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Protein

Citrate synthase 2, peroxisomal

Gene

CSY2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Peroxisomal citrate synthase required for the fatty acid respiration in seedlings, citrate being exported from peroxisomes into mitochondria during respiration of triacylglycerol (TAG). Indeed, complete respiration requires the transfer of carbon in the form of citrate from the peroxisome to the mitochondria.1 Publication

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.PROSITE-ProRule annotation

Pathwayi: tricarboxylic acid cycle

This protein is involved in step 1 of the subpathway that synthesizes isocitrate from oxaloacetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Citrate synthase 5, mitochondrial (CSY5), Citrate synthase 1, peroxisomal (CSY1), Citrate synthase 2, peroxisomal (CSY2), Citrate synthase 3, peroxisomal (CSY3), Citrate synthase 4, mitochondrial (CSY4)
  2. Aconitate hydratase 3, mitochondrial (ACO3), Aconitate hydratase 1 (ACO1), Aconitate hydratase 2, mitochondrial (ACO2)
This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei324PROSITE-ProRule annotation1
Active sitei363PROSITE-ProRule annotation1
Active sitei419PROSITE-ProRule annotation1

GO - Molecular functioni

  • citrate (Si)-synthase activity Source: TAIR

GO - Biological processi

  • fatty acid beta-oxidation Source: TAIR
  • tricarboxylic acid cycle Source: UniProtKB-UniPathway

Keywordsi

Molecular functionTransferase
Biological processTricarboxylic acid cycle

Enzyme and pathway databases

BioCyciARA:AT3G58750-MONOMER
UniPathwayiUPA00223; UER00717

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase 2, peroxisomal (EC:2.3.3.16)
Gene namesi
Name:CSY2
Ordered Locus Names:At3g58750
ORF Names:T20N10.100
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G58750
TAIRilocus:2098989 AT3G58750

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000005482? – 514Citrate synthase 2, peroxisomal
Transit peptidei1 – ?PeroxisomeSequence analysis

Proteomic databases

PaxDbiQ9LXS6
PRIDEiQ9LXS6

PTM databases

iPTMnetiQ9LXS6

Expressioni

Tissue specificityi

Widely expressed. Expressed throughout the shoot. Expressed in flower, silique, stem, cauline leaf, young leaf, mature leaf and senescent leaf.1 Publication

Developmental stagei

Expressed throughout seedling growth.1 Publication

Gene expression databases

ExpressionAtlasiQ9LXS6 baseline and differential
GenevisibleiQ9LXS6 AT

Interactioni

Protein-protein interaction databases

BioGridi10359, 5 interactors
IntActiQ9LXS6, 4 interactors
STRINGi3702.AT3G58750.1

Structurei

3D structure databases

ProteinModelPortaliQ9LXS6
SMRiQ9LXS6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2617 Eukaryota
COG0372 LUCA
HOGENOMiHOG000021224
InParanoidiQ9LXS6
KOiK01647
OMAiYGCFLYT
OrthoDBiEOG0936084F
PhylomeDBiQ9LXS6

Family and domain databases

Gene3Di1.10.230.10, 1 hit
1.10.580.10, 2 hits
InterProiView protein in InterPro
IPR016142 Citrate_synth-like_lrg_a-sub
IPR016143 Citrate_synth-like_sm_a-sub
IPR002020 Citrate_synthase
IPR019810 Citrate_synthase_AS
IPR024176 Citrate_synthase_bac-typ
IPR036969 Citrate_synthase_sf
PANTHERiPTHR11739 PTHR11739, 1 hit
PfamiView protein in Pfam
PF00285 Citrate_synt, 1 hit
PIRSFiPIRSF001369 Citrate_synth, 1 hit
PRINTSiPR00143 CITRTSNTHASE
SUPFAMiSSF48256 SSF48256, 1 hit
PROSITEiView protein in PROSITE
PS00480 CITRATE_SYNTHASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9LXS6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEISQRVKAR LAVLTAHLAV SDTVGLEQVL PAIAPWCTSA HITAAPHGSL
60 70 80 90 100
KGNLTIVDER TGKKYQVPVS EHGTVKAVDL KKITTGKDDK GLKLYDPGYL
110 120 130 140 150
NTAPVRSSIC YIDGDEGILR YRGYPIEELA ESSTFIEVAY LLMYGNLPSQ
160 170 180 190 200
SQLADWEFTV SQHSAVPQGV LDIIQSMPHD AHPMGVLVSA MSALSIFHPD
210 220 230 240 250
ANPALSGQDI YKSKQVRDKQ IVRILGKAPT IAAAAYLRTA GRPPVLPSAN
260 270 280 290 300
LSYSENFLYM LDSMGNRSYK PNPRLARVLD ILFILHAEHE MNCSTAAARH
310 320 330 340 350
LASSGVDVYT ACAGAVGALY GPLHGGANEA VLKMLAEIGT AENIPDFIEG
360 370 380 390 400
VKNRKRKMSG FGHRVYKNYD PRAKVIKKLA DEVFSIVGRD PLIEVAVALE
410 420 430 440 450
KAALSDEYFV KRKLYPNVDF YSGLIYRAMG FPPEFFTVLF AVPRMAGYLS
460 470 480 490 500
HWRESLDDPD TRIMRPQQAY TGVWMRHYEP VRERTLSSDS DKDKFGQVSI
510
SNASRRRLAG SSAL
Length:514
Mass (Da):56,603
Last modified:October 1, 2000 - v1
Checksum:i1226E3B4AFF662B7
GO

Sequence cautioni

The sequence BAD93857 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353032 Genomic DNA Translation: CAB88292.1
CP002686 Genomic DNA Translation: AEE79826.1
BT015884 mRNA Translation: AAU95420.1
BT020195 mRNA Translation: AAV59261.1
AK220724 mRNA Translation: BAD93857.1 Different initiation.
PIRiT49158
RefSeqiNP_191434.1, NM_115737.3

Genome annotation databases

EnsemblPlantsiAT3G58750.1; AT3G58750.1; AT3G58750
GeneIDi825044
GrameneiAT3G58750.1; AT3G58750.1; AT3G58750
KEGGiath:AT3G58750

Similar proteinsi

Entry informationi

Entry nameiCISY2_ARATH
AccessioniPrimary (citable) accession number: Q9LXS6
Secondary accession number(s): Q570I4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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