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Protein

Plant cysteine oxidase 1

Gene

PCO1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Oxidizes N-terminal cysteine residues, thus preparing the protein for N-end rule pathway-mediated proteasomal degradation. Controls the preparation of ERF-VII proteins for degradation via the 26S proteasome. Not active on Cys located inside or at the C-terminus of a peptide. Represses the anaerobic response.1 Publication

Catalytic activityi

L-cysteine + O2 = 3-sulfinoalanine.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi148Iron; catalyticBy similarity1
Metal bindingi150Iron; catalyticBy similarity1
Metal bindingi211Iron; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

  • anaerobic respiration Source: TAIR
  • detection of hypoxia Source: TAIR
  • peptidyl-cysteine oxidation Source: TAIR
  • response to hypoxia Source: TAIR

Keywordsi

Molecular functionOxidoreductase
LigandIron, Metal-binding

Enzyme and pathway databases

ReactomeiR-ATH-1614558 Degradation of cysteine and homocysteine

Names & Taxonomyi

Protein namesi
Recommended name:
Plant cysteine oxidase 11 Publication (EC:1.13.11.20)
Alternative name(s):
Hypoxia-responsive unknown protein 291 Publication
Gene namesi
Name:PCO11 Publication
Synonyms:HUP291 Publication
Ordered Locus Names:At5g15120Imported
ORF Names:F8M21.10Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)Imported
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G15120
TAIRilocus:2150866 AT5G15120

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004324491 – 293Plant cysteine oxidase 1Add BLAST293

Proteomic databases

PaxDbiQ9LXG9

PTM databases

iPTMnetiQ9LXG9

Expressioni

Developmental stagei

Expressed throughout development, with the highest expression in mature siliques and during seed germination.1 Publication

Inductioni

Up-regulated by hypoxia (PubMed:20097791). Up-regulated by the ERF-VII transcription factor RAP2-12 during hypoxia (PubMed:24599061).2 Publications

Gene expression databases

ExpressionAtlasiQ9LXG9 baseline and differential
GenevisibleiQ9LXG9 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G15120.1

Structurei

3D structure databases

ProteinModelPortaliQ9LXG9
SMRiQ9LXG9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cysteine dioxygenase family.Curated

Phylogenomic databases

eggNOGiKOG4281 Eukaryota
ENOG4111Y3H LUCA
HOGENOMiHOG000240285
KOiK10712
OMAiPEDFWCG
OrthoDBiEOG09360JAX
PhylomeDBiQ9LXG9

Family and domain databases

InterProiView protein in InterPro
IPR012864 PCO/ADO
IPR011051 RmlC_Cupin_sf
PfamiView protein in Pfam
PF07847 PCO_ADO, 1 hit
SUPFAMiSSF51182 SSF51182, 1 hit

Sequencei

Sequence statusi: Complete.

Q9LXG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFEMKPEKE VLELISSKNQ CKSNPNSVKK KNKNKNKKMM MTWRRKKIDS
60 70 80 90 100
PADGITAVRR LFNTCKEVFS NGGPGVIPSE DKIQQLREIL DDMKPEDVGL
110 120 130 140 150
TPTMPYFRPN SGVEARSSPP ITYLHLHQCD QFSIGIFCLP PSGVIPLHNH
160 170 180 190 200
PGMTVFSKLL FGTMHIKSYD WVVDAPMRDS KTRLAKLKVD STFTAPCNAS
210 220 230 240 250
ILYPEDGGNM HRFTAITACA VLDVLGPPYC NPEGRHCTYF LEFPLDKLSS
260 270 280 290
EDDDVLSSEE EKEGYAWLQE RDDNPEDHTN VVGALYRGPK VED
Length:293
Mass (Da):33,014
Last modified:October 1, 2000 - v1
Checksum:iEF8037CEABA5E9AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL353993 Genomic DNA Translation: CAB89322.1
CP002688 Genomic DNA Translation: AED92119.1
BT008337 mRNA Translation: AAP37696.1
AK228354 mRNA Translation: BAF00293.1
PIRiT49947
RefSeqiNP_197016.1, NM_121516.4
UniGeneiAt.43329

Genome annotation databases

EnsemblPlantsiAT5G15120.1; AT5G15120.1; AT5G15120
GeneIDi831364
GrameneiAT5G15120.1; AT5G15120.1; AT5G15120
KEGGiath:AT5G15120

Similar proteinsi

Entry informationi

Entry nameiPCO1_ARATH
AccessioniPrimary (citable) accession number: Q9LXG9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 2015
Last sequence update: October 1, 2000
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health