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Q9LXD7

- MYST2_ARATH

UniProt

Q9LXD7 - MYST2_ARATH

Protein

MYST-like histone acetyltransferase 2

Gene

HAG5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Histone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4.1 Publication

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei269 – 2691By similarity
    Active sitei311 – 3111NucleophileBy similarity
    Binding sitei314 – 3141Acetyl-CoABy similarity
    Binding sitei349 – 3491Acetyl-CoABy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri203 – 22523C2HC-typeAdd
    BLAST

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: TAIR
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. DNA repair Source: TAIR
    2. histone acetylation Source: GOC
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW
    4. response to UV-B Source: TAIR
    5. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Acyltransferase, Chromatin regulator, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciARA:AT5G09740-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MYST-like histone acetyltransferase 2 (EC:2.3.1.48)
    Gene namesi
    Name:HAG5
    Ordered Locus Names:At5g09740
    ORF Names:F17I14.70
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G09740.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: TAIR

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 445445MYST-like histone acetyltransferase 2PRO_0000238465Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei269 – 2691N6-acetyllysine; by autocatalysisBy similarity

    Post-translational modificationi

    Autoacetylation at Lys-269 is required for proper function.By similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PRIDEiQ9LXD7.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9LXD7.

    Interactioni

    Protein-protein interaction databases

    BioGridi16112. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9LXD7.
    SMRiQ9LXD7. Positions 172-440.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini74 – 13360ChromoAdd
    BLAST
    Domaini169 – 440272MYST-type HATAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni319 – 3257Acetyl-CoA bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi14 – 4027Pro-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the MYST (SAS/MOZ) family.Curated
    Contains 1 C2HC-type zinc finger.Curated
    Contains 1 chromo domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri203 – 22523C2HC-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5027.
    HOGENOMiHOG000182457.
    InParanoidiQ9LXD7.
    KOiK11308.
    OMAiPPEYNDS.
    PhylomeDBiQ9LXD7.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR002717. MOZ_SAS.
    IPR025995. Tudor-knot.
    IPR015880. Znf_C2H2-like.
    [Graphical view]
    PfamiPF01853. MOZ_SAS. 1 hit.
    PF11717. Tudor-knot. 1 hit.
    [Graphical view]
    SMARTiSM00298. CHROMO. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view]
    SUPFAMiSSF54160. SSF54160. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEiPS51726. MYST_HAT. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9LXD7-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGSSANTETN GNAPPPSSNQ KPPATNGVDG SHPPPPPLTP DQAIIESDPS    50
    KKRKMGMLPL EVGTRVMCRW RDGKHHPVKV IERRRIHNGG QNDYEYYVHY 100
    TEFNRRLDEW TQLDQLDLDS VECAVDEKVE DKVTSLKMTR HQKRKIDETH 150
    IEGHEELDAA SLREHEEFTK VKNISTIELG KYEIETWYFS PFPPEYNDCV 200
    KLFFCEFCLN FMKRKEQLQR HMRKCDLKHP PGDEIYRSGT LSMFEVDGKK 250
    NKVYAQNLCY LAKLFLDHKT LYYDVDLFLF YVLCECDDRG CHMVGYFSKE 300
    KHSEEAYNLA CILTLPSYQR KGYGKFLIAF SYELSKKEGK VGTPERPLSD 350
    LGLLSYRGYW TRVLLEILKK HKGNISIKEL SDVTAIKAED ILSTLQSLEL 400
    IQYRKGQHVI CADPKVLDRH LKAAGRGGLD VDASKLIWTP YKDQS 445
    Length:445
    Mass (Da):51,367
    Last modified:October 1, 2000 - v1
    Checksum:i3BA39F07E2E47C33
    GO
    Isoform 2 (identifier: Q9LXD7-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         135-135: S → N
         172-249: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:367
    Mass (Da):42,007
    Checksum:i74D19D94047E699D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti129 – 1291V → L in AAM63720. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei135 – 1351S → N in isoform 2. 1 PublicationVSP_018609
    Alternative sequencei172 – 24978Missing in isoform 2. 1 PublicationVSP_018610Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL353994 Genomic DNA. Translation: CAB89356.1.
    AB020752 Genomic DNA. Translation: BAB09532.1.
    CP002688 Genomic DNA. Translation: AED91440.1.
    AK117126 mRNA. Translation: BAC41804.1.
    AY086663 mRNA. Translation: AAM63720.1.
    PIRiT49924.
    RefSeqiNP_196536.1. NM_121011.3. [Q9LXD7-1]
    UniGeneiAt.32464.

