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Q9LXS6

- CISY2_ARATH

UniProt

Q9LXS6 - CISY2_ARATH

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Protein

Citrate synthase 2, peroxisomal

Gene
CSY2, At3g58750, T20N10.100
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Peroxisomal citrate synthase required for the fatty acid respiration in seedlings, citrate being exported from peroxisomes into mitochondria during respiration of triacylglycerol (TAG). Indeed, complete respiration requires the transfer of carbon in the form of citrate from the peroxisome to the mitochondria.1 Publication

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei324 – 3241 By similarity
Active sitei363 – 3631 By similarity
Active sitei419 – 4191 By similarity

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: TAIR

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. fatty acid beta-oxidation Source: TAIR
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciARA:AT3G58750-MONOMER.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase 2, peroxisomal (EC:2.3.3.16)
Gene namesi
Name:CSY2
Ordered Locus Names:At3g58750
ORF Names:T20N10.100
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G58750.

Subcellular locationi

Peroxisome 1 Publication

GO - Cellular componenti

  1. peroxisome Source: TAIR
  2. plasmodesma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 514Citrate synthase 2, peroxisomalPRO_0000005482
Transit peptidei1 – ?Peroxisome Reviewed prediction

Proteomic databases

PaxDbiQ9LXS6.
PRIDEiQ9LXS6.

Expressioni

Tissue specificityi

Widely expressed. Expressed throughout the shoot. Expressed in flower, silique, stem, cauline leaf, young leaf, mature leaf and senescent leaf.1 Publication

Developmental stagei

Expressed throughout seedling growth.1 Publication

Gene expression databases

GenevestigatoriQ9LXS6.

Interactioni

Protein-protein interaction databases

BioGridi10359. 5 interactions.
IntActiQ9LXS6. 4 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ9LXS6.
SMRiQ9LXS6. Positions 62-484.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000021224.
InParanoidiQ9LXS6.
KOiK01647.
OMAiKFPTIVA.
PhylomeDBiQ9LXS6.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LXS6-1 [UniParc]FASTAAdd to Basket

« Hide

MEISQRVKAR LAVLTAHLAV SDTVGLEQVL PAIAPWCTSA HITAAPHGSL    50
KGNLTIVDER TGKKYQVPVS EHGTVKAVDL KKITTGKDDK GLKLYDPGYL 100
NTAPVRSSIC YIDGDEGILR YRGYPIEELA ESSTFIEVAY LLMYGNLPSQ 150
SQLADWEFTV SQHSAVPQGV LDIIQSMPHD AHPMGVLVSA MSALSIFHPD 200
ANPALSGQDI YKSKQVRDKQ IVRILGKAPT IAAAAYLRTA GRPPVLPSAN 250
LSYSENFLYM LDSMGNRSYK PNPRLARVLD ILFILHAEHE MNCSTAAARH 300
LASSGVDVYT ACAGAVGALY GPLHGGANEA VLKMLAEIGT AENIPDFIEG 350
VKNRKRKMSG FGHRVYKNYD PRAKVIKKLA DEVFSIVGRD PLIEVAVALE 400
KAALSDEYFV KRKLYPNVDF YSGLIYRAMG FPPEFFTVLF AVPRMAGYLS 450
HWRESLDDPD TRIMRPQQAY TGVWMRHYEP VRERTLSSDS DKDKFGQVSI 500
SNASRRRLAG SSAL 514
Length:514
Mass (Da):56,603
Last modified:October 1, 2000 - v1
Checksum:i1226E3B4AFF662B7
GO

Sequence cautioni

The sequence BAD93857.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL353032 Genomic DNA. Translation: CAB88292.1.
CP002686 Genomic DNA. Translation: AEE79826.1.
BT015884 mRNA. Translation: AAU95420.1.
BT020195 mRNA. Translation: AAV59261.1.
AK220724 mRNA. Translation: BAD93857.1. Different initiation.
PIRiT49158.
RefSeqiNP_191434.1. NM_115737.2.

Genome annotation databases

EnsemblPlantsiAT3G58750.1; AT3G58750.1; AT3G58750.
GeneIDi825044.
KEGGiath:AT3G58750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL353032 Genomic DNA. Translation: CAB88292.1 .
CP002686 Genomic DNA. Translation: AEE79826.1 .
BT015884 mRNA. Translation: AAU95420.1 .
BT020195 mRNA. Translation: AAV59261.1 .
AK220724 mRNA. Translation: BAD93857.1 . Different initiation.
PIRi T49158.
RefSeqi NP_191434.1. NM_115737.2.

3D structure databases

ProteinModelPortali Q9LXS6.
SMRi Q9LXS6. Positions 62-484.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 10359. 5 interactions.
IntActi Q9LXS6. 4 interactions.

Proteomic databases

PaxDbi Q9LXS6.
PRIDEi Q9LXS6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G58750.1 ; AT3G58750.1 ; AT3G58750 .
GeneIDi 825044.
KEGGi ath:AT3G58750.

Organism-specific databases

TAIRi AT3G58750.

Phylogenomic databases

eggNOGi COG0372.
HOGENOMi HOG000021224.
InParanoidi Q9LXS6.
KOi K01647.
OMAi KFPTIVA.
PhylomeDBi Q9LXS6.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .
BioCyci ARA:AT3G58750-MONOMER.

Gene expression databases

Genevestigatori Q9LXS6.

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF001369. Citrate_synth. 1 hit.
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Arabidopsis ORF clones."
    Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.
    Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 408-514.
    Strain: cv. Columbia.
  5. "Arabidopsis peroxisomal citrate synthase is required for fatty acid respiration and seed germination."
    Pracharoenwattana I., Cornah J.E., Smith S.M.
    Plant Cell 17:2037-2048(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCISY2_ARATH
AccessioniPrimary (citable) accession number: Q9LXS6
Secondary accession number(s): Q570I4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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