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Protein

Histone deacetylase 17

Gene

HDA17

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 17 (EC:3.5.1.98)
Gene namesi
Name:HDA17
Ordered Locus Names:At3g44490
ORF Names:F14L2.40
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G44490.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002800921 – 158Histone deacetylase 17Add BLAST158

Proteomic databases

PaxDbiQ9LXN8.

Expressioni

Gene expression databases

GenevisibleiQ9LXN8. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G44490.1.

Structurei

3D structure databases

ProteinModelPortaliQ9LXN8.
SMRiQ9LXN8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni3 – 50Histone deacetylaseAdd BLAST48

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi28 – 31Poly-Gly4
Compositional biasi116 – 156Asp-richAdd BLAST41

Sequence similaritiesi

Belongs to the histone deacetylase family.Curated

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
HOGENOMiHOG000112868.
InParanoidiQ9LXN8.
KOiK06067.
OMAiDNEGESH.
PhylomeDBiQ9LXN8.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9LXN8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFSMLFTGH AECVKFVKKF NLPLLVTGGG GYTKENVARC WTVETGILLD
60 70 80 90 100
TELPNEISEN DYIKYFAPDF SLKIPGGHIE NLNTKSYISS IKVQILENLR
110 120 130 140 150
YIQHAPSVQM QEVPPDFYIP DFDEDEQNPD VRVDQRSRDK QIQRDDEYFD

GDNDNDAS
Length:158
Mass (Da):18,116
Last modified:October 1, 2000 - v1
Checksum:iB4C29ACF84F232E0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti58S → P in BT014712 (Ref. 3) Curated1
Sequence conflicti94Q → R in BT014712 (Ref. 3) Curated1
Sequence conflicti133V → A in BT014712 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353818 Genomic DNA. Translation: CAB88531.1.
CP002686 Genomic DNA. Translation: AEE77907.1.
BT014712 mRNA. No translation available.
PIRiT48929.
RefSeqiNP_190035.1. NM_114317.2.
UniGeneiAt.66492.

Genome annotation databases

EnsemblPlantsiAT3G44490.1; AT3G44490.1; AT3G44490.
GeneIDi823574.
GrameneiAT3G44490.1; AT3G44490.1; AT3G44490.
KEGGiath:AT3G44490.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353818 Genomic DNA. Translation: CAB88531.1.
CP002686 Genomic DNA. Translation: AEE77907.1.
BT014712 mRNA. No translation available.
PIRiT48929.
RefSeqiNP_190035.1. NM_114317.2.
UniGeneiAt.66492.

3D structure databases

ProteinModelPortaliQ9LXN8.
SMRiQ9LXN8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G44490.1.

Proteomic databases

PaxDbiQ9LXN8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G44490.1; AT3G44490.1; AT3G44490.
GeneIDi823574.
GrameneiAT3G44490.1; AT3G44490.1; AT3G44490.
KEGGiath:AT3G44490.

Organism-specific databases

TAIRiAT3G44490.

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
HOGENOMiHOG000112868.
InParanoidiQ9LXN8.
KOiK06067.
OMAiDNEGESH.
PhylomeDBiQ9LXN8.

Miscellaneous databases

PROiQ9LXN8.

Gene expression databases

GenevisibleiQ9LXN8. AT.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHDA17_ARATH
AccessioniPrimary (citable) accession number: Q9LXN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.