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Q9LXS7

- CISY1_ARATH

UniProt

Q9LXS7 - CISY1_ARATH

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Protein

Citrate synthase 1, peroxisomal

Gene

CSY1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei321 – 3211PROSITE-ProRule annotation
Active sitei360 – 3601PROSITE-ProRule annotation
Active sitei416 – 4161PROSITE-ProRule annotation

GO - Molecular functioni

  1. transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer Source: InterPro

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciARA:AT3G58740-MONOMER.
ReactomeiREACT_242439. Citric acid cycle (TCA cycle).
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase 1, peroxisomal (EC:2.3.3.16)
Gene namesi
Name:CSY1
Ordered Locus Names:At3g58740
ORF Names:T20N10.90
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G58740.

Subcellular locationi

Peroxisome Curated

GO - Cellular componenti

  1. peroxisome Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 480Citrate synthase 1, peroxisomalPRO_0000005481
Transit peptidei1 – ?PeroxisomeSequence Analysis

Proteomic databases

PaxDbiQ9LXS7.
PRIDEiQ9LXS7.

Expressioni

Tissue specificityi

Expressed only in siliques. Not expressed in flower, stem, cauline leaf, young leaf, mature leaf and senescent leaf.1 Publication

Developmental stagei

Weakly or not expressed during seedling growth.1 Publication

Gene expression databases

GenevestigatoriQ9LXS7.

Interactioni

Protein-protein interaction databases

BioGridi10358. 1 interaction.
IntActiQ9LXS7. 1 interaction.
STRINGi3702.AT3G58740.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9LXS7.
SMRiQ9LXS7. Positions 59-477.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000021224.
InParanoidiQ9LXS7.
KOiK01647.
OMAiIFYPDAN.
PhylomeDBiQ9LXS7.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LXS7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEISERARAR LAVLNAHLTV SEPNQVLPAI EPWCTSAHIT AAPHGSLKGN
60 70 80 90 100
LKIVDERTGN EYQVPVSEHG TVKTVDLKKI TTGKDDKGLN LYDPGYLNTA
110 120 130 140 150
PVRSSISYID GDEGILRYRG YPVEELAEKS TYTEVTYLLI YGNLPSQRQL
160 170 180 190 200
ADWEFAISQN SAVPQGVLDM IQSMPNDVHP VGALVTAMSA LSIFYPDANP
210 220 230 240 250
SLMGLGVYKS KQVRDKQIVR VLGQAPTIAA AAYLRKAGKP PVQPLSNLSY
260 270 280 290 300
SENFLYMVES MGDRSYKPNP RLARVLDILF ILQAEHEMNC STAAARHLSS
310 320 330 340 350
SGGDVYTAVS GGVGAIYGPL HGGAVEATIN MLSEIGTVEN IPEFIESVKN
360 370 380 390 400
KKRRLSGFGH RIYKNYDPRG KVVKKLADEV FSILGRDPLV EVGDALEKAA
410 420 430 440 450
LSDEYFVKRK LYPNVDFYSG LINRAMGIPS SFTAVSRIAG YLSHWRESLD
460 470 480
DPDTKIMRPQ QVYTGAGIRH YETVRERTKL
Length:480
Mass (Da):52,895
Last modified:October 1, 2000 - v1
Checksum:i51E680C04B438C92
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353032 Genomic DNA. Translation: CAB88291.1.
CP002686 Genomic DNA. Translation: AEE79825.1.
AY099611 mRNA. Translation: AAM20462.1.
BT002169 mRNA. Translation: AAN72180.1.
PIRiT49157.
RefSeqiNP_191433.1. NM_115736.2.

Genome annotation databases

EnsemblPlantsiAT3G58740.1; AT3G58740.1; AT3G58740.
GeneIDi825043.
KEGGiath:AT3G58740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353032 Genomic DNA. Translation: CAB88291.1 .
CP002686 Genomic DNA. Translation: AEE79825.1 .
AY099611 mRNA. Translation: AAM20462.1 .
BT002169 mRNA. Translation: AAN72180.1 .
PIRi T49157.
RefSeqi NP_191433.1. NM_115736.2.

3D structure databases

ProteinModelPortali Q9LXS7.
SMRi Q9LXS7. Positions 59-477.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 10358. 1 interaction.
IntActi Q9LXS7. 1 interaction.
STRINGi 3702.AT3G58740.1-P.

Proteomic databases

PaxDbi Q9LXS7.
PRIDEi Q9LXS7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G58740.1 ; AT3G58740.1 ; AT3G58740 .
GeneIDi 825043.
KEGGi ath:AT3G58740.

Organism-specific databases

TAIRi AT3G58740.

Phylogenomic databases

eggNOGi COG0372.
HOGENOMi HOG000021224.
InParanoidi Q9LXS7.
KOi K01647.
OMAi IFYPDAN.
PhylomeDBi Q9LXS7.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .
BioCyci ARA:AT3G58740-MONOMER.
Reactomei REACT_242439. Citric acid cycle (TCA cycle).

Gene expression databases

Genevestigatori Q9LXS7.

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF001369. Citrate_synth. 1 hit.
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Arabidopsis peroxisomal citrate synthase is required for fatty acid respiration and seed germination."
    Pracharoenwattana I., Cornah J.E., Smith S.M.
    Plant Cell 17:2037-2048(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCISY1_ARATH
AccessioniPrimary (citable) accession number: Q9LXS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3