-protein interaction databases

IntActiQ9LY15. 1 interaction.
STRINGi3702.AT5G07460.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LY15.
SMRiQ9LY15. Positions 38-218.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1635. Eukaryota.
COG0225. LUCA.
HOGENOMiHOG000263862.
InParanoidiQ9LY15.
KOiK07304.
OMAiYAGGHTK.
PhylomeDBiQ9LY15.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9LY15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSSLKTQEP QVVETSPSPV AQEPPQVADK PAIVPSPIAQ EPDNDVPAPG
60 70 80 90 100
NEFAEFAAGC FWGVELAFQR IPGVTVTEVG YTHGISHNPS YEDVCTNTTN
110 120 130 140 150
HAEVVRVQYD PKECTYETLL DLFWSRHNPT TLNRQGELLG AQYRSGIYFY
160 170 180 190 200
TPEQEKLARE SLEKEQKKLE DKIVTEILPA KKFYKAEEYH QQYLVKGGMH
210
GNAQSPAKSC KDPIRCYG
Length:218
Mass (Da):24,434
Last modified:October 1, 2000 - v1
Checksum:iCF0F5D30515D4B4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL163912 Genomic DNA. Translation: CAB87935.1.
CP002688 Genomic DNA. Translation: AED91161.1.
BT010708 mRNA. Translation: AAR20765.1.
BT012426 mRNA. Translation: AAS92342.1.
PIRiT49885.
RefSeqiNP_196363.1. NM_120828.3.
UniGeneiAt.32719.

Genome annotation databases

EnsemblPlantsiAT5G07460.1; AT5G07460.1; AT5G07460.
GeneIDi830637.
GrameneiAT5G07460.1; AT5G07460.1; AT5G07460.
KEGGiath:AT5G07460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL163912 Genomic DNA. Translation: CAB87935.1.
CP002688 Genomic DNA. Translation: AED91161.1.
BT010708 mRNA. Translation: AAR20765.1.
BT012426 mRNA. Translation: AAS92342.1.
PIRiT49885.
RefSeqiNP_196363.1. NM_120828.3.
UniGeneiAt.32719.

3D structure databases

ProteinModelPortaliQ9LY15.
SMRiQ9LY15. Positions 38-218.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9LY15. 1 interaction.
STRINGi3702.AT5G07460.1.

PTM databases

iPTMnetiQ9LY15.

Proteomic databases

PaxDbiQ9LY15.
PRIDEiQ9LY15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G07460.1; AT5G07460.1; AT5G07460.
GeneIDi830637.
GrameneiAT5G07460.1; AT5G07460.1; AT5G07460.
KEGGiath:AT5G07460.

Organism-specific databases

TAIRiAT5G07460.

Phylogenomic databases

eggNOGiKOG1635. Eukaryota.
COG0225. LUCA.
HOGENOMiHOG000263862.
InParanoidiQ9LY15.
KOiK07304.
OMAiYAGGHTK.
PhylomeDBiQ9LY15.

Enzyme and pathway databases

BioCyciARA:AT5G07460-MONOMER.
ReactomeiR-ATH-5676934. Protein repair.

Miscellaneous databases

PROiQ9LY15.

Gene expression databases

GenevisibleiQ9LY15. AT.

Family and domain databases

Gene3Di3.30.1060.10. 1 hit.
HAMAPiMF_01401. MsrA.
InterProiIPR028427. Met_Sox_Rdtase.
IPR002569. Met_Sox_Rdtase_MsrA.
[Graphical view]
PANTHERiPTHR10173. PTHR10173. 1 hit.
PfamiPF01625. PMSR. 1 hit.
[Graphical view]
SUPFAMiSSF55068. SSF55068. 1 hit.
TIGRFAMsiTIGR00401. msrA. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Arabidopsis ORF clones."
    Shinn P., Chen H., Cheuk R.F., Kim C.J., Ecker J.R.
    Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Arabidopsis peptide methionine sulfoxide reductase2 prevents cellular oxidative damage in long nights."
    Bechtold U., Murphy D.J., Mullineaux P.M.
    Plant Cell 16:908-919(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ENZYME REGULATION, DISRUPTION PHENOTYPE.
  5. "Plant methionine sulfoxide reductase A and B multigenic families."
    Rouhier N., Vieira Dos Santos C., Tarrago L., Rey P.
    Photosyn. Res. 89:247-262(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-205, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Root.

Entry informationi

Entry nameiMSRA2_ARATH
AccessioniPrimary (citable) accession number: Q9LY15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: October 1, 2000
Last modified: February 17, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.