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Q9LXS7

- CISY1_ARATH

UniProt

Q9LXS7 - CISY1_ARATH

Protein

Citrate synthase 1, peroxisomal

Gene

CSY1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei321 – 3211PROSITE-ProRule annotation
    Active sitei360 – 3601PROSITE-ProRule annotation
    Active sitei416 – 4161PROSITE-ProRule annotation

    GO - Molecular functioni

    1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Enzyme and pathway databases

    BioCyciARA:AT3G58740-MONOMER.
    UniPathwayiUPA00223; UER00717.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Citrate synthase 1, peroxisomal (EC:2.3.3.16)
    Gene namesi
    Name:CSY1
    Ordered Locus Names:At3g58740
    ORF Names:T20N10.90
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G58740.

    Subcellular locationi

    Peroxisome Curated

    GO - Cellular componenti

    1. peroxisome Source: TAIR

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 480Citrate synthase 1, peroxisomalPRO_0000005481
    Transit peptidei1 – ?PeroxisomeSequence Analysis

    Proteomic databases

    PaxDbiQ9LXS7.
    PRIDEiQ9LXS7.

    Expressioni

    Tissue specificityi

    Expressed only in siliques. Not expressed in flower, stem, cauline leaf, young leaf, mature leaf and senescent leaf.1 Publication

    Developmental stagei

    Weakly or not expressed during seedling growth.1 Publication

    Gene expression databases

    GenevestigatoriQ9LXS7.

    Interactioni

    Protein-protein interaction databases

    BioGridi10358. 1 interaction.
    IntActiQ9LXS7. 1 interaction.
    STRINGi3702.AT3G58740.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LXS7.
    SMRiQ9LXS7. Positions 59-477.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the citrate synthase family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0372.
    HOGENOMiHOG000021224.
    InParanoidiQ9LXS7.
    KOiK01647.
    OMAiIFYPDAN.
    PhylomeDBiQ9LXS7.

    Family and domain databases

    Gene3Di1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    [Graphical view]
    PANTHERiPTHR11739. PTHR11739. 1 hit.
    PfamiPF00285. Citrate_synt. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001369. Citrate_synth. 1 hit.
    PRINTSiPR00143. CITRTSNTHASE.
    SUPFAMiSSF48256. SSF48256. 1 hit.
    PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9LXS7-1 [UniParc]FASTAAdd to Basket

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    MEISERARAR LAVLNAHLTV SEPNQVLPAI EPWCTSAHIT AAPHGSLKGN    50
    LKIVDERTGN EYQVPVSEHG TVKTVDLKKI TTGKDDKGLN LYDPGYLNTA 100
    PVRSSISYID GDEGILRYRG YPVEELAEKS TYTEVTYLLI YGNLPSQRQL 150
    ADWEFAISQN SAVPQGVLDM IQSMPNDVHP VGALVTAMSA LSIFYPDANP 200
    SLMGLGVYKS KQVRDKQIVR VLGQAPTIAA AAYLRKAGKP PVQPLSNLSY 250
    SENFLYMVES MGDRSYKPNP RLARVLDILF ILQAEHEMNC STAAARHLSS 300
    SGGDVYTAVS GGVGAIYGPL HGGAVEATIN MLSEIGTVEN IPEFIESVKN 350
    KKRRLSGFGH RIYKNYDPRG KVVKKLADEV FSILGRDPLV EVGDALEKAA 400
    LSDEYFVKRK LYPNVDFYSG LINRAMGIPS SFTAVSRIAG YLSHWRESLD 450
    DPDTKIMRPQ QVYTGAGIRH YETVRERTKL 480
    Length:480
    Mass (Da):52,895
    Last modified:October 1, 2000 - v1
    Checksum:i51E680C04B438C92
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL353032 Genomic DNA. Translation: CAB88291.1.
    CP002686 Genomic DNA. Translation: AEE79825.1.
    AY099611 mRNA. Translation: AAM20462.1.
    BT002169 mRNA. Translation: AAN72180.1.
    PIRiT49157.
    RefSeqiNP_191433.1. NM_115736.2.

    Genome annotation databases

    EnsemblPlantsiAT3G58740.1; AT3G58740.1; AT3G58740.
    GeneIDi825043.
    KEGGiath:AT3G58740.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL353032 Genomic DNA. Translation: CAB88291.1 .
    CP002686 Genomic DNA. Translation: AEE79825.1 .
    AY099611 mRNA. Translation: AAM20462.1 .
    BT002169 mRNA. Translation: AAN72180.1 .
    PIRi T49157.
    RefSeqi NP_191433.1. NM_115736.2.

    3D structure databases

    ProteinModelPortali Q9LXS7.
    SMRi Q9LXS7. Positions 59-477.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 10358. 1 interaction.
    IntActi Q9LXS7. 1 interaction.
    STRINGi 3702.AT3G58740.1-P.

    Proteomic databases

    PaxDbi Q9LXS7.
    PRIDEi Q9LXS7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G58740.1 ; AT3G58740.1 ; AT3G58740 .
    GeneIDi 825043.
    KEGGi ath:AT3G58740.

    Organism-specific databases

    TAIRi AT3G58740.

    Phylogenomic databases

    eggNOGi COG0372.
    HOGENOMi HOG000021224.
    InParanoidi Q9LXS7.
    KOi K01647.
    OMAi IFYPDAN.
    PhylomeDBi Q9LXS7.

    Enzyme and pathway databases

    UniPathwayi UPA00223 ; UER00717 .
    BioCyci ARA:AT3G58740-MONOMER.

    Gene expression databases

    Genevestigatori Q9LXS7.

    Family and domain databases

    Gene3Di 1.10.230.10. 1 hit.
    1.10.580.10. 1 hit.
    InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
    IPR016143. Citrate_synth-like_sm_a-sub.
    IPR002020. Citrate_synthase-like.
    IPR016141. Citrate_synthase-like_core.
    IPR019810. Citrate_synthase_AS.
    IPR024176. Citrate_synthase_bac-typ.
    [Graphical view ]
    PANTHERi PTHR11739. PTHR11739. 1 hit.
    Pfami PF00285. Citrate_synt. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001369. Citrate_synth. 1 hit.
    PRINTSi PR00143. CITRTSNTHASE.
    SUPFAMi SSF48256. SSF48256. 1 hit.
    PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Arabidopsis peroxisomal citrate synthase is required for fatty acid respiration and seed germination."
      Pracharoenwattana I., Cornah J.E., Smith S.M.
      Plant Cell 17:2037-2048(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiCISY1_ARATH
    AccessioniPrimary (citable) accession number: Q9LXS7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Citrate synthase is found in nearly all cells capable of oxidative metabolism.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3