    Genome annotation databases

    EnsemblPlantsiAT5G09740.1; AT5G09740.1; AT5G09740. [Q9LXD7-1]
    GeneIDi830834.
    KEGGiath:AT5G09740.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL353994 Genomic DNA. Translation: CAB89356.1 .
    AB020752 Genomic DNA. Translation: BAB09532.1 .
    CP002688 Genomic DNA. Translation: AED91440.1 .
    AK117126 mRNA. Translation: BAC41804.1 .
    AY086663 mRNA. Translation: AAM63720.1 .
    PIRi T49924.
    RefSeqi NP_196536.1. NM_121011.3. [Q9LXD7-1 ]
    UniGenei At.32464.

    3D structure databases

    ProteinModelPortali Q9LXD7.
    SMRi Q9LXD7. Positions 172-440.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 16112. 1 interaction.

    Proteomic databases

    PRIDEi Q9LXD7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G09740.1 ; AT5G09740.1 ; AT5G09740 . [Q9LXD7-1 ]
    GeneIDi 830834.
    KEGGi ath:AT5G09740.

    Organism-specific databases

    TAIRi AT5G09740.

    Phylogenomic databases

    eggNOGi COG5027.
    HOGENOMi HOG000182457.
    InParanoidi Q9LXD7.
    KOi K11308.
    OMAi PPEYNDS.
    PhylomeDBi Q9LXD7.

    Enzyme and pathway databases

    BioCyci ARA:AT5G09740-MONOMER.

    Gene expression databases

    Genevestigatori Q9LXD7.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000953. Chromo_domain/shadow.
    IPR016197. Chromodomain-like.
    IPR002717. MOZ_SAS.
    IPR025995. Tudor-knot.
    IPR015880. Znf_C2H2-like.
    [Graphical view ]
    Pfami PF01853. MOZ_SAS. 1 hit.
    PF11717. Tudor-knot. 1 hit.
    [Graphical view ]
    SMARTi SM00298. CHROMO. 1 hit.
    SM00355. ZnF_C2H2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54160. SSF54160. 1 hit.
    SSF55729. SSF55729. 1 hit.
    PROSITEi PS51726. MYST_HAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
      Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
      , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
      Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. "Structural analysis of Arabidopsis thaliana chromosome 5. IX. Sequence features of the regions of 1,011,550 bp covered by seventeen P1 and TAC clones."
      Kaneko T., Katoh T., Sato S., Nakamura Y., Asamizu E., Kotani H., Miyajima N., Tabata S.
      DNA Res. 6:183-195(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: cv. Columbia.
    5. "Full-length cDNA from Arabidopsis thaliana."
      Brover V., Troukhan M., Alexandrov N., Lu Y.-P., Flavell R., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Erasure of histone acetylation by Arabidopsis HDA6 mediates large-scale gene silencing in nucleolar dominance."
      Earley K., Lawrence R.J., Pontes O., Reuther R., Enciso A.J., Silva M., Neves N., Gross M., Viegas W., Pikaard C.S.
      Genes Dev. 20:1283-1293(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes."
      Pandey R., Mueller A., Napoli C.A., Selinger D.A., Pikaard C.S., Richards E.J., Bender J., Mount D.W., Jorgensen R.A.
      Nucleic Acids Res. 30:5036-5055(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION, NOMENCLATURE.

    Entry informationi

    Entry nameiMYST2_ARATH
    AccessioniPrimary (citable) accession number: Q9LXD7
    Secondary accession number(s): Q8GZ97, Q8LCD4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3