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Protein

Citrate synthase 1, peroxisomal

Gene

CSY1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Citrate synthase 5, mitochondrial (CSY5), Citrate synthase 1, peroxisomal (CSY1), Citrate synthase 2, peroxisomal (CSY2), Citrate synthase 3, peroxisomal (CSY3), Citrate synthase 4, mitochondrial (CSY4)
  2. Aconitate hydratase 3, mitochondrial (ACO3), Aconitate hydratase 1 (ACO1), Aconitate hydratase 2, mitochondrial (ACO2)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei321PROSITE-ProRule annotation1
Active sitei360PROSITE-ProRule annotation1
Active sitei416PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processTricarboxylic acid cycle

Enzyme and pathway databases

BioCyciARA:AT3G58740-MONOMER
UniPathwayiUPA00223; UER00717

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase 1, peroxisomal (EC:2.3.3.16)
Gene namesi
Name:CSY1
Ordered Locus Names:At3g58740
ORF Names:T20N10.90
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G58740
TAIRilocus:2099089 AT3G58740

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000005481? – 480Citrate synthase 1, peroxisomal
Transit peptidei1 – ?PeroxisomeSequence analysis

Proteomic databases

PaxDbiQ9LXS7
PRIDEiQ9LXS7

PTM databases

iPTMnetiQ9LXS7

Expressioni

Tissue specificityi

Expressed only in siliques. Not expressed in flower, stem, cauline leaf, young leaf, mature leaf and senescent leaf.1 Publication

Developmental stagei

Weakly or not expressed during seedling growth.1 Publication

Gene expression databases

ExpressionAtlasiQ9LXS7 differential
GenevisibleiQ9LXS7 AT

Interactioni

Protein-protein interaction databases

BioGridi10358, 1 interactor
IntActiQ9LXS7, 1 interactor
STRINGi3702.AT3G58740.1

Structurei

3D structure databases

ProteinModelPortaliQ9LXS7
SMRiQ9LXS7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2617 Eukaryota
COG0372 LUCA
HOGENOMiHOG000021224
InParanoidiQ9LXS7
KOiK01647
OMAiTENLLYM
OrthoDBiEOG0936084F
PhylomeDBiQ9LXS7

Family and domain databases

Gene3Di1.10.230.10, 1 hit
1.10.580.10, 2 hits
InterProiView protein in InterPro
IPR016142 Citrate_synth-like_lrg_a-sub
IPR016143 Citrate_synth-like_sm_a-sub
IPR002020 Citrate_synthase
IPR019810 Citrate_synthase_AS
IPR024176 Citrate_synthase_bac-typ
IPR036969 Citrate_synthase_sf
PANTHERiPTHR11739 PTHR11739, 1 hit
PfamiView protein in Pfam
PF00285 Citrate_synt, 1 hit
PIRSFiPIRSF001369 Citrate_synth, 1 hit
PRINTSiPR00143 CITRTSNTHASE
SUPFAMiSSF48256 SSF48256, 1 hit
PROSITEiView protein in PROSITE
PS00480 CITRATE_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LXS7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEISERARAR LAVLNAHLTV SEPNQVLPAI EPWCTSAHIT AAPHGSLKGN
60 70 80 90 100
LKIVDERTGN EYQVPVSEHG TVKTVDLKKI TTGKDDKGLN LYDPGYLNTA
110 120 130 140 150
PVRSSISYID GDEGILRYRG YPVEELAEKS TYTEVTYLLI YGNLPSQRQL
160 170 180 190 200
ADWEFAISQN SAVPQGVLDM IQSMPNDVHP VGALVTAMSA LSIFYPDANP
210 220 230 240 250
SLMGLGVYKS KQVRDKQIVR VLGQAPTIAA AAYLRKAGKP PVQPLSNLSY
260 270 280 290 300
SENFLYMVES MGDRSYKPNP RLARVLDILF ILQAEHEMNC STAAARHLSS
310 320 330 340 350
SGGDVYTAVS GGVGAIYGPL HGGAVEATIN MLSEIGTVEN IPEFIESVKN
360 370 380 390 400
KKRRLSGFGH RIYKNYDPRG KVVKKLADEV FSILGRDPLV EVGDALEKAA
410 420 430 440 450
LSDEYFVKRK LYPNVDFYSG LINRAMGIPS SFTAVSRIAG YLSHWRESLD
460 470 480
DPDTKIMRPQ QVYTGAGIRH YETVRERTKL
Length:480
Mass (Da):52,895
Last modified:October 1, 2000 - v1
Checksum:i51E680C04B438C92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353032 Genomic DNA Translation: CAB88291.1
CP002686 Genomic DNA Translation: AEE79825.1
AY099611 mRNA Translation: AAM20462.1
BT002169 mRNA Translation: AAN72180.1
PIRiT49157
RefSeqiNP_191433.1, NM_115736.2

Genome annotation databases

EnsemblPlantsiAT3G58740.1; AT3G58740.1; AT3G58740
GeneIDi825043
GrameneiAT3G58740.1; AT3G58740.1; AT3G58740
KEGGiath:AT3G58740

Similar proteinsi

Entry informationi

Entry nameiCISY1_ARATH
AccessioniPrimary (citable) accession number: Q9LXS7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